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Philadelphia University Faculty of Pharmacy Lecturer: Dr. Abdel Naser dakka Internal Reviewer : Dr. Mohammed Department of Pharmaceutical Sciences Abdul Hady Student Name: Course Name: pharmaceutical Calculations Course Number: 0511222 Sections: 1, Final Exam Student Number: 1st Semester of Academic Year 2009/2010 Date: 28/01/ 2010 Time: Two hours Information for Candidates 1.This examination paper contains 7… questions, totaling...50 marks. 2.The marks for parts of questions are shown in round brackets. Notes to Candidates 1. You should attempt all questions. 2. You should write your answers clearly. Q.1. Choose the correct answer. 1- Drugs that are measured in units include: a- Penicillin V,insulin, and heparin. b- Co-trimezole. c- Cough medicine. d- All of the above. 2- Electrolytes are measured in: a- Grains. b- Milligrams. c- Milliequivalent. d- Meter. 3- The abbreviation for p.o. is. a- ampul. b- By mouth. c- Cap. d- Drop. 4- The abbreviation for t.i.d. is. a- Twice a day. b- Once a day. c- Three times a day. d- None of the above. 5- The equivalent in milliliters of 55 U of insulin(U100) is: a- 55 ml. b- 0.5 ml. c- 5.5 ml. d- 0.55 ml. 1 (20 marks) 6- The order morphine 4 mg I.M. q4h p.r.n. pain, hold for respiratory rate <12 BPM means: a- give morphine 4 mg intramuscularly 4 times a day for pain, hold for respiratory rate less than 12 breaths per minute 7- b- give morphine 4 mg intramuscularly every 4 hours for pain, hold for rate grater than 12 breaths per minute. c- give morphine 4 mg intramuscularly every 4 hours as needed for pain, hold for rate less than 12 breaths per minute. d- all of the above. " Give Dilantin 150 mg by mouth twice a day at 9:00 hours and 21:00 hours, draw Dliantin levels every other day" can be written on a drug order as: 8- 9- 10- a- Dilantin 150 mg P.O. b.i.d at 9:00 a.m and 9:00 p.m, draw Dliantin levels q.o.d. b- Dilantin 150 mg P.O. t.i.d at 9:00 a.m and 9:00 p.m, draw Dliantin levels q.o.d. c- Dilantin 150 mg P.V. b.i.d at 9:00 a.m and 9:00 p.m, draw Dliantin levels q.o.d. d- Dilantin 150 mg P.M. b.i.d at 9:00 a.m and 9:00 p.m, draw Dliantin levels The five "rights" of drug administration are: a. drug, dose, route, time, patient. b. drug, filter, solution, doctor, shift. c. drug, order, signature, time, patient. d. none of the above. The equation used to convert pound to Kilograms is: akilogram divided by 2.2 bpound divided by 2.2 cmilligrams divided by 2.2 dkilogram divided by 3.3 If the suggested pediatric dosage for a drug is 35 mg /kg / day, the amount to an infant weighing 5 kg is: a250 mg b175 mg c75 mg d50 mg 2 11- 12- 13- 14- 15- 16 If the average adult dose of a drug is 250 mg, how many milligrams should you give to a6-year-old? a38 mg b83 mg c183 mg d73 mg An order written according to the international System of Units would read: agentamicin 400 mg in 100 ML normal saline I.V. q24 hours. bgentamicin 400 mG in 100 ML normal saline I.V. q24 hours. cgentamicin 400 mg in 100 ml normal saline I.V. q24 hours. dnone of the above. The information on the patient's admission data plate is: a full name, social security number, birth date, and doctor's name. b full name, hospital identification number, bed location, unit number and doctor's name. c full name, address, and doctor's name. d none of the above. When reading a drug label, first check the: a- dose strength. b- generic name. c- trade name. d- Expire date. The term percent or the symbol %, when used without qualification means: afor solutions or suspensions of solids in liquids, percent weight / volume. bfor solutions or suspensions of solids in liquids, percent volume / volume. cfor solutions or suspensions of solids in liquids, percent weight /weight. dall of the above. Among the items that pharmacist should check for the correct reading and Interpretation of a prescription or medication order is (are). a- bcd- prescriber information, including address and telephone, drug enforcement administration (DEA). date of the order and its currency to request for filing drug prescribed, including dose, preparation strength, dosage form and quantity. all of the above. 3 17 Occasionally, the drop (abbreviated gtt) is used as measurement for: a- small volumes of liquid medications. bmoderate volumes of liquid medications. clarge volumes of liquid medications. db- + c- 18 When water and alcohol are mixed, there is a physical concentration such that the resultant volume is: aless than the total of the individual volumes of the two liquids. b- more than the total of the individual volumes of the two liquids. cless than the total of the individual volumes of the one liquid. dnone of the above. 19- The measure that's equivalent to a milliliter is: aa cubic centimeter. b- a kiloliter. c- a hectoliter. d- 20 b- + c- How many grams of a 1:10 trituration are required to obtain 25 mg of drug? a0.025 mg. b- 0.25 ml. c0.25 g. d- 0.25 mg. Q.2. Define the following. 1- Alligation: (5 marks) 2- Alligation medial: 3- Triturations: 4- Stock Solutions: 6- Isotonic: 4 Q.3. From the following formula for a topical anesthetic. Calculate the quantity of ingredient required to make 240 g of product. Rx. (5 marks) Benzocaine 14% Butylaminobenzoate 2% Tetracaine Hydrochloride 2% Cetyl Dimethyl Chloride 1.5% Ammonium Bromide 0.005% Aquagel q.s. ad 30 g w/w w/w w/w w/w w/w Q.4. what is the percentage strength (v/v) of alcohol in a mixture of 3000 ml of 40 % v/v alcohol, 1000 ml of 60% v/v alcohol and 1000 ml of 70% v/v alcohol? Assume no concentration of volume after mixing (5 marks) 5 Q.5. A person is to receive 2 mEq sodium chloride per kilogram of body weight. If the person weighs 132Ib., how many milliliters of a 0.9% sterile solution of sodium chloride should be administered? (5marks) Q.6. Ciprofloxacin (CIPRO) oral suspension contains 250 mg of ciprofloxacin per 5 ml. A physician prescribed 125 mg of ciprofloxacin q.t.d.×10 day. a- How many doses are needed? b- How many milliliters should be given per dose? c- How many milliliters of ciprofloxacin oral suspension containing 250 mg per 5 ml should be dispensed? (6 marks) Q.7. An effervescent tablet has the following formula: (4 marks) Rx. Acetoaminophen Calcium Carbonate Citric Acid Potassium Bicarbonate Sodium bicarbonate 325 mg 280 mg 900 mg 300 mg 465 mg a- Calculate the total weight, in grams, of the ingredient in the each tablet. b- How many tablets could be made with supply of 5 kg of an effervescent? GOOD LUCK 6 7