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Download Psychology Department Colloquium Andrew Aschenbrenner Washington University
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PsychologyDepartmentColloquium AndrewAschenbrenner WashingtonUniversity DiscriminatingHealthyAgingfromPreclinicalAlzheimerDisease:Insights fromCognitiveModelsofAttentionalControlandModelsofADPathology Thereisconsiderableinterestinunderstandingaspectsofcognitiveperformancethatcan discriminatecognitivelyhealthyagingfromtheearlieststagesofneurodegenerative disorderssuchasAlzheimerdisease(AD).Recentevidenceindicatesthatthepathological hallmarksofADaccumulate10‐15yearsbeforethemanifestationofclinicalsymptoms, whichsuggeststhatevenstudiesof“healthy”olderadultsarelikelytobecontaminatedby individualsinthepreclinicalstagesofthedisease.However,evidencefortherelationship betweenbiologicalmarkersofADandconcurrentcognitivefunctionhasbeenmixed.This talkwillfocusonchangesinattentionalcontrolasaparticularlysensitivecognitivemarker ofpreclinicalAD.Usingdatafromalargescale,longitudinalstudy,age‐relateddeclinesin attentionareshowntobeexaggeratedwhenADpathologyishigh,eveninotherwise clinicallyhealthyolderadults.Incross‐sectionaldatafromasimilarcohort,the contributionofattentionalcontroltoimpairmentsinotherdomains,specificallysemantic memoryretrieval,isexamined.Underconditionsofhighattentionaldemands,theinfluence ofestablishedADbiomarkersmultiplicativelyimpairscategorizationperformanceina mannerconsistentwithahypothesizedmodelofpathologyaccumulation.Implicationsfor cognitivetheoryandapplicationstoclinicaldrugtrialsarediscussed. Thursday,January21,4pm Refreshmentsservedat3:45 108WestVillageG
