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What is embryonic development? -The sequence of events that gradually changes a Zygote into a functional organism Zygote- Fertilized egg Embryo- an organism in the early stages of development (up to week 8) Fertilized Egg Stage: After fertilization, zygote begins A series of cell divisions called CLEAVAGE (mitosis) Fertilization Fertilized egg divides by MITOSIS -Zygote DOES NOT grow in size Solid Ball Stage (Morula): -Result of cleavage -About 100 tiny cells. All identical Blastula Stage: -Solid ball rearranges. All cells pushed To the outside creating a hollow ball (1 cell thick and filled with fluid) Stem cells are taken at this point. 5 days After fertilization -Specialized changes that transform embryonic cells Into specialized cells, tissues and organs Gastrula Stage: Gastrulation occurs: Cells push in on one side of blastula, forming a two layered embryo 3 Primary Germ Layers form giving rise to organs and tissues Primary Germ Layer Ectoderm (Outer Layer) Mesoderm (middle layer) Endoderm (Inner Layer) Structures Give Rise To -Nervous System, skin, hair, nails -Muscles, Circulatory, and Skeletal Systems Sex organs (testes and ovaries) -Lining of digestive and respiratory Tracts, parts of liver and pancreas Bird Embryo: Chorion & Allantois (Chorioallantoic Membrane): -Combine to help embryo exchange Gases and remove wastes Yolk Sac: -Surrounds the yolk which is the food source for The embryo Amnion: -Surrounds embryo, protects it, and holds it in a Solution of salt water (similar to the ocean) Human embryo: The following extraembryonic membranes develop AFTER Implantation (embryo burrows in uterine lining): Chorion: Connects to uterine wall Amnion: Contains amniotic fluid which surrounds and Protects the embryo (shock absorbency) Combination of fetal and maternal tissue that Placenta: Nourishes the embryo by providing it with Oxygen and nutrients and removes wastes *** The blood of the fetus and mother NEVER mix. They are close enough for DIFFUSION to occur. Umbilical Cord:Connects the placenta to the fetus (at Belly button). Transports oxygen, nutrients, And wastes between fetus and mother (placenta) How do the placenta and the umbilical cord work together? -Nutrients, oxygen, and wastes diffuse across the Placenta. The umbilical cord transports these materials between the fetus and the placenta. 1 egg + 1 sperm (egg splits giving Identical Twins: rise to 2 separate zygotes with Identical DNA) Fraternal Twins: 2 eggs and 2 sperm cells (2 eggs released and each fertilized with a different sperm cell) Involves 3 Processes that ALL begin with fertilization: 1. Growth- Increase in # of cells by MITOTIC CELL DIVISION (no increase in size) 2. Development- As cells develop they move within the embryos body and arrange themselves into specific layers 3. Differentiation- Each cell becomes specialized to Perform specific tasks (heart cells, brain cells, skin cells given their identity) Meiosis Fertilization Birth Mitosis Differentiation (Creates gametes) (zygote) (growth/development) How long does human pregnancy last? -About 266 days of development (fertilization to birth) called the GESTATION PERIOD 1st Trimester: -All organ systems begin to form -Most critical time; most Sensitive to outside influences 6 Weeks -1st detectable brain waves 8 weeks -Now called a FETUS (living organism in the later stages of development. Week 8 and on) -Eyes well developed and fingers lengthen 12 Weeks -End of 1st trimester -Fetus able to move (mother unable to sense) 14 Weeks 2nd Trimester: -Rapid body growth -Fetus more flexible with movement 18 Weeks -Phases of sleep and awakening At 20 weeks (5 months): -May suck thumb -Rapid brain development 21 Weeks -Fetus begins to kick - 8” in length 24 Weeks -Response to light and sound from outside the uterus -End of 2nd trimester 32 Weeks (8 months) 3rd trimester: -Mass more than triples -During 8th month Eyes open/close -Fully mature at 35 Weeks (20”) -Perfect hearing What are some of the first signs of birth? -”water breaks” (Amniotic sac breaks and fluid is released Into the vagina) -Muscular contractions cause cervix to widen (dilate) -Baby moves further from the uterus towards the vagina What is afterbirth? -The placenta separates from the uterus and exits through the vaginal canal What are some dangers facing a fetus? -Radiation (X-rays)- may stop cell division -Genetic mutations (chromosome #) -Infectious Illness (can lead to brain damage, miscarriage) -Inadequate Diet -Harmful Lifestyle- (smoking, drugs, alcohol, std’s) may lead to still birth, brain damage, low birth weight, mental retardation, learning disabilities Artificial Insemination-Donor sperm is inserted into vaginal canal of female during ovulation and internally fertilizes the egg in the oviduct -Baby contains ½ of mother’s DNA and ½ from the donor In Vitro Fertilization-Sperm and egg are combined EXTERNALLY -Embryo implanted into female’s uterus for development Amniocentesis-Technique used to extract fetal cells and examine DNA for possible genetic defects (can be risky) Cloning-Technique in which the nucleus is removed from a Normal body cell and used to replace the nucleus of An egg cell -Egg is implanted into female’s uterus for development -Offspring is IDENTICAL to parent (no variation) -Offspring ages faster than normal -Not successful in humans as to date (moral and ethical issues involved) Stem Cell Research-UNDIFFERENTIATED embryonic cells are removed (around day 5) and treated with chemicals to develop into specific tissues and organs -Moral and ethical debates -Belief is that this technique can be used to cure many diseases and disorders