Download A phase 1/2 study of an adjuvanted varicella-zoster virus - E

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Transcript
Humoral, Cellular
and Combined
Immune Response
Humoral:
 ALL but (1) had antigE before vac
 ALL had antigE after vac (4x increase in GMC or 4x Min conc in seroneg)
 peak in the 4th month (but not as high as expected after 2nd vac)
 better response: 3x DOSEs
 AFTER 15th month: 54.5% had antibodies
 DISEASE AFFECTS HUMORAL RESPONSE
Cell-mediated:
 2x increase in CD4+(2+) cells
 BEST 3x AS01B (100%) BUT none did signif. Better!
Combined:
3x gE/AS01B > 2x
AS01B>AS01E
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