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Brochure
More information from http://www.researchandmarkets.com/reports/2860734/
Cell Culture: The World Market for Media, Sera, and Reagents
Description:
As the biopharmaceutical market grows, so will the cell culture products market. Cell culture is a major
foundation of biopharmaceutical development, bioprocessing and manufacturing. Biopharmaceutical
products are developed from large, complex protein molecules, which require equally complex
manufacturing methods and an array of analytical techniques. As growing cells for biopharmaceutical
production is slow, expensive and complicated, optimizing cell culture development is of paramount
concern to companies developing biopharmaceuticals.
This report is focused on cell culture used in the research and production of biopharmaceuticals, analyzing
the world cell culture market and the major trends driving this market in three specific segments:
Media,
Sera, and
Reagents
In addition to a thorough discussion of the technologies and techniques currently employed and emerging
in the cell culture area, the Kalorama's exhaustive report provides specific information on:
Market Size, growth, and forecasts of the segments through 2011
Competitive Market Share by leading supplier as of 2005.
Estimated Market Share by Media Type (this is not available in other reports)
Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines,
seasonal vaccine production, biomedical R&D directions, and the future of transgenic plant and animal
production.
Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical
product manufactured by these systems
Discussion of the trends and preferences in media types vying for dominance in the market, including the
following:
ADCF - animal derived component free media
CD - chemically defined media
CSFM - complete serum free medium
PF - protein free media
SF - serum free media
SFM - serum free medium
Profiles of 28 leading suppliers and information about M&A activities since 2003.
The information for this report was gathered using both primary and secondary research including
comprehensive research of secondary sources such as company literature, databases, investment reports,
and medical and business journals. Telephone interviews and email correspondence were the primary
method of gathering information. For the purpose of this study Kalorama Information conducted interviews
with key industry officials, consultants, and government personnel. These sources were the primary basis in
gathering information specifically relating to revenue and market share data presented in this report.
Specific interviews with pharmaceutical company and cell culture supply company representatives included
marketing directors, division managers, and product representatives.
Contents:
Chapter One: Executive Summary
Scope and Methodology
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Cell Lines and Cell Banks
Fermentors and Bioreactors
Stirred-Tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-Fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environment: Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Lysogeny broth (LB)
Classical Media
Serum-Free Media
Protein-Free Media
Chemically Defined Media
Specialty Media
Sera
Reagents
Shifting Towards Non-Animal Derived Reagents
Addressing Reagent Safety Issues
World Cell Culture Market
Impact of Shift to Serum-free Products on Cell Culture Suppliers
Impact of Shift to Serum-Free Products On Research
Impact of Shift to Serum-Free Products on Biopharmaceutical Manufacturers
Market Drivers
Cell Culture Market Forecast
Trends Impacting The Cell Culture Market
Chapter Two: Genetically Modified Cells for Biopharmaceutical Development
Overview
Growing Demand for Biopharmaceuticals
Demand Increasing for Cell Culture Products
A Brief History of Biotechnology
Science of Genetic Manipulation
From Petri Dish to Biopharmaceutical
Upstream Bioprocessing: Cell Culture Expression Systems
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Advantages/Disadvantages of Cell Culture Systems
Cell Lines and Cell Banks
Biopharmaceuticals Produced from Cell Culture
Cell Culture Practices and Regulatory Guidelines
Validation of Facilities
Maintaining Sterilization Standards
Chapter Three: Cell Culture Technology
Introduction and Overview
Cell Lines for Bioproduction
Predominant Cell Lines
Chinese Hamster Ovary (CHO)
SP2/0, and NS0
HEK 293 and PER. C6
Sources: Largest Collections of Cell Lines
The European Collection of Cell Cultures (ECACC)
The American Type Cell Culture (ATCC)
Fermentors and Bioreactors
Types of Bioreactors/Fermentors
Stirred-Tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environment:
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Lysogeny Broth (LB)
Classical Media
Serum-Free Media
Protein-Free Media
Chemically Defined Media
Specialty Media
Sera
Sources of Sera
Bovine Serum Safety Issues and Regulations
Shift to Serum-Free Media
Reagents
Major Types of Biologic Reagents
Amino Acids
Growth Factors and Cytokines
Albumin
Transferrin
Thrombin
Growth Supplements
Protease Inhibitor
Attachment Factors
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
Chapter Four: Trends and Market Analysis
Shift Away From Serum-Based Cell Culture
Impact of Shift to Serum-Free Products on Cell Culture Suppliers
Impact of Shift to Serum-Free Products on Research
Impact of Shift Serum-Free Products on Biopharmaceutical Manufacturers
Cell Culture Market
Market Drivers
Cell Culture Market and Forecast
Segment Analysis
Media
Sera
Reagents
Market Characteristics
Major Acquisitions
Competitive Market Share
Trends Impacting The Cell Culture Market
Stem Cell Research
Invitrogen
Sigma-Aldrich
Millipore Corporation
Cell Culture-Based Vaccine Production
Transgenically Produced Biopharmaceuticals
Chapter Five: Company Profiles
Advanced Biotechnologies, Inc.
History and Lines of Business
Cell Culture Products and Services
AMRESCO, Inc.
History and Lines of Business
Cell Culture Products
Analytical Biological Services Inc.
History and Lines of Business
Cell Culture Products
Mammalian Cell Culture
Cell in Microtiter Plates for HTS
Primary Cultures
Insect Cell Culture
Atlanta Biologicals, Inc.
History and Lines of Business
Cell Culture Products
Athena Enzyme Services
History and Lines of Buiness
Cell Culture Products
Biochrom AG
History and Lines of Business
Cell Culture Products
BD Biosciences
History and Lines of Business
Cell Culture Products
Clinical and Clinical Research Reagents
Financial Information
Cambrex Corporation
History and Lines of Business
Cell Culture Products
Financial Information
Cell Essentials, Inc.
History and Lines of Business
Cell Culture Products
CellGenix Technologie Transfer GmbH
History and Lines of Business
Cell Culture Products and Services
Fisher Scientific International, Inc.
History and Lines of Business
Cell Culture Products
Financial Information
Invitrogen Corporation
History and Lines of Business
Cell Culture Products
Financial Information
Irvine Scientific
History and Lines of Business
Cell Culture Products
J R Scientific, Inc.
History and Development
Cell Culture Products
Hyclone Laboratories
History and Lines of Business
Cell Culture Products
Kemp Biotechnologies, Inc.
History and Lines of Business
Cell Culture Products
Cell Culture - Fermentation
Cell Culture - Stable Mammalian
Cell Culture - Mammalian Transient Transfection
Cell Culture - Baculovirus (Insect Cell)
Mediatech, Inc.
History and Lines of Business
Cell Culture Products
Millipore Corporation
History and Lines of Business
Cell Culture Products
Financial Information
PAA Laboratories, Inc.
History and Lines of Business
Cell Culture Products
PromoCell GmbH
History and Lines of Business
Cell Culture Products
Quality Biological, Inc.
History and Lines of Business
Cell Culture Products
R&D Systems, Inc.
History and Lines of Business
Cell Culture Products
SBH Sciences
History and Lines of Business
Cell Culture Products
Selexis SA
History and Lines of Business
Cell Culture Products
SeraCare Life Sciences, Inc.
History and Lines of Business
Cell Culture Products
Sigma-Aldrich Corporation
History and Lines of Business
Cell Culture Products
Financial Information
USB Corporation
History and Lines of Business
Cell Culture Products
Wisent, Inc.
History and Lines of Business
Cell Culture Products
Appendix: Company Directory
List of Exhibits
Chapter One: Executive Summary
Exhibit 1-1: Market Summary: World Cell Culture Market 2002-2011
Chapter Two: Genetically Modified Cells for Biopharmaceutical Development
Exhibit 2-1: Biopharmaceuticals Appoved in the US or the EU in 2005 (Product, Expression, Indications,
Company)
Exhibit 2-2: Approximate Times from Introduced Gene to Protein Production at Useable Levels by
Expression System (Bacteria, Yeast, Mammilian, Insect)
Exhibit 2-3: Disadvantages/Advantages of Cell Culture Systems by Expression System (Bacteria, Yeast,
Animal, Insect)
Exhibit 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells (Expression
System, Product, Manufacturer, Indication)
Chapter Three: Cell Culture Technology
Exhibit 2-1: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma,
Myeloma, and CHO cell lines (Company, Product, Type [ADCF, CD, CSFM, PF, SF, SFM], Cell Line)
Chapter Four: Trends and Market Analysis
Exhibit 4-1: Selected Brand Name Serum-Free Formulations of Cell Culture Products Currently on the
Market (Brand, Product, Manufactuer)
Exhibit 4-2: World Cell Culture Market Revenues and Growth 2002-2011
Exhibit 4-3: Cell Culture World Market Share by Geographical Region 2006
Exhibit 4-4: Estimated Share of Cell Culture Media Market by Media Type (Animal Sourced vs Animal Free
and Animal Free vs Chemically Defined)
Exhibit 4-5: World Cell Culture Market Revenues by Segment (Media, Sera, Reagents) 2002-2011
Table 4-6: Major Acquisitions in the Cell Culture Industry 2003-2006
Exhibit 4-7: Cell Culture Revenues and Market Share by Leading Competitor 2005
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