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LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE (University of London) FACULTY OF INFECTIOUS AND TROPICAL DISEASES Department of Immunology and Infection POST NAME: Malaria Centre Coordinator (0.4 FTE) FURTHER PARTICULARS 1. ADVERTISEMENT Malaria Centre Coordinator We are seeking to appoint a Malaria Centre Coordinator. The Malaria Centre at the London School of Hygiene and Tropical Medicine houses the largest number of malaria researchers, students and support staff in Europe. The Centre is unique in its size and breadth and draws together the diverse research and teaching activities carried out at the School as well as developing tools, techniques and knowledge about malaria, a strong emphasis is placed on translating research outcomes into practice. Centre members also play an instrumental role in the world-class teaching and training of malaria students and professionals across the world. The Centre has a range of facilities that contribute to the diagnosis, treatment and research of malaria. The Coordinator will bring the members together through regular seminars and events and will provide support to research projects in malaria endemic countries. The successful applicant will coordinate the Malaria Centre’s day-to-day activities, often working independently and requiring use of strong initiative to drive activities forward in the absence of the Malaria Centre Director/Deputy Director. Organising and promoting regular meetings and seminars held by the Malaria Centre including annual retreats to which overseas partners are usually invited. Applicants should have experience in budgets, monitoring expenditure & income, and providing quarterly financial statements: Liaising with the Director of the Malaria Centre and Faculty Administrators in respect of monitoring grant submissions and awards to ensure that the Malaria Centre levy is applied for and/or collected. A background in communications would be advantageous as the successful applicant will be working with LSHTM External Relations Department to develop and implement a communications and advocacy strategy for the Malaria Centre and producing educational and other materials as necessary for dissemination to various target audiences. The post is funded by the Wellcome Trust for a period of 1 year and is available as soon as possible. Full time equivalent Salary is £31,756 pro-rata for 0.4 FTE (inclusive of London Weighting). Applications should be made online via our website at jobs.lshtm.ac.uk. The closing date is 20th June 2013 and the reference for this post is MCC13. Online applications will be accepted by the automated system until midnight of the closing date. Any queries regarding the application process may be addressed to [email protected]. The supporting statement section should set out how your qualifications, experience and training meet each of the selection criteria. Please provide one or more paragraphs addressing each criterion. The supporting statement is an essential part of the selection process and thus a failure to provide this information will mean that the application will not be considered. An answer to any of the criteria such as “Please see attached CV” will not be considered acceptable. Please note that if you are shortlisted and are unable to attend on the interview date it may not be possible to offer you an alternative date. The London School of Hygiene & Tropical Medicine is committed to being an equal opportunities employer 2. GENERAL INFORMATION The London School of Hygiene & Tropical Medicine The London School of Hygiene & Tropical Medicine is one of Europe’s leading schools of Public Health and a leading postgraduate institution worldwide for research and postgraduate education in global health. Part of the University of London, the London School is the largest institution of its kind in Europe with a remarkable depth and breadth of expertise encompassing many disciplines. The School was ranked one of the top 3 research institutions in the country in the Times Higher Education’s 'table of excellence', which is based on the 2008 Research Assessment Exercise (RAE). In 2009, the School became the first UK institution to win the Gates Award for Global Health. The School’s environment is a rich multicultural one: there are almost 4000 students from 100+ countries following 22 taught masters courses delivered either in London (~650) or through distance learning (~2700), and undertaking research degree training (~400). Over 40% of these students are from non-European countries. The largest growth has been in distance learning students (>40% over 3 years), though the London-based student population (where accommodation limits growth) is at its highest level ever. Alumni are working in more than 180 countries. The School has about 1500 staff drawn from over 60 nationalities. There are research collaborations with over 100 countries throughout the world, utilizing our critical mass of multidisciplinary expertise which includes clinicians, epidemiologists, statisticians, social scientists, economists, molecular biologists, immunologists, ophthalmologists, anthropologists, virologists, pharmacologists and nutritionists. At any one time around 100 School staff are based overseas, particularly in Africa and Asia. We have a strong commitment to partnership with institutions in low and middle income countries to support the development of teaching and research capacity. The School has expanded greatly in recent years. Its research funding now exceeds £67M per annum, much of it from highly competitive national and international sources. The commitment of staff to methodological rigour, innovative thinking and policy relevance will ensure that the School continues to occupy a leadership position in national and global health, adapting quickly to new challenges and opportunities. Mission To improve health and health equity in the UK and worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice. Faculty of Infectious and Tropical Diseases The Faculty of Infectious and Tropical Diseases encompasses all of the laboratorybased research in the School as well as that on the clinical and epidemiological aspects of infectious and tropical diseases. It is headed by David Mabey, who is Professor of Communicable Diseases. The range of disciplines represented in the faculty is very broad and inter-disciplinary research is a feature of much of our activity. The spectrum of diseases studied is wide and there are major research groups with a focus on malaria, tuberculosis, HIV/AIDS and other sexually transmitted diseases, vaccine development and evaluation, and vector biology and disease control. The Faculty is organised into four large research departments comprising: Pathogen Molecular Biology, Immunology and Infection, Disease Control, and Clinical Research. There is close interaction between scientists in different research teams. The Faculty has strong overseas links, which provide a basis for field studies and international collaborations in developed and developing countries. The teaching programme includes MSc courses, taught in-house and by distance learning, which are modular in structure, a variety of short-courses and an active doctoral programme (PhD and DrPH). Department of Immunology and Infection (Head: Dr Colin Sutherland) Research in the Department of Immunology and Infection centres on analysis of the host response to infection at the molecular, cellular and population levels. The goals are to develop a greater understanding of basic mechanisms of immunological protection versus pathology, and to apply this knowledge to the development of immunological interventions and the identification of correlates of immune status. Our work involves application of state-of-the-art cellular and molecular approaches to the in vitro analysis of pathogen-host cell interactions, to in vivo studies in models and to the study of immunity at the population level in disease endemic areas. Main areas of research include the regulation of acute and chronic inflammation; macrophagepathogen interactions; cellular pharmacology; the production of cytokines during innate and acquired immune responses; T-cell function and antigen recognition; the mechanisms of immunopathology; the development of vaccines; and delivery systems for vaccines and drugs. Current research includes the role of acute phase proteins in resistance to infection, homeostasis and inflammatory disease, mechanisms of macrophage activation, control of cytokine synthesis and mammalian lectin interactions (J. Raynes); intracellular trafficking and secretory pathways of cells of the immune system (T. Ward); the role of innate responses in resistance to the bacterial pathogens, Mycobacterium tuberculosis and Burkholderia pseudomallei, activity and regulation of natural killer cells and their effect on macrophage activation and recruitment, regulation of chemokine receptors during infection and granulomatous tissue responses in the lung against Cryptococcus neoformans and Mycobacterium tuberculosis (G. Bancroft); longitudinal studies on immune correlates of protection against malaria in Uganda and a cluster-randomized trial on the impact of targeted Interventions on malaria transmission in Kenya and Mali (T. Bousema); identification and evaluation of novel drugs and formulations for the treatment of leishmaniasis, malaria, human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease). This research includes projects on miltefosine, AmBisome and topical paromomycin as well as on drug – immune response interactions and PK PD relationships (S Croft); correlates of protection against tuberculosis and studies of BCG vaccination, human CD8+ T-cell responses to mycobacterial antigens and synthetic peptides, use of whole blood assays in immuno-epidemiology (H. Dockrell); innate and adaptive immunity to malaria including activation of natural killer cells, cytokine regulation in clinical immunity and immunopathology, regulation of antibody production and immunoglobulin class switching (E. Riley); induction and regulation of innate and adaptive immune responses to malaria pre-erythrocytic stage and blood stage parasites (J. Hafalla); using anti-malarial antibodies as a marker of malaria exposure & assessment of the use of sero-epidemiology to monitor and target malaria control measures www.seromap.com (C. Drakeley) transmission of Plasmodium falciparum malaria including antibody responses to gametocyte-infected erythrocyte surface antigens, effect of gamete antigen variability on transmission, gametocyte sequestration and development and gametocyticidal drug therapy (C. Sutherland); characterisation of protective immune mechanisms and defined antigens in attenuated vaccine models of schistosomiasis (Q. Bickle); impact of concomitant viral, bacterial, protozoal and helminth infections on induction of immune responses and immunopathology and T cell regulation and induction of mucosal immune responses during intestinal nematode infections (H. Helmby); the immunoregulatory function of L-arginine metabolism in infectious diseases, both experimentally and in endemic areas in Africa, with special emphasis on leishmaniasis and HIV (P Kropf); innate and adaptive immunity to Leishmania infection by sand fly bite including the influence of sand fly saliva and parasite glycoconjugates on macrophage and neutrophil activation, dermal T-cell function, wound response to vector bites and immunoepidemiology of leishmaniasis using antibodies to sand fly saliva as serological markers of vector exposure (M Rogers); anti-protozoal chemotherapy with focus on anti-leishmanial drug discovery and development including drug combinations and drug delivery systems, anti-leishmanial vaccine development and immunotherapies, models for drug and vaccine development and the role of macrophages in context of anti-leishmanial drug treatment (K Seifert); the identification and evaluation of novel drugs and drug delivery systems for leishmaniasis, trypanosomiasis and malaria, interaction between antiprotozoal drugs and the immune response (V. Yardley) (Streptococcus pneumoniae), Bluetongue viral disease of livestock, Herpesviridae, SARS, the hemorrhagic fever virus (RVFV) and the enteric rotavirus that cause significant diarrhoeal disease in infants developing countries. The long-term aim of PMBD research is to gain a fully rounded understanding of the complex and dynamic ways by which pathogens modulate virulence and interact with the human host. Such a holistic approach will vastly increase the scope for the rational of design of long-term intervention strategies to reduce the burden of infectious disease. In recent years such a mission has been significantly enhanced by the availability of whole genome sequences. Members of the Department are, or have been, involved in several pathogen genome projects including Herpes, Campylobacter jejuni, Yersinia pestis, Clostridium difficile, Entamoeba and Trypanosome species. In particular, post genome studies have facilitated research on more complex parasites such as Plasmodium, Entamoeba and Trypanosome species. The interpretation and exploitation of this basic information is the platform for numerous new avenues of research on pathogenesis, epidemiology and the evolution of virulence. Teaching The School offers 22 one year full-time taught courses leading to the Master of Science (MSc) degree of the University of London and the Diploma of the London School of Hygiene and Tropical Medicine (DLSHTM). The Faculty of Infectious and Tropical Diseases runs or contributes substantially to ten of these courses and the “Immunology of Infectious Diseases” course is run from within the Department of Immunology and Infection. In addition, the Faculty is responsible for the three-month Diploma in Tropical Medicine and Hygiene (DTM&H) and offers a range of specialist short courses lasting usually one or two weeks. Three MSc courses are also offered by Distance-based Learning, including one on Infectious Diseases. Teaching requirements For research assistants and research fellows: To contribute to the Faculty teaching programme, up to 10% of your time per annum, subject to the policy of any funding agency (by agreement, some staff may make a greater contribution than this). For lecturers and above: To contribute to the Faculty teaching programme, up to 15% of your time per annum, subject to the policy of any funding agency (by agreement, some staff may make a greater contribution than this). Research Training The School offers two doctoral training programmes. The MPhil/PhD degrees are designed for those who wish to go on to a full time research career. The DrPH is directed towards those who expect their careers to be more in the practice of public health. 3. JOB DESCRIPTION Post: Malaria Centre Coordinator (12 month post, 0.4 FTE) Grade: PSP 5 Responsible to: Dr Chris Drakeley, Director Malaria Centre Dept: Immunology and Infection Start date: As soon as possible Main duties and responsibilities: 4. Coordinating the Malaria Centre’s day-to-day activities, often working independently and requiring use of strong initiative to drive activities forward in the absence of the Malaria Centre Director/Deputy Director Organising and promoting regular meetings and seminars held by the Malaria Centre including annual retreats to which overseas partners are usually invited Managing the Malaria Centre budget: monitoring expenditure & income, and providing quarterly financial statements for the Director/Deputy Director and the LSHTM Executive Officer (EO) Assisting, when necessary, in the administration of funds grants received by the Malaria Centre from external funding bodies: monitoring expenditure & income (as above), and providing any required reports to the funding bodies as stipulated in the funding agreement(s) Liaising with the EO, Director of the Malaria Centre and Faculty Administrators in respect of monitoring grant submissions and awards to ensure that the Malaria Centre levy is applied for and/or collected Working with LSHTM External Relations Department to develop and implement a communications and advocacy strategy for the Malaria Centre and producing educational and other materials as necessary for dissemination to various target audiences Work with the focal points persons for different activities (epidemiology, clinical trials, economics etc) to support them to bridge/engage individual researchers with the Malaria Centre. Maintaining, developing and updating regularly the Malaria Centre’s web pages including an inventory of malaria studies Collating information for, preparing and disseminating the biennial report on the Malaria Centre’s activities Receiving enquiries and distributing information to Malaria Centre members, such as calls for research proposals, job opportunities and handling enquiries from prospective students and collaborators Acting as the first point of contact about malaria activities in the School for outside enquirers Providing administrative support, as necessary, to the Director and Deputy Director of the Malaria Centre based at LSHTM. PERSON SPECIFICATION Essential Proven experience in the administration of scientific, research or other projects in a relevant area Proven experience in preparing and monitoring budgets and preparing financial reports Proven experience of organising meetings and workshops Excellent written and oral communications skills including a high level of accuracy and a proven ability to write reports to a high standard Proven ability to take initiative, to work independently and to escalate issues appropriately Excellent organisational skills including a proven ability to prioritise effectively Excellent IT skills including the use of word processing packages, databases and an advanced working knowledge of Excel Excellent interpersonal skills, including a proven ability to establish and maintain effective working relationships with individuals from different backgrounds and cultures Proven experience of designing and maintaining web-pages and a good working knowledge of Web authoring tools and content management systems Proven experience of using desk top publishing software (e.g. Abobe InDesign or QuarkXpress) to produce documents for publication An interest in developing countries and/or malaria A willingness to undertake UK or non-UK work related travel Desirable 5. Experience of/or interest in developing countries and/or malaria SALARY AND CONDITIONS OF APPOINTMENT The post is funded by the Wellcome Trust for a period of 1 year in the first instance and is available from 1st June 2013 Salary is on the Professional Support Pathway Grade 5 salary scale at £31,376 (inclusive of London Weighting) pro rata for 0.4 FTE. Annual leave entitlement is 30 working days per year for all staff (pro-rata for parttime staff). In addition to this there are 6 fixed-date "Director's Days". 6. APPLICATIONS Applications should be made online via our website at http://jobs.lshtm.ac.uk The reference for this post is MCC13. Applications should also include the names and email contacts of 2 referees who can be contacted immediately if shortlisted. Any queries regarding the application process may be addressed to [email protected]. Closing date for the receipt of applications is 20 June 2013. The London School of Hygiene & Tropical Medicine is committed to being an equal opportunities employer