Engrailed cooperates with extradenticle and homothorax to repress
... complete repression of slp by hs-En. (C) Control to show that TM3 itself does not affect repression of slp by hs-En (genotype hs-En; +/+, stained in parallel with the others). (D) An hth mutant (genotype hthP2/hthP2, distinguishable in the same population as in A by the absence of β-galactosidase st ...
... complete repression of slp by hs-En. (C) Control to show that TM3 itself does not affect repression of slp by hs-En (genotype hs-En; +/+, stained in parallel with the others). (D) An hth mutant (genotype hthP2/hthP2, distinguishable in the same population as in A by the absence of β-galactosidase st ...
gsea user guide
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
Different susceptibility of two animal species infected with isogenic
... strains within a species, have different pathogenicities for different animal hosts. For example, strains of M. tuberculosis are not as virulent as strains of M. bovis in rabbits but both species appear similarly virulent in guinea pigs (Dannenberg & Collins, 2001); and South Indian strains of M. tu ...
... strains within a species, have different pathogenicities for different animal hosts. For example, strains of M. tuberculosis are not as virulent as strains of M. bovis in rabbits but both species appear similarly virulent in guinea pigs (Dannenberg & Collins, 2001); and South Indian strains of M. tu ...
Quantitative analysis of SMN1 and SMN2 genes based on DHPLC
... the disease with onset after the age of 18 months, and with patients gaining the ability to walk. A locus for the three clinical types of SMA was mapped to chromosome 5q13 by linkage analysis [Scheffer et al., 2001; Wirth, 2000] and was refined to the location of the survival motor neuron (SMN) gene ...
... the disease with onset after the age of 18 months, and with patients gaining the ability to walk. A locus for the three clinical types of SMA was mapped to chromosome 5q13 by linkage analysis [Scheffer et al., 2001; Wirth, 2000] and was refined to the location of the survival motor neuron (SMN) gene ...
Ethanol exposure affects gene expression in the embryonic
... Fetal Alcohol Spectrum Disorder (FASD) is a set of developmental malformations caused by alcohol consumption during pregnancy. Fetal Alcohol Syndrome (FAS), the strongest manifestation of FASD, results in short stature, microcephally and facial dysmorphogenesis including microphthalmia. Using Xenopu ...
... Fetal Alcohol Spectrum Disorder (FASD) is a set of developmental malformations caused by alcohol consumption during pregnancy. Fetal Alcohol Syndrome (FAS), the strongest manifestation of FASD, results in short stature, microcephally and facial dysmorphogenesis including microphthalmia. Using Xenopu ...
PDF
... melanogaster embryos, sro1/sroO4-105 trans-heterozygous embryos were collected 6-9 hours AEL, dechorionated and incubated with or without 100 mM 20E for 3 hours as previously described (Ono et al., 2006). After incubation, the embryos were washed and allowed to develop further on agar-apple juice pl ...
... melanogaster embryos, sro1/sroO4-105 trans-heterozygous embryos were collected 6-9 hours AEL, dechorionated and incubated with or without 100 mM 20E for 3 hours as previously described (Ono et al., 2006). After incubation, the embryos were washed and allowed to develop further on agar-apple juice pl ...
GSEA - Bioinformatics Unit
... Enrichment statistic : To calculate the enrichment score, GSEA first walks down the ranked list of genes increasing a running-sum statistic when a gene is in the gene set and decreasing it when it is not. The enrichment score is the maximum deviation from zero encountered during that walk. This para ...
... Enrichment statistic : To calculate the enrichment score, GSEA first walks down the ranked list of genes increasing a running-sum statistic when a gene is in the gene set and decreasing it when it is not. The enrichment score is the maximum deviation from zero encountered during that walk. This para ...
Creating order from chaos: epigenome dynamics in
... activation of TEs (Lippman et al., 2003; Kato et al., 2004). Interestingly, in at least one ...
... activation of TEs (Lippman et al., 2003; Kato et al., 2004). Interestingly, in at least one ...
The splanchnic mesodermal plate directs spleen and
... the pre-splenic rudiment relative to the stomach and pancreatic primordia at the initiation of organogenesis. Histological analysis of late gestation mammalian embryos indicates that the splenic rudiment is recognisable as a single condensation of mesenchyme along the left side of the mesogastrium d ...
... the pre-splenic rudiment relative to the stomach and pancreatic primordia at the initiation of organogenesis. Histological analysis of late gestation mammalian embryos indicates that the splenic rudiment is recognisable as a single condensation of mesenchyme along the left side of the mesogastrium d ...
The splanchnic mesodermal plate directs spleen and
... the pre-splenic rudiment relative to the stomach and pancreatic primordia at the initiation of organogenesis. Histological analysis of late gestation mammalian embryos indicates that the splenic rudiment is recognisable as a single condensation of mesenchyme along the left side of the mesogastrium d ...
... the pre-splenic rudiment relative to the stomach and pancreatic primordia at the initiation of organogenesis. Histological analysis of late gestation mammalian embryos indicates that the splenic rudiment is recognisable as a single condensation of mesenchyme along the left side of the mesogastrium d ...
Perspectives in Diabetes Glucokinase Gene Structure
... isoform generated in the liver ( L l ) differs from those gen- generate the glucokinase activity measured in insulin-proerated in insulin-producing cells (B1 and 82) by sequences ducing cells. It would be surprising if activity of the B1 isoform at the NH,-terminal. This difference accounts for no m ...
... isoform generated in the liver ( L l ) differs from those gen- generate the glucokinase activity measured in insulin-proerated in insulin-producing cells (B1 and 82) by sequences ducing cells. It would be surprising if activity of the B1 isoform at the NH,-terminal. This difference accounts for no m ...
Molecular cloning of a laccase isozyme gene from
... the absorbance spectrum of native laccase. All these copper ions appear to be involved in the catalytic mechanism. Amino acid sequence analysis of different laccases indicates that the copper-binding sites, involving ten-histidine residues, are very highly conserved. Various fungi, several insects ( ...
... the absorbance spectrum of native laccase. All these copper ions appear to be involved in the catalytic mechanism. Amino acid sequence analysis of different laccases indicates that the copper-binding sites, involving ten-histidine residues, are very highly conserved. Various fungi, several insects ( ...
Signaling Pathways of Heme Oxygenase
... broad spectrum and chemical diversity of reagents that induce HO-1 suggests that various signaling pathways are involved in the regulation of this gene such as mitogen-activated protein kinases (MAPK), protein kinase C (PKC), cAMP-dependent protein kinase A (PKA), or cGMP-dependent protein kinase G ...
... broad spectrum and chemical diversity of reagents that induce HO-1 suggests that various signaling pathways are involved in the regulation of this gene such as mitogen-activated protein kinases (MAPK), protein kinase C (PKC), cAMP-dependent protein kinase A (PKA), or cGMP-dependent protein kinase G ...
Regulation of limb bud initiation and limbtype
... fish) development has not been addressed. Significantly, transplantation of wild-type cells that contribute to the somites in raldh2 mutant hosts is sufficient to rescue pectoral fin formation, suggesting that this axial tissue is an important source of RA signal during normal pectoral fin induction (Gib ...
... fish) development has not been addressed. Significantly, transplantation of wild-type cells that contribute to the somites in raldh2 mutant hosts is sufficient to rescue pectoral fin formation, suggesting that this axial tissue is an important source of RA signal during normal pectoral fin induction (Gib ...
C57BL/6 - Envigo
... humans is linked to macular degeneration and other age-related vision loss. Mice with this mutation are nearly blind by the time they are 8 weeks of age. ...
... humans is linked to macular degeneration and other age-related vision loss. Mice with this mutation are nearly blind by the time they are 8 weeks of age. ...
Figures 1
... Several independent groups have shown that ghrelin levels are significantly elevated in hyperphagic older children and adults with PWS before and after meals.8–12 Ghrelin is a potent circulating orexigenic hormone that is produced mainly in the stomach. Circulating ghrelin levels rise after fasting ...
... Several independent groups have shown that ghrelin levels are significantly elevated in hyperphagic older children and adults with PWS before and after meals.8–12 Ghrelin is a potent circulating orexigenic hormone that is produced mainly in the stomach. Circulating ghrelin levels rise after fasting ...
Gene replacement with the human BRCA1 locus
... otherwise lethal phenotype observed in the homozygous Brca17/7 mice. We isolated human BRCA1 protein from these lines and found a correlation between expression level and rescue. Furthermore, the protein was correctly translated and stabilized following exposure to DNA damage. From these results, it ...
... otherwise lethal phenotype observed in the homozygous Brca17/7 mice. We isolated human BRCA1 protein from these lines and found a correlation between expression level and rescue. Furthermore, the protein was correctly translated and stabilized following exposure to DNA damage. From these results, it ...
as Adobe PDF - Edinburgh Research Explorer
... currently too few characterized target genes and CRMs known to make accurate models about Biniou’s direct regulatory role; only three direct target genes have been identified to date. Biniou provides positive feedback regulation to bagpipe during trunk VM specification (Zaffran et al. 2001). The two ...
... currently too few characterized target genes and CRMs known to make accurate models about Biniou’s direct regulatory role; only three direct target genes have been identified to date. Biniou provides positive feedback regulation to bagpipe during trunk VM specification (Zaffran et al. 2001). The two ...
Defining characteristics of Tn5 Transposase non
... A review of current literature reveals evidence of nonspecific DNA binding by transposases (Tnp), site-specific recombinases and retroviral integrases. Two of the three domains of the bacteriophage Mu Tnp (MuA) independently bind DNA non-specifically. Filter binding experiments with proteolytic frag ...
... A review of current literature reveals evidence of nonspecific DNA binding by transposases (Tnp), site-specific recombinases and retroviral integrases. Two of the three domains of the bacteriophage Mu Tnp (MuA) independently bind DNA non-specifically. Filter binding experiments with proteolytic frag ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... nucleosomes could confer an epigenetic mark for gene repression. The constitutive DNA binding of the ATF2/JUND heterodimer to the IL-8 enhancer recruits macroH2A-containing nucleosomes in B cells, thus inhibiting transcriptional activation (Agelopoulos and Thanos, 2006). Heat shock or osmotic stress ...
... nucleosomes could confer an epigenetic mark for gene repression. The constitutive DNA binding of the ATF2/JUND heterodimer to the IL-8 enhancer recruits macroH2A-containing nucleosomes in B cells, thus inhibiting transcriptional activation (Agelopoulos and Thanos, 2006). Heat shock or osmotic stress ...
The amelogenin gene
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
34386 - PubAg
... constants as described for BX1 (10). The Michaelis constant KmIGP of 0.1 mM is ⬇8-fold higher compared with BX1, but the catalytic rate constant kcat of 2.3 s⫺1 is similar for both enzymes. The kcat兾KmIGP of 23 mM⫺1䡠s⫺1 proves that IGL is catalyzing the formation of indole, and is ⬇3 times more effi ...
... constants as described for BX1 (10). The Michaelis constant KmIGP of 0.1 mM is ⬇8-fold higher compared with BX1, but the catalytic rate constant kcat of 2.3 s⫺1 is similar for both enzymes. The kcat兾KmIGP of 23 mM⫺1䡠s⫺1 proves that IGL is catalyzing the formation of indole, and is ⬇3 times more effi ...
An AT-hook gene is required for palea formation and floral organ
... Consistent with this controversy of sepal equivalent organ in rice and other grasses, class A genes in rice remain difficult to determine. Similar to rice, the maize outer whorl organ identity remains elusive that molecular dissection of regulatory pathways has just started (Thompson et al., 2009; Wh ...
... Consistent with this controversy of sepal equivalent organ in rice and other grasses, class A genes in rice remain difficult to determine. Similar to rice, the maize outer whorl organ identity remains elusive that molecular dissection of regulatory pathways has just started (Thompson et al., 2009; Wh ...
Disheveled hair and ear (Dhe) - eScholarship@UMMS
... Mapping the mutation and identifying a destabilizing Lmna mutation Initial mapping of the Dhe mutation was performed in Dr. Benjamin Taylor’s laboratory at The Jackson Laboratory (JAX) in 1994, using the MEV multiple ecotropic provirus linkage testing stock [11,12], and was found to be on mouse Chro ...
... Mapping the mutation and identifying a destabilizing Lmna mutation Initial mapping of the Dhe mutation was performed in Dr. Benjamin Taylor’s laboratory at The Jackson Laboratory (JAX) in 1994, using the MEV multiple ecotropic provirus linkage testing stock [11,12], and was found to be on mouse Chro ...