Download Non-Invasive Cancer Diagnostics Market, 2015 - 2030 Brochure

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Non-Invasive Cancer Diagnostics Market, 2015 - 2030
Description:
Cancer is an extremely complex disease and medical science is still struggling to figure out the reasons and
factors influencing the disease origin, propagation, spread (metastasis) and relapse. In addition to satisfying
the unmet market need for advanced and efficient treatment interventions, cancer prevention, early
detection and management is extremely important. The high cancer mortality rate is primarily due to delay
in detection of the disease.
Early diagnosis and screening makes it possible to cure the disease completely and/or increase survival
rates. Over the years, various technological advances have helped medical professionals understand cancer
better. Recent research in cancer biology has led to a lot of innovation in the development of a number of
new diagnostic tools. These modern diagnostic techniques can help detect and classify cancer with
increased accuracy and sensitivity.
It is also important to highlight that the cost of management and treatment of cancer is a growing concern
considering its highly progressive and fatal nature. Performing a biopsy includes costs associated with the
equipment, cost of the procedure itself, consultation fees, hospital fees, costs of analytical tests and those
associated with post-operative care. To manage this financial burden, the introduction of novel non-invasive
techniques, which are cost-effective and more accurate, has become an indispensable necessity.
There are several advanced approaches, which are non-invasive or minimally invasive in nature, and these
outweigh the limitations posed by invasive diagnostic procedures. Specifically, liquid biopsy has emerged as
a promising non-invasive cancer diagnostic tool for early detection as well as monitoring the disease’s
progress.
This technique of tracing the presence of circulating biomarkers in blood and other biological fluids of
cancer patients is becoming increasingly popular in the medical fraternity.In addition to liquid biopsy, the
market is gradually witnessing the emergence of several other non-invasive diagnostic technologies.
These include techniques based on molecular imaging, advanced genomic and transcriptomic methods of
detection of clinically significant biomarkers and identification of nucleosomal levels. All such non-invasive
tests hold a significant promise to enhance the quality of patient care.
Chapter Outlines:
- Chapter 2 presents an executive summary of the report. It offers a high level view on where the market for
liquid biopsy and other novel non-invasive diagnostics is headed in the mid to long term.
- Chapter 3 provides a general introduction to cancer statistics and burden of the disease worldwide. In this
section, we have also highlighted the importance of early detection of the disease through diagnosis and
asymptomatic screening. The chapter outlines the conventional invasive diagnostic tests, which are widely
used for cancer diagnosis and prognosis.
- Chapter 4 discusses in detail the need for non-invasive cancer diagnostics and their importance. We have
highlighted the underlying concept of liquid biopsy and other non-invasive tests. In addition, we have
mentioned the principle behind common imaging tests that are deployed in cancer diagnosis.
- Chapter 5 provides a holistic view of the non-invasive cancer diagnostics landscape. It enlists the liquid
biopsy tests, technologies and systems. In addition, it offers a list of other non-invasive tests. These lists
include information on the developer, technology used by the product, test sample source and indication.
We have also mapped the geographical presence of the enlisted non-invasive cancer diagnostics developers.
- Chapter 6 offers a comprehensive discussion on liquid biopsy. We have talked about the emerging need for
liquid biopsy highlighting its advantages and challenges. In addition, we have provided technology profiles
and product profiles of several liquid biopsy products. The chapter also mentions the liquid biopsy
companion diagnostics, which are being co-developed as part of strategic collaborations.
- Chapter 7 provides an overview of the other novel non-invasive diagnostics used in oncology. It highlights
the different imaging based diagnostic procedures, biomarker and nucleosome based diagnostics, skin
lesion and breath based diagnostics. The diagnostic procedures discussed in this chapter are backed up by
several examples.
- Chapter 8 highlights the market forecast and sizing of the overall non-invasive cancer diagnostics market.
This chapter discusses, in detail, the parameters likely to influence the evolution of liquid biopsy market. In
addition, we have also presented the market share of other non-invasive diagnostic tests and an opportunity
analysis for the key indications likely to have the maximum impact on the overall market.
- Chapter 9 provides detailed company profiles of the leading players in the market involved in the
development of liquid biopsy as well as other non-invasive tests. Amongst other details, each profile
includes information such as the company overview, financial performance, product portfolio and recent
collaborations.
- Chapter 10 summarises the overall report. In this chapter, we list the key takeaways and provide our
independent opinion based on the research and analysis described in previous chapters.
- Chapter 11 is a collection of interview transcripts of the discussions that were held during the course of this
study.
- Chapter 12 is an appendix, which provides tabulated data and numbers for all the figures provided in the
report.
- Chapter 13 is an appendix, which provides the list of companies and organisations mentioned in the
report.
Contents:
1. Preface
1.1. Scope Of The Report
1.2. Research Methodology
1.3. Chapter Outlines
2. Executive Summary
3. Introduction
3.1. Chapter Overview
3.2. Cancer Statistics And Burden Of The Disease
3.3. Importance Of Early Detection In Cancer
3.4. Detecting Cancer: Screening Versus Diagnosis
3.5. Conventional Invasive Cancer Diagnostic Tests
3.5.1. Biopsy
3.5.2. Endoscopy
3.6. Need For Non-Invasive Approaches
4. Concept Of Non-Invasive Cancer Screening And Diagnostics
4.1. Chapter Overview
4.2. Diagnostic Imaging
4.2.1. Magnetic Resonance Imaging (Mri)
4.2.2. Mammography
4.2.3. Bone Scan
4.2.4. Computerised Tomography (Ct) Scan
4.2.5. Integrated Pet-Ct Scan
4.2.6. Ultrasound
4.2.7. Barium Enema
4.3. Screening Assays
4.3.1. Pap Test And Hpv Test
4.3.2. Tumour Marker Tests
4.3.3. Faecal Occult Blood Tests (Fobt)
4.3.4. Digital Rectal Exam (Dre)
4.3.5. Muga Scan
4.4. Advanced Non-Invasive Approaches
4.4.1. Liquid Biopsy
4.4.2. Cytogenetic/Gene Expression Studies
4.4.3. Molecular Signature Based Non-Invasive Methods
4.4.4. Saliva-Based Oral Cancer Diagnostics
4.4.5. Vital Staining
4.4.6. Optical Biopsy
4.4.7. Other Techniques
5. Market Overview
5.1. Chapter Overview
5.2. Liquid Biopsy: Market Landscape
5.2.1. Liquid Biopsy: Distribution By Type Of Analysis
5.2.2. Liquid Biopsy: Distribution By Sample Source
5.2.3. Liquid Biopsy: Distribution By Indication
5.2.4. Liquid Biopsy: Distribution By Region
5.3. Liquid Biopsy Technologies And Systems/Instruments
5.4. Other Non-Invasive Cancer Diagnostic Tests: Market Landscape
5.4.1. Other Non-Invasive Tests: Distribution By Sample Source
5.4.2. Other Non-Invasive Tests: Distribution By Indication
5.4.3. Other Non-Invasive Tests: Distribution By Region
6. Liquid Biopsy: Detailed Outlook
6.1. Chapter Overview
6.2. Non-Invasive Detection Of Cancer Over Biopsies
6.3. Circulating Biomarkers For Cancer
6.3.1. Ctcs And Ctcdna
6.3.2. Ctdna
6.3.3. Exosomes
6.4. Liquid Biopsy Based Technology, Systems And Tests
6.4.1. Apostream® Technology And Apostream® Ctc Test (Apocell)
6.4.1.1. Overview
6.4.1.2. Results
6.4.1.3. Collaborations
6.4.1.4. Funding
6.4.2. Biofluidica Ctc Isolation Technology And Ctc Analysis System (Biofluidica/Roche)
6.4.2.1. Overview
6.4.3.2. Results
6.4.3.3. Collaborations
6.4.3. Cellsearch® System And Cellsearch® Ctc Test (Janssen Diagnostics)
6.4.3.1. Overview
6.4.3.2. Results
6.4.3.3. Collaborations
6.4.3.4. Other Developments
6.4.4. Liquidbiopsy® Rare Cell Isolation Platform And Clearid Test (Cynveniobiosystems)
6.4.4.1. Overview
6.4.4.2. Collaborations
6.4.4.3. Other Developments
6.4.4.4. Funding
6.4.5. Parsortix System (Angle)
6.4.5.1. Overview
6.4.5.2. Results
6.4.5.3. Collaborations
6.4.5.4. Funding
6.4.6. Quantigene® Viewrna Ctc Platform And Assay (Affymetrix)
6.4.6.1. Overview
6.4.6.2. Collaborations
6.4.7. Ivdxtx Platform Technology And Ivd Ctc Assays (Ivdiagnostics)
6.4.7.1. Overview
6.4.7.2. Collaborations
6.4.7.3. Other Developments
6.4.7.4. Funding
6.4.8. Icellate® (Icellate Ab)
6.4.8.1. Overview
6.4.8.2. Collaborations
6.5. Liquid Biopsy And Companion Diagnostic Products
6.5.1. Tokai Pharmaceuticals And Qiagen
6.5.2. Astrazeneca And Qiagen
6.5.3. Sysmexinostics And Bayer Healthcare
7. Other Novel Non-Invasive Technologies
7.1. Chapter Overview
7.2. Imaging Based Diagnostics
7.3. Biomarker And Nucleosome Detection
7.4. Skin Lesion Based Diagnosis
7.5. Diagnostic Breath Testing
8. Market Sizing And Forecast
8.1. Chapter Overview
8.2. Methodology
8.3. Overall Non-Invasive Cancer Diagnostic Market
8.4. Liquid Biopsy Market
8.4.1. Initial Diagnosis
8.4.2. Recurrence Monitoring
8.4.3. Patient Monitoring
8.4.4. Market Forecast Projections, 2015-2030
8.5. Opportunity Analysis For Important Indications
8.5.1. Prostate Cancer
8.5.2. Breast Cancer
8.5.3. Colorectal Cancer
8.5.4. Lung Cancer
8.6. Non-Invasive Cancer Diagnostics Market: Regional Distribution
9. Company Profiles
9.1. Chapter Overview
9.2. Companies With Focus On Liquid Biopsy
9.2.1. Biocept
9.2.1.1. Company Overview
9.2.1.2. Financial Performance
9.2.1.3. Product Portfolio
9.2.1.4. Collaborations
9.2.2. Exosome Diagnostics
9.2.2.1. Company Overview
9.2.2.2. Product Portfolio
9.2.2.3. Collaborations
9.2.4. Genomic Health
9.2.4.1. Company Overview
9.2.4.2. Financial Performance
9.2.4.3. Product Portfolio
9.2.4.4. Collaborations
9.2.5. Guardant Health
9.2.5.1. Company Overview
9.2.5.2. Product Portfolio
9.2.5.3. Collaborations
9.2.6. Qiagen
9.2.6.1. Company Overview
9.2.6.2. Financial Performance
9.2.6.3. Product Portfolio
9.2.6.4. Collaborations
9.2.7. Trovagene
9.2.7.1. Company Overview
9.2.7.2. Financial Performance
9.2.7.3. Product Portfolio
9.2.7.4. Collaborations
9.3. Companies With Focus On Other Non-Invasive Diagnostic Techniques
9.3.1. Biomérieux
9.3.1.1. Company Overview
9.3.1.2. Financial Performance
9.3.1.3. Product Portfolio
9.3.1.4. Collaborations
9.3.2. Cepheid
9.3.2.1. Company Overview
9.3.2.2. Financial Performance
9.3.2.3. Product Portfolio
9.3.2.4. Collaborations
9.3.3. Dermtech
9.3.3.1. Company Overview
9.3.3.2. Product Portfolio
9.3.3.3. Collaborations
9.3.4. Diagnocure
9.3.4.1. Company Overview
9.3.4.2. Financial Performance
9.3.4.3. Product Portfolio
9.3.4.4. Collaborations
9.3.5. Exact Sciences
9.3.5.1. Company Overview
9.3.5.2. Financial Performance
9.3.5.3. Product Portfolio
9.3.5.4. Collaborations
9.3.7. Pacific Edge
9.3.7.1. Company Overview
9.3.7.2. Financial Performance
9.3.7.3. Product Portfolio
9.3.7.4. Collaborations
10. Conclusion
10.1. Improved Cancer Detection And Patient Care: A Growing Necessity
10.2. Introduction Of Sophisticated Molecular Diagnostics: A Solution To The Existing Unmet Need
10.3. Liquid Biopsy: The Potential Replacement To Invasive Techniques
10.4. Other Non-Invasive Tests: Further Enhancing The Cancer Diagnostics Portfolio
10.5 With Liquid Biopsy At The Forefront, Non-Invasive Cancer Diagnostics Expected To Emerge As A MultiBillion Dollar Market
11. Interview Transcripts
11.1. Christer Ericsson, Chief Scientific Officer, Icellate Ab
11.2. Philippe Nore, Ceo And Co-Founder, Mindera Corporation
11.3. Dr. Jake Micallef, Chief Scientific Officer, Volitionrx
12. Appendix 1: Tabulated Data
13. Appendix 2: List Of Companies And Organisations
List of Figures:
Figure 3.1 Worldwide Incidence: Distribution by Type of Cancer
Figure 3.2 Lung Cancer: Estimated New Cases in 2015 (in’000s)
Figure 3.3 Breast Cancer: Estimated New Cases in 2015 (in ‘000s)
Figure 3.4 Colorectal Cancer: Estimated New Cases in 2015 (in ‘000s)
Figure 3.5 Factors Determining Useful Cancer Screening
Figure 3.6 Conventional Cancer Diagnosis Methods
Figure 3.7 Needle Biopsy and Open Biopsy: Demerits
Figure 4.1 Broad Categories of Non-Invasive Cancer Screening and Diagnostics
Figure 4.2 Types of Diagnostic Imaging
Figure 4.3 Types of Screening Assays
Figure 4.4 Types of Advanced Non-Invasive Approaches
Figure 5.1 Liquid Biopsy: Distribution by Type of Analysis
Figure 5.2 Liquid Biopsy: Distribution by Sample Source
Figure 5.3 Liquid Biopsy: Distribution by Indication
Figure 5.4 Liquid Biopsy: Distribution by Region
Figure 5.5 Other Non-Invasive Tests: Distribution by Sample Source
Figure 5.6 Other Non-Invasive Tests: Distribution by Indication
Figure 5.7 Other Non-Invasive Tests: Distribution by Region
Figure 6.1 Circulating Biomarkers for Cancer
Figure 6.2 ApoStream® Technology: Advantages
Figure 6.3 BioFluidica CTC Isolation System Workflow
Figure 6.4 BioFluidica System: Advantages
Figure 6.5 CELLSEARCH® System: Basic Steps
Figure 6.6 CELLSEARCH® System Workflow
Figure 6.7 LiquidBiopsy® Workflow
Figure 6.8 LiquidBiopsy® and Ion Torrent PGM Workflow Components
Figure 6.9 Parsortix System Workflow
Figure 6.10 ViewRNA CTC Platform Workflow
Figure 6.11 iCellate® Workflow
Figure 8.1 Non-Invasive Cancer Diagnostic Market (USD Million), Short Term, Base Case, 2015-2022
Figure 8.2 Non-Invasive Cancer Diagnostic Market (USD Million), Mid-Long Term, Base Case, 2022-2030
Figure 8.3 Liquid Biopsy Market (USD Million), Short Term, Base Case, 2015-2022
Figure 8.4 Liquid Biopsy Market (USD Million), Mid-Long Term, Base Case, 2022-2030
Figure 8.5 Prostate Cancer Liquid Biopsy Market (USD Million)
Figure 8.6 Breast Cancer Liquid Biopsy Market (USD Million)
Figure 8.7 Colorectal Cancer Liquid Biopsy Market (USD Million)
Figure 8.8 Lung Cancer Liquid Biopsy Market (USD Million)
Figure 8.9 Non-Invasive Cancer Diagnostics Market: Regional Analysis, 2022
Figure 8.10 Non-Invasive Cancer Diagnostics Market: Regional Analysis, 2030
Figure 9.1 Biocept Revenues, 2012- H1 2015 (USD Million)
Figure 9.2 Genomic Health Revenues, 2010- H1 2015 (USD Million)
Figure 9.3 Qiagen Revenues, 2010-Q1 2015 (USD Billion)
Figure 9.4 Qiagen Revenues, Q1 2015, Distribution by Business Segments (Share in %)
Figure 9.5 Trovagene Revenues, 2010-Q1 2015 (USD Million)
Figure 9.6 bioMérieux Revenues, 2011-Q1 2015 (EUR Billion)
Figure 9.7 bioNexia® FOB versus Guaiac Based Tests: Sensitivity for Positive Results
Figure 9.8 Cepheid Revenues, 2010- H1 2015 (USD Million)
Figure 9.9 Cepheid Revenues: Distribution by Type of Sales, 2014 (USD Million)
Figure 9.10 DiagnoCure Revenues, 2010-H1 2015 (USD Million)
Figure 9.11 Exact Sciences Revenues, 2010-HI 2015 (USD Million)
Figure 9.12 Pacific Edge Revenues, 2010-2014 (USD Million)
Figure 9.13 Cxbladder®: Biomarker Genes
Figure 10.1 Non-Invasive Cancer Diagnostic Market (USD Million), 2015, 2022 and 2030
List of Tables:
Table 3.1 Survival on Early Diagnosis of Cancer
Table 3.2 Cost of Biopsy for Different Cancer Indications
Table 3.3 Common Endoscopic Procedures
Table 4.1 Examples of Tumour Markers
Table 5.1 Non-Invasive Cancer Diagnostics: Liquid Biopsy Tests
Table 5.2 Non-Invasive Cancer Diagnostics: Liquid Biopsy Technologies
Table 5.3 Non-Invasive Cancer Diagnostics: Liquid Biopsy Systems/ Instruments
Table 5.4 Non-Invasive Cancer Diagnostics: Other Screening and Diagnostic Tests
Table 6.1 Aspects of Biopsies versus Liquid Biopsies
Table 6.2 Liquid Biopsy Based Diagnostics: Example List
Table 6.3 Comparison between ApoStream CTC Test and CELLSEARCH® CTC Test
Table 6.4 ApoCell: Funding Instances
Table 6.5 Comparison of the Clinical Sensitivity of BioFluidica Technology and CELLSEARCH® Technology
Table 6.6 CELLSEARCH® CTC Test: Cut-offs For Disease Prognosis
Table 6.7 CynvenioBiosystems: Funding Rounds
Table 6.8 ANGLE: Funding Rounds
Table 6.9 IVD CTC Tests: Potential Indications
Table 6.10 IVDiagnostics: Funding Rounds
Table 7.1 Sensitivity/Specificity: Individual Technologies versus Combination
Table 7.2 Imaging Based Diagnostics: Example List
Table 7.3 Biomarker and Nucleosome Detection Based Diagnostics: Example List
Table 7.4 Skin Lesion Based Diagnostics: Example List
Table 7.5 Diagnostic Breath Testing Devices: Example List
Table 8.1 Liquid Biopsy for Initial Diagnosis: Market Forecast Assumptions
Table 8.2 Liquid Biopsy for Recurrence Monitoring: Market Forecast Assumptions
Table 8.3 Liquid Biopsy for Patient Monitoring: Market Forecast Assumptions
Table 9.1 Q1Aamp® Circulating Nucleic Acid Kit: Specifications
Table 9.2 VIDAS® Tumour Markers: Specifications
Table 9.3 VIDAS® Tumour Markers, 2011-2014
Table 9.4 Xpert® HPV: Comparative Clinical Performance
Table 9.5 ImmunoCyt™/uCYT+™: Comparison with Other Urinary Cancer Biomarker Assays
Table 9.6 PCA3 Test: Launch Years for Respective Geographies
Table 12.1 Worldwide Incidence: Distribution by Type of Cancer
Table 12.2 Lung Cancer: Estimated New Cases in 2015 (in ‘000s)
Table 12.3 Breast Cancer: Estimated New Cases in 2015 (in ‘000s)
Table 12.4 Colorectal Cancer: Estimated New Cases in 2015 (in ‘000s)
Table 12.5 Liquid Biopsy: Distribution by Type of Analysis
Table 12.6 Liquid Biopsy: Distribution by Sample Source
Table 12.7 Liquid Biopsy: Distribution by Indication
Table 12.8 Liquid Biopsy: Distribution by Region
Table 12.9 Other Non-Invasive Diagnostic Tests: Distribution by Sample Source
Table 12.10 Other Non-Invasive Diagnostic Tests: Distribution by Indication
Table 12.11 Other Non-Invasive Diagnostic Tests: Distribution by Region
Table 12.12 Non-Invasive Cancer Diagnostic Market (USD Million), Short Term, Base Case, 2015-2022
Table 12.13 Non-Invasive Cancer Diagnostic Market (USD Million), Mid-Long Term, Base Case, 2022-2030
Table 12.14 Non-Invasive Cancer Diagnostic Market (USD Million), Short Term, Optimistic Case, 2015-2022
Table 12.15 Non-Invasive Cancer Diagnostic Market (USD Million), Mid-Long Term, Optimistic Case, 20222030
Table 12.16 Non-Invasive Cancer Diagnostic Market (USD Million), Short Term, Conservative Case, 2015-2022
Table 12.17 Non-Invasive Cancer Diagnostic Market (USD Million), Mid-Long Term Conservative Case, 20222030
Table 12.18 Liquid Biopsy Market (USD Million), Short Term, Base Case, 2015-2022
Table 12.19 Liquid Biopsy Market (USD Million), Mid-Long Term, Base Case, 2022-2030
Table 12.20 Liquid Biopsy Market (USD Million), Short Term, Optimistic Case, 2015-2022
Table 12.21 Liquid Biopsy Market (USD Million), Mid-Long Term, Optimistic Case, 2022-2030
Table 12.22 Liquid Biopsy Market (USD Million), Short Term, Conservative Case, 2015-2022
Table 12.23 Liquid Biopsy Market (USD Million), Mid Long Term, Conservative Case, 2022-2030
Table 12.24 Prostate Cancer Liquid Biopsy Market (USD Million)
Table 12.25 Breast Cancer Liquid Biopsy Market (USD Million)
Table 12.26 Colorectal Cancer Liquid Biopsy Market (USD Million)
Table 12.27 Lung Cancer Liquid Biopsy Market (USD Million)
Table 12.28 Non-Invasive Cancer Diagnostics Market: Regional Analysis, 2022
Table 12.29 Non-Invasive Cancer Diagnostics Market: Regional Analysis, 2030
Table 12.30 Biocept Revenues, 2012- H1 2015 (USD Million)
Table 12.31 Genomic Health Revenues, 2010- H1 2015 (USD Million)
Table 12.32 Qiagen Revenues, 2010-Q1 2015 (USD Billion)
Table 12.33 Qiagen Revenues, Q1 2015, Split by Business Segments (Share in %)
Table 12.34 Trovagene Revenues, 2010-Q1 2015 (USD Million)
Table 12.35 bioMérieux Revenues, 2011-Q1 2015 (EUR Billion)
Table 12.36 bioNexia® FOB versus Guaiac Based Tests: Sensitivity for Positive Results
Table 12.37 Cepheid Revenues, 2010- H1 2015 (USD Million)
Table 12.38 Cepheid Revenues: Distribution by Type of Sales, 2014 (USD Million)
Table 12.39 DiagnoCure Revenues, 2010-H1 2015 (USD Million)
Table 12.40 Exact Sciences Revenues, 2010-HI 2015 (USD Million)
Table 12.41 Pacific Edge Revenues, 2010-2014 (USD Million)
Table 12.42 Lung Cancer Liquid Biopsy Market (USD Million), 2015, 2022, 2030
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