Download BDS Ist YEAR EXAMINATION 2008-09

MBBS II (Second) Professional Examination 2012-13
Course Code: MBS201
Paper ID: 0322402
Pathology-I
Time: 2 Hours 40 Minutes
Max Marks: 30
Note: Attempt all questions. Draw proper diagrams to support
your answer.
Part ‘B’
1.
Discuss Apoptosis in detail.
2.
c)
d)
A 42 year old man was referred with 2 weeks history of
fever, gum hypertrophy and bleeding gums. The total
leukocyte count was>1 lakh/cumm.
(1+2+2+2)
What is your diagnosis?
Draw and describe peripheral smear and bone marrow
findings.
Write the WHO classification of the disease.
Describe use of cytochemistry to subtype the disease.
(2x4=8)
a)
b)
c)
d)
Write short notes on:
I.T.P.
Type I Hypersensitivity reaction
Genetic basis of Thalassemia
Metastasis
Describe briefly:
Mechanism of Irreversible injury
Calcification
Embolism
Healing by Primary intention
(2x4=8)
a)
b)
c)
d)
a)
b)
3.
4.
(7)
MBBS II (Second) Professional Examination 2012-13
Roll No.
Student’s Name
Student’s Signature
Invigilator’s Signature
Course Code: MBS201
Paper ID: 0322402
Pathology-I
Part ‘A’
Time: 20 Minutes
Max Marks: 10
Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.
2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed.
3. For answering please use Ball- pen only.
Q.1
Hypertrophy is a type of:
a)
Cell injury
b)
Cellular adaptation
c)
Carcinoma
d)
Cell aging
b)
c)
d)
Q.7
Q.2
Basement membrane
mediated by:
a.
Metalloproteases
b.
Oxidases
c.
Elastasis
d.
Hydrocyclases
Q.3
The commonest mode of inheritance of von
Willebrand’s disease:
a)
Codominant
b)
Autosomal recessive
c)
Autosomal dominant
d)
X-linked recessive
Q.4.
degeneration
is
Most common translocation in follicular
lymphomas:
a)
t 14;18
b)
t 17;19
c)
t 11;14
d)
t 9;22
Q.5
Deficiency of the intrinsic factor causes:
a)
Megaloblastic anemia
b)
Pernicious anemia
c)
Aplastic anemia
d)
Iron deficiency anemia
Q.6
In  - thalassemia there is:
 in  chain,  in alpha chain
a)
 in  -chain,  in alpha chain
 in  -chain,  in alpha chain
 in  -chain,  in alpha chain
The primary defect which leads to sickle
cell anemia is:
a)
An abnormality in porphyrin part of
hemoglobin
b)
Replacement of glutamate by valine
 in chain of Hb A
c)
A nonsense mutation in the  chain
of Hb A
d)
Substitution of valine by glutamate
in the alpha chain of Hb A
Q.8
Osmotic fragility is increased in:
a)
Sickle cell anemia
b)
Thalassemia
c)
Hereditary spherocytosis
d)
Chronic lead poisoning
Q.9
An example of cancer suppressor gene is:
a)
Bcl
b)
P 53
c)
Ras
d)
C -myc
Q.10
When a functional gene is inherited from
one parent only, the condition is know as:
a)
Genomic imprinting
b)
Alleles
c)
Mosacism
d
Chimerism
P.T.O
Q.11
Q.12
All of the enzymes are involved in free
radical scavenger reactions except:
a)
Catalase
b)
Superoxide dismutase
c)
Creatine phosphokinase
d)
Glutathione peroxidase
Which of the following is not a component
of Virchow’s triad:
a)
Activation of coagulation cascade
b)
Endothelial injury
c)
Stasis of blood
d)
Blood hypercoagulability
Q.13
Which of the following is not an oncogenic
DNA virus:
a)
HPV
b)
EBV
c)
HTLV - I
d)
HBV
Q.14
During inflammation, VCAM-1 molecules
on endothelium binds with:
 1 - integrin
a)
b)
Sialyl-Lewis X
c)
L - selectin
 2 - integrin
d)
Q.15
Which of the following vitamins are
involved in formation of collagen:
a)
Vitamin A
b)
Vitamin B
c)
Vitamin C
d)
Vitamin D
Q.16
Which of the following is not a type of
hemolytic anemia?
a)
Hereditary spherocytosis
b)
G6PD deficiency anemia
c)
Thalassemia
d)
Megaloblastic anemia
Q.17
All of the following subtypes of Hodgkin’s
lymphoma are associated with Ebstein Barr
virus infection except:
a)
Mixed cellularity
b)
Lymphocyte rich
c)
Nodular sclerosis
d)
Lymphocyte depletion
Q.18
Genes encoding MHC complex of proteins
are located on:
a)
Chromosome 3
b)
Chromosome 6
c)
Chromosome 9
d)
Chromosome 16
Q.19
All of the following are features of
congenital syphilis except:
a)
Hepar lobatum
b)
Interstitial keratitis
c)
Hutchinson teeth
d)
8th nerve deafness
Q.20
Genetic defect seen in Burkitt lymphoma is:
a)
t(9;22)
b)
t(8;14)
c)
t(15;17)
d)
inv. of chromosome 16