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Curriculum Vitae
January 2009
Kevin D. Nelson
Founder and Chief Scientific Officer
TissueGen, Inc.
2110 Research Row, Suite 527.
Dallas, TX 75235
EDUCATION
Brigham Young University
Brigham Young University
University of Texas Southwestern
Medical Center at Dallas
Phone: (214) 351-1922
FAX: (775) 855-4771
email: [email protected]
BS 1981-1985
MS 1985-1986
Ph.D. 1989-1995
Mechanical Engineering
Mechanical Engineering
Biomedical Engineering
PERSONAL
Citizenship
US
Marital Status Married, five children
Birth date
March 6, 1960
APPOINTMENTS
1986-1988
Software Engineer, General Dynamics, San Diego, CA
1988-1989
Structural Dynamics Engineer, General Dynamics, San Diego, CA
1989-1995
Graduate Research Assistant University of Texas Southwestern Medical Center
at Dallas
1993-1994
Student Intern, Quest Medical Inc., Allen, TX
1995-1996
Assistant Instructor, Biomedical Engineering, University of Texas at Arlington
1996-1997
Visiting Assistant Professor, Biomedical Engineering, University of Texas at
Arlington
1997-2003
Assistant Professor, Biomedical Engineering, University of Texas at Arlington
2003-2005
Associate Professor, Biomedical Engineering, University of Texas at Arlington
1997-present Special Adjunct Professor, University of Texas Southwestern Medical Center at
Dallas
2000-2005
President, Founder and Chief Scientific Officer, TissueGen Inc.
2005-present Founder and Chief Scientific Officer, TissueGen, Inc.
2005-present Adjunct Professor, Bioengineering, University of Texas at Arlington
HONORS
1978-1979
1981-1982
1981-1985
1991-1992
1995
1997
2002
Dean’s Honor Role – Wright State University, Dayton, Ohio
Dean’s Honor Role – Brigham Young University
Academic Scholarship – Brigham Young University
President of Biomedical Engineering Student Society – University of Texas
Southwestern medical Center at Dallas
Alfred and Jan Potvin outstanding Ph.D. student of the year, University of Texas
at Arlington
Young Investigator Award, 35th Japanese Society for Artificial Organs
College of Engineering “Outstanding Educator of the Year”
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MEMBERSHIP IN PROFESSIONAL SOCIETIES
Controlled Release Society
AD-HOC REVIEWER FOR THE FOLLOWING JOURNALS
Tissue Engineering
Advanced Functional Materials
Journal of Biomaterials Science, Polymer Edition
Tissue Engineering
PEER REVIEWED JOURNAL PUBLICATIONS
1. Eberhart RC, Huo HH and Nelson KD: Cardiovascular materials. MRS Bull 16(9):50-54,
1991. (Review Article)
2. Walker AK, Wu Y, Timmons RB, Kinsel GR, Nelson KD: Effects of Protein Surface
Interactions on Protein Ion Signals in MALDI Mass Spectrometry. Analytical Chemistry
71(1):268-272 (1999)
3. Carlisle ES, Mariappan MR, Nelson KD, Thomes BE, Timmons RB, Constantinescu A,
Eberhart RC, Bankey PE.: Enhancing hepatocyte adhesion by pulsed plasma deposition
and polyethylene glycol coupling. Tissue Engineering 6(1):45-52, 2000
4. Walker AK, Land CM, Kinsel GR, Nelson KD: Quantitative Determination of the
Peptide Retention of Polymeric Substrates Using Matrix-Assisted Laser
Desorption/Ionization Mass Spectrometry. Journal of the American Society for Mass
Spectrometry 11(1): 62-68, 2000
5. Alikacem N., Yoshizawa T., Nelson KD, and Wilson CA. Quantitative MR Imaging
Study of Intravitreal Sustained Release of VEGF in Rabbits. Invest. Ophthalmol. Vis.
Sci., 41(6):1561-1569, May 2000
6. Rangappa N, Romero A, Nelson KD, Eberhart RC, Smith GM: Laminin-coated
poly(L-lactide) filaments induce robust neurite growth while providing directional
orientation. J Biomed Mater Res. 2000 Sep 15;51(4):625-34.
7. Hu Z, Wang C, Nelson KD, Eberhart RC.: Controlled Release from a Composite
Silicone/Hydrogel Membrane. ASAIO Journal 46(4):431-434,2000
8. Teri T Ngo, Paula J Waggoner, Andres A. Romero, Kevin D. Nelson, Robert C. Eberhart,
and George M. Smith “Poly(L-Lactide) microfilaments enhance peripheral nerve
regeneration across extended nerve lesions. J Neurosci Res. 2003 Apr 15;72(2):227-38.
9. Shih-Horng Su, Robert Y.N. Chao, Charles Landau, Kevin D. Nelson, Richard B.
Timmons, Robert S. Meidell, Robert C. Eberhart. Expandable Bioresorbable
Endovascular Stent: I. Fabrication and Properties. Annals of Biomedical Engineering
31:(6):667-77, 2003 Jun
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10. Robert C. Eberhart, Shih-Horng Su, Kytai Truong Nguyen, Meital Zilberman, Liping
Tang, Kevin D. Nelson and Peter Frenkel. Bioresorbable Polymeric stents: Current Status
and Future Promise. J Biomaterials Science: Polymer Edition 14 (4): 299-312 (2003)
Review Article
11. Sagiv A, Parker N, Parkhi V, Nelson KD. Initial burst measures of release kinetics from
fiber matrices. Ann Biomed Eng. 2003 Oct;31(9):1132-40
12. Kevin D. Nelson, Andres Romero, Paula Waggoner, Brent Crow, Angela Borneman,
George M. Smith. Technique Paper for Wet-Spinning Poly(L-lactic acid) and Poly(DLlactide-co-glycolide) monofilament fibers. Tissue Engineering 9(6):1323-30 (2003)
13. Elizabeth M. Cronin, Frederick A. Thurmond, Rhonda Bassel-Duby, R. Sanders
Williams, Woodring E. Wright, Kevin D. Nelson, Harold R. Garner. “Proteincoated poly(L-lactic acid) fibers provide a substrate for differentiation of human
skeletal muscle cells”. Journal of Biomedical Materials Research Part A, 69(3):
373-381 (2004)
14. Tang, Xiao-Qing; Cai, Jie; Nelson, Kevin D; Peng, Xue-Jun; Smith, George M.
Functional repair after dorsal root rhizotomy using nerve conduits and
neurotrophic molecules. European Journal of Neuroscience. 20(5):1211-1218,
September 2004.
15. Cai J, Peng X, Nelson KD, Eberhart R, Smith GM. Synergistic improvements in
cell and axonal migration across sciatic nerve lesion gaps using bioresorbable
filaments and heregulin-beta1. J Biomed Mater Res A. 2004 May 1;69(2):247-58
16. Crow BB, Borneman AF, Hawkins DL, Smith GM, Nelson KD. “Evaluation of in
vitro drug release, pH change, and molecular weight degradation of Poly(L-lactic
acid) and Poly(D,L-lactide-co-glycolide) fibers”. Tissue Engineering 11 (7-8),
Jul-Aug. 2005, pp.1077-1084
17. Meital Zilberman, Kevin D. Nelson and Robert C. Eberhart. Mechanical
Properties and In Vitro Degradation of Bioresorbable Fibers and Expandable
Fiber-Based Stents. Journal of Biomedical Materials Research Part B: Applied
Biomaterials. Vol. 74B (2), August 2005: 792-799
18. Jie Cai, Xuejun Peng, Kevin D. Nelson, Robert Eberhart, George M. Smith.
Permeable guidance channels containing microfilament scaffolds enhance axon
growth and maturation. J Biomed Mater Res A. 75A(2):374-386 (2005)
19. Crow BB, Nelson KD. “Release of bovine serum albumin from a hydrogel-cored
biodegradable polymer fiber” Biopolymers 81(6):419-27(2006)
20. A. Braden, M. Roner, J. Ganter , and K. Nelson. Enhanced Delivery of Bioactive
Molecules to Intracellular Environments Utilizinga Cytosolically Reducable
Grafted Analogof Polyethylenimine. Journal of Nanoscience and Nanotechnology
7, 1–12, 2007
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21. A. Braden, M. Roner, J. Ganter, and K. Nelson. Transport of Biologically Active
Molecules to Intracellular Environments Utilizing a Lyzosomally Cleavable
Random Block Copolymer of Polyethylenimine. Journal of Biomedical
Nanotechnology 3, 1–11, 2007
BOOK CHAPTERS
1.
Eberhart, R.C., Su, S-H., Nguyen, K.T., Zilberman, M., Tang, L. Nelson, K.D., and
Frenkel, P. Bioresorbable polymeric stents: current status and future promise. In Cells,
Proteins and Materials. H. Sheardown and S.L. Cooper, (Eds.). VSP, Utrecht, 2003, pp.
389-402.
FULL PAPERS WITHOUT COMPLETE REVIEW
1. Nelson, K.D., Adams B.L., Fricke W.G.Jr.: Correlation on Earing in Hot Rolled 3004
Aluminum with the Crystallite Orientation Distribution Function. Eigth International
Conference on Textures of Materials, ICOTOM8. Ed. Kallend JS, and Gottstein G.
Metallurgical Society 1988, pages 1097-1102
2. Nelson KD, Huo HH, Kulik EA, Sevastianov VI, Constantinescu A. and Eberhart RC:
Analysis of albumin deposits on hydroxylated siloxane films: Implications for surface
treatment of medical devices. ASAIO J., 39(3):M310-M313, 1993
3. Nelson KD, Elsenbaumer R, Pomerantz M, Eberhart RC: High Affinity Poly(Ethylene
Oxide) for Improved Biocompatibility. ASAIO J., 42(5): M884-M889, 1996
4. Ye Y-W., Landau C., Meidell RS., Willard J., Moskowitz A., Aziz S., Carlisle E., Nelson
KD., Eberhart RC.,: Improved Microporous Bioresorbable Intravascular Stents for Gene
therapy Applications, ASAIO J, 42(5): M823-M827, 1996
5. Rajasubramanian S, Nelson KD, Shastri P, Consantinescu A, Kulkarni P, Jessen M,
Eberhart RC: Design of an oxygenator with enhanced gas transfer efficiency. ASAIO J,
43(5): M710-M714, 1997.
INVITED PRESENTATIONS
Nelson, KD., Prager M., Pomerantz M, Elsenbaumer R., Eberhart RC., Albumin
Passivation by Warfarin Attached to Poly(Ethylene Oxide)., By invitation of Dr.
Kazunori Kataoka at the Science University of Tokyo, September 16, 1997
Kevin D. Nelson, Brent B. Crow, Deepal Panchal, Joana Ganter, Jason Fleming. Drug
delivery fibers for potential solid tumor treatment, IEEE MetroCon, Arlington, TX,
September 29, 2004
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PRESENTATIONS AND ABSTRACTS
1. Nelson, K.D., Tsai, C.C., Huo, H.H. and Eberhart, R.C.: An improved method to enhance
the biocompatibility of silicone rubber; Hydroxylation by hydroboration. Proc 9th South
Biomed Eng Conf, Pergamon Press, 1990. (Abstract)
2. Huo, H.H., Tsai, C.C., Nelson, K.D., and Eberhart, R.C.: PEO-modified vinylmethylsiloxane as a biomaterial coating. Proc 9th South Biomed Eng Conf, Pergamon Press,
1990. (Abstract)
3. Tsai, C.C., Nelson, K.D., and Eberhart, R.C.: Method to reduce complement activation
by silicone rubber. Extracorp. Life Support Organization, Ann Arbor, November 1990.
(Abstract)
4. Nelson, K.D., Tsai, C.C., Kulik, E.A., Sevastianov, V.I., and Eberhart, R.C.: Analysis of
hydroxylated siloxane films for medical devices. Houston Society for Engineering in
Medicine and Biology, Houston, TX, Feburary, 1993. (Abstract)
5. Nelson, K.D., Tsai, C.C., Kulik, E.A., Sevastianov, V.I., and Eberhart, R.C.: Analysis of
albumin deposits on hydroxylated siloxane films: Implications for surface treatment of
medical devices. 39th Annual Meeting ASAIO, New Orleans, LA, April 29 - May 1,
1993. (Abstract)
6. Eberhart RC., Nelson KD., Ye Y-W., Landau C., Willard JE., Meidell RS.: Biomaterials
and Gene Therapy: Prospectives and Problems. Society for Biomaterials Annual
Meeting, New Orleans, LA. April 30-May 4, 1997 (Abstract)
7. Nelson KD., Su S., Phansalkar AR., Romero AA., Ye Y-W., Eberhart RC., Landau C.,
Meidell RS.: New Fabrication Techniques for Polymeric Intravascular Stents.
IMECE97, Dallas, TX. November 16-21, 1997
8. Nelson KD., Phansalkar AR., Romero AA., Eberhart RC., Landau C., Meidell RS.:
Degradation of Poly(L-lactic acid) Monofilaments. IMECE97, Dallas, TX. November
16-21, 1997
9. Eberhart RC., Nelson KD., Ye Y-W., Landau C., Willard JE., Meidell RS.: Local
Delivery of Gene Therapy via Porous Stents. Invited paper - Mini-symposium on
Restenosis and Drug Delivery Strategies. Controlled Release Society, June 1997,
Stockholm Sweden.
10. Nelson KD, Romero AA, Su S, Phansalkar AR, Ye, Y-W, Eberhart RC, Landau C,
Meidell RS.: Recent Advances in Porous, bioresorbable Intravascular Stents for Gene
Therapy. 35th Japanese Society for Artificial Organs, September 14-15, 1997, Yokohama
Japan.
11. Su SH, Nelson KD, Romero AA, Meidell RS, Landau C, Eberhart RC. New Fabrication
Procedure for Polymeric Stents with Smooth Interior and Porous Exterior Surfaces.
Society for Biomaterials Conference, April 22-26, 1998, San Diego, CA.
12. Nelson KD, Phansalkar AA, Landau C, Meidell RS, Eberhart RC.: Tissue Engineering
via Bioresorbable Microporous Stents that Deliver Recombinant Adenovirus Gene
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Transfer Vectors to the Arterial Wall. BECON symposium at the NIH, February 27-28,
1998
13. Eberhart RC, Su S., Li J., Nelson, KD.: Influence of blood flow rate on platelet adhesion
to medical devices as measured by gamma scintigraphy. Biomedical Engineering Society
Annual Meeting, Cleveland, OH. October 10-13, 1998.
14. Nagarathnamma R, Nelson KD, Romero AA, Smith G: In vitro growth of axons on
laminin coated fibers. Biomedical Engineering Society Annual Meeting, Cleveland, OH.
October 10-13, 1998.
15. Romero AA, Smith GM, Nelson KD.: Biodegradable Fibers By A Wet-Spinning Process.
Biomedical Engineering Society Annual Meeting, Cleveland, OH. October 10-13, 1998.
16. Su Shih-Horng, Wu J., Landau C., Chao RYN., Timmons R. B., Meidell R. S., Nelson K.
D., and Eberhart R. C.: Progress in bioresorbable polymer stent development Society For
Biomaterials 25th Annual Meeting Providence, RI, April 26-May 2,1999
17. Hu Z, Wang C, Nelson KD, Eberhart RC.: Controlled Release from a composite
Silicone/Hydrogel Membrane. The American Society for Artificial Internal Organs, June
3-5, 1999
18. Alikacem N, Yoshizawa T, Wilson C, Nelson KD.: In Vitro Measurement of Drug
Release Concentrations Using MR Imaging. International Society for Magnetic
Resonance in Medicine, Philadelphia, PA, May 1999
19. Alikacem, N., Yoshizawa, T., Wilson, C., Nelson, KD. MRI Quantitation of Sustained
VEGF Induced Blood-Retinal Barrier Breakdown: A Rabbit Study. International
Society for Magnetic Resonance in Medicine, Eighth Scientific Meeting, Denver, USA,
March 31-April7th, 2000.
20. Alikacem, N., Yoshizawa, T., Wilson, C., Alappatt, J., Nelson, KD. Retinal
Hyperpermeability Induced By Intravitreal VEGF Sustained Release: A Quantitative
MRI Study In Rabbits. ARVO, 2000.
21. SH Su, KD Nelson, RB Timmons, RS Meidell, and RC Eberhart. Expandable,
bioresorbable endovascular stent with drug delivery capability. American Heart
Association, 2001.
22. Nagarathnamma Rangappa, Paula J. Waggoner, Kevin D. Nelson, Robert C. Eberhart
and George M. Smith. Cellular responses to implantation of poly (L-lactide)
microfilaments into the lesioned spinal cord. Biomedical Engineering Society Annual
Meeting 2001.
23. T.T.B. Ngo, P.J. Waggoner, A.A. Romero, K.D. Nelson, R.C. Eberhart, G.M. Smith.
Bioresorbable filaments promote peripheral nerve regeneration across extended nerve
lesions. Society of Neuroscience Annual meeting 2001.
24. Nagarathnamma Rangappa, Kevin D. Nelson, George M. Smith. Cellular responses to
implantation of poly (L-lactide) microfilaments into the lesioned spinal cord. Biomedical
Engineering Society Meeting, October 4-7, 2001; Durham, NC
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25. Nagarathnamma Rangappa, Paula Waggoner, Kevin D. Nelson and George M. Smith.
“Strategies to Induce Axonal Regeneration in the Injured Spinal Cord” Kentucky Spinal
Cord and Head Injury Research Trust (KSCHIRT) Symposium June 2002 held in
Lexington, KY
26. Kevin D. Nelson, Brent B. Crow, Nagrathnama Rangupa, Nadir Alikacem, George M.
Smith. Innovative Fiber format for the Delivery of Proteins. International Controlled
Release Society Meeting, July 21-25, 2002, Seoul, Korea.
27. Delia Radulescu, Kevin D. Nelson. Chitosan-Based Scaffolds for Nerve Regeneration.
International Congress on Biological and Medical Engineering, 4-7 Dec 2002; Singapore
28. C.J. Chuong, K. Nelson, K. Behbehani and R.C. Eberhart. A Five-Year Degree Program
Leading to a Bachelor of Science in Biology and a Master of Science in Biomedical
Engineering. American Society for Engineering Education. March 20-21, 2003.
Arlington, TX
29. Khosrow Behbehani, Kevin D. Nelson and Robert C. Eberhart. A Biomedical
Engineering Graduate Industrial Internship Program: Structure, Implementation, and
Evaluation. American Society for Engineering Education. March 20-21, 2003. Arlington,
TX
30. XQ Tang, J Cai, K Nelson, XJ Peng, GM Smith. Functional regeneration of sensory
afferents in severe dorsal root injury after bioresorbable guidance tube implantation and
neurotrophin gene therapy. Neuroscience, 2003.
31. J. Cai, K.D. Nelson, R. Eberhart, G.M. Smith. Synergistic Improvements of Cell/Axon
Migration Using Resorbable Filaments and Human Heregulin-beta1. National BMES
meeting October 2-4, 2003, Nashville, TN, USA.
32. A. W. Beck, S. Holloway, Ganter J L M S, Nelson K, Eberhart R, Fleming JB, FACS.
Ultrasound-guided placement of Bioresorbable Fibers into Pancreatic Adenocarcinoma
Tumors achieves prolonged adenoviral gene transfer. American Chemical Society (ACS)
Spring National Event, U. Virginia Newport News, VA February 26 to February 28, 2004
33. Kevin D. Nelson, Joana Ganter, Jason Fleming. New Bi-Component Fibers Capable of
Releasing Viruses with Retained Biological Activity. International Controlled Release
Society, annual meeting. Honolulu, Hawaii, June 12-16, 2004
PATENTS
Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith, Paula
Waggoner, Delia Radulescu, Zhibing Hu: “Drug releasing biodegradable fiber implant”.
US 6,596,296
Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith, Paula
Waggoner, Delia Radulescu, Zhibing Hu: “Fabrication of drug-loaded, biodegradable polymer
fibers”. US 6,858,222
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Brent B. Crow, Kevin D. Nelson: “Drug releasing biodegradable fiber implant of various
material and structural compositions used for the delivery of therapeutics”. US 7,033,603B2
Brent B. Crow, Kevin D. Nelson: “Drug releasing biodegradable fiber implant of various
material and structural compositions used for the delivery of therapeutics”.
China 2004 8 0018348.8
Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith,
Paula Waggoner, Delia Radulescu, Zhibing Hu: Fabrication of drug loaded biodegradable
polymer fibers”. US 7514095
Kevin D. Nelson, Brent B. Crow: “Self expanding Medical Device” Application number
61/090,162 filed August 19, 2008.
CONSULTING OPPORTUNITIES
Date
May – July 1994
Company
St. Jude Medical, Inc.
June – August,
1996
Nov. 1996 – June
1997
Sept-December
1997
June – August,
1999
Johnson & Johnson
Medical, Inc.
Mentor HS
Mark Brodeur,
Attorney at Law
Ball Semiconductor,
Inc.
Brief Description
Discover cause of blood clot formation on heart
valve leaflet
Full time consultant – Surgical Adhesion
Prevention
Detectable physiochemical changes in drug
content
Expert Witness – Dental implant failure analysis
Full time consultant- Medical uses of spherical
semiconductor
8