Download document 8924557

Undergraduate Medical Student Research Programs
Research Abstract Proposal
Program BScMed
Date: 9/7/15
Proposed ResearchTitle:
Antibiotic use in early life and development of chronic diseases in childhood.
Proposed Research - Abstract (250 word maximum)
Background: Antibiotics are commonly used by pregnant women and young children, where they are
often prescribed inappropriately for viral infections. Early antibiotic exposure can disrupt the natural
development of the gut microbiome, a complex community of microbes that play a fundamental role in
host immunity and metabolism. Microbiome dysbiosis has been associated with multiple chronic
diseases including asthma, allergies, inflammatory bowel disease and diabetes.
Objectives: To determine if early antibiotic exposure is associated with increased risk for chonic
diseases in childhood, and to describe time trends in antibiotic prescribing in Manitoba.
Methods: We will use the Manitoba Centre for Health Policy data repository to access linked
prescription recrods and healthcare utilization data for all children born in Manitoba since 1995.
Prenatal exposures will also be captured through linkage with maternal records. Antibiotic exposures
will be classified by frequency (number of prescriptions), type (narrow vs. broad-spectrum), indication
(from physician claims preceding prescription) and timing (trimester of pregnancy or child's age at
prescription). Chronic disease outcomes will be identified from hospital records and physician billing
claims using ICD diagnostic codes. Multiple logistic regression will be used to estimate the risk of
disease following antibiotic exposure, controlling for socioeconomic status, rural/urban living and other
potential confounders. Statistical analyses will be coordinated by an experienced programmer at the
Manitoba Vaccine and Drug Evaluation Center.
Significance: Evidence of increased chronic disease risk following early life antibiotic exposure will
send a paradigm-shifting message to parents and physicians about the judicious use of antibiotics in
pregnant women and young children.
Please include a brief description of the student's role
The student will conduct a literature review, assist with statistical analyses, and write a manuscript
of the results.
Contact Information:
Name:
Dr. Meghan Azad
Address: 501G - 715 McDermot Ave (Children's Hospital Research Institute of Manitoba)
Phone:
204-975-7754
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/25/15
Assessing mechanisms of small cell lung cancer (SCLC) drug resistance in circulating tumor cells
(CTCs).
Proposed Research - Abstract (250 word maximum)
Background: SCLC is the most aggressive subtype of lung cancer and accounts for 13% of lung cancer diagnoses.
Median survival, even with treatment is under 10 months and 5-year survival is <5%. Most patients are treated with
chemotherapy and radiation. The limited role of surgery means few biological specimens are available for research.
In the clinic, 70% of patient tumours initially respond to chemotherapy, but almost all will relapse within months
with resistant disease. Understanding the mechanism leading to treatment resistance will be important to
improving patient outcomes in SCLC.
A consequence of SCLC being an aggressive disease is that cancer cells disperse into the bloodstream of patients,
and modern methods can detect these cells in peripheral blood. These `circulating tumor cells', if successfully
captured can provide insight into the biology of this disease.
Hypothesis: We believe that CTCs from patients with SCLC will provide an ideal surrogate tissue source for studying
drug resistance. We will examine CTCs to assess 1. If they have similar features with the primary tumor; and 2. If
CTCs obtained from treatment-resistant patients will have different molecular profiles than those from
treatment-sensitive patients.
Methods: We will use a size-filtration based method for isolating CTCs from the peripheral blood of patients seen in
the lung cancer clinics at CancerCare Manitoba. These isolated CTCs will then be examined in the laboratory for
markers associated with drug-sensitivity and resistance in SCLC.
Please include a brief description of the student's role
In year 1, the student will be responsible for consenting patients for the study, and facilitate the
regular collection of CTCs from the blood laboratory, and primary tumor samples from the thoracic
surgeons. In years 1 and 2, the student will learn and perform the methods required for the
molecular analysis of the SCLC CTCs, assisted by members of the laboratory.
Contact Information:
Name:
Shantanu Banerji
Address: ON5050 CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9
Phone:
204-787-8776
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Proposed Research - Abstract (250 word maximum)
Rationale: Chronic Lymphocytic Leukemia has been associated with dysregulation of circadian
rhythm genes compared to patients without CLL. These alterations were further amplified in patients
who had CLL and were shift workers. Central to the homeostasis of circadian rhythm is the
NAD-dependent regulation of SIRT 1. We have recently shown that a small molecule FK866 causes
depletion of NAD and loss of SIRT 1 and thus CLL cell death. What is not known is if sub lethal doses
of FK866 are used, could we restore NAD dysregulation and prevent abhorrent cell cycling and
proliferation. This may benefit patients in offering a alternate therapy opposed to chemotherapy but
also at potentially non-toxic doses.
Hypothesis: Manipulation of NAMPT by FK866 will alter and potentially restore the rhythm of
circadian target genes (CRG: period 1, period 2, CLOCK, CRY1, CRY2 , Bmal1). This may in turn alter
cell cycle regulators c-MYC and Cyclin D1 and thus reduce cell cycling and proliferation.
Approach: As a proof of principle, B-cell malignancy lines (Raji, MEC2, BJAB and JVM-3) will be
compared to non-malignant B-cell line. Initially, cells will be synchronized by a well-established
serum starve/shock protocol and samples for qPCR will be obtained every 4 hours for 24hrs. RNA
will be extracted (RNeasy kit), and converted to cDNA. qPCR will be performed on the cDNA. The
level of target gene will be normalized to the reference elongation initiation factor 2alpha (eIf2alpha)
(not circadian regulated) to obtain the normalized circadian gene expression (ȜCT) value. The ȜCT of
malignant cells will be compared to the ȜCT of non-malignant cells. The fold change in gene
expression is calculated by taking 2-ȜȜCT for values greater than 1 and -1/2-ȜȜCT for values less than 1.
To examine the effect of low-dose FK866 on the expression patterns of target circadian genes, FK886
1nM (sub-lethal) will be added post synchronization of cells and evaluated at 24 hours later. Once we
have established the impact of low dose FK866 treatment on the circadian gene expression in B cell
Please include a brief description of the student's role
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Versha Banerji
Address:
Phone:
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Pediatric Respiratory Analysis
Proposed Research - Abstract (250 word maximum)
Asthma is the most common and earliest of the chronic, complex diseases to present in childhood. It is also the
most common chronic disease for which children are seen in Emergency Departments and admitted to hospitals.
Asthma typically presents with an acute episode of wheezing in almost 50% of children in preschool years, however
only a minority have “true” asthma by school age. Parental reporting of ‘wheeze’ is often difficult to interpret.
Technology to assist physicians to better define wheezing episodes for a lay audience is needed. The ability to
distinguish between different wheezing phenotypes is critical to assist health care professionals to effectively
diagnose and better manage this common problem.
We propose to gather breath sound recordings from 25 healthy controls and 25 children who present to the
Emergency Department with ‘breathing difficulty’. The target population for this study is under 6 years of age
(pre-school children). Once participants are recruited and data has been collected, the recordings will be analyzed
and classified based on pitch, frequency and spectral characteristics using RALES software. These results will be
used to identify key features that distinguish between the normal and adventitious breath sounds of the pediatric
population. The data will be important in helping to educate health care providers and families. We believe this
study will contribute to better diagnosis and treatment of wheezing episodes.
Please include a brief description of the student's role
- Consenting study participants
- Collecting data from pediatric populations (primarily at children's emergency)
- Analyzing data using RALES software
- The clinical component includes shifts at the Children’s Allergy Clinic
Contact Information:
Name:
Allan B. Becker
Address: CHRIM, 505-JBRC, 715 McDermot Avenue, Winnipeg MB R3E 3P4
Phone:
204-789-3978
Email:
[email protected]
PRINT
SUBMIT
SAVE
Program
9/30/15
BScMed
Understanding the health and healthcare utilization trends of persons living with HIV in Manitoba
"#!
In Canada, HIV has been managed largely by specialists and providers in HIV-focused practice
rather than by general primary care providers. With improvements in treatment and acute care,
persons living with HIV are living longer and enjoying better quality of life. However, these
advances have also transformed HIV from an acute disease to a chronic condition, characterized
by multiple diseases of aging such as diabetes, cardiovascular disease and cancer. While it was
effective during the early stages of the HIV epidemic in Canada, this narrow, disease focused
model of HIV care has led to substantive gaps in the continuum of care, leaving many people
living with HIV without comprehensive care despite access to universal healthcare.
The Living with HIV (LHIV) Innovation Team, comprised of research scientists and clinicians from
Manitoba, Ontario and Newfoundland, proposes that shifting routine management and care of
people living with HIV from specialized clinics to the community-based primary healthcare setting
will make the most effective use of the skills and resources within our healthcare systems and
lead to improved quality of care. As part of this research program, a provincial cohort of persons
living with HIV was established to understand the current state of health and healthcare utilization
trends among patients in Manitoba. It is also the aim of this cohort study to describe the current
gaps in the continuum of care among Manitobans living with HIV.
Please include a brief description of the student's role
Working with the Manitoba LHIV team, the student will become familiarized with the clinical and
administrative datasets linked to the Manitoba HIV cohort and assist in data analysis and writing
examining the current status of health and healthcare utilization of Manitobans living with HIV.
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Marissa Becker
R070 Med Rehab Bldg, 771 McDermot Ave, Wpg, MB, R3E 0T6
204 272 3151
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Effect of a 10-week exercise class program on physical function and quality of life in individuals
with chronic kidney disease
Proposed Research - Abstract (250 word maximum)
Background: Individuals with chronic kidney disease (CKD) have low levels of physical function
and activity that decline over time. We hypothesize that attendance at a 10-week education and
exercise class targeted to individuals with CKD improves physical function and HRQOL over 1
year as compared to individuals with CKD who do not attend such a program.
Methods: This health services research evaluation uses a retrospective quasi-experimental
pretest-posttest nonequivalent control group design to evaluate the effect of participation in an
established 10-week exercise class program on physical function and HRQOL over 1 year. We
will compare 60 individuals with CKD in Manitoba who attended this program with 120 individuals
with CKD in two distinct comparison groups who did not.
Outcomes: Primary outcome: physical function measured by Short Physical Performance Battery
Score. Secondary outcomes include HRQOL; hospitalization rate; exercise capacity and
proportion of deaths in the year following baseline assessment.
Data Analysis: Propensity score matching on key intervening variables will be utilized to adjust for
baseline differences in groups. We will compare differences in outcomes within and between
exposed and comparison groups at baseline and 1-year.
Expected Outcomes: Individuals that attend the 10-week program will have improved physical
function as compared with those who do not attend.
Project Significance: Manitoba has the highest rates of renal disease in Canada. The potential for
Please include a brief description of the student's role
The BScMed student will be involved in data collection, analysis and interpretation of results with
the support of supervisors and study statistician.
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Clara Bohm/Navdeep Tangri/Claudio Rigatto
Address: GE445B, Health Sciences Centre
Phone:
204-787-3583
Email:
[email protected]
PRINT
SUBMIT
SAVE
Program
BScMed
Sept. 30, 2015
Validation of a Tool to assess Nursing Workload in Hemodialysis
"#!
Background: Manitoba has over 1000 hemodialysis (HD) patients. Hemodialysis is nursing
resource intensive, contributing to its high cost (approximately $80,000 per patient per year).
Individuals have multiple comorbidities and variable requirements for care during their regular HD
treatments that are currently not considered when scheduling patients. In large HD units, the
development of a valid Patient Classification Scale (PCS) to appropriately match patients care
needs to nursing resources is necessary for effective and equitable health system performance.
At present, no such tool exists for in-centre HD treatments in Canada.
Research Objective: This expansion of a pre-existing LEAN project seeks to further assess the
validity and reliability of the current version of PCS tool created within the Manitoba Renal
Program (MRP), Health Sciences Centre (HSC) Site. The ultimate goal of this project is to
implement a fully validated PCS tool into routine clinical practice to help with nursing assignments
and staffing ratios within large HD units in the province.
Methods: Over an 18-month period, 5 additional stages of validation (including time series,
responsiveness and reliability studies), implementation and evaluation will be performed within
multiple in-centre HD units within Winnipeg.
Expected Outcomes: By aligning nursing assignments with patient needs, such a tool will
optimize nurse:patient ratio. This will ensure standardization of workload assignment processes
in a sustainable and transparent way with the ultimate goal of more effective use of nursing
resources, improved work environment for HD staff, better patient flow due to more efficient care,
improved patient safety and a better overall patient experience.
Please include a brief description of the student's role
The BScMed student will be involved in data collection and data management related to time
series, reliability and responsiveness studies. With the support of supervisors and a statistician,
the student will have the opportunity to participate in statistical analysis and interpretation of the
results.
In addition, the student will have the opportunity to participate in knowledge translation activities
Joe Bueti / Clara Bohm/Paul Komenda
GG621 - Health Sciences Centre
204-787-3099
[email protected]
PRINT
SUBMIT
SAVE
Program
BScMed
Sep 29, 2015
High risk, High Cost: a literature review of best practices for improving care for a community's most
complex patients.
"#!
Medically and socially complex patients in the community often have frequent presentations to
emergency rooms, may have recurrent admissions to hospital and when they are admitted, their
length of stay can be prolonged as dispostion can be challenging. They often have difficulty with
regularly accessing a primary care provider and their speciality care may not be well coordinated.
Patients may have difficulty with self management and self care of their medical conditions and
may have difficulty navigating other social aspects of their life including: finances, housing, meals
and transportation. Family members and care givers can feel overwhelmed in caring for their
loved ones. Recently there has been more focus on improving care for these complex patients can this be achieved while also reducing overall system cost and improving patient flow through
the system? Novel approaches to addressing care for these patients are being developed across
Canada and Internationally - what can be learned from these initial programs to guide further
improvements in caring for complex patients?
For this project, we propose a systematic review of the literature of programs that innovatively
address improving care for complex patients while reducing cost. What outcomes have been
measured? What are key success factors among these programs? What can be learned in the
Canadian and international context?
Please include a brief description of the student's role
The student will develop a search strategy to identify relevant papers, review them and identify
common themes. As part of this work, the student will get to participate in various aspects of the
clinical work of the River East/Transcona Hospital Home Team.
Amanda Condon
975 Henderson Hwy
204-938-5050
[email protected]
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Nimodipine therapy for juvenile ferrets with hydrocephalus.
Proposed Research - Abstract (250 word maximum)
Hydrocephalus is a common neurological condition where cerebrospinal fluid (CSF) flow dynamics are
altered, leading to enlargement of ventricular cavities in the brain. The brain damage caused by
hydrocephalus is multifactorial with mechanical factors leading to primary destruction of periventricular
axons due to gradual physical stretching and compression, accumulation of metabolic waste products in the
CSF, and ischemic changes causing decreased white matter blood flow that contributes to axonal and
oligodendroglial damage (Del Bigio, 2010). Elevated Ca2+ and calcium-mediated proteolysis are
associated with axonal cytoskeletal damage found in hydrocephalus. (Del Bigio et al., 2000). We previously
showed that the calcium channel blocker nimodipine is protective in a rat model of hydrocephalus.
Preclinical development of drug therapies for neurological diseases mandate use of animals with more
complex brains. The proposed work will use a 2 week ferret model of hydrocephalus developed in our lab
(DiCurzio et al. 2013). Aluminum silicate (Kaolin) will be injected into the cisterna magna; this causes mild
inflammation and fibrosis in the subarachnoid space thereby interfering with CSF flow. Magnetic resonance
imaging will be used to demonstrate hydrocephalus. After 2-3 weeks the ferrets will be randomized to
receive injections of nimodipine or saline in a blinded manner. During the 2-week treatment period they
will undergo repeated behavioral testing. MR imaging will be done at the end of the experiment and then
the animals will be euthanized to allow histological and biochemical analysis of the brains.
Please include a brief description of the student's role
The student will: Assist in animal surgery, conduct the behavioral analysis, share in drug injection
duties, assist in animal euthanasia, perform the histological analysis, and assist in the
biochemical analysis. A graduate student and a research associate will also be involved.
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Marc Del Bigio
Address: Department of Pathology (office 600JBRC)
Phone:
204 789-3378
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/29/15
A novel approach to establish in vitro models for hereditary mitochondrial disorders using induced
pluripotent stem cells
Proposed Research - Abstract (250 word maximum)
Hereditary mitochondrial disorders are generally multisystem disorders with a significant proportion
involving abnormal cardiac function in terms of cardiomyopathy, arrhythmia and even congenital heart
defects. Mitochondrial diseases are caused by mutations in the nuclear genome or mitochondrial DNA
leading to dysfunction in mitochondrial respiratory chain complexes, adversely affecting energy production
in many cell types of the body, including cardiomyocytes. There are no bonafide effective treatments
available for hereditary mitochondrial disorders. Furthermore, due to the unavailability of study models
there is a dearth of knowledge in the causal mechanisms of heart diseases which are affected by
mitochondrial malfunction. Given the dire nature of mitochondrial disorders, instituting a proper disease
model to test new lead molecules and effecting drug discovery becomes extremely important.
In our studies, we aim to reprogram blood mononuclear cells from the patients with mitochondrial
disorders into pluripotent stem cells. These induced pluripotent stem cells (iPSCs) will provide us with in
vitro models that directly mimic the genotypic, phenotypic and physiological characteristics found in the
patient. Once the iPSCs have been attained, they will be differentiated into cardiac cells, using an in-house
protocol. These cardiac cells, will be then compared with normal ones using techniques like genetic arrays
and protein assays. The aim of these endeavours is to uncover those pathways which have specifically
deviated in the patient cells compared to the normal ones. As more light is thrown on the errant
mechanisms, we hope to pinpoint candidate genes/proteins which will provide opportunities for medical
interventions and drug development.
Please include a brief description of the student's role
The student will be involved in the research proposal development, conducting the experiments,
analysis of the research data and compilation of her/his thesis. The student will present his
research work at Undergraduate Medical Research Symposium.
Contact Information:
Name:
Dr. Sanjiv Dhingra
Address: St. Boniface Hospital Research Centre, R3028, 351 Tache Avenue, Winnipeg, R2H2A6
Phone:
204-235-3454
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Menopausal Management in Patients with Surgical Treatment (Hysterectomy and Bilateral
Oophorectomy) of Endometriosis: What are current practice patterns and what is best for our
patents?
Proposed Research - Abstract (250 word maximum)
Endometriosis is a common gynecological condition affecting a significant portion of reproductive
aged women. It can be described as a hormonally sensitive inflammation, with estrogen tending
to make the disease worse, and improvements seen after menopause. It manifests as
dysmenorrhea, infertility and chronic pelvic pain. First line treatments include anti-inflammatories
and analgesia. Hormonal management is the next step in the treatment algorithm. This includes
combined contraceptives and progestin-only options, including Depo-provera, the levonorgestrel
IUS and Visanne, or even aromatase inhibitors. Rarely, a patient with severe, debilitating
symptoms will require more dramatic measures - surgical treatment that induces a premature
menopause. It is theses patents specifically, those managed by total hysterectomy and bilateral
salpingooophorectomy, that are of interest to us for this study.
Women that have surgically induced menopause tend to have abrupt onset of bothersome
symptoms, often more severe than their naturally-menopausal counterparts. Additionally,
because of risk for cardiovascular disease, osteoporosis and other long term, negative health
outcomes, it is recommended that women who enter menopause early are treated with hormone
replacement therapy (HRT). This is to improve morbidity and mortality in these patients. Typically,
hormone replacement therapy consists of estrogen and progestogen. The estrogen component is
beneficial for the majority of menopausal symptoms and for maintenance of longterm health
outcomes. A progestin is required in women with an intact uterus, for protection against
endometrial hyperplasia and cancer.
However, in patients with a history of endometriosis treated surgically, it is not clear what sort of
menopausal treatment is most appropriate. Estrogen is required, but may induce resurgence of
endometriosis symptoms. This is especially true if the surgeon was unable to remove all signs of
disease in the pelvis. Many physicians therefore prescribe both the estrogen and progestogen
component of HRT in these patients No large trials have been completed to help guide
Please include a brief description of the student's role
The student will conduct a chart review of patients at the Mature Women's Centre, Victoria
General Hospital. They will create a database of all patients who were treated with hysterectomy
and bilateral oophorectomy for endometriosis. We will analyze treatment patterns with regards to
their hormone replacement therapy. Estrogen replacement, with or without the addition of
progestogen (and testosterone) will be looked at. We will look at resurgence of pelvic pain,
Contact Information:
Name:
Dr. Debra Evaniuk, Assistant Professor
Address: Mature Women's Centre, Victoria General Hospital, 3N-2340 Pembina Highway, Winnipe
Phone:
204-477-3505
Email:
[email protected]; [email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Adjuvant chemotherapy in colon cancer: A closer look at rates of initiation and discontinuation in
Manitoba
Proposed Research - Abstract (250 word maximum)
Adjuvant chemotherapy (AC) following surgery for colon cancer can reduce local recurrence rates. In Manitoba, 12
cycles of modified 5-Fluorouracil, Leucovorin and Oxaliplatin (m FOLFOX6) every 2 weeks, OR 8 cycles of
Capecitabine and Oxaliplatin (XELOX) every 3 weeks is considered standard care for patients with Stage II and III
colon cancer following surgical resection. Both regimens have proven efficacy, but toxicity can be an issue and
many patients are unable to continue AC for the recommended number of cycles. Though discontinuation of AC is
common, the extent to which it happens, factors associated with it, and its impact on patient outcomes is unclear
and the literature notably lacking. As such, many patients struggle with therapeutic decisions when toxicity
becomes an issue, fearing that prematurely discontinuing AC will have a negative impact on disease-free survival.
Utilizing CancerCare Manitoba's (CCMBs) provincial patient records, this project will take an important first step in
quantifying rates of AC initiation and discontinuation amongst patients with colon cancer in Manitoba following
resection, while identifying factors associated with AC initiation and discontinuation - information which is of great
importance to the patient population affected and the providers involved in their care.
A retrospective analysis of data will be completed on a cohort of patients undergoing AC following surgical resection
for colon cancer to determine patient characteristics/demographics and treatment adherence. This information will
be used to evaluate the rates of both AC initiation and discontinuation, as well as to identify potential patient
characteristics associated with early discontinuation.
Please include a brief description of the student's role
During the first summer term the student will complete a review of the literature and collect retrospective patient
data on the relevant cohort from CCMBs patient records in order to identify important patient characteristics and
factors relevant to rates of AC initiation and discontinuation.
The second summer term will allow the student to synthesize and complete data collection, analyze the data, and
ti i t i
ti
f
i tifi
t/
i td
ibi th
t
f th
h
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Tunji Fatoye
Address: Kildonan Medical Ctr, Seven Oaks Gen Hosp 2300 McPhillips St Wpg MB R2V 3M3
Phone:
204-632 3203
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/22/15
Mechanistic role of AMPK in regulation of mitochondrial function and axonal regeneration in neurons
Proposed Research - Abstract (250 word maximum)
AMP-activated protein kinase (AMPK) detects the energy status of cells and when ATP levels drop this
enzyme triggers enhanced mitochondrial function. Neurons are high energy consuming cells and during
nerve regeneration it is critical that mitochondrial function is optimal. In a number of diseases of the
nervous system impaired mitochondrial function leads to synaptic loss, axonal degeneration and neuronal
death. My lab is interested in how AMPK is regulated in neurons with the aim of identifying drugs that can
activate AMPK and so augment mitochondrial function in neurodegenerative disease. The project will
focus on the role of Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta). This enzyme
phosphorylates AMPK causing activation of the enzyme. No work has been done on this pathway in
neurons.
Recent publications:
Habash, T. et al (2015) Experimental Neurology 273, 177-189.
Saleh, A. et al (2013). Neuropharmacology. 65, 65-73.
Saleh, A. et al (2013). Molecular Brain. 6, 45-60.
Roy Chowdhury, S.K.. et al (2013). Neurobiology of Disease. 51, 56-65.
Roy Chowdhury, S.K. et al (2012). Brain. 135, 1751-1766.
Akude, E. et al (2011). Diabetes. 60, 287-299.
Roy Chowdhury, S. K. et al (2010). Diabetes. 59, 1082-1091.
Funding: CIHR and NIH
Please include a brief description of the student's role
The student will learn primary neuron cell culture, preparation of plasmids, cell transfection, Western
blotting and techniques for quantifying mitochondrial function and axonal regeneration. The primary
objective will be to manipulate CaMKKbeta expression/activity using an array of mutants delivered via
plasmid transfection of primary neurons.
Contact Information:
Name:
Paul Fernyhough
Address: R4046 - 351 Tache Ave, St Boniface Research Centre
Phone:
(204) 235-3692 or 3939
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Program BScMed
Date: 9/30/15
Proposed ResearchTitle:
“Has MCHP made a difference? An assessment of the impact of findings and recommendations of reports using
administrative data on programs and services provided by the province of Manitoba”
Proposed Research - Abstract (250 word maximum)
The Manitoba Centre for Health Policy (MCHP) does a set of five “deliverable” research projects each year for the
province of Manitoba - working primarily through Manitoba Health, Healthy Living and Seniors (HHLS). Most
reports contain implications or recommendations for how things could be changed for the future. The purpose of
this project is to document specific impacts MCHP research projects have had, by interviewing senior policymakers
in HHLS.
The student will be provided with a list of selected deliverables from the past 5 years. The student will meet with
the Principal Investigator of each report to review main findings / conclusions / recommendations that could have
been acted upon in the time since the report's release. The student and PI will develop a short list of specific
questions to be put to appropriate decision makers at Manitoba Health - and the student will then meet with that
person(s) to ask those questions.
The student will prepare a report which describes the process and the findings of the project, in a form which can
be submitted for academic publication.
Please include a brief description of the student's role
TBA
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Randy Fransoo, MCHP/CHS, and Kathryn Sibley, CHI/CHS
Address: Manitoba Centre for Health Policy, Community Health Sciences, College of Medicine
Phone:
(204) 789-3543
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Genetics-based target identification in IBD drug discovery
Proposed Research - Abstract (250 word maximum)
Inflammatory bowel disease (IBD) is a complex disorder affecting 0.5% of Canadians. The complications
of IBD have a severe impact on patient's quality of life and are associated with high costs for treatment.
Recent genome-wide analyses have identified more than 230 IBD genetic risk loci, which explain
approximately 25% heritability. Although there are these significant findings, the pathogenesis of IBD is
still elusive, and there is no cure for IBD.
The objective of this project is to link the genes with or close to these genetic variants and the targets of the
transcription factors affected by these genetic variants to potential drug targets for IBD using computational
approaches. To validate the plausible new drugs or drug combinations for IBD, we will search the evidence
from phase I/II/III randomized controlled trials or animal studies (PubMed, Clinicaltrials.gov). It is
expected that the findings from this study can provide some new clues to better treat IBD patients using
existing drugs.
Dr. Hu's lab (http://www.hu-bioinformaticslab.org) focuses on translational medicine research in
bioinformatics and statistical genetics. Dr. Bernstein's lab focuses on IBD's clinical research. The student
will be trained to analyze genetic and genomic data using available bioinformatics tools and translate the
knowledge towards IBD clinical care.
Please include a brief description of the student's role
1. Collect data
2. Perform basic data analysis
3. Make public presentation(s)
4. Write a research report
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Pingzhao Hu (supervisor, Genetics), Charles Bernstein (Co-supervisor, Internal Medicine
Address: Room 308 - Basic Medical Sciences Building, 745 Bannatyne Avenue
Phone:
204-789-3229
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/8/15
The art of preventing broken hearts in colorectal and renal cell cancer
Proposed Research - Abstract (250 word maximum)
Colorectal and renal cell cancer are major public health concerns in Canada. An increased understanding
of the biology of cancer has allowed for the development of new and effective therapies which utilize
various pathways to suppress tumor growth. Two types of targeted therapy currently in use include
monoclonal antibodies (Bevacizumab; BVZ) and tyrosine kinase inhibitors (Sunitinib; SNT). An unexpected
consequence of the use of these two anti-cancer drugs, however, is the development of cardiotoxicity in
nearly 25% of colorectal (CRC) and renal cell cancer (RCC) patients.
In the emerging field of Cardio-Oncology, specialized collaborative efforts amongst Cardiologists and
Oncologists are developing in multiple academic centers across Canada, including the University of
Manitoba, to address the cardiotoxic side effects of anti-cancer drugs. Serial monitoring of left ventricular
ejection fraction (LVEF) using noninvasive cardiac imaging is the single most important clinical diagnostic
tool in the recognition of cardiac dysfunction in cancer patients. Once symptomatic heart failure develops
in the setting of a reduced LVEF, however, irreversible cardiac injury may have potentially occurred in this
cancer population.
Although novel cardiac imaging techniques including tissue velocity and strain imaging using
echocardiography are able to detect early evidence of left ventricular systolic dysfunction due to
anti-cancer drugs, the more important clinical question is whether the prophylactic administration of
cardioprotective agents can prevent cardiac injury from developing at the onset. Currently, there are no
known therapies approved for the prevention of cardiotoxicity in the CRC and RCC populations.
This innovative research proposal will be the first study of its kind to explore whether the prophylactic
administration of renin-angiotensin system (RAS) antagonists can prevent BVZ and/or SNT mediated
cardiotoxicity in a murine model.
Please include a brief description of the student's role
The BSc Med student will be exposed to animal models of chemotherapy mediated cardiotoxicity,
acquisition and analysis of murine echocardiograms, histological analysis using light and electron
microscopy, protein studies, and statistical analysis.
Contact Information:
Name:
Dr. Davinder S. Jassal MD, FACC, FRCPC
Address: Y3531-Bergen Cardiac Care Centre, St. Boniface General Hospital
Phone:
204-237-2023
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/27/15
Uncovering the role and therapeutic benefits of Neuregulin-1 for myelin repair in multiple sclerosis
Proposed Research - Abstract (250 word maximum)
Rationale: Multiple sclerosis (MS) is a progressive autoimmune condition of the central nervous system
(CNS) that is characterized by immune-mediated demyelination (loss of myelin sheath around axons), and
consequent axonal damage and functional impairments. MS inflicts millions of individuals world-wide who
are mostly young adults. Canada has a high prevalence of MS with nearly 23.9 per 100,000 population.
While functional impairments are reversible at early stages of MS due to spontaneous myelin repair, with
disease progression and re-occurrence of autoimmune demyelination, axons degenerate permanently
resulting in irreparable damage to neural circuitry. Current treatment for MS are mostly immunomodulatory
in nature to attenuate disease progression with no effective repair strategy to renew myelin sheath around
denuded axons (remyelination).
Recent investigations in our lab have provided compelling evidence that the neuronal Neuregulin-1
(Nrg-1), an essential factor for axons and oligodendrocytes development and physiology, is dysregulated
in MS-like lesions and its depletion correlates closely with the period of demyelination.
Main objective: In this project, we will extend our initial discoveries to further deconstruct the role of
Nrg-1 in myelin repair and determine the ramifications of its severe decline on remyelination and
inflammation in MS lesions. We will employ Nrg-1 therapy in an experimental MS model. We will assess
the efficacy of Nrg-1 therapy for MS repair using a variety of cutting edge techniques in regenerative
medicine including microneurosurgery, stem cell cultures, in vivo drug delivery, MRI, physiological
assessments as well as histopathology.
Impact: Nrg-1 is a safe drug approved by Food and Drug Administration (FDA) with ideal pharmakinetics
that allows its entry to the brain and spinal cord tissue through blood-brain-barrier. Thereby, if shown
promising effects, it has high translational potential.
Please include a brief description of the student's role
BSc Student Summer Researcher would have the opportunity to work closely with our research team to
contribute to the project. The student will be trained to participate in histolopathological assessments of tissue
samples. Karimi's laboratory is located in the newly formed Regenerative Medicine Program in the Faculty of
Medicine. Lab homepage: http://home.cc.umanitoba.ca/~karimis/
Contact Information:
Name:
Dr. Soheila Karimi
Address: Regen Med Program, 629 Basic Medical Sciences Building
Phone:
(204)-272-3109
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Program BScMed
Date: 9/28/15
Proposed ResearchTitle:
The contribution of connexin36 proteins to neural communication in spinal sensory networks
Proposed Research - Abstract (250 word maximum)
Connexin proteins form gap junctions that allow very fast communication between neighbouring neurons by means
of electrical and not the typical chemical signals. Connexin proteins have been recognized to be significant
contributors to neural circuit function in young animals; however, their role in the adult nervous system, specifically
in spinal sensory networks, has not been defined well. The goal of this project is to test whether electrical synapses
between spinal neurons formed by the connexin36 protein contribute significantly to the processing of sensory
input and the reflexive motor output.
Several surgical procedures and electrophysiological techniques will be used in adult mice under anesthesia.
Sensory input will be applied by electrical stimulation of hindlimb nerves at different levels (that corresponds to
different types of fibres) and recordings of electrical activity will be collected from spinal neurons with
micro-electrodes. Various stimulation combinations of the nerves allow to examine specific sensory neural
pathways. This work will also require follow-up neuroanatomical tests to verify recording electrode location that
will be combined with basic immunohistochemical tests (fixation of tissue, cryostating thin tissue sections etc.).
The invited participant will be able to obtain biosafety training (transferable to several Canadian institutions), to
perform small animal surgery including anesthesia and monitoring, application of drugs during the surgical and
experimental procedures. This project should be of great advantage for students interested in neurosurgery,
neurology, neuropathology, surgery or any other type of research in the future involving small animal surgery.
Please include a brief description of the student's role
Small animal (mouse) surgery including anesthesia and monitoring, cannulation of artery, nerve
dissections, laminectomy, electroneurogram recordings and electrophysiological data collection
from micro-electrodes inserted in the spinal cord.
Contact Information:
Name:
Katinka Stecina, Ph.D. and James Nagy, Ph.D.
Address: BMSB 409 / BMSB 408
Phone:
204 789 3761
Email:
[email protected]
PRINT
SUBMIT
SAVE
Program
BScMed
Sept 29, 2015
Mechanisms of Radiosensitivity and Radioresistance of Lung Cancer
"#!
In 2014, 20,500 Canadians will die from lung cancer. There is a great need to improve the
treatment and prognoses of this devastating disease. Lung cancer stem cells, during a 6-7 week
course of radiotherapy, incur significant and lethal DNA damage through formation of several
DNA strand breaks. Accelerated repopulation of tumour cells during a prolonged course of
radiotherapy, hypoxia and the intrinsic sensitivity of these cells to radiation define the individual
patient outcome. Changes in the activity of particular DNA repair pathways in response to altering
radiation fractionation, with or without radiosensitizing agents (or with other modes of therapy
including EGFR-directed monoclonal antibody and tyrosine kinase inhibitors) remain poorly
understood and a significant hurdle in the management of lung cancer.
Aim
To analyze radiation response biomarkers at varying dose fractionation schedules in conjunction
with novel targeted radiosensitizing agents.
Methods
Using a novel and one-of-a-kind high throughput DNA damage analysis and imaging platform, we
propose to assess DNA damage repair and cell survival in response to these agents combined
with different radiation schedules. Using an irradiator installed at the Research Institute in
Oncology and Hematology (housed within CancerCare Manitoba) and commercially available
lung carcinoma cell lines, we will perform in vitro DNA damage assays, including alkaline comet
and ionizing radiation induced foci forming assays. Using targeted radiosensitization agents, we
will assess their tumour-killing efficacy in conjunction with ionizing radiation. Those agents that
achieve an additive DNA damage effect (over IR alone) will be selected for additional in vitro
validation, primarily using cell survival/proliferation assays. Our long-term goal is to use these
agents in tumour-bearing mouse models, to generate improved lung cancer pre-clinical treatment
strategies in vivo.
Please include a brief description of the student's role
Using a variety of lung cancer cell lines, the student will assess DNA damage repair and cell
survival in response to radio sensitizing agents combined with different radiation schedules. The
goal is to identify the most efficacious treatment combination to be translated into pre-clinical
models and clinical practice.
Dr. Sachin Katyal, Assistant Professor, Dept. of Pharmacology and Therapeutics
CancerCare Manitoba, 675 McDermot Ave, ON5010, Winnipeg, MB, R3E0V9
204-787-2765
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/26/15
Sharing research findings with First Nations Communities: A Qualitative Action Research Study
Proposed Research - Abstract (250 word maximum)
Innovation in Community Based Primary Healthcare Supporting Transformation in the Health of First Nations and
Rural/remote Manitoba Communities: iPHIT is a 5 year CIHR funded program of research. It includes both
qualitative and quantitative components focused on 8 First Nations (FN) communities.
The student research project will focus on two aspects of the research: 1. the synthesis of the qualitative and
quantitative data from each community (likely concentrating on 4 of the 8) 2. Sharing these findings with the
communities (both leadership and through town hall meetings) in a community centred respectful way to support
community efforts to extract the lessons of the research.
This project uses an action research model where the community play a central role in all aspects of the research.
The data collection to date has followed this model and applied the OCAP ethics principles developed for research
with FN in Canada.
The student will work with the preceptors and team members from the Assembly of Manitoba Chiefs to develop an
appropriate knowledge translation mechanism for each community. The process followed will be documented and
interactions with community members audio-recorded and analysed to explore the strengths and weaknesses of
the process as well as the discussion on the content presented. All recommendations coming out of the program of
research require meaningful FN input. This is one phase in that process. The student will also keep a reflective diary
on his/her experience throughout the process.
The student will be expected to have previous experience with FN communities, qualitative research methods and a
knowledge of primary care service delivery in FN communities.
Please include a brief description of the student's role
The student will read the summaries of the qualitative interviews and synthesize the findings with
the results of the qualitative surveys and administrative claims analysis. He/She will then present
these to the communities. Finally the student will analyse the recordings of these interactions.
Contact Information:
Name:
Alan Katz
Address: Manitoba Centre for Health Policy, 408-727 McDermot Ave
Phone:
204-789-3442
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/16/15
Immune activation and Blood-brain barrier dysfunction as a novel biomarker
and therapeutic target for HIV-associated neurocognitive disorders
Proposed Research - Abstract (250 word maximum)
Manitoba has some of the highest rates of HIV per capita in Canada with more than 1,200 people currently
enrolled in care and an estimated 400 more being unaware of their infection. Once diagnosed individuals
are linked to care and with current treatment guidelines, most individuals are offered antiretroviral therapy
(ART) soon thereafter. The majority of patients that achieve HIV viral suppression ART experience an
increase in CD4+ T-cell counts and with this lifesaving therapy, life expectancy that is similar to
individuals who are not infected with HIV. Immune activation decreases on effective ART but remains
higher than non-infected individuals. This heightened activation is associated with end organ dysfunction,
morbidity and premature mortality. Neurocognitive dysfunction is more common among individuals
infected with HIV despite viral suppression.
Knowledge gap: The high levels of immune activation that persist despite effective viral suppression may
result in breach of BBB integrity. Correlating immune activation with MRI measures of BBB integrity and
neurocognitive sequelae will improve understanding of the pathogenesis of these changes and may pave the
way to therapeutic interventions.
HIV infected individuals that underwent MRI will be approached for consent to this study. MRI will be
analyzed according to an algorithm developed by collaborating group from the Univesrity of Dalhousie.
Systemic immune activation will be measured and correlated with BBB permeability and neurocognitive
function.
Hypothesis:
Higher levels of systemic immune activation associated with breach of BBB and neurocognitive
dysfunction
S ifi bj i
Please include a brief description of the student's role
Conduct neurocognitive assessment using standard questionnaire
Measure immune activation
Contact Information:
Name:
Yoav Keynan
Address: Rm 507 BMSB, 745 Bannatyne Ave
Phone:
204-9775681
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Program BScMed
Date: 9/30/15
Proposed ResearchTitle:
Use of Wearable Technology in Real World Clinical Settings to Improve Patient Outcomes
Proposed Research - Abstract (250 word maximum)
The ability to track precise location and movement of individuals is now a common and accessible technology using
smartphones and wearable tech. Enhanced devices such as the iWatch have made the collection of real time heart
rate data and 2-way communication easier than ever before. These technologies have many possible applications
within healthcare that must be prospectively evaluated in a research context.
This project proposes a theme of research exploring the utilization of wearable tech in partnership with Research
and Innovation personnel at the Manitoba Telephone System. Three projects using a similar data platform will be
explored including the monitoring of patients waiting to be seen in the Emergency Department (Acute Care),
monitoring patients at high risk of kidney failure around the time of dialysis start (Chronic Disease) and the
enhancement of prescription medication adherence using a SIM enabled pill bottle (adherence).
Please include a brief description of the student's role
The student will work closely with technology partners and clinician scientists at the Seven Oaks Hospital Chronic
Disease Innovation Centre to carry out the proposed projects that will determine feasibility, clinical outcomes,
technology outcomes and patient acceptance of these devices in a real world clinical context. The SOGH CDIC has a
well-developed infrastructure for world class research and a proven track record of mentoring many highly
successful BSc Med projects that go on to publish their work in high impact journals and present abstracts at
Contact Information:
Name:
Paul Komenda MD, MHA (Research Director, SOGH), Co-supervisor Ricardo Lobato de Faria (Chief Medic
Address: 2PD07-2300 McPhillips Street
Phone:
204-632-3383
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program BScMed
Date: Sep 29, 2015
Mental Health Outcomes in Survivors of Necrotizing Fasciitis Compared to Matched
Controls
Proposed Research - Abstract (250 word maximum)
Introduction: Necrotizing fasciitis (NF) is associated with extensive surgery, amputations,
and prolonged hospitalization that may increase stress on a patient and have deleterious
consequences. What is not known is whether or not NF results in an increased incidence of
mental disorders and associated healthcare utilization in the years after the infection
compared to before infection.
Hypothesis: We hypothesize that the incidence of mental health disorders and associated
health care utilization due to these outcomes will be significantly higher among the NF
cohort than a matched control cohort.
Methods: We have identified approximately 180 NF patients that will meet inclusion criteria.
This clinical data is linked with administrative data at the Manitoba Centre for Health Policy.
Cases will be matched 1:5 with controls from the general population based on age, sex and
geographical region and aggregated diagnostic group, an indicator of co-morbidities.
Outcomes will be both diagnoses and associated health care utilization for the 2 years’
duration prior compared to the 2 years’ duration post NF injury.
Expected Results: We expect that NF patients will have a significantly higher incidence of
mental health diagnosis and associated health care utilization compared to the match
control cohort 2 years pre- and post-NF infection.
Please include a brief description of the student's role
You will be involved in writing the literature review, refining the research question and
assisting with the analysis. In addition, you will also be invited to attend research rounds and
methods seminars on statistical analysis and scientific writing. There will also be an
opportunity to attend burn clinic as well as burn/trauma operations.
Contact Information: (all projects require a co-supervisor which you will identify on the application form)
Name:
Dr. Sarvesh Logsetty
Address: GF431-820 Sherbrook St, Winnipeg, MB, R3A 1R9
Phone:
204-7870-7638
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/2/15
How does Lysosomal Malfunction Contribute to Cerebellar Neurogenesis Defect
Proposed Research - Abstract (250 word maximum)
The cerebellum is a brain region important for motor control, cognition, and emotion. Neurogenesis is a
fundamental process that is common to the entire nervous system and is initiated during early brain
development. The cerebellar neurogenesis, cell proliferation, migration, and differentiation are protracted
from the embryonic period well into the first year of life in humans; therefore, it is extremely sensitive to
genetic, physical, and chemical insults. The underlying cause of many serious cerebellar diseases, the
mis-regulation of neurogenesis, causes neurodevelopmental disorders, neurodegeneration, and severe
cognitive impairments. The main goal of our studies is to understand the developmental precursors of a key
set of neurons and molecules that impact cerebellar function and disorders, ranging from movement
disorders such as ataxia to behavioural conditions such as autism spectrum disorders.
A spontaneous mutation in Acp2 (Lysosomal acid phosphatse 2) causes a neurocutaneous disorder. We
have discovered that mis-regulation of Acp2 results in severe neurodevelopmental disorder and
neurodegeneration that classic apoptosis may not responsible for all neuronal death. Developmental
investigations showed that autophagy is involved in caspase-independent cell death. As the Acp2 mutation
causes lysosomal damage and dysfunction, we hypothesise that autophagy is involved in neuronal death in
cerebellum. Based on our preliminary data, we will perform several experiments to investigate whether
autophagy down-regulation in the Acp2 model will cause cerebellar neuronal death. Finally, we will try to
restore the putative affected molecules in the autophagy pathway by the administration of the same
molecules both in vitro and in vivo
Please include a brief description of the student's role
This proposal is innovative because we propose to use cutting edge molecular genetic approaches to
elucidate the cellular and molecular mechanisms underlying cerebellar development in health and disease.
Our multi-disciplinary approach of understanding the logic of how cerebellum develop will provide a wide
range of research training opportunities. My laboratory is well equipped and established to perform all of the
proposed experiments. The student will encounter and learn a range of experimental techniques (whole
Contact Information:
Name:
Hassan Marzban
Address: Department of Human Anatomy and Cell Science The Children's Hospital Foundation University
Phone:
204 789 3467
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/3/15
Randomized Clinical Trial Comparing Mini-Arc with Trans-Vaginal Obturator Tape (TVT-O) for Surgical
Management of Stress Urinary Incontinence
Proposed Research - Abstract (250 word maximum)
Surgical techniques to correct Stress Urinary Incontinence (SUI) include suburethral mesh implantation but
there is no consensus on the best surgical procedure.
The first minimally invasive mid urethral tape introduced was the TVT in 1996. This procedure was
effective but had high rates of complications including injury to the bladder, gastrointestinal tract, large
vessels and retropubic hematoma. The TVT-O procedure was introduced in 2001 with the goal of avoiding
some of these complications by going through the obturator foramen instead of the retro-pubic space. This
still leaves the possibility for injury to the obturator nerve and vessels while passing the device through the
obturator foramen. Novel devices to avoid this potential complication have sprung up requiring a single
incision.
The Mini-Arc Percise is one such devise. The Mini-Arc does not pass through the obturator foramen and
exit the groin, but rather is anchored to the obturator muscle or membrane using a barbed end. It is hoped
that the Mini-Arc Precise may be as effective as traditional slings, while sharing in the advantages of less
operating time, less post operative pain and fewer complications.
At present, the number of good quality studies is too limited to conclude the Mini-Arc system has
equivalent efficacy to older meshes. Most existing studies we found were single arm and so lacked a
control. Our objective is to compare in a randomized fashion the Mini-Arc Precise to the TVT-O approach
to add to the body of evidence supporting the use of this sling.
Please include a brief description of the student's role
- Collecting, analyzing and reporting data from patient questionnaires and tests that were
conducted before and after their Mesh procedure.
- This study will result in a high quality manuscript in the field of Urogynecology
- This is a unique opportunity for anyone interested in any Obstetrics and Gynecology, Urology,
General Surgery, or those wanting to get experience in conducting a randomized controlled trial.
Contact Information:
Name:
Dr. K. Maslow (PI), Dr. Sara Hosseini(Resident)
Address: St. Boniface Hospital
Phone:
204-292-4001
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 10/1/15
The efficacy of Transracial Magnetic Stimulation in treatment of non-epileptic seizure
Proposed Research - Abstract (250 word maximum)
Background: Patients with Psychogenic Nonepileptic Seizures (PNES) demonstrate an increased
prevalence of mood and anxiety disorders, and exhibit phenotypic characteristics of emotional
dysregulation, dissociation and psychological trauma. Functional imaging studies suggest a role of the right
temporoparietal junction (TPJ) in the pathophysiology of this condition. The TPJ is involved in analyzing
signals from self-produced actions. Impaired function in this area may result in an inability to take
authorship of ones' movements, thus perceiving them as involuntary. Currently, there is no effective
treatment for PNES.
This study aims to 1) explore the prevalence of psychiatric disorders in patients with PNES and 2)
investigate the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) - a non-invasive method of
brain stimulation - in decreasing the frequency of PNES episodes.
Methods: 20 patients with PNES (confirmed by video and EEG monitoring) will be recruited. Patients'
mood, anxiety, dissociative states, psychological trauma, impulsivity and functional disability will be
profiled before and after rTMS using Research Electronic Data Capture (REDCap). Brain stimulation will
involve 30 sessions of high frequency (10Hz) rTMS - known to increase focal cortical excitability applied over the right TPJ. Sessions will be administered daily with a total of 3,000 pulses per session.
Linear regression analyses will be used to look at the correlations between patients' symptom severity and
scores on REDCap scales.
Significance: The results of this study will help uncover the relationship between psychiatric conditions
and PNES symptoms, and could provide the groundwork for the use of rTMS as a new treatment for this
Please include a brief description of the student's role
Krystyna Peterson:
Krystyna will assist with data collection using RedCap website as well as data compilation and
analysis
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Mandana Modirrousta
Address: SBGH McEwen Building
Phone:
204 237 2606
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/29/15
Trauma Exposure, DSM-5 Posttraumatic Stress Disorder, and Maladaptive Health Behaviors: Results from a
Nationally Representative Sample of Men and Women in the United States
Proposed Research - Abstract (250 word maximum)
Important links between trauma exposure, post-traumatic stress disorder (PTSD), and engagement in health
risk behaviors have been demonstrated. However, most previous studies have utilized self-report measures
rather than diagnostic interviews in assessing post-traumatic stress symptoms, have assessed PTSD using
DSM-IV rather than contemporary DSM-5 diagnostic criteria, and have focused their investigations on
select maladaptive health behaviors (e.g., substance use, smoking) and/or populations (e.g., clinical
samples, women). Importantly, possible gender differences in the occurrence of these associations have
been neglected. The current study will execute three aims in a nationally representative sample of the US
general population:
1)
Examine the impact of trauma exposure, PTSD, and subthreshold PTSD on a number of health risk
behaviors (i.e., overeating, risky sexual behavior, smoking, and lack of physical activity), irrespective of the
presence of comorbid mental disorders.
2)
Investigate whether these associations differ in men and women.
3)
Clarify whether the specific nature of the trauma (e.g., child abuse, motor vehicle accident, natural
disaster) and PTSD symptom clusters display differential links with health risk behaviors.
Participants and Methodology: Data will come from the National Epidemiologic Survey on Alcohol and
Related Conditions (NESARC-III: 2012-2013), a nationally representative sample of 36,309
non-institutionalized adults residing in the US. PTSD and other mental disorders were assessed with a
computer-assisted, structured diagnostic interview. All interviews were conducted face-to-face.
Implications: The results of this study could guide the development of population-based approaches for
targeting health behavior change within trauma-exposed populations, and inform gender-specific pathways
between posttraumatic symptoms and specific physical health conditions.
Please include a brief description of the student's role
Student’s Role: The student will play an integral role in the execution of this project, including conducting a
literature review, gaining mentored exposure in statistical analyses with large datasets, developing scientific
writing skills, and preparing a manuscript that ultimately culminates in a publication.
Contact Information:
Name:
Primary: Natalie Mota, PhD; Secondary: Renee El-Gabalawy, PhD
Address: 817 Bannatyne Ave., Winnipeg, MB
Phone:
204-940-8478
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/20/15
The Changing Face of Thyroid Cancer in a Population Based Cohort
Proposed Research - Abstract (250 word maximum)
In North America, the incidence of thyroid cancer is increasing by over 6% / year. A population based
cohort of 2306 consecutive thyroid cancers (170-2010) has already been established and followed in the
province of Manitoba, Canada for a median period of 10.5 years. There has been a change in the treatment
recommendations for thyroid cancer over the past 4 decades with more use of total thyroidectomy and
radioactive iodine. The trends and factors influencing thyroid cancer incidence, its clinical presentation, and
treatment outcome of 2306 patients seen during 1970-2010 will be compared with that of 575 patients from
2011-2015. The data from 2306 patients seen during 1970-2010 is already available and this seen during
1970-2010 project will involve review of electronic and paper charts of 575 patients. Age standardized
incidence rate (ASIR) will be used to evaluate any change in the incidence of thyroid cancer. Disease
specific survival and disease free survival will be estimated by the Kaplan-Meier method and intergroup
comparisons will be made by log rank test. The independent influence of various prognostic factors was
evaluated by Cox Proportional Hazard models.
Please include a brief description of the student's role
Brief description of student's role: The student is expected to complete data collection in 4 months and in
the last two months analysis and paper will be completed. The student will be involved at all steps. No
previous research or biostatistics experience is required. Mentorship will be provided to write the project,
collect the data and analyze it.
Contact Information:
Name:
K. Alok Pathak, MD, FRCSC Canada
Address: ON 2048, CancerCare Manitoba 675 McDermot Avenue Winnipeg R3E 0V9
Phone:
+1-204-7878040 (Office)
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Long term mental health outcomes of pediatric surgery patients
Proposed Research - Abstract (250 word maximum)
Pediatric medical traumatic stress has been defined as “a set of psychological and physiological responses of
children and their families to pain, injury, serious illness, medical procedures, and invasive or frightening treatment
experiences”.1 It refers to a continuum of PTSD symptoms (e.g., arousal, re-experiencing, avoidance) which may be
present without meeting criteria for a full diagnosis of PTSD or ASD2, and which may contribute to later mental
health difficulties, such as anxiety and depression. Currently, little is known about the long term mental health
outcomes of pediatric surgical patients, particularly when surgery is more invasive. The purpose of this project will
be to use existing administrative data to compare the mental health outcomes of pediatric patients who received
more invasive surgical procedures (e.g., required hospitalization) as compared to less invasive surgical procedures
(e.g., outpatient care only) with matched controls between the years of 1981 and 1991. We will compare the
mental health outcomes of these groups over time from 1991 to 2015, including clinical diagnoses of depression or
anxiety and psychotropic drug prescriptions. We hypothesize that children who experienced more invasive
surgeries will also experience more mental health difficulties in adulthood than children who experienced less
invasive surgeries or matched controls.
1.
2.
National Child Traumatic Stress Network. Definition of medical traumatic stress. Paper presented at:
Medical Traumatic Stress Working Group2003; Philadelphia PA.
Kazak A, Kassam-Adams N, Schneider S, Zelikovsky N, Alderfer M, Rourke M. An Integrative Model of
Pediatric Medical Traumatic Stress. J Ped Psych. 2006;31(4):343-355.
Please include a brief description of the student's role
The role of the BSc Med student will be to learn how to apply for permission to access the administrative data, code
and analyze the data under supervision, review the scientific literature, and summarize the results.
Contact Information:
Name:
Caroline Piotrowski, Sarvesh Logsetty, Shahin Shooshtari, Laurence Katz
Address: 217 Human Ecology Bldg Fort Garry Campus
Phone:
474-8053
Email:
[email protected]
PRINT
SUBMIT
SAVE
BScMed
Sept 25, 2015
Extent of resection in newly diagnosed glioblastoma: integrating clinical and molecular data to
predict outcome
"#!
There has been ongoing debate in the Neuro-Oncology literature regarding the value of extensive
surgical resections for patients diagnosed with glioblastoma multiforme, an extremely aggressive
primary brain tumor. Neurosurgical practice globally varies across a spectrum, with those who
aggressively pursue maximal tumour resection versus a more cautious approach adopted by
others who only perform a biopsy to minimize the risk of neurological deficits.
The primary objective of this study will be to test the hypothesis that Progression Free Survival
(PFS) is correlated with extent of resection (EoR), in other words, do patients who have more
extensive resections have a longer duration without disease progression. The secondary
objective will be to develop a risk-stratification algorithm that takes into account EoR, molecular
markers of known prognostic significance, and established prognostic factors such as age and
Karnofsky Performancy Status (KPS).
This will be achieved by selecting patient records from the Manitoba Cancer Registry. Patients
will be included if they have a KPS > 70 and confirmed unifocal supratentorial glioblastoma.
Those with recurrent disease or who were deceased within 28 days of surgery will be excluded.
Preoperative images for each patient will be shown to a blinded panel of neurosurgeons with
extensive experience in tumour resection to determine if an extensive resection would have been
feasible at the patient's initial presentation. Image source data will then be used to compute preand post-operative tumour volume to determine EoR. This information will then be subjected to
multivariable analysis along with demographic, clinical, molecular, and treatment data obtained
from review of patient charts in order to determine if any association exists between EoR and
PFS. A stratification algorithm will be proposed based upon variables of prognostic significance.
Please include a brief description of the student's role
The student will be responsible for capturing the relevant data from the CancerCare Manitoba
patient record, and the imaging database. Once patient images are selected, the student will be
involved in volumetric analysis and calculation of EoR using advanced imaging software.
Marshall Pitz
CancerCare Manitoba 675 McDermot
2047871815
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/21/15
Presentation to EPAC with just an hCG. Can we predict the risk of early pregnancy failure based
on hCG alone?
Proposed Research - Abstract (250 word maximum)
A database has been created from the initiation of the Early Pregnancy Assessment Clinic
(EPAC) in January 2006 to January 2012. Criteria for referral to EPAC includes patients from the
Health Sciences Centre (HSC) Emergency Room with bleeding in pregnancy under 14 weeks
gestation who are suitable for outpatient management. All patients get an hCG in the Emergency
Room and the majority of them are seen within 72 hours of this test in EPAC. We would look at
all patients in the database who receive an ultrasound within 72 hours of their initial hCG to see
what the initial ultrasound shows and the time to final diagnosis. This would better help the
Emergency Room to let patients know which hCG values are associated with the highest risk of
viable pregnancies, pregnancy losses, and ectopic pregnancies.
Please include a brief description of the student's role
The student would be involved in transferring the patient information into the database from a
datasheet to an SPSS file for patients from January 2012 to June 2016. For any datasheet that is
missing information the patient's Health Sciences Centre chart would be reviewed. This could also
include missing information in the previous database. The SPSS program can then summarize the
result of the early ultrasound done within 72 hours for each hCG range and the final outcome and
Contact Information:
Name:
Helen Pymar
Address: WS-021 735 Notre Dame Ave- Women's Hospital
Phone:
204-787-4184
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/29/15
The role of Oxidized Phosphatidylcholines in Degenerative Aortic Valve Stenosis
Proposed Research - Abstract (250 word maximum)
Aortic valve stenosis is the third leading cause of adult heart disease and the most common form of acquired heart
valve disease in developed countries. Although there are multiple causes of valvular aortic stenosis, in North
America and Europe aortic valve disease is primarily due to calcific disease of a native trileaflet or a congenital
bicuspid valve. Chronic inflammation at the valvular level appears to be the overarching concept driving the
multifactor process resulting in valvular stenosis. As part of this process, leaflets are invaded by mononuclear
inflammatory cells and calcium is deposited. The overall result is that the leaflets become even less compliant,
which reinforces the inciting cytokine-mediated molecular abnormality. Recent clinical studies have implicated
increased levels of Lipoprotein (a) (Lp(a)) as a risk factor for developing aortic stenosis. Lp (a) has been shown to
exert its inflammatory effects through its role as a carrier of oxidized phospholipids. The most abundant of these
phospholipids are the Phosphatidylcholines (PC). Once PC molecules are oxidized (OxPC) the OxPCs acquire novel
biological activities not characteristic of their un-oxidized precursors, including the ability to potentiate oxidative
stress. There is currently no medical therapy to prevent or reduce the progression of Aortic valve stenosis in
humans.
We aim to identify and quantitate OxPC molecules present in stenotic aortic valves. The OxPC levels will be
correlated to the severity of aortic valve stenosis and the will also be compared to non-degenerated valves needing
replacement.
Please include a brief description of the student's role
The student will be involved in lipidomic analysis of stenotic human aortic valves. They will also
participate in data analysis. All valvular samples are currently collected and the student will only
be involved in sample analysis.
Contact Information:
Name:
Amir Ravandi
Address: St. Boniface General Hospital, 409 Tache Avenue Y3508 Winnipeg, Manitoba R2H 2A6
Phone:
204-237-2315
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/29/15
The effect of contrast material used for voiding cystourethrograms on the radiation dose in the
pediatric population.
Proposed Research - Abstract (250 word maximum)
Background: Knowledge about radiation dose from diagnostic imaging is of great importance,
particularly in the radiosensitive pediatric population. The goal of this study is to determine the
change in radiation dose when using iodinated contrast versus not using contrast during a voiding
cystourethrogram (VCUG). Voiding cystourethrograms are one of the most common fluoroscopic
studies performed in the pediatric population, thus a suitable fluoroscopic study to examine.
Methods: A phantom model will be constructed to simulate the anatomy of interest in a voiding
cystourethrogram study, namely bladder, ovaries, uterus, testes, and ureters. Dosimeters will be
embedded within the phantom to measure the radiation dose to the organs of interest. A baseline
trial will be done with no iodinated contrast being used, followed by trials with contrast. The
iodinated contrast will be instilled into the phantom bladder and into variable sized tubes to
simulate the ureters. Statistical methods will be utilized to analyze the data.
Please include a brief description of the student's role
The student's role will include:
-work in conjunction with the medical physics and the pediatric radiology departments
-indepth literature review
-writing a manuscript
-working in the fluoroscopy unit to obtain the radiation dose measurements
Contact Information:
Name:
Dr. Martin Reed
Address: Pediatric Radiology Children's Hospital 840 Sherbrook Street Winnipeg MB R3A 1S1
Phone:
204-787-1402
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Cost effectiveness model of assisted peritoneal dialysis
Proposed Research - Abstract (250 word maximum)
End stage renal disease (ESRD) is a global health epidemic that is increasing in incidence and
prevalence locally and internationally. Renal replacement therapy (RRT) modalities for the treatment
of ESRD include in center hemodialysis (ICHD), peritoneal dialysis (PD), home hemodialysis and
renal transplant. Renal transplant is the optimal form of RRT with the most relative improvement in
morbidity, mortality but there are waiting lists given a unfavorable supply and demand. Cost effective
RRT is a priority given increasing health care costs associated with RRT with similar outcomes
between modalities but a preference for home based therapies for patient health related quality of
life. Assisted PD is a home modality in which health care providers (HCP) assist patients in
performing PD if they are not deemed safely independent, usually with multiple barriers to care. It is
a strategy to increase incident and prevalent use of PD in an aging ESRD population with barriers to
self-care including visual loss, hearing loss, cognitive impairment and frailty. Programs exist across
the world including France, Denmark, Canada and the United Kingdom but there is heterogeneity in
practice patterns including training, HCP (community nurses vs health care aides), frequency of
visits, reimbursement, rates of peritonitis, technique failure and mortality. The purpose of this
project is to evaluate the cost effectiveness of different models of assisted peritoneal dialysis
comparing outcomes to ICHD.
Please include a brief description of the student's role
The student will perform a literature review and populate a Markov model with costing and QALY
estimates for assisted PD and ICHD. They will be responsible for extracting data, designing the model,
performing statistical analysis including sensitivity analysis as well as writing a manuscript with the
goal of a deliverable publication. Attendance at weekly research meeting is mandatory with the
potential for involvement in other ongoing research projects.
Contact Information:
Name:
Claudio Rigatto, Dr. Paul Komenda Co-Supervisor
Address: 2PD07-2300 McPhillips Street
Phone:
204-632-3834
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Program BScMed
Date: 9/26/15
Proposed ResearchTitle:
Infective Endocarditis: Initiation and maintenance of Registry, Analysis of outcomes of medically and surgically
treated patients and formation of provincial management guidelines.
Proposed Research - Abstract (250 word maximum)
Background: Infective endocarditis is infection of heart valves. Its presentation is a diagnostic challenge and a
management dilemma. The Standard committee at St Boniface hospital has requested provincial guidelines to have
uniformity in its management throughout the province.
Research Plan: We currently have all information of 378 surgically treated patients from 1995-2015 in MaCS
(Manitoba cardiac surgery database) which is linked to MCHP (Manitoba centre of health policy) for long term
outcomes. We have subsequently identified potentially 652 patients who have undergoing non-surgical management
from 2009 through 2014 via the St. Boniface echocardiographic and provincial home iv databases.
This project will undertake
1] Manual chart data abstraction of demographic and medical treatment from medically managed I.E. patients.
2] Generation and maintenance of a new Provincial I.E. registry which will house all information retrospective and
subsequent prospective of all patients treated medically and surgically for I.E.
3] To link the medically treated patients to MCHP for accessing long-term data.
4] Formulate guidelines for management of various presentations of Infective endocarditis for province of Manitoba
in association with AHA and ESC guidelines.
Research Significance: This registry will be then able to provide information on short and long term outcomes, of
most of the identifiable patients treated for IE in province of Manitoba. The outcomes of this study will help Medical
fraternity focus at the optimal management for all presentations of I.E. This will allow uniform management of this
condition throughout the province by all treating physicians. This will in turn felicitate timely and streamline referral,
better patient outcomes and better health care resource management.
Please include a brief description of the student's role
1st Term: Finalizing the registry through information from medical records and start analyzing data; 2nd Term:
finalizing the data, comparing outcomes of medically and surgically treated patients, literature review, preparation of
its manuscript and presentation and be a part in formulating provincial guidelines .
Contact Information:
Name:
Pallav Shah
Address: St Boniface General Hospital, Y3537,409 Tache Avenue, Winnipeg, MB R2H 2A6
Phone:
204-451-5641
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Molecular mechanisms of neuronal synapse development
Proposed Research - Abstract (250 word maximum)
Project Abstract
Brain development requires accurate connectivity between nerve cells. These connections are specialized sites
known as synapses. Synaptic adhesion proteins bridge the two compartments of a synapse, the pre-synapse and the
post-synapse. Synaptic adhesion proteins also organize synapses- the vesicle release machinery on the pre-synapse
and the neurotransmitter receptors and postsynaptic machinery on the post-synapse. A number of different
synaptic adhesion protein families have been discovered. This project will explore the functional interactions
between two classes of synaptic adhesion proteins and how they co-operate or compete in the formation of
excitatory synapses, the predominant type of synapses in the brain. The project will utilize a number of cell biology
and optical microscopy methods.
Please include a brief description of the student's role
The student will join an ongoing project investigating the role of synaptic adhesion proteins in
synapse development. The student will perform biochemical experiments and manage cell culture
(both primary and cell-line). The student will also be required to image using optical microscopy
and analyze experimental data sets.
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Tabrez J. Siddiqui, PhD , Neuroscience Research Program, Kleysen Institute for Advanced Med
Address: 710 William Avenue, Winnipeg R3E 0Z3,
Phone:
204-318-2564
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Where do I stand? Exploring the perceptions of testicular cancer patients, their partners and family
physicians about health risk and survivorship care
Proposed Research - Abstract (250 word maximum)
The high cure rate for testicular cancer is one of the great successes of
oncology, but survivors of this disease, usually younger men, face a variety of
immediate and delayed onset health risks after treatment, particularly if they
have received chemo- and/or radiation therapy. Follow-up care is usually
provided by cancer centres, rather than in primary care, and tends to focus on
surveillance for disease recurrence and side effects of treatment, and less on
broader health promotion and disease prevention. In Manitoba, there is no
formal program to educate and enlist family physicians (FPs) to play this latter
role in the care of these higher risk patients. It is unknown to what extent
these men and their FPs recognize and actively respond to these increased
health risks, and what role their partners or caregivers play in their
health-related behaviours. In this study, 10-15 consenting patients at least
one year post-diagnosis of testicular cancer who received chemo- or radiation
therapy will be recruited by mail through the Manitoba Cancer Registry. These
men will be invited to participate in a semi structured interview with their
partner present to explore these questions. Interviews will be taped and
transcribed, and analyzed using qualitative research methods. Participants
will be asked to identify their FP who will be contacted and invited to be
Please include a brief description of the student's role
The student will perform a literature review and work with the supervisors to
develop the research methodology and proposal. They will contact and
interview the participants and analyze all transcripts, working closely with the
supervisors. A clinical exposure in genitourinary cancer clinic at CancerCare
✔
✔
I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
✔
✔
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Contact Information:
Name:
Jeff Sisler
Address: 260-727 McDermot
Phone:
204-789-3237
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/3/15
Health Conditions at Age 75 and Subsequent Trajectory of Quality of Life
Proposed Research - Abstract (250 word maximum)
Background: Diseases cluster together (multimorbidity) and accumulate over time, and this
cumulative effect is more important than the effect of any one disease in isolation. However, the
effect of multimobidity on quality of life trajectories is not clear. Objectives: To determine
cumulative effect of six common diseases on: 1.The trajectory of physical functioning; and 2. The
trajectory of psychosocial functioning. Proposed Population: The Manitoba Follow-up Study
(MFUS) is one of the longest running cohort studies in the world. It consists of 3983 men recruited
from the Royal Canadian Air Force at the end of World War II. At entry to the study, 1 July 1948,
their mean age was 31 years. Routine medical examinations were conducted at regular intervals
over time. The research focus was expanded in 1996 to explore the roles of physical, mental and
social functioning. On 1 July 2013, 429 original cohort members were alive with a mean age of 92
years. Measures: Age, education, and the presence of six disease states (ischemic heart disease,
cancer, cerebrovascular disease, diabetes mellitus, peripheral arterial disease, and chronic
obstructive pulmonary disease) will be used as predictor variables. Outcome: The Short-form-36
is a widely used, reliable and valid measure of quality life, measuring two domains; physical and
social functioning. We have identified different trajectories for these domains (eg Persistently
good / Low baseline function with early death / Rapid decline to death / and slow decline).
Proposed analyses: Multinomial logistic regression models will be constructed, with the outcome
of the quality of life trajectory. Relevance: Understanding the role of multimorbidity on quality of
life trajectories is important for planning care for individual patients, as well as for setting health
care policy. Designing care models for individuals with multimorbidity will be important as our
population ages. Learning objectives: The trainees will: 1. Understand epidemiological study
design and medical statistics; 2. Understand measures of quality of life; and 3. To understand the
importance of disease.
Please include a brief description of the student's role
The data are already gathered. The student would learn data management and statistical
techniques, prepare and check variables, conduct analyses, and prepare a manuscript.
Contact Information:
Name:
Phil St John and Bob Tate
Address: GE547 Health Sciences Centre, 820 Sherbrook Street
Phone:
204-787-3365
Email:
[email protected]
PRINT
SUBMIT
SAVE
September 30, 2015
FAMILIAL HYPERCHOLESTEROLEMIA (FH): FINDING THE AFFECTED CHILDREN
Program
BScMed
"#!
Heterozygous Familial Hypercholesterolemia (FH) is a common genetic cholesterol condition that
should be treated in childhood to prevent young adult cardiovascular disease. People with FH
have very high cholesterol levels owing to increases in LDL, “the bad cholesterol”. Those who are
not treated develop serious cardiovascular disease even though they are physically fit and not
overweight. Classically heart attacks occur in the 30’s or 40’s for men and 40’s or 50’s for women.
The two major treatments are nutritional modification and cholesterol-lowering medications. New
Canadian guidelines issued in December 2014 lowered the recommended start age for
medication to 8-10 years of age in both sexes; previously medication had been suggested to start
between 10-17 years of age, closer to 10 for boys and 15 for girls. An estimated 2 per 1,000 Canadians have FH. The 2 per 1,000 estimate would translate to 2,000
people in Manitoba (population 1 million), including 480 under the age of 17 years age. However,
while the Adult Lipid Clinic sees hundreds of patients with this condition and other affected adults
are treated elsewhere, there are very few children diagnosed and followed at the Children’s
Hospital Lipid Clinic. The primary goal of this project is to identify children who have undiagnosed
heterozygous FH.
Please include a brief description of the student's role
The student will initiate screening of family members of affected patients (cascade screening),
supported by a multidisciplinary team. The project will consist of three phases: 1) learning and
preparation for cascade screening, 2) conducting initial screening of Manitoba families, and 3)
summarizing future recommendations regarding program feasibility.
Preparation for cascade screening includes adapting materials from other jurisdictions. I affirm that the supervisor has a minimum appointment of Assistant Professor in the College of Medicine
I affirm that the co-supervisor (named later on the application) has a minimum appointment of Assistant Professor
within the University of Manitoba
Dr. Shayne P Taback, Department of Pediatrics and Child Health
Room JBRC 510, 715 McDermot Avenue (Children's Hospital Research Institute of MB)
204-789-3618
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/30/15
Frailty affects treatment decisions and outcomes for patients with chronic kidney disease.
Proposed Research - Abstract (250 word maximum)
Chronic kidney disease (CKD) is a major public health problem with increasing incidence and
prevalence in North America and worldwide. CKD disproportionately affects the elderly, and leads
higher risks of kidney failure, cardiovascular events and all cause mortality. ln this
population,CKD is also associated with additional comorbid conditions, and an increased
prevalence of frailty and disability.
Frailty is a multidimensional syndrome characterized by loss of lean body mass
(sarcopenia),weakness, and decreased endurance, leading to reduced activity and a poor
response to stressors. Several prospective studies in the general population have shown that
measures of frailty are strongly associated with death and hospitalization in older individuals, and
moreover that this association is independent of other clinical risk factors and comorbid
conditions.
We believe that frailty is highly prevalent in patients with CKD, and is associated with treatment
decisions and outcomes. ln order to explore this hypothesis, we are presently conducting a
prospective cohort study examining frailty in individuals with advanced CKD. Our study will enroll
500 patients with CKD Stages 4-5, and perform tests of physical function and cognition. We will
then associate frailty and its components (physical function, cognition, depression) with treatment
preferences and adverse outcomes in the CKD population. The cross sectional component of this
study will be completed by July 2016, and the longitudinal analysis can begin in June 2017.
Please include a brief description of the student's role
The student will join our multidisciplinary research team, and participate in every aspect of this
prospective study. Responsibilities will include patient enrollment and consent, frailty
evaluation,data abstraction and management and participation in statistical analysis and
manuscript preparation. Our research group has a co-supervision model; this study will be
primarily supervised by Dr. Tangri with Drs. Rigatto and Komenda acting as co-supervisors.
Contact Information:
Name:
Navdeep Tangri
Address: 2PD07 - 2300 McPhillips Street
Phone:
204-632-3834
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/29/15
Survival of Primary Total Knee Replacement Implants utilizing Constrained Polyethylene Inserts
Proposed Research - Abstract (250 word maximum)
Total knee replacement is highly effective but does require intact and balanced collateral ligaments to
function properly. If one ligament is lax, the result can be instability, pain and dysfunction.
Constrained liners with a large central post that engage both the tibial and femoral components were
designed to manage this issue. Originally designed for long-stemmed revision implants, these resists
varus/valgus moments transferring the load to the implants rather than through the damaged
ligaments. In 2007, a modification allowed the use of constrained liners in primary knees. In these
cases, the load is also transferred to the implants, but rather than transfer the load to bone through
the more stable stemmed implants, the load is applied to the implant-metaphyseal bone interface.
Concern has been raised that this could lead to early implant loosening and failure of the knee
replacement.
The Concordia Joint Replacement Group has used a significant number of constrained polyethylene
liners with primary knee replacement over the last 8 years. This study will retrospectively identify
patients who have this combination of implants from the prospectively collected CJRG research
database that contains data on over 13,000 patients from our practice. The patient charts will be
reviewed to determine clinical success or failure and radiographs will be assessed to determine if
failure could be pending. Survival of the implants will be plotted and analyzed both on its own and
after controlling for demographic variables. Clinical outcome measures from the database will also
be reviewed and compared to historical controls.
Please include a brief description of the student's role
The student will be responsible for assisting in identifying patients in the database, reviewing
charts and radiographs to assess for failure or impending failure, data assembly and analysis.
Research co-ordinators and I will assist the student in working with the CJRG database and
statistical software.
Contact Information:
Name:
Thomas Turgeon
Address: 310-1155 Concordia Ave., Winnipeg, MB
Phone:
(204) 926-1218
Email:
[email protected]
PRINT
SUBMIT
SAVE
Undergraduate Medical Student Research Programs
Research Abstract Proposal
Proposed ResearchTitle:
Program
BScMed
Date: 9/28/15
Exploration of immune regulatory networks in the hematopoietic stem/progenitor cell transplant
setting
Proposed Research - Abstract (250 word maximum)
Hematopoietic stem cell transplantation (HSCT) is an important tool in the treatment of marrow
failure/dysfunction and leukemias. We have recently found that the early myeloid recovery is
immune active and could impact both the development of immune dysregulation (graft-vs.-host
disease) and antileukemic effect. Research opportunity is to study the function of immature
myeloid cells with immune regulatory properties (myeloid-derived suppressor cells) in patients
following HSCT and when they are treated for GVHD. The project may involve murine models or
human samples depending on the interests of the student. Opportunity to work with a dynamic
multidisciplinary team.
Please include a brief description of the student's role
The student will design a research project that will ask a specific question about how the MDSC
interact with other immune cells post transplant.
Clinical exposure tailored to student interests and can include adult/pediatrics, inpatient/outpatient.
Opportunity to participate in multidisciplinary team meetings.
Contact Information:
Name:
Donna Wall
Address: ON 2009, CancerCare Manitoba
Phone:
204-787-3594
Email:
[email protected]
PRINT
SUBMIT
SAVE