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Functional and Metabolic Imaging of the Brain: New Perspectives for Biomedical Imaging, from Physics to Biomedicine Rolf Grütter Centre d'Imagerie BioMédicale, Lausanne, Switzerland This presentation will cover the aspects of modern biomedical imaging as related to the study of brain function and metabolism. Today's biomedical problems increasingly rely on imaging as a crucial means to extract non-invasively increasingly precise information from the living tissue. The comprehensive understanding of the bases and mechanisms leading to characteristic signals (contrast) requires an approach that critically intertwines basic physics research with engineering approaches to (bio)chemistry and medical applications. In the context of addressing important paradigms of neuroscience, such as the role of brain glycogen, the compartmentalized nature of neurotransmitter metabolism between astrocytes and neurons and glucose metabolism, the pluridisciplinary approach shall be illustrated and an outlook of the strategic goal of biomedical imaging initiatives in Switzerland shall be given.