Classification Scheme of Eukaryotic Transcription Factors
... (see below). In most c1asses, subgrouping into families is evident. Thus, within the bZIP class the distinction between AP-I-, CREB-, and C/EBP-like cornponents is obvious from structural and functional considerations. In many cases, they should be classified further into subfamilies, whereas in oth ...
... (see below). In most c1asses, subgrouping into families is evident. Thus, within the bZIP class the distinction between AP-I-, CREB-, and C/EBP-like cornponents is obvious from structural and functional considerations. In many cases, they should be classified further into subfamilies, whereas in oth ...
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... splice was expressed predominantly in testis. The C2 splice had a more general expression pattern. Therefore, in addition to the distinct features revealed by amino acid sequences, these splice variants also were expressed in a tissue-specific manner. Because the N0 splice contained sequences shared ...
... splice was expressed predominantly in testis. The C2 splice had a more general expression pattern. Therefore, in addition to the distinct features revealed by amino acid sequences, these splice variants also were expressed in a tissue-specific manner. Because the N0 splice contained sequences shared ...
Bone Morphogenetic protein-4 active
... Recombinant Human Bone Morphogenetic Protein -4 (rh BMP-4) Synonyms: BMP2B. Introduction: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the TGF-beta superfamily which includes large families of growth and differentiation factors. Bone morphoge ...
... Recombinant Human Bone Morphogenetic Protein -4 (rh BMP-4) Synonyms: BMP2B. Introduction: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the TGF-beta superfamily which includes large families of growth and differentiation factors. Bone morphoge ...
Detection of plum pox potyviral protein–protein interactions in planta
... in FRQI) and the C-terminal part (D in FDFY) of the CPs, which are important for the assembly of particles. However, neither the core nor the C-terminal region was determined to be necessary for the physical self-interaction of the CPs in SMV-G7H (Kang et al., 2006) and PPV. This may indicate that t ...
... in FRQI) and the C-terminal part (D in FDFY) of the CPs, which are important for the assembly of particles. However, neither the core nor the C-terminal region was determined to be necessary for the physical self-interaction of the CPs in SMV-G7H (Kang et al., 2006) and PPV. This may indicate that t ...
12551_2008_5_MOESM1_ESM - Springer Static Content Server
... of the N- and C-terminal domains and the predicted structure and function of the Cterminal domains of type I and II chains. J Struct Biol 122: 67-75 The sequence immediately C-terminal to the rod domain in keratin intermediate filament chains is predicted to form a four-stranded antiparallel pleated ...
... of the N- and C-terminal domains and the predicted structure and function of the Cterminal domains of type I and II chains. J Struct Biol 122: 67-75 The sequence immediately C-terminal to the rod domain in keratin intermediate filament chains is predicted to form a four-stranded antiparallel pleated ...
Leukaemia Section inv(16)(p13q22) t(16;16)(p13;q22) del(16)(q22)
... basophilic granules, NASCA+, in the bone marrow (but normal in blood: this M4 do not show the ‘eo’ characteristic in blood). Prognosis High CR rate; better prognosis than most other ANLL; median survival may be 5 yrs. ...
... basophilic granules, NASCA+, in the bone marrow (but normal in blood: this M4 do not show the ‘eo’ characteristic in blood). Prognosis High CR rate; better prognosis than most other ANLL; median survival may be 5 yrs. ...
Proteomic analyses of the time course responses of mice infected
... using MALDI-TOF MS. The results of the protein identification analysis are shown in Table 3. These data revealed that multiple immunogenic proteins at different locations on 2DE-immunoblotting showed diverse Mr and pI values and were correlated with theoretical values. Evidence of the subcellular lo ...
... using MALDI-TOF MS. The results of the protein identification analysis are shown in Table 3. These data revealed that multiple immunogenic proteins at different locations on 2DE-immunoblotting showed diverse Mr and pI values and were correlated with theoretical values. Evidence of the subcellular lo ...
Protein methylation at the surface and buried deep
... Protein lysine methylation: not just for histones Although most protein lysine methyltransferases are SETdomain family members [4,9], there is an increasing number of seven-beta-strand enzymes being reported that catalyze similar reactions [16–19]. These enzymes result in the formation of monomethyl ...
... Protein lysine methylation: not just for histones Although most protein lysine methyltransferases are SETdomain family members [4,9], there is an increasing number of seven-beta-strand enzymes being reported that catalyze similar reactions [16–19]. These enzymes result in the formation of monomethyl ...
Amino acid substitutions that specifically impair the transcriptional
... HPV types. As affinity ligands, we used the TADs of HPV11 E2 (amino acids 1–209) and HPV31 E2 (amino acids 1–208), which we expressed and purified from bacteria as fusion proteins with glutathione-S-transferase (GST). These purified proteins are shown in Fig. 1C. First, we prepared a 40 μl affinity ...
... HPV types. As affinity ligands, we used the TADs of HPV11 E2 (amino acids 1–209) and HPV31 E2 (amino acids 1–208), which we expressed and purified from bacteria as fusion proteins with glutathione-S-transferase (GST). These purified proteins are shown in Fig. 1C. First, we prepared a 40 μl affinity ...
2-D Quant Kit - GE Healthcare Life Sciences
... humans or animals. Do not use internally or externally in humans or animals. ...
... humans or animals. Do not use internally or externally in humans or animals. ...
Structure and Function of the Groucho Gene Family and Encoded
... protein functions as a promoter-bound repressor; specifically, an intact bHLH region is required for the Hairy protein to bind to specific DNA sites, where it then uses its WRPW motif to recruit the Groucho corepressor protein. The Groucho protein, once recruited as a non-DNA binding corepressor, ca ...
... protein functions as a promoter-bound repressor; specifically, an intact bHLH region is required for the Hairy protein to bind to specific DNA sites, where it then uses its WRPW motif to recruit the Groucho corepressor protein. The Groucho protein, once recruited as a non-DNA binding corepressor, ca ...
Proteomic capacity of recent fluorescent dyes for
... up to 40%. The two other fluorescent dyes displayed an intermediary distribution. On the other hand, the second population showed higher variability with variation coefficients amounting to 50–60% whatever the dye. This minor population included spots covering all the range of molecular weight, and was ...
... up to 40%. The two other fluorescent dyes displayed an intermediary distribution. On the other hand, the second population showed higher variability with variation coefficients amounting to 50–60% whatever the dye. This minor population included spots covering all the range of molecular weight, and was ...
Light-dependent Dl Protein Synthesis and Translocation Is
... bind are found not only in the pure stromal membrane fraction (144 K) as in higher plants (7, 13) but also in the intermediate fraction (40 K) and to some extent also in the grana fraction as isolated by the method (15) used in this work. Therefore, in view of this difference and considering the res ...
... bind are found not only in the pure stromal membrane fraction (144 K) as in higher plants (7, 13) but also in the intermediate fraction (40 K) and to some extent also in the grana fraction as isolated by the method (15) used in this work. Therefore, in view of this difference and considering the res ...
Review Structural glycobiology: A game of snakes and ladders
... Computational docking methods have evolved to help overcome difficulties in obtaining experimental 3D structures of multiple ligands to a common receptor. Docking strategies can utilize experimental or modeled protein structures to aid in the discovery new lead compounds for drug design. In the fiel ...
... Computational docking methods have evolved to help overcome difficulties in obtaining experimental 3D structures of multiple ligands to a common receptor. Docking strategies can utilize experimental or modeled protein structures to aid in the discovery new lead compounds for drug design. In the fiel ...
Dm1-MMP, a Matrix Metalloproteinase from Drosophila with a
... residue that distinguishes MMPs from other metalloproteinases. This catalytic domain also has a Met residue seven residues COOH-terminal to the zinc-binding site, conserved in all MMPs and proposed to play an essential role in the structure of the active sites of these enzymes (37). Finally, the ded ...
... residue that distinguishes MMPs from other metalloproteinases. This catalytic domain also has a Met residue seven residues COOH-terminal to the zinc-binding site, conserved in all MMPs and proposed to play an essential role in the structure of the active sites of these enzymes (37). Finally, the ded ...
cytoplasm nucleus and the A specific subset of
... ongoing transcription and is not mediated by a canonical nuclear localization signal. A carboxy-terminal sequence in hnRNP A1, termed M9, which is involved in both nuclear import and export, has been identified (Michael et al. 1995b; Siomi and Dreyfuss 1995; Weighardt et al. 1995). It has been shown ...
... ongoing transcription and is not mediated by a canonical nuclear localization signal. A carboxy-terminal sequence in hnRNP A1, termed M9, which is involved in both nuclear import and export, has been identified (Michael et al. 1995b; Siomi and Dreyfuss 1995; Weighardt et al. 1995). It has been shown ...
subunits of Snf1 kinase are required for kinase function and
... protein kinase domain at the N-terminus and a regulatory domain at the C-terminus. The presence and sequence of the regulatory domain is one feature that distinguishes the Snf1 family from other protein kinases. The kinase domain of Snf1 is most closely related to the CaMK subfamily of protein kinas ...
... protein kinase domain at the N-terminus and a regulatory domain at the C-terminus. The presence and sequence of the regulatory domain is one feature that distinguishes the Snf1 family from other protein kinases. The kinase domain of Snf1 is most closely related to the CaMK subfamily of protein kinas ...
Function of Conserved Tryptophans in the Aspergillus niger
... residues of G1 are important for fully functional starch binding. Large deletions of SBD residues result in alteration of the folding and stability properties of the protein and eliminate ligand binding. Recently, the solution structure of the G1 SBD has been solved by nuclear magnetic resonance (NM ...
... residues of G1 are important for fully functional starch binding. Large deletions of SBD residues result in alteration of the folding and stability properties of the protein and eliminate ligand binding. Recently, the solution structure of the G1 SBD has been solved by nuclear magnetic resonance (NM ...
Product Specification
... Blk, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. Blk is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted t ...
... Blk, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. Blk is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted t ...
Selective Dimerization of a C2H2 Zinc Finger Subfamily
... fingers comprise a bona fide dimerization domain. Dimerization is highly selective, however, as homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros. Ikaros-Hunchback selectivity is determined by 11 residues concentrate ...
... fingers comprise a bona fide dimerization domain. Dimerization is highly selective, however, as homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros. Ikaros-Hunchback selectivity is determined by 11 residues concentrate ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.