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True cat lovers take great pride in growing old with their feline family members. Cat fanciers, more affectionately known as “cat people”, have great insight about their cats’ behaviors and habits. Therefore, when a previously sedentary, aging cat suddenly becomes more active and energetic, the initial reaction of a cat owner might be pleasant surprise followed by suspicion. The culprit in such a change in mature cat behavior is likely to be a disease called Feline Hyperthyroidism. Like their human counterparts, cats have thyroid glands on both sides of their neck. These glands secrete hormones that are responsible for regulating the body’s rate of metabolism. Hyperthyroidism is a disorder characterized by the overproduction of thyroid hormone and a subsequent increase in the metabolic rate. One or both of the thyroid glands may enlarge, although this enlargement is usually a non-malignant change. Hyperthyroid cats typically are middle aged or older with an average age of 12 years. Due to the increased rate of metabolism, these cats tend to have significant weight loss. To attempt to compensate for the weight loss, the cat’s appetite will increase. Even in the face of increased food intake, most hyperthyroid cats will lose weight. Other symptoms of feline hyperthyroidism include hyperactivity, increased thirst and urinations, vomiting, voluminous stools or diarrhea. The cat’s hair coat will usually become quite unkempt, often feeling greasy and matted. As the disease progresses, anorexia may develop. Some cats will develop high blood pressure and heart disease secondary to this disorder. Diagnosis of Feline Hyperthyroidism is relatively easy and is achieved by measuring the thyroxine (or T4) hormone level in the blood. Veterinarians also are very adept at feeling for enlarged thyroid glands on all cats, especially mature cats. Three treatment options exist for Feline Hyperthyroidism. Any one of them may be appropriate in certain situations. The first option is administration of an oral anti-thyroid medication that can control the effects of the over-active thyroid gland. Some cats do very well on this drug, while others may develop side effects such as vomiting, anorexia, fever and anemia. Periodic blood tests should be done to keep the dosage regulated. A second treatment option is to surgically remove the abnormal gland after lowering the thyroid hormone levels in the blood with anti-thyroid medication. Since hyperthyroid cats are usually over 8 years old, there is a degree of anesthetic risk involved, especially if the cat has blood pressure or heart disease concerns secondary to the hyperthyroidism. The final treatment option is to destroy the abnormal thyroid tissue via injections of radioactive iodine. Because of governmental regulations, this treatment is limited to veterinary teaching hospitals and referral centers, but is very effective in controlling the disease. While many owners of hyperthyroid cats may be reluctant to treat the disorder due to the cat’s advanced age, the outcomes of medical, surgical or radiation therapy for this disease are usually very good. If your senior cat suddenly has the energy of a kitten and is losing weight, ask your veterinarian to test the cat’s thyroid level.