Download Neurological, Endocrine, Mitochondria, and Oxidative Stress Cycles

Chronic Immune Dysfunction and Inflammatory State, Infection(s), Neurological, Endocrine, Mitochondria, and Oxidative Stress Cycles
HPA Axis
Dysfunctional state from infections,
chronic inflammation, toxins, and
oxidative and nitrosative stress damage.
Effects of chronic stress . Adrenal
Exhaustion and Dysfunctions. Thyroid,
Hypothalmus and Pituitary dysfunctions.
Cortisol, DHEA, CRH, ACTH, GH,
Dopamine, Oxytocin, and Melatonin
abnormalities. Sleep disorder. Excessive
Reverse T3. Ion channel interruption &
dysfunctions. Genetic susceptibilities.
Deficient ATP effects.
Dysfunctional
Feedback
Oxidative
and
Nitrosative
stress.
Inflammation
& Damage
ATP Deficiency
Vital Cellular and Mitochondria nutrients
Depletion of antioxidant status through
oxidative and nitrosative stress
Deficiency of Magnesium, Co-Q10,
D-Ribose, Carnitine, NAD, Sulphur, Zinc,
Phospholipids, Omega-3 fats, Vitamin B
complex and C, SOD, Glutathione.
Methylation cycle blockage effects.
Lack of clean filtered water in the diet
Blockages in circulation and microcirculation affecting nutrient uptake and
by-product excretion.
Antioxidant Genetic factors.
Pathogen and Toxin Load Factors
Virus(es) / Lyme / Chlamydia / Mycoplasma / Bacteria /
Parasites. Microbiota of bacteria which include L-form,
biofilm, and intracellular bacterial forms (Dr. Marshall).
Triggering agent / perpetuating factor in illness.
Reactivated latent pathogens. Inflammatory
nm
immune
system, chronically activated. Mold and Mycotoxins &
chronic inflammation. Organophosphates, heavy metals,
additives, various toxins. Detoxification failure. Blood brain
barrier breached. Oxidative and Nitrosative stress,
increased COX2, TNF-a , ROS, NOS, Peroxynitrite loop (Dr.
Martin Pall). VDR deficiency (Dr. Marshall). Methylation
cycle blockage. Microbes & their genes. Intestinal dysbiosis,
increased LPS, H2S. Sleep disorders. Blockages in
circulation and micro-circulation affecting nutrients uptake
and by product excretion. Genetic weaknesses.
.
Oxidative and Nitrosative stress.
Inflammation & Damage
Nutritional
Deficiency
Effects on
Heart,
Muscles,
Liver &
Intestines
Oxidative
and
Nitrosative
stress.
Inflammation
& Damage
ATP Deficiency
Mitochondria and Krebs cycle
Oxidative & Nitrosative stress damage to inner &
outer membranes, cristae, proteins, and DNA of
mitochondria. Krebs cycle blocks. Redox failure. Ion
channel interruption & dysfunctions affecting Ca.
Mg. and K levels. Deficient Electron Transport
Chain. Impaired ATP production and Oxidative
Phosphorylation. Impaired Translocator protein
activity. Acceleration of AMP & glycolysis.
Methylation cycle blockages effects. Deficient ATP
production.
ATP Deficiency
Excess
demand for
ATP. Oxidative
and Nitrosative
stress.
Inflammation
& Damage
Nervous System
Neurotoxic state from infection(s), toxins, autoimmune
disease. Blood brain barrier breached. Poor blood and
oxygen delivery to brain due to heart malfunction
caused by mitochondria dysfunction. Inflammatory
cytokines and inflammatory and oxidative damage to
the nervous system and depletion of vital
neurotransmitters, hormones & signalling systems.
Brain hypoperfusion. Microglia activation. Brain
lesions. EEG abnormalities. Astrocyte dysfunction. ANS
dysfunction. Ion channel dysfunctions. Neurological
Gating deficits. Impaired cerebral glucose metabolism.
Excess Quinolic acid, ROS & NMDA activity. GABA
depletion. Abnormal proteins in spinal fluid. ATP down
effects.
Oxidative and
Nitrosative stress,
Inflammation &
Damage
Immune System
Dysfunctional
Feedback
Dysfunctional, depleted and chronically activated immune
system. Excessive inflammatory cytokines and damage.
RnaseL and PKR abnormalities, Ion channel interruption &
dysfunctions. Interferon poisoning. Depleted Suppressor T
cells & overactive immune system. VDR deficiency (Dr.
Marshall). Increased nuclear factor-κB, COX2, TNF-a and
loss of p53. NK cell dysfunction & abnormalities. B cell
abnormalities. Fighting chronic infection(s) /allergens /
mycotoxins. Progression to autoimmune factors and
responses. Intestinal dysbiosis and LPS effects on immune
system. Methylation cycle blockage effects on immunity.
Genetic susceptibilities. Deficient ATP effects on Immunity
system.