Increased Mesolimbic GABA Concentration Blocks Heroin Self
... Heroin is the most rapidly acting and most abused of the opiates. Unfortunately, its high abuse liability is not matched by effective pharmacological therapy. Currently, the most effective treatment strategy is opiate replacement therapy with methadone or its derivative, l-␣-acetylmethadone. However ...
... Heroin is the most rapidly acting and most abused of the opiates. Unfortunately, its high abuse liability is not matched by effective pharmacological therapy. Currently, the most effective treatment strategy is opiate replacement therapy with methadone or its derivative, l-␣-acetylmethadone. However ...
cortical limbic system: a computational model. PhD thesis. htt
... and made my experience at Glasgow so enjoyable. First and foremost, I would like to thank my supervisor Bernd Porr for believing in me, as well as the guidance he has given throughout the years. His positive energy for science fuelled and motivated me when I was exhausted from hitting walls. I would ...
... and made my experience at Glasgow so enjoyable. First and foremost, I would like to thank my supervisor Bernd Porr for believing in me, as well as the guidance he has given throughout the years. His positive energy for science fuelled and motivated me when I was exhausted from hitting walls. I would ...
“left or right” Decision-making beyond
... conceptual models of decision-making into biophysically realistic systems. These neural network models are then used to simulate and predict neural activity during the choice process. Before getting started by reviewing state of the art experimental and modeling approaches on decision-making, it is ...
... conceptual models of decision-making into biophysically realistic systems. These neural network models are then used to simulate and predict neural activity during the choice process. Before getting started by reviewing state of the art experimental and modeling approaches on decision-making, it is ...
ATLAS OF FUNCTIONAL NEUROANATOMY
... University with an honors program in psychology. His first experimental work was with rats that had lesions of the hippocampus, which was then a little-known area of the brain. At that time, Professor Donald Hebb was the chair of the Psychology Department and was gaining prominence for his theory kn ...
... University with an honors program in psychology. His first experimental work was with rats that had lesions of the hippocampus, which was then a little-known area of the brain. At that time, Professor Donald Hebb was the chair of the Psychology Department and was gaining prominence for his theory kn ...
Virtual dissection and comparative connectivity of the superior
... temporal cortex, particularly the middle temporal gyrus, which plays an important role in semantic representation (Orban et al., 2004; Rilling et al., 2008; Hecht et al., 2013a). Beyond tool-use, actual tool-making involves longer action chains with more complex, abstract goals. There has been relat ...
... temporal cortex, particularly the middle temporal gyrus, which plays an important role in semantic representation (Orban et al., 2004; Rilling et al., 2008; Hecht et al., 2013a). Beyond tool-use, actual tool-making involves longer action chains with more complex, abstract goals. There has been relat ...
Projections of the amygdala to the thalamus in the cynomolgus
... found throughout the medial basal nucleus (Fig. 4).though there was a tendency for them to be concentrated in its medial half. The lateral basal nucleus contained the second highest number of HRP-positive cells in these three monkeys, though there were considerably fewer than in the medial basal nuc ...
... found throughout the medial basal nucleus (Fig. 4).though there was a tendency for them to be concentrated in its medial half. The lateral basal nucleus contained the second highest number of HRP-positive cells in these three monkeys, though there were considerably fewer than in the medial basal nuc ...
Chapter 3 Two parts of nucleus prepositus hypoglossi project to two
... The dorsolateral column of the mesencephalic periaqueductal gray (PAG) is a separate part of the PAG. Its afferent sources, efferent targets and neurochemical properties differ from the adjacent PAG columns. The dorsolateral PAG is thought to be associated with aversive behaviors, but it is not yet ...
... The dorsolateral column of the mesencephalic periaqueductal gray (PAG) is a separate part of the PAG. Its afferent sources, efferent targets and neurochemical properties differ from the adjacent PAG columns. The dorsolateral PAG is thought to be associated with aversive behaviors, but it is not yet ...
Spatial Organization of Facial Vibrissae and Cortical Barrels in the
... proposed by Sikich et al. (1986), who described six rows of mystacial vibrissae, designated A–F in a dorsal to ventral direction, and reported that these rows differ from those of mice and rats in that they are more irregularly aligned with respect to one another. However, this arbitrary nomenclatur ...
... proposed by Sikich et al. (1986), who described six rows of mystacial vibrissae, designated A–F in a dorsal to ventral direction, and reported that these rows differ from those of mice and rats in that they are more irregularly aligned with respect to one another. However, this arbitrary nomenclatur ...
Cadherin Expression by Embryonic Divisions and
... text only. Table 1 lists the immunoreactivity of cad6B, cad7, Rcad, and Ncad for all anatomic structures that were defined in the current study. With the few exceptions noted in the text, cadherin immunoreactivity did not change from E11 to E15 in these structures. In addition to cadherin expression ...
... text only. Table 1 lists the immunoreactivity of cad6B, cad7, Rcad, and Ncad for all anatomic structures that were defined in the current study. With the few exceptions noted in the text, cadherin immunoreactivity did not change from E11 to E15 in these structures. In addition to cadherin expression ...
Calcium homeostasis in aging neurons
... (K d = 100 nM) but a very slow turnover, whereas NCX has a much lower affinity (K d = 1000 nM) but a higher turnover. Both types of transporters are co-expressed in neurons and in astrocytes (DiPolo and Beauge, 1983; Juhaszova et al., 2000). However, the precise role that each plays in removing exces ...
... (K d = 100 nM) but a very slow turnover, whereas NCX has a much lower affinity (K d = 1000 nM) but a higher turnover. Both types of transporters are co-expressed in neurons and in astrocytes (DiPolo and Beauge, 1983; Juhaszova et al., 2000). However, the precise role that each plays in removing exces ...
Social regulation of aggression by pheromonal activation of Or65a
... We found olfactory communication to be important for modulating Drosophila aggression. Although acute exposure to the male-specific pheromone 11-cis-vaccenyl acetate (cVA) elicited aggression through Or67d olfactory receptor neurons (ORNs), chronic cVA exposure reduced aggression through Or65a ORNs. ...
... We found olfactory communication to be important for modulating Drosophila aggression. Although acute exposure to the male-specific pheromone 11-cis-vaccenyl acetate (cVA) elicited aggression through Or67d olfactory receptor neurons (ORNs), chronic cVA exposure reduced aggression through Or65a ORNs. ...
What the young brain tells the spinal cord: top down modulation of
... information in the spinal cord. In adults, the rostroventral medulla (RVM) can inhibit and facilitate somatosensory processing in the adult dorsal horn, providing powerful control of pain behaviours. In neonates, balanced descending control of processing of dorsal horn activity is immature. Here, I ...
... information in the spinal cord. In adults, the rostroventral medulla (RVM) can inhibit and facilitate somatosensory processing in the adult dorsal horn, providing powerful control of pain behaviours. In neonates, balanced descending control of processing of dorsal horn activity is immature. Here, I ...
Learning and memory in zebrafish larvae
... Even relatively simple instances of learning in vertebrates can involve complex interactions of hundreds of molecules, each with distinct spatial and temporal kinetics, as well as neural circuits containing hundreds to thousands of neurons, and thousands to tens of thousands of synapses, which must ...
... Even relatively simple instances of learning in vertebrates can involve complex interactions of hundreds of molecules, each with distinct spatial and temporal kinetics, as well as neural circuits containing hundreds to thousands of neurons, and thousands to tens of thousands of synapses, which must ...
REGENERATION OF AN IDENTIFIED CENTRAL NEURON IN THE
... duced beneath. With this procedure no nerves or trachnerves entering or leaving the terminal ganglion, such as eoles entering the ganglion were cut. For intracellular the cereal nerve or the central connectives. Within a few recordings from the MGI soma located on the lateral days post-axotomy, many ...
... duced beneath. With this procedure no nerves or trachnerves entering or leaving the terminal ganglion, such as eoles entering the ganglion were cut. For intracellular the cereal nerve or the central connectives. Within a few recordings from the MGI soma located on the lateral days post-axotomy, many ...
the properties and neural substrate of eye movements
... and patients may experience oscillopsia— illusory movement of their visual environment (see Video Display: Treatments for Nystagmus). Just how steadily must images of the world be held on the retina for vision to remain clear and stable? The amount of retinal image motion that can be tolerated befor ...
... and patients may experience oscillopsia— illusory movement of their visual environment (see Video Display: Treatments for Nystagmus). Just how steadily must images of the world be held on the retina for vision to remain clear and stable? The amount of retinal image motion that can be tolerated befor ...
Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have
... The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the ...
... The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the ...
The Journal of Neuroscience http://jneurosci.msubmit.net Ana
... These results suggest a complex role of BDNF in maintaining the dendritic and spine morphology of hippocampal neurons and the associated volume of the hippocampal formation. The inability of CRS to modify the dendritic structure of CA3 pyramidal neurons in BDNF+/mice suggests an indirect, perhaps pe ...
... These results suggest a complex role of BDNF in maintaining the dendritic and spine morphology of hippocampal neurons and the associated volume of the hippocampal formation. The inability of CRS to modify the dendritic structure of CA3 pyramidal neurons in BDNF+/mice suggests an indirect, perhaps pe ...
show - FACETS Project
... This report is dedicated to the study of nonlinear bidimensional neuron models, which from a mathematical point of view are hybrid dynamical systems, i.e. whose dynamics is defined by a continuous-time dynamical system modelling the subthreshold behavior of the neuron, coupled with a discrete dynami ...
... This report is dedicated to the study of nonlinear bidimensional neuron models, which from a mathematical point of view are hybrid dynamical systems, i.e. whose dynamics is defined by a continuous-time dynamical system modelling the subthreshold behavior of the neuron, coupled with a discrete dynami ...
Serum kisspeptin levels across different phases of the menstrual
... expression were found in diet-induced obese experimental rats compared with controls.16 Serum concentrations of kisspeptin and oestradiol both increased statistically significantly in the preovulatory phase when compared with the early follicular phase (table 1). Hence, our study indicates that as t ...
... expression were found in diet-induced obese experimental rats compared with controls.16 Serum concentrations of kisspeptin and oestradiol both increased statistically significantly in the preovulatory phase when compared with the early follicular phase (table 1). Hence, our study indicates that as t ...
Might the olfactory bulb be an origin of olfactory auras in focal
... because of divergent neuroanatomical localization, and indeed their relation to epileptic olfactory auras, are unresolved issues. Data are lacking from experimental animals or humans on whether the unique laminated cortical architecture of the olfactory bulb and its synaptic circuitry possess a pote ...
... because of divergent neuroanatomical localization, and indeed their relation to epileptic olfactory auras, are unresolved issues. Data are lacking from experimental animals or humans on whether the unique laminated cortical architecture of the olfactory bulb and its synaptic circuitry possess a pote ...
Central Control of the Cardiovascular and Respiratory Systems and
... control of the cardiovascular system and, more specifically in the present context, in the central nervous and reflex generation of cardiorespiratory interactions. The central theme of this review is the evolution of the mechanisms of integration and coordination that match blood flow to ventilatory ...
... control of the cardiovascular system and, more specifically in the present context, in the central nervous and reflex generation of cardiorespiratory interactions. The central theme of this review is the evolution of the mechanisms of integration and coordination that match blood flow to ventilatory ...
Primary open-angle glaucoma
... field. The disease has an adult onset, with open anterior chamber angles of normal appearance and an absence of other known explanations for the change in the optic nerve. If detected early, disease progression can frequently be arrested or slowed with medical and surgical treatment. Assessment of t ...
... field. The disease has an adult onset, with open anterior chamber angles of normal appearance and an absence of other known explanations for the change in the optic nerve. If detected early, disease progression can frequently be arrested or slowed with medical and surgical treatment. Assessment of t ...
Flint_Chapter 163_main.indd
... about it. Relative to the canal walls, the endolymph effectively moves in the opposite direction as the head. Inside the ampulla, a swelling at the end of the canal where it meets the utricle, pressure exerted by endolymph deflects the cupula, an elastic membrane that spans a crosssection of the amp ...
... about it. Relative to the canal walls, the endolymph effectively moves in the opposite direction as the head. Inside the ampulla, a swelling at the end of the canal where it meets the utricle, pressure exerted by endolymph deflects the cupula, an elastic membrane that spans a crosssection of the amp ...
Central Control of the Cardiovascular and Respiratory Systems
... resides in the central nervous system that integrates afferent inputs from a range of central and peripheral receptors and coordinates central interactions between pools of neurons generating the respiratory rhythm and determining heart rate variability. Thus, although the absence of a heart beat si ...
... resides in the central nervous system that integrates afferent inputs from a range of central and peripheral receptors and coordinates central interactions between pools of neurons generating the respiratory rhythm and determining heart rate variability. Thus, although the absence of a heart beat si ...
Are there three subdivisions in the primate subthalamic nucleus? Max C. Keuken
... With respect to the animal studies, we included studies only on nonhuman primates: just as in humans, the STN in nonhuman primates is a closed nucleus (i.e., dendrites are restricted to the nucleus), in contrast for example to the rat STN (Smith et al., 1990; Marani et al., 2008). With respect to th ...
... With respect to the animal studies, we included studies only on nonhuman primates: just as in humans, the STN in nonhuman primates is a closed nucleus (i.e., dendrites are restricted to the nucleus), in contrast for example to the rat STN (Smith et al., 1990; Marani et al., 2008). With respect to th ...