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KEY: Chapter 4 Review Questions Multiple Choice/Matching 1. (a) Connective = Tissue type composed almost entirely of nonliving extracellular matrix; important in protection and support (c) Muscle = Tissue immediately responsible for movement (d) Nervous = The tissue that enables us to be aware of the external environment and to react to it (b) Epithelium = The tissue that lines body cavities and covers surfaces 2. An epithelium that has several layers, with an apical layer of flattened cells is called: (c) Stratified (layered) (d) Squamus (flattened apical, top, layer) 3. Match epithelial tissue to appropriate description: Column A Column B Lines most of the digestive tract Simple columnar Lines the esophagus Stratified squamous (non-keratinized) Lines much of the respiratory tract Psuedostratified ciliated columnar Forms the walls of the air sacs of the lungs Simple squamous Found in urinary tract organs transitional Endothelium and Mesothelium Simple squamous 4. (B) an exocrine gland is a gland that secretes products (i.e., milk, saliva, bile or sweat) through a duct 5. (C) mucous membranes line body cavities that open to the exterior (dig., resp. or urinary tract) 6. (B) scar tissue is a variety of connective tissue Short Answer/Essay Questions 7. Tissue = collection of structurally similar cells with related function; The four primary tissues are epithelial, connective, muscle & nervous 8. Four important functions of epithelial tissue with an example of each Epithelial Tissue Function Example Protection Skin protect from mechanical & chemical injury and bacterial invasion Absorption Lining of the digestive tract Secretion Glands Filtration Kidneys (tissue of kidneys perform all but sensory) Sensory Reception Skin contains nerve endings that respond to various stimuli (heat, pressure) 9. The criteria used to classify covering and lining epithelia are: - the number of layers present - the shape of its cells 10. On the basis of their duct structures, multicellular exocrine glands are first classified as either simple, with a single unbranched duct or compound, with a branched duct. They are further classified based on their secretory units. Tubular if the secretory cells form tubes, alveolar if they form small, flasklike sacs and tubuloaveolar if they contain both types of secretory units. Examples of Multicellular Exocrine Gland Classification Simple tubular Simple branched tubular Simple alveolar Simple branched alveolar Compound tubular Compound alveolar Compound tubuloalveolar Intestinal glands Stomach (gastric) glands **no important examples in humans** Sebaceous (oil) glands Brunner’s glands of small intestine Mammary glands Salivary glands 11. Four important functions of connective tissue with example: Connective Tissue Function Example Binding & Support Bone and cartilage support organs Protection Bone and cartilage protect organs; Fat Insulation Fat Transportation blood 12. The primary cell type in - connective tissue proper: is the fibroblast - Cartilage: is the chondroblast - Bone: is the osteoblast 13. The two major components of matrix are ground substance and fibers. - Ground substance is composed of interstitial (tissue) fluid, cell adhesion proteins and proteoglycans - Fibers can be collagen, elastic or reticular fibers 14. Extracellular matrix gets to its characteristic position outside the cell when the mitotically active, undifferentiated, immature ‘-blast’ cell of a secretes the ground substance and fibers characteristic of the matrix of the particular connective mature cell they are forming. After the matrix is synthesized, the ‘-blast’ cells assume their less active, mature ‘-cyte’ mode. 15. Specific type of connective tissue found in the following locations: Location Type of Connective Tissue Forming soft packing around organs Connective Tissue Proper > Loose > Areolar Supporting the ear pinna Elastic cartilage Forming “stretchy” ligaments Connective Tissue Proper > Dense regular connective tissue First connective tissue in the embryo Embryonic Connective Tissue > Mesenchyme Forming the intervertebral discs Cartilage > Fibrocartilage Covering the ends of joints at joint surfaces Cartilage > Hyaline cartilage Main components of subcutaneous tissue Connective Tissue Proper > Loose > Adipose 16. Macrophages are important cells in the immune system. Their function is to actively engulf a broad variety of foreign material, from bacteria to dust. They also dispose of dead tissue cells. 17. Nervous tissue includes both neurons and supporting cells. Neurons are highly specialized nerve cells whose function is to generate and conduct nervous impulses. Supporting cells are nonconductive cells that support, insulate and protect the delicate neurons. 18. Compare and contrast cardiac, skeletal and smooth muscle tissue: Tissue Type Structure Body Location Skeletal Cylindrical, striated, Attached to bones of the multinucleated skeleton Cardiac Striated, branching, Wall of the heart intercalated disc junction, uninucleate Smooth No striations, spindleWalls of hollow organs shaped, one central nucleus other than heart (dig, urinary tract, uterus, blood vessels) Specific Function Form flesh; Cause body movement by pulling bones Help propel blood through vessels Squeeze substance through organs by alternately contracting and relaxing 19. Tissue repair occurs in two major ways, regeneration and fibrosis, depending on the type of tissue damaged and the severity of the injury. Inflammation kicks off the repair process, allowing WBCs and plasma fluid with clotting proteins antibodies etc. into the area, which results in the formation of a clot. This is followed by organization during which the clot is replaced by granulation tissue. Regeneration and fibrosis occurs to complete the repair. If the injury is strictly infection (pimple or sore throat), only regeneration is involved in repair. 20. Embryonic germ layers and tissue classes derived from each: Embryonic Germ Layer Primary Tissue Classes Derived From Layer Ectoderm Epithelium, nervous Mesoderm Epithelium, muscle and connective Endoderm Epithelium Critical Thinking and Clinical Application: 1. John should not expect a quick uneventful recovery from a torn knee cartilage. Cartilage is avascular and aging cartilage cells lose their ability to divide, so cartilages heal slowly when injured. 2. Keratinized stratified squamous epithelium is better than a mucosa of simple columnar epithelium at protecting external surfaces because it is thick (as opposed to the one layer in the simple columnar), it’s basal cells are constantly mitotic allowing continual replacement of surface cells and the tough keratin protein provides additional protection. Simple columnar epithelium is designed for absorption and secretion rather than protection. 3. Adding more elastic fibers to the ligaments binding bones would increase flexibility but it would also lead to problems such as being easier to tear/break as the ligaments would stretch thinner and movement would be less controlled. 4. Epithelial cells give rise to most cancers. This is because they have the highest need for replacement and therefore divide most frequently and they are the most likely to be exposed to mutagens. 5. Cindy’s rationale for wanting to transform some of her white fat to brown fat is that brown fat, or “good” fat consumes its nutrient stores, therefore burning calories, to release energy/generate heat whereas white fat simply takes up (stores) or releases fat becoming plumper or more wrinkly, rather than being consumed.