Download advanced non-invasive techniques in diagnosis of oral

ADVANCED NON-INVASIVE TECHNIQUES IN
EARLY DETECTION OF ORAL CANCER
 PRESENTED BY:
Abhishek Ghosh
3rd prof. B.D.S.
Dr.R.Ahmed Dental
college &Hospital
 GUIDED BY:
Dr. Jay Gopal Ray
H.O.D.
Dept. Of Oral &
Maxillofacial
Pathology
ORAL CANCER : SOME DEADLY STATISTICS
• Every hour 1
American dies of
oral cancer
• Death rate is
higher than
cervical cancer
• 25%cases have no
risk factor
IMPORTANCE
OF EARLY
DETECTION
70% cases are
diagnosed in late
stages
It leads to 5 year
survival rate of 57%
patients
Oral cancer is
90% curable when
detected early
Why non-invasive techniques?
• Painless and bloodless
technique
• Biopsy is not possible in
screening examination
• Helpful for follow-up
cases
• Easy and simple for
operator
• Patient’s medical status
is fragile for biopsy
• Patient refuses for biopsy
EXFOLIA
-TIVE
CYTOLOGY
INTRA
ORAL
VITAL
STAINING
IR
THERMO
-GRAPHY
VIZILITE
EXFOLIATIVE CYTOLOGY
 It is the histopathological
examination of cells
obtained by their
physical
removal,followed by
placement on glassslide and then
appropriately stained.
Preparation of ‘Pap-smear’
VIZILITE
Simple painless noninvasive technology
to visualize
suspicious areas at
earlier stages what
we may not see by
naked eyes .It’s based
on the principle of
CHEMILUMINESCENCE
ACTION OF VIZILITE
 Under vizilite
normal healthy
tissue will absorb
light & appear
dark. Abnormal
tissue will appear
white.
HOW VIZILITE WORKS?
Mouth
rinse
• Removes
mucosal
glycoprotei
-n
• Increase
N-C ratio
Light
stick
• Differentia
-te
between
normal &
abnormal
tissue
STEPS
Encourage the
patient after
routine exam
Rinse with
1%acetic acid for
30-60 sec
Shake vigorously
to mix content of
light stick
Bend outer light
stick breaking
inner vial
Insert it into open
end of retractor &
assemble
Make the room dark & re-examine the oral
cavity with vizilite
Intra-oral
vital
staining
With Toluidine
blue helps to
identify
dysplastic and
malignant
mucous
membrane in
the oral cavity.
STEPS
Drying of
mucosa with
gauge
Mouth rinse with
1% T-blue for 1-2
min
1 min rinse with
1% acetic acid for
decolourisation
Malignant cells
have
more
metaboli
-c rate
They
retain
the stain
Normal
mucosa
decolourises
VIZILITE &TOLUIDINE BLUE
VIZILITE
TBLUE
SITE
FOR
BIOPSY
IR THERMOGRAPHY
 It uses the heat of our
body to aid in making
diagnosis.It is completely
safe and uses no
radiation.
2
parts-1.IR CAMERA
2.HIGH
RESOLUTION
COMPUTER
MECHANISM
Detection of breast cancer
Use in oral cancer –on way
Malignant
tissue has more
vascularity
Raised surface
temperature
Detected by
thermograph
ADJUNCT TO SURGICAL BIOPSY
Visual
examinati
-on
Screening
Biopsy
Confirm diagnosis
CONCLUSION
 These screening
techniques help in
early detection of
malignancy with an
accuracy of 90 %
and thus
%
THANK YOU