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Signal Transduction. Edition No. 3
Description:
A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition
of previous editions, in providing a historical overview of how the concept of stimulus-response coupling
arose in the early twentieth century and shaped our current understanding of the action of hormones,
cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to
signal transduction, the book provides a concise overview of receptor mechanisms, from receptor - ligand
interactions to post-translational modifications operational in the process of bringing about cellular
changes. The phosphorylation process, from bacteria to men, is discussed in detail.
Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts
such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite,
oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects
have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological
condition.
- In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search
for novel therapeutic interventions
- Essential signaling events embedded in rich physiological and pathological contexts
- Extensive conceptual colour artwork to assist with comprehension of key topics
- Special emphasis on how molecular structure determines protein function and subcellular localization
- Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene
databases, allowing the learner to extend his/her exploration on the web
Contents:
Chapter 1 Prologue: Signal Transduction from a Historical Perspective Chapter 2 An Introduction to Signal
Transduction Chapter 3 Regulation of Muscle Contraction by Receptors Chapter 4 Cholinergic Signaling and
Muscle Contraction Chapter 5 Sensory Signal Processing
Visual Transduction and Olfaction Chapter 6 Intracellular Calcium Chapter 7 Bringing the Signal into the
Nucleus: Regulation of Gene Expression Chapter 8 Nuclear Receptors Chapter 9 Protein Kinase C and
Oncogenic Transformation and Cell Polarity Chapter 10 Regulation of Cell Proliferation by Receptor Tyrosine
Protein Kinases Chapter 11 Signal Transduction to and from Adhesion Molecules Chapter 12 WNT Signaling
and the Regulation of Cell Adhesion and Differentiation Chapter 13 Activation of the Innate Immune System:
the Toll-Like Receptor-4 and Signaling through Ubiquitylation Chapter 14 Chemokines and Traffic of White
Blood Cells Chapter 15 Activating the Adaptive Immune System: Role of Non-receptor Tyrosine Kinases
Chapter 16 Signaling through the Insulin Receptor: Phosphoinositide 3-Kinases and AKT Chapter 17 TGFß
and Signaling through Receptor Serine/Threonine Protein Kinases Chapter 18 Protein Phosphates Chapter
19 Cell Fate Determination by Notch
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