Download Norman Fleischer, M.D. NAME: CURRENT POSITION:

Norman Fleischer, M.D.
CURRICULUM VITAE
NAME:
NORMAN FLEISCHER, M.D., F.A.C.P.
CURRENT POSITION:
Jacob and Jeanne Barkey Professor of Medicine,
Director, Division of Endocrinology
Albert Einstein College of Medicine and
Montefiore Medical Center
1300 Morris Park Ave., Bronx, N.Y. 10461
EDUCATION:
1958
A.B., Vanderbilt University
1961
M.D., Vanderbilt University
POSTGRADUATE TRAINING:
1961-62
Intern, Department of Medicine
Bronx Municipal Hospital Center
Albert Einstein College of Medicine,
Bronx, New York
1962-64
Resident, Department of Medicine
Bronx Municipal Hospital Center
Albert Einstein College of Medicine,
Bronx, New York
1964-66
Fellowship in Endocrinology (with Grant
W. Liddle),
Department of Medicine, Vanderbilt University
School of Medicine, Nashville, TN.
PROFESSIONAL EMPLOYMENT
AND HOSPITAL APPOINTMENTS:
2004-present
Co-Director, Diabetes Research Center of Albert Einstein College
of Medicine
2000-2002
Vice-Chairman, Department of Medicine, Albert Einstein College
of Medicine
1999-present
Director of Endocrinology, Montefiore Medical Center
1991-present
Jacob A. and Jeanne E. Barkey Professor of Medicine, Albert
Einstein College of Medicine
1988-2002
Director, The Diabetes Research Center of Albert Einstein College
of Medicine
1977-2004
Principal Investigator, Diabetes Research and Training Center,
Albert Einstein College of Medicine
1977-present
Professor, Department of Medicine
Albert Einstein College of Medicine
1976-present
Director, Division of Endocrinology
Albert Einstein College of Medicine
1974-77
Assistant Director, General Clinical Research Center
Albert Einstein College of Medicine, Bronx, N.Y.
1973-77
Associate Professor, Department of Medicine
Albert Einstein College of Medicine, Bronx, New York
1973-76
Co-Director, Division of Endocrinology
Albert Einstein College of MedicineBronx, New York.
1971-73
Assistant Program Director, Baylor General Clinical Research
Center Houston, Texas
1969-73
Director of Endocrinology, Ben Taub General Hospital
Houston, Texas
1971-1973
Associate Professor of Medicine
Baylor College of Medicine, Houston, Texas
1967-71
Assistant Professor of Medicine
Baylor College of Medicine, Houston, Texas
1966-67
Instructor, Department of Medicine
Baylor College of Medicine, Houston, Texas
1964-66
Instructor, Department of Medicine
Vanderbilt University School of Medicine
Nashville, Tennessee
Norman Fleischer, M.D.
BOARD CERTIFICATION:
1968
1973
LICENSURE:
Internal Medicine
Endocrinology
New York State
Texas State Board of Medical Examiners
PROFESSIONAL SOCIETY MEMBERSHIP:
Fellow, American College of Physicians
Council, New York State Chapter 1982-85
Fellow, American College of Clinical Endocrinology
American Association for the Advancement of Science
American Federation for Clinical Research
The Endocrine Society
Manpower Committee 1987-1990
Annual Meeting Steering Committee 1997-2000
American Society for Biochemistry and Molecular Biology
Southern Society for Clinical Investigation
International Society for Neuroendocrinology
American Society for Clinical Investigation
New York Academy of Sciences
American Diabetes Association
Research Committee 1983-86
Fellow, Clinical Society of the New York Diabetes Association
Chairperson, Research Committee 1981-84
Association of American Physicians
New York State Council on Diabetes 1987-1989
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Norman Fleischer, M.D.
NIH RELATED ACTIVITIES:
Member, Multiple Review Panels
Recent: Ad Hoc Review Diabetes Centers
Current: NIH Loan RepaymentStudy Section
Principal Investigator:
Pituitary and Islet Hormone Secretion 1969-79
Diabetes Research and Training Center 1977-2002
Diabetes Training Grant 1985-1990
Diabetes Research and Training Center, 1976-2002
Program Project: Preservation and Replacement of Beta Cells in IDDM 19972008
Co-Investigator:
Diabetes Control and Complications Trial, 1985-94
Generation of Non-Immunogenic Functional Islet Cells, 1992-97
Co-Director, Diabetes Research and Training Center, 2004-present
CURRENT COLLEGE AND DEPARTMENTAL ADMINISTRATIVE ROLES
Division Director (Medicine), Endocrinology, Einstein and Montefiore Medical Center
Co-Director, Diabetes Research Center
Internal Advisory Committee, M.D./Ph.D. Training Program
AWARDS AND HONORS:
Phi Beta Kappa
Alpha Omega Alpha
Davidoff Society of AECOM
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Norman Fleischer, M.D.
INVITED PRESENTATIONS AT SYMPOSIA (SELECTED)
The Effect of Thyrotropin Releasing Factor (TRF) on Plasma TSH in Subjects with Pituitary
Tumors. Serono Foundation Conference on Hypothalamic Hormones, Acapulco, Mexico, 1972.
Hypothalamic Hypophsiotropic Hormones. Biological Council Synposium on Peptide
Hormones, London, 1973.
Calcium and the Secretion of Insulin and Thyrotropin: Studies with Calcium Antagonists.
American Physiological Society Symposium on Calcium Antagonists, Toronto, 1980.
Calcium-dependent Insulin Secretion and Protein Phosphorylation: Possible Role for
Calmodulin. Annual Meeting of American Society of Biological Chemists, Mini-symposium on
Calmodulin, May, 1981. (Presented by U.K. Schubart)
Cell Mediated Immunity In Streptozotocin-Induced Insulitis. Juvenile Diabetes Foundation
Symposium on Beta Cell Injury, Princeton, 1982.
The Role of Calcium and Cyclic AMP in Polypeptide Hormone Secretion. Symposium on
Hormone Action, Sharik Zadek Hospital, Jerusalem, Israel, 1984.
Cushing's Disease. Grant W. Liddle Honorary Symposium, Vanderbilt University, Nashville,
Tennessee, 1985
Intracellular Mechanisms for the Regulation of Insulin Secretion. NIH Colloquium on Signal
Transmission and Diabetes, Bethesda, 1988.
Visiting Professor, Emory University School of Medicine, 1993.
Generation of Correctly Regulated Pancreatic Beta Cell Lines by Transgenic Methodology.
Forty-First Annual Clinical Society Scientific Meeting, American Diabetes Association, New
York Downstate Affiliate, 1993.
Cushing's Syndrome: Diagnosis and Management. American Diabetes Association: 43rd Annual
Advanced Postgraduate Course, New York, NY, 1996
Beta Cell Transplantation, NIH/JDF Symposium, Bethesda, Md. 1998.
Insulin Secretion from BTC Cells, Columbia University, April, 2001
Transplantation Therapy of Diabetes with Conditionally Transformed Beta cells. Endocrine
Grand Rounds, College of Physicians and Surgeons, New York, May 2002.
Insulin Secretion from Beta Cell Lines: From Mouse to Man. Inter-Institutional Clinical
Endocrine Grand Rounds, NIH, Bethesda, MD, June, 2003
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Norman Fleischer, M.D.
Publications
1.
Fleischer N and Walker R. Gastric Carcinoma Following Successful Therapy for
Primary Gastric Lymphosarcoma. Southern Med. J. 53: 965-968, 1960.
2.
Fleischer N, Givens JR, Abe K, Nicholson WE and Liddle GW. Studies of ACTH
Antibodies and their Reactions with Inactive Analogues of ACTH. Endocrinology 78:
1067-1075, 1966.
3.
Fleischer N, Abe K, Liddle GW, Orth DN and Nicholson WE. ACTH Antibodies in
Patients Receiving Depot Porcine ACTH to Hasten Recovery from Pituitary-Adrenal
Suppression. J. Clin. Invest. 46: 196-204, 1967.
4.
Abe K, Island DP, Liddle GW, Fleischer N and Nicholson WE. Radioimmunologic
Evidence for alpha-MSH (Melanocyte Stimulating Hormone) in Human Pituitary and
Tumor Tissues. J. Clin. Endocr. 27: 46-52, 1967.
5.
Fishman LM, Liddle GW, Island DP, Fleischer N and Kuchel O. Effects of
Amino-Glutethimide on Adrenal Function in Man. J. Clin. Endocr. 27: 481-490, 1967.
6.
Fleischer N and Battarbee H. Inhibition of Dexamethasone Suppression of ACTH
Secretion in vivo by Actinomycin D. Proc. Soc. Exp. Biol. Med. 126: 922-925, 1967.
7.
Fleischer N and Vale W. Inhibition of Vasopressin-induced ACTH Release from the
Pituitary by Glucocorticoids in vitro. Endocrinology 83: 1232-1236, 1968.
8.
Fleischer N, Brown H, Graham DY and Delena S. Chronic Laxitive-induced
Hyperaldosteronism and Hypokalemia Simulating Bartter's Syndrome. Ann. Intern. Med.
70:791-798, 1969.
9.
Hauger-Klevene J, Brown H and Fleischer N. ACTH Stimulation and Glucocorticoid
Inhibition of Renin Release in the Rat. Proc. Soc. Exp. Biol. Med. 131: 539-542, 1969.
10.
Fleischer N, Donald RA and Butcher RW. Involvement of Adenosine
3',5'-monophosphate in Release of ACTH. Am. J. Physiol. 217: 1287-1291, 1969.
11.
Fleischer N, Burgus R, Vale W, Dunn T and Guillemin R. Preliminary Observations on
the Effect of Synthetic Thyrotropin Releasing Factor on Plasma Thyrotropin Levels in
Man. J. Clin. Endocr. 31: 109-112, 1970.
12.
Zimmerman G and Fleischer N. Role of Calcium Ions in the Release of ACTH in Rat
Pituitary Tissue in vitro. Endocrinology 87: 426-429, 1970.
13.
Fleischer N and Rawls W P. ACTH Synthesis and Release in Rat Pituitary Monolayer
Culture: The Effect of Dexamethasone. Amer. J. Physiol. 219: 445-448, 1970.
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Norman Fleischer, M.D.
14.
Fleischer N, Lorente M, Kirkland J, Kirkland R, Clayton G and Calderone,M. Synthetic
Thyrotropin Releasing Factor as a Test of Pituitary TSH Reserve. J. Clin. Endocr. 43:
617-624, 1972.
15.
Fleischer N, Coscia AM and Lorente M: The effect of Thyrotropin Releasing Factor
(TRF) on Plasma TSH in Subjects with Pituitary Tumors. In, Hypothalamic
Hypophysiotropic Hormones (Physiological and Clinical Studies), C. Gual (ed.),Excerpta
Medica, Amsterdam, pp. 326-331, 1972.
16.
Fleischer N, Guillemin R: The Clinical Applications of Hypothalamic Releasing Factors.
Adv. Intern. Med. 18: 303-323, 1972.
17.
Fleischer N, Zimmerman G, Schindler W and Hutchins M: Stimulation of
Adrenocorticotropin (ACTH) and Growth Hormone (GH) Release by Ouabain:
Relationship to Calcium. Endocrinology 91: 1436-1441, 1972.
18.
Fleischer N.: Diagnostic Considerations in Secondary Hypertension. Texas Medicine 69:
64-70, 1973.
19.
Fleischer N and McMillin Wood J: Ouabain Stimulation of Calcium Influx in the Rat
Pituitary. Endocrinology 92: 1555-1559, 1973.
20.
Zlatkis A, Bertsch W, Lichtenstein HA, Tishbee A, Shumbo F, Liebich HN, Coscia AM
and Fleischer N: Profile of Volatile Metabolites in Urine by Gas Chromatography-Mass
Spectrometry. Ann. Chem. 45: 763-767, 1973.
21.
Lash B and Fleischer N: Radioimmunoassay of Angiotensin 1 for Estimation of Plasma
Renin Activity. Clin. Chem. 20: 620-623, 1974.
22.
Eto S, Wood JM, Hutchins M and Fleischer N: Pituitary 45Ca++ Uptake and the
Release of ACTH, GH and TSH. Am. J. Physiol. 26: 1315-1320, 1974.
23.
Coscia AM, Fleischer N, Brown L, Besch PK and Desiderio D: The Effect of Synthetic
Luteinizing Hormone-releasing Factor on Plasma LH Levels in Pituitary Disease. J. Clin.
Endocr. 38: 83-88, 1974.
24.
Brown LP, Skelly DS, Besch PK, Buttram VC and Fleischer N: An Overnight
Radioimmunoassay for Human Luteinizing Hormone. J. Lab. Clin. Med. 84: 129-133,
1974.
25.
Shin S, Baum SG, Fleischer N and Rosen OM: Retention of Endocrine Function by an
Insulin-secreting Pancreatic Islet Cell Tumor from Syrian Hamster Through Serial
Transplantation in Nude Mice. J. Cell. Sci. 18: 199-206, 1975.
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Norman Fleischer, M.D.
26.
Shapiro S, Eto S, Fleischer N and Baum SG: Regulation of in vitro Insulin Release from
a Transplantable Syrian Hamster Insulinoma. Endocrinology 97: 442-447, 1975.
27.
Eto S, and Fleischer N: Regulation of Thyrotropin (TSH) Release and Production in
Monolayer Cultures of Transplantable TSH-producing Mouse Tumors. Endocrinology
98: 114-122, 1976.
28.
Fleischer N and Guillemin R: Hypothalamic Hypophysiotropic Hormones. In, Peptide
Hormones, J. Parsons, (ed.), MacMillan Press, Ltd., London, pp. 317-335, 1976.
29.
Fleischer N, Rosen OM and Reichlin M: Radioimmunoassay of Bovine Heart Protein
Kinase: Subunit, Tissue and Species Specificity. Proc. Natl. Acad. Sci. U.S.A. 73: 54-58,
1976.
30.
Schubart UK, Shapiro S, Fleischer N and Rosen OM: Cyclic 3':5'-Adenosine
Monophosphate-mediated Insulin Secretion and Ribosomal Protein Phosphorylation in a
Hamster Islet Cell Tumor. J. Biol. Chem. 252: 92-101, 1977.
31.
Fleischer N: Treatment of Cushing's Syndrome. In, Current Therapy, H. Conn. (ed.), pp.
489-492, 1977.
32.
Mortimer RH, Fleischer N, Lev-Gur M and Freeman RG: Correlation between Integrated
Basal LH and FSH Levels and the Response to Luteinizing Hormone Releasing Factor
(LRF). J. Clin. Endocr. 43: 1242-1249, 1976.
33.
Shapiro S, Kaneko Y, Baum SG and Fleischer N: The Role of Calcium in Insulin
Release from Hamster Insulinoma Cells. Endocrinology 101: 485-493, 1977.
34.
Shin S, Reid LC, Colburn PC, Kadish AS, and Fleischer N.: Development of
Transplantable Functional Endocrine Tumor Lines in Nude Mice. In, Proc. of 2nd
Internatinal Workshop on Nude Mice, Tokyo, pp. 375-393, 1977.
35.
Mortimer R, Lev-Gur M, Freeman R and Fleischer N: Pituitary Response to Bolus and
Continuous IV infusion of Luteinizing Hormone Releasing Factor (LRF) in Normal
Women with Polycystic Ovarian Syndrome (PCOS). Am. J. Obs. Gynec 103: 630-634,
1978.
36.
Mortimer RH and Fleischer N: Hypothalamic Control of Pituitary Function. In, Nuclear
Medicine and Endocrinology, B. Rothfeld, (ed.), J.B. Lippincott Co., Philadelphia, Pa.,
pp. 141-158, 1978.
37.
Rubin CS, Rangel-Aldao R, Sarkar D, Erlichman J and Fleischer N: Characterization and
Comparison of Membrane-associated and Cytosolic cAMP-dependent Protein Kinases.
Physicochemical and Immunological Studies on Bovine Cerebral Cortex Protein Kinases.
J. Biol. Chem. 254: 3797-3805, 1979.
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Norman Fleischer, M.D.
38.
Erlichman J, Schubart UK, and Fleischer N: Sulfhydryl Reagent Induced Insulin Release
and 45Ca++ Fluxes in Syrian Hamster Insulinoma Cells. Endocrinology 105:
1183-1190, 1979.
39.
Schubart UK, Erlichman J and Fleischer N: The Role of Calmodulin in the Regulation of
Protein Phosphorylation and Insulin Release in Hamster Insulinoma Cells. J. Biol.
Chem. 255: 4120-4124, 1980.
40.
Erlichman J, Sarkar D, Fleischer N and Rubin CS: Identification of Two Sublcasses of
Type II cAMP-dependent Protein Kinases. Neural-specific and Non-neural Protein
Kinases. J. Biol. Chem. 255: 8179-8184, 1980.
41.
Paik S, Fleischer N and Shin S: Insulin-dependent Diabetes Mellitus Induced by
Subdiabetogenic Doses of Streptozotocin: Obligatory Role of Cell-mediated Autoimmune
Processes. Proc. Natl. Acad. Sci. U.S.A. 77: 6129-6133, 1980.
42.
Schubart UK, Fleischer N and Erlichman J: Ca2+-dependent Protein Phosphorylation
and Insulin Release in Intact Hamster Insulinoma Cells: Inhibition by Trifluoperazine. J.
Biol. Chem. 255: 11063-11066, 1980.
43.
Rubin CS, Fleischer N, Sarkar D and Erlichman J: Neural-specific and Non-neural
Protein Kinases. Subclasses of Type II Protein Kinases. Cold Spring Harbor Symposia
on Cell Proliferation, Vol. 8, pp. 1333-1346, 1981.
44.
Fleischer N, Sarkar D, Rubin CS and Erlichman J: Radioimmunoassay of Type II cyclic
AMP-dependent Protein Kinases. Methods in Enzymology, 74: 310-320, 1981.
45.
Fleckman A, Erlichman J, Schubart UK and Fleischer N: Effect of Trifluoperazine,
D600, and Phenytoin on Depolarization and TRH-induced TSH Release from Rat
Pituitary Tissue. Endocrinology 108: 2072-2077, 1981.
46.
Fleischer N, Schubart UK, Fleckman A and Erlichman J: Calcium and the Secretion of
Insulin and Thyrotropin: Studies with Calcium Antagonists. In, New Perspectives on
Calcium Antagonists, G.B. Weiss (ed.), Clinical Physiology American Physiological
Society, pp. 177-190, 1981.
47.
Schubart UK, Erlichman J and Fleischer N: Insulin Release and Protein Phosphorylation:
Possible Role of Calmodulin. Federation Proceedings 41: 2278-2282, 1982.
48.
Paik S, Blue M, Fleischer N and Shin S: Diabetes Susceptibility of BALB/cBOM Mice
Treated with Streptozotocin: Inhibition by Lethal Irradiation and Restoration by Splenic
Lymphocytes. Diabetes 31: 808-815, 1982.
49.
Fleischer N: Disorders of the Hypothalamus and Anterior Pituitary. In, "Internal
9
Norman Fleischer, M.D.
Medicine" J.H. Stein, (ed.), Little, Brown & Co., Boston, pp. 1716-1728, 1983.
50.
Schubart UK, Erlichman J and Fleischer N: Regulation of Insulin Release and Protein
Phosphorylation by Calcium and Cyclic AMP: Possible Role for Calmodulin. In,
Calcium and Cell Function, W.Y. Cheung, (ed.), Academic Press, N.Y. pp. 381-400,
1982.
51.
Shin S, Paik SG and Fleischer N: The Role of Autoimmune Processes in the
Development of Insulin-dependent Diabetes Mellitus in Mice Treated with
Streptozotocin. In, Proc. of Symposium on Basic and Clinical Aspects of Immunity to
Insulin, K. Keck and P. Erb. (eds.), Walter DeGruyter, Berlin, pp. 303-317, 1981.
52.
Fleckman AM, Schubart UK, Danziger A and Fleischer N: Empty Sella of Normal Size
in Sheehan's Syndrome. Am. J. Med. 75: 585-591, 1983.
53.
Axen KV, Schubart UK, Blake A and Fleischer N: Calcium-induced
Phosphatidylinositol Metabolism and Insulin Release in Rat Islets of Langerhans: Role of
Ca2+ and cAMP. J. Clin. Invest. 72: 13-21, 1983.
54.
Sarkar D, Erlichman J, Fleischer N and Rubin CS: Use of Immunological Approaches to
Identify a Brain Protein Kinase Isoenzyme. Methods in Enzymology 99: 187-196, 1983.
55.
Erlichman J, Litvin Y, Pasmantier R and Fleischer N: Differential Activation of
cAMP-dependent Protein Kinases in AtT20 Cells by Corticotropin Releasing Factor.
Annals New York Academy of Sciences. 435: 145-147, 1984.
56.
Litvin Y, Pasmantier R, Fleischer N and Erlichman J: Hormonal Activation of the
cAMP-dependent protein kinases in AtT20 cells: Preferential activation of protein kinase
I by corticotropin releasing factor, isoproterenol and forskolin. J. Biol. Chem. 259:
10296-10302, 1984.
57.
Erlichman J, Litvin Y, and Fleischer N: Immunological and Molecular Characterization
of cAMP-dependent Protein Kinases in AtT-20 cells. J. Biol. Chem. 259: 10289-10295,
1984.
58.
Litvin Y, Leiser M, Fleischer N, and Erlichman J: Somatostatin Inhibits Corticotropin
Releasing Factor Stimulated Adrenocorticotropin Release, Adenylate Cyclase and
Activation of Cylic AMP-dependent Protein Kinase Isoenzymes in AtT20 Cells.
Endocrinology 119: 737-745, 1986.
59.
Matz R and Fleischer N: Diabetic Coma, In: Clinical Endocrinology, Peter Kohler. Ed.,
Chapter 18, pp. 623-632, John Wiley and Sons, New York, N.Y. 1986
60.
Pasmantier R, Danoff A, Fleischer N, and Schubart U: PP16, a Hormonally Regulated
Phosphoprotein of Peptide Hormone-producing Cells: Secretagogue induced
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Norman Fleischer, M.D.
Phosphorylation in AtT20 Mouse Pituitary Tumor Cells and in Rat and Hamster
Insulinoma Cells. Endocrinology 119: 1229-1238, 1986.
61.
Danoff A, Lorber D, and Fleischer N: Adrenocortical Micronodular Dysplasia, Cardiac
Myxomas, Cutaneous Lentigines, and Spindle Cell Tumors: Report of a Kindred. Arch.
of Int. Med. 147: 443-448, 1987.
62.
Leiser M, Fleischer N and Erlichman J: Enhanced Activation of cAMP-dependent
Protein Kinase by Rapid Synthesis and Degradation of cAMP. J. Biol. Chem. 261:
15486-15490, 1986.
63.
Fleischer N: Disorders of the Hypothalamus and Anterior Pituitary. In, Internal
Medicine: A Systematic Approach, J.H. Stein (ed.), Little, Brown & Co., Boston, pp.
1895-1908, 1986.
64.
Bilezikjian LM, Erlichman J, Fleischer N and Vale WW: Differential activation of type I
and type II cAMP-dependent protein kinases by growth hormone releasing factor.
Molecular Endocrinology 1: 137-146,1987.
65.
Fleischer N and Erlichman J: Intracellular signals and protein phosphorylation:
regulatory mechanisms in the control of insulin secretion from the pancreatic beta cell.
In, Drazin B, Melmed S and LeRoith D (eds.), " Molecular and Cellular Biology of
Diabetes Mellitus: Vol. I, Insulin Secretion, Alan R. Liss, Inc., New York, pp. 107-116,
1989.
66.
Fleischer N, Liker H, Stoller T, D'Ambra R and Shields D: Retrovirus-Mediated
Expression of Preprosomatostatin in Rat Pituitary GH3 Cells: Targeting of Somatostatin
to the Regulated Secretory Pathway. Molecular Endocrinology. 3:1652-1658, 1989.
67.
Fleischer N, Fein FS, Sonnenblick EH: The Heart and Endocrine Disease. In, J. Willis
Hurst (ed), "The Heart", 7th edition, McGraw-Hill Book Company, New York, 1988.
68.
Wylie-Rosett J., Engel S, D'Eramo G, Mazze R, Murphy J, Shamoon H, Slagel S,
Villeneuve M, Wilson J and Fleischer N: Delivery of Diabetes Care to Low-Income
Patients: Assessment of a Federally Funded Program. Diabetes Educator 15:366-369,
1989.
69.
Leiser M, Fleischer N, and Erlichman J: Cyclic AMP turnover and signal amplification: a
reply. Biochem 257:623-624, 1989 (Letter).
70.
Lomasky SJ, D'Eramo G, Shamoon H and Fleischer N: Relation of Insulin Secretion abd
Glycemic Recovery to Dietary Intervention in Non-Insulin-Dependent Diabetes. Arch.
Intern. Med. 150:169-172, 1990.
71.
Efrat S, Fleischer N, and Hanahan D: Diabetes Induced in Male Transgenic Mice by
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Norman Fleischer, M.D.
Expression of Human H-ras Oncoprotein in Pancreatic ß Cells. Mol. Cell. Biol. 10:
1779-1783, 1990.
72.
D'Ambra RD, Surana M, Efrat S, Starr RG, and Fleischer N: Regulation of Insulin
Secretion from Beta Cell Lines Derived from Transgenic Mice Insulinomas Resembles
That of Normal Beta Cells. Endocrinology 126: 2815-2822, 1990.
73.
Socolow EL and Fleischer N: Thyroid disease and the heart. In: J. Willis Hurst (ed.)
"Current Therapy in Cardiovascular Disease, Third Edition", B.C. Becker, 1991, pp 384389.
Efrat S, Surana M, and Fleischer N: Glucose induces insulin gene transcription in a
murine ß-cell line. J. Biol. Chem., 266:11141-11143, 1991.
74.
75.
Tal M, Thorens B, Surana M, Fleischer N, Lodish H F, Hanahan D, Efrat S: Glucose
transporter isotypes switch in transformed pancreatic ß cells. Mol. and Cell. Biol.
12:422-432, 1992.
76.
Tal M, Wu Y-J, Leiser M, Surana, M., Lodish H, Fleischer N., Weir G, and Efrat S:
[Val12]HRAS downregulates GLUT2 in ß cells of transgenic mice without affecting
glucose homeostasis. Proc. Natl. Acad. Sci. USA, 89:5744-5748, 1992.
77.
Efrat S, Leiser M, Surana M, Tal M, Fusco-DeMane D, and Fleischer N: A murine
insulinoma cell line with normal glucose-regulated insulin secretion. Diabetes 42:901907, 1993
78.
Efrat S, Leiser M, Wu Y-J, Fusco-DeMane D, Emran O, Surana M, Weir G, Jetton T,
Magnuson MA and Fleischer N: Ribozyme-mediated attenuation of pancreatic ß-cell
glucokinase expression in transgenic mice results in impaired glucose-induced insulin
secretion. Proc. Natl. Acad. Sci (USA), 91:2051-2055, 1994.
79.
Knaack D, Fiore DM, Surana M, Leiser M, Laurance M, Fusco-DeMane D, Fleischer N,
and Efrat S: Clonal insulinoma cell line which maintains correct glucose responsiveness.
Diabetes 43:1413-1417, 1994
80.
Leiser M, Efrat S, and Fleischer N: Evidence that RAP1 carboxylmethylation is involved
in regulated insulin secretion. Endocrinology 136: 2521-2530, 1995.
81.
Bali D, Svetlanov A, Lee H, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M,
Hou H, Fleischer N, DePinho R, Rossetti L, and Efrat S: Animal model for maturityonset diabetes of the young generated by disruption of the mouse glucokinase gene. J.
Biol. Chem., 270:21464-21467, 1995.
82.
Efrat S, Leiser M, Wu Y-J, Fusco-DeMane D, Weir G, Fleischer N: Manipulation of
glucokinase gene expression in transgenic mice. In Diabetes 1994 - Excerpta Medica
International Congress Series 1100 (S Baba, T Kaneko, eds.), Elsevier Science,
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Norman Fleischer, M.D.
Amsterdam, pp. 165-172, 1995
83.
Efrat S, and Fleischer N: Engineering the pancreatic β-cell. In Diabetes Mellitus (D.
LeRoith, S. Taylor, J. Olefsky, eds.) Lippincott-Raven, Philadelphia, 1996 pp 438-443.
84.
Leiser M and Fleischer N: cAMP-Dependent Phosphorylation of the Cardiac-type α1
Subunit of the Voltage-dependent Ca++ Channel in a Murine Pancreatic ß-Cell Line.
Diabetes 45:1412-1418, 1996
85.
Fleischer N, Chen C, Surana M, Leiser M, Rossetti L, Pralong W, and Efrat S:
Functional Analysis of a Conditionally-Transformed Pancreatic ß-Cell Line. Diabetes 47:
1419-1425, 1998
86.
Han P, Werber J, Surana M, Fleischer N and Michaeli T: The calcium calmodulin
dependent phosphodiesterase PDE1C down-regulates glucose induced insulin secretion.
J. Biol. Chem. 274:22337-44, 1999.
87.
Sooy K, Schermerhorn T, Noda M, Rhoten WB, Meyer M, Fleischer N, Sharp GWG,
Christakos S: Calbindin-D28k controls [Ca2+]i and insulin release: evidence obtained from
calbindin-D28k knockout mice and cell lines. J. Biol. Chem., 274: 34343-49, 1999.
88.
Efrat S, and Fleischer N: Engineering the pancreatic β-cell. In Diabetes Mellitus (D.
LeRoith, S. Taylor, J. Olefsky, eds.) Lippincott-Raven, Philadelphia, p535-541, 2000
89.
Cases JA, Gabriely I, Xiao HM, Xiao MY, Michaeli T, Fleischer N, Rossetti L, Barzilai,
N: Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo.
Diabetes 50: 348-352, 2001.
90.
Milo-Landesman D, Surana M, Berkovich I, Compagni A, Christofori G, Fleischer N
and Efrat S. Correction of hyperglycemia in diabetic mice transplanted with reversiblyimmortalized pancreatic β cells controlled by the tet-on regulatory system. Cell
Transplantation 10:645-659, 2001
91.
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