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The Illinois Bio-Grid: A Software Framework for Industry
... • Correlate protein expression levels to biological function. Use protein or peptide biomarkers to identify disease states in patients. • Use the structure of the relevant proteins as targets for developing new therapeutic techniques (drugs etc..). ...
... • Correlate protein expression levels to biological function. Use protein or peptide biomarkers to identify disease states in patients. • Use the structure of the relevant proteins as targets for developing new therapeutic techniques (drugs etc..). ...
Outline of MALDI mass spectrometric analysis
... MALDI (Matrix-Assisted Laser desorption/ionisation ESI (electrospray ionization) 2. Mass spectrometer (separation based on mass/charge of the protein, m/z ratio) 3. Activation ...
... MALDI (Matrix-Assisted Laser desorption/ionisation ESI (electrospray ionization) 2. Mass spectrometer (separation based on mass/charge of the protein, m/z ratio) 3. Activation ...
AP Ch 03 apchapt3r1
... Commercial brass is an alloy of Cu and Zn. It reacts with HCl by the following reaction. Zn(s) + 2HCl(aq) ZnCl2 (aq) + H2(g) Cu does not react. When 0.5065 g of brass is reacted with excess HCl, 0.0985 g of ZnCl2 are eventually isolated. What is the composition of the brass? ...
... Commercial brass is an alloy of Cu and Zn. It reacts with HCl by the following reaction. Zn(s) + 2HCl(aq) ZnCl2 (aq) + H2(g) Cu does not react. When 0.5065 g of brass is reacted with excess HCl, 0.0985 g of ZnCl2 are eventually isolated. What is the composition of the brass? ...
Module 1 - Hartismere
... = Atomic mass (also known as Relative Atomic Mass/ RAM ) Remember: this is the mass of an atom of a particular element compared with / relative to the mass of an atom of carbon-12. This number is different for each element and you get it straight from the periodic table box (it’s the bigger of the 2 ...
... = Atomic mass (also known as Relative Atomic Mass/ RAM ) Remember: this is the mass of an atom of a particular element compared with / relative to the mass of an atom of carbon-12. This number is different for each element and you get it straight from the periodic table box (it’s the bigger of the 2 ...
Unit 12 Math and Moles
... –Under the same conditions of temperature and pressure, equal volumes of two different gases will have the same number of particles regardless of mass. –At STP, this number of particles is Avogadro’s number or 6.02 x 1023 or 1 mole ...
... –Under the same conditions of temperature and pressure, equal volumes of two different gases will have the same number of particles regardless of mass. –At STP, this number of particles is Avogadro’s number or 6.02 x 1023 or 1 mole ...
Chapter 3 Review: Mass Relationships in Chemical Reactions Will
... Law of conservation of mass: Matter can neither be created nor destroyed, just changed in form. Equations need to be balanced in order to satisfy this law. Balancing tips: Never start with (H) or (O). Treat polyatomic ions as chunks not separate atoms. 12. Interpret the meaning of chemical equ ...
... Law of conservation of mass: Matter can neither be created nor destroyed, just changed in form. Equations need to be balanced in order to satisfy this law. Balancing tips: Never start with (H) or (O). Treat polyatomic ions as chunks not separate atoms. 12. Interpret the meaning of chemical equ ...
Supplemental Methods
... Recovered amino acids were derivatized to the N-heptafluorobutyryl n-propyl esters, dissolved in ethyl acetate, and analyzed by a GC-MS (Agilent 5973 mass spectrometer coupled to an Agilent 6890 gas chromatograph) in the methane-negative chemical ionization mode with selective ion monitoring at m/z ...
... Recovered amino acids were derivatized to the N-heptafluorobutyryl n-propyl esters, dissolved in ethyl acetate, and analyzed by a GC-MS (Agilent 5973 mass spectrometer coupled to an Agilent 6890 gas chromatograph) in the methane-negative chemical ionization mode with selective ion monitoring at m/z ...
Metalloprotein/Metallocofactor Mass Spectrometry
... • Carbon is by definition 12.000000. • Using this standard, mass spectrometrist realized that no other atom mass ends in “.000000 • Nuclei that are more stable than carbon weigh a bit less (32S “weighs” 31.97 Da), and less stable weight a bit more (226Rn, with a few millisecond halflife, “weighs” ...
... • Carbon is by definition 12.000000. • Using this standard, mass spectrometrist realized that no other atom mass ends in “.000000 • Nuclei that are more stable than carbon weigh a bit less (32S “weighs” 31.97 Da), and less stable weight a bit more (226Rn, with a few millisecond halflife, “weighs” ...
: BIOGRAPHICAL SKETCH
... Recently, Dr. Lim’s research is more focused on the cancer biomarker discovery. She is developing independent and significant predictive measures of tumor behavior for head and neck squamous cell carcinoma and hepatocellular carcinoma. Quantitative measurements of protein expression either in tiss ...
... Recently, Dr. Lim’s research is more focused on the cancer biomarker discovery. She is developing independent and significant predictive measures of tumor behavior for head and neck squamous cell carcinoma and hepatocellular carcinoma. Quantitative measurements of protein expression either in tiss ...
Protocol S3 – Proteomic analysis
... trypsin, Applied Biosciences cat# 2-3127-00) was added and the samples incubated with gentle shaking overnight at 30ºC. The peptide mixtures were then acidified with formic acid and loaded using an autosampler onto a 150-μm inner diameter microcapillary fused silica column packed with ~10 cm of reve ...
... trypsin, Applied Biosciences cat# 2-3127-00) was added and the samples incubated with gentle shaking overnight at 30ºC. The peptide mixtures were then acidified with formic acid and loaded using an autosampler onto a 150-μm inner diameter microcapillary fused silica column packed with ~10 cm of reve ...
UNIT 2 – Chemical Quantities
... Ex 3. During WWI, chlorine gas was used as a weapon. When chlorine gas enters the lungs it reacts with water and forms corrosive hydrochloric acid and oxygen gas. How many molecules of chlorine react to produce 5.0g of HCl? ...
... Ex 3. During WWI, chlorine gas was used as a weapon. When chlorine gas enters the lungs it reacts with water and forms corrosive hydrochloric acid and oxygen gas. How many molecules of chlorine react to produce 5.0g of HCl? ...
2007 - Thompson Rivers University
... 22. The Montreal Protocol effectively reduced the use of chlorofluorocarbons (CFCs) and manufacturers have developed hydrofluorocarbons (HFCs) as an alternative. HFC-134a is a popular one, with the formula C2H2F4. The percent fluorine by mass in HFC-134a is: (a) (b) (c) → (d) ...
... 22. The Montreal Protocol effectively reduced the use of chlorofluorocarbons (CFCs) and manufacturers have developed hydrofluorocarbons (HFCs) as an alternative. HFC-134a is a popular one, with the formula C2H2F4. The percent fluorine by mass in HFC-134a is: (a) (b) (c) → (d) ...
Attachment: Click to download
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams Use atomic mass units. an atomic mass unit (amu) is one twelfth the mass of a carbon-12 atom This gives us a basis for comparison The decimal numbers on the table are atomic masses in amu ...
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams Use atomic mass units. an atomic mass unit (amu) is one twelfth the mass of a carbon-12 atom This gives us a basis for comparison The decimal numbers on the table are atomic masses in amu ...
Document
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams Use atomic mass units. an atomic mass unit (amu) is one twelfth the mass of a carbon-12 atom This gives us a basis for comparison The decimal numbers on the table are atomic masses in amu ...
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams Use atomic mass units. an atomic mass unit (amu) is one twelfth the mass of a carbon-12 atom This gives us a basis for comparison The decimal numbers on the table are atomic masses in amu ...
Microsoft Word
... capillary electrophoresis, nuclear magnetic resonance, use of chiral reagents in chromatography, etc. Although mass spectrometry was originally thought of as a chirally blind technique, now it represents as a powerful analytical tool for differentiating enantiomeric compounds through their interacti ...
... capillary electrophoresis, nuclear magnetic resonance, use of chiral reagents in chromatography, etc. Although mass spectrometry was originally thought of as a chirally blind technique, now it represents as a powerful analytical tool for differentiating enantiomeric compounds through their interacti ...
P F I
... Network to serve the Lead Institution and research throughout the state as part of the IDeA Program mission of building research infrastructure. The facility provides a central resource of mass spectrometry-based proteomics technologies to identify, characterize and quantify target proteins in vario ...
... Network to serve the Lead Institution and research throughout the state as part of the IDeA Program mission of building research infrastructure. The facility provides a central resource of mass spectrometry-based proteomics technologies to identify, characterize and quantify target proteins in vario ...
Mole Relationships in chemistry
... based on two laws from Joseph-Louis Proust in 1797 O The Law of Definite Proportions O This states that compounds always have a definite proportion of ...
... based on two laws from Joseph-Louis Proust in 1797 O The Law of Definite Proportions O This states that compounds always have a definite proportion of ...
Chapter 3 Zumdahl
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams. Use atomic mass units. an atomic mass unit (amu) is one twelth the mass of a carbon-12 atom. This gives us a basis for comparison. The decimal numbers on the table are atomic masses in amu. ...
... Atomic Mass Atoms are so small, it is difficult to discuss how much they weigh in grams. Use atomic mass units. an atomic mass unit (amu) is one twelth the mass of a carbon-12 atom. This gives us a basis for comparison. The decimal numbers on the table are atomic masses in amu. ...
MS - eLisa UGM
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
Document
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
Document
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
... 1960’s by Malcolm Dole but put into practice in 1980’s by John Fenn (Yale) • MALDI first introduced in 1985 by Franz Hillenkamp and Michael Karas (Frankfurt) • Made it possible to analyze large molecules via inexpensive mass analyzers such as quadrupole, ion trap and TOF ...
Mass spectrometry
Mass spectrometry (MS) is an analytical chemistry technique that helps identify the amount and type of chemicals present in a sample by measuring the mass-to-charge ratio and abundance of gas-phase ions.A mass spectrum (plural spectra) is a plot of the ion signal as a function of the mass-to-charge ratio. The spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical structures of molecules, such as peptides and other chemical compounds. Mass spectrometry works by ionizing chemical compounds to generate charged molecules or molecule fragments and measuring their mass-to-charge ratios.In a typical MS procedure, a sample, which may be solid, liquid, or gas, is ionized, for example by bombarding it with electrons. This may cause some of the sample's molecules to break into charged fragments. These ions are then separated according to their mass-to-charge ratio, typically by accelerating them and subjecting them to an electric or magnetic field: ions of the same mass-to-charge ratio will undergo the same amount of deflection. The ions are detected by a mechanism capable of detecting charged particles, such as an electron multiplier. Results are displayed as spectra of the relative abundance of detected ions as a function of the mass-to-charge ratio. The atoms or molecules in the sample can be identified by correlating known masses to the identified masses or through a characteristic fragmentation pattern.