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Partner Profile and Search
Form
Date 2009 06
31
Deadline 2009 10
29
CONTACT
Organisation
Contact person
Address
State Medical and
Pharmaceutical University
“Nicolae Testemitanu”
Dr. biol. Victor Popescu
Department Laboratory of Genetics
Male/female Male
Postcode
Str. Stefan cel Mare nr.165, mun. Email
Chisinau, Rep. Moldova
Fax
2004
City
Mun. Chisinau
Telephone
068555076
Country
Rep. Moldova
Website
www.usmf.md
[email protected]
00373-22-242344
Are you familiar with the European Framework Programme?
YES
NO
PROJECT
Title
„Identification of DNA methylic
markers in thyroid tumors”
Project type
Planned to
participate as
Call identifier
Workprogramme
Topic you are
interested in
Your main research
areas / Description
of research
activities
Network of
Large
Collaborative Project Excellence
coordinator
partner
Acronym:
Biomarkers
Small
Collaborative Project
Other:
HEALTH.2010.1.2-2
Stratification approaches and
methodologies to select from a wide range of biomarkers
relevant candidates for clinical validation.
Institutional topic, aa. 2006-2010:
Study of ischemic cadriopaty genetics with identification of persons at high risk
of the desease.
Hypothesis:
Identification of new genetic risk factors in population of R.Moldova for
preventing of some cardiovascular deseases.
Objectives:
1) Identification of new genetic causal factors of some cardiovascular diseases.
2) Solving of problems on early diagnosis and differential-genetic diagnosis
regarding health improvement at regional frame.
3) Identification of persons in the population of R.Moldova at high risk of various
cardiovascular diseases.
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Description of the
know-how/expertise
and equipment you
can provide
Our project implies a fundamental scientific value as well as a substantial
contribution to maintaining of the public health, in the manners stated as
follows:
1) Determining of DNA methylic profiles in thyroid tumors and normal
paratumoral tissues in order to establish some DNA methylic markers as a new
prognostic tool for thyroid cancer;
2) Introducing of a populational screening program with preclinical
establishment of thyroid neoplastic processes.
Keywords
DNA methylic markers, thyroid cancer, prognostic tool.
Project description
In this project we engage to establish some DNA methylic markers as
new diagnostic tool for thyroid cancer.
This way, we plan to collect fragments from thyroid
tumors/paratumoral tissue from patients at the Oncological Institute of the
R.Moldova. Subsequently it will be determined DNA methylation status in
some tumor suppressor genes.
In the case of confirmation of some dangerous methylation DNA
parameters, a populational screening program for the establishment thyroid
cancer risk of people. In that manner it would be possible to identify persons at
high risk with genomic alterations/instability followed by a recommendation to
see an oncologist in order to catch a presumptive tumor at an early stage.
At present in our laboratory we have technical support for performing the
following procedures: 1) DNA extraction integral blood; 2) Applying MSP
technique for determining of the gene methylation status [Herman J. et al., 1996];
3) Analysis of PCR products by gel-electrophoresis; 4) Interpreting of the results;
5) Elaboration of a data-base for monitoring persons with high risk of leukemia.
Have you already
identified Partners
for projects you are
interested in?
Partners already
involved ( Contact
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No
Have you already contacted
other partners?
Yes
No
―
Name, Name of
organization, e-mail
address)
Project budget (for
the running
projects)
250 000 EUR
Budget reserved for
SMEs
250 000 EUR
If you want to coordinate / build a consortium or have already formed a consortium, you may
need additional partners. To identify suitable partners please state what expertise / equipment
is required:
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Profile of Partner sought
Role
Country /region
Start of partnership
Expertise required
technology development
research
training
dissemination
demonstration
other:
mid-term
end-phase
start-up phase
Applying alternative techniques (DNA sequencing, DNA hybridization) for
the determining of gene methylation status others than MSP procedure [Herman
J. et al., 1996].
Interested Consortia and Partners should directly get in touch with the contact person given on
page one.
I agree with the publication of my data
Please fill-in and return it to:
Health National Contact Point, Republic of Moldova
Angela PARASCHIV, PhD
By email to: [email protected]
The data given will not be subjected to any technical pre-selection or control in regard to the quality or
potential of the inquiry/requester.
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