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BI432 Immunology
Exam #2
Winter, 1997
1
Name:
1. ANSWER EITHER “1A” OR “1B”
POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!!
1A. Complete the following table by placing a “D” for DNA in boxes indicating a rearrangement that occurs at
the level of the gene, an “R” for RNA in boxes indicating a rearrangement that occurs at the level of
transcript processing and an “N” for NO in boxes indicating rearrangements that do not occur. (20)
H chain

TCR 
TCR 
LV
VJ
VD
DJ
JC
1B. Complete the following table by placing a “D” for DNA in boxes indicating a source of diversity that
occurs at the level of the gene, an “P” for PROTEIN in boxes indicating a source of diversity that occurs
at the level of the protein and an “N” for NO in boxes indicating a sources of diversity that do not exist.
(20)
H chain

TCR 
TCR 
combinatorial joining
alternative D gene
segment joining
junctional flexibility
somatic mutation
combinatorial
associaton of chains
2. What gene rearrangement, transcription or transcript processing event(s) determine whether the membrane or
secreted forms of the  heavy chain is expressed? (10)
3. ANSWER EITHER “3A” OR “3B”
POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!!
3. A. Diagram a class I MHC antigen and state the cells on which the class I MHC antigen is expressed (10 pts)
3.B. Diagram a class II MHC antigen and state the cells on which the class II MHC antigen is expressed (10 pts)
I am answering question 3_____.
4. Define each of the following and BRIEFLY state the role, if any, of the structure or process in generating
diversity in expression of MHC genes. (15 points)
allelic polymorphism:
cellular expression of MHC peptides
5. Define ONLY TWO of the following terms and state IN ONE SENTENCE the role of the term in antigen
processing. (5 points each)
invariant chain
ubiquitin
transporter of antigenic peptides
BI432 Immunology
Exam #2
Winter, 1997
Name:
6. Several membrane molecules, in addition to the T-cell receptor, are involved in antigen recognition and T
cell activation. Describe the properties and distinct functions of ANY TWO AND ONLY TWO of the
following T-cell membrane molecules (10 points)
CD3
CD 4 and CD8
CD2
7.A. What function is common to NF-B, NF-AT and CD28RC during the activation of TH cells?(7 points)
7.B. How do NF-B, NF-AT and CD28RC differ in their involvement in the activation of TH cells? (8 points)
8. Briefly describe the similarities and differences among cytokines, growth factors and hormones. (10 points)
3
9. ANSWER EITHER “9A” OR “9B”
POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!!
9. A. Complete the following table. (15 pts)
Property
Primary Antibody Response
Secondary Antibody Response
Responding B cell
Lag period following antigen
administration
Time & magnitude of peak antibody
response
Isotype produced
Antigens
Antibody affinity
9. B.. Complete the following table. (15 pts)
Location in lymph node
Paracortex
Primary Follicle
Secondary Follicle Germinal Center:
Dark Zone
Secondary Follicle Germinal Center:
Basal Light Zone
Secondary Follicle Germinal Center:
Apical Light Zone
Secondary Follicle Germinal Center:
Follicular Mantle
Event(s) in B-cell immune response