Download LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
THIRD SEMESTER – NOVEMBER 2010
BT 3953 - PHARMACEUTICAL BIOTECHNOLOGY
Date : 11-11-10
Time : 9:00 - 12:00
Dept. No.
Max. : 100 Marks
Part A
I Choose the correct answer
(5 x 1 = 5)
1. _____________ drug is used to control infection from MRSA bacterium.
a) Avonex
b) Griseofulvin
c) Statins
d) Fusidic acid
2. Severe anemia with kidney damage can be treated with _____________.
a) Engerix-B
b) Procrit
c) Protropin
d) Activase
3. ____________ is isolated from Penicillium sclerotiorium.
a) Geodin
b) Erdin
c) Rotiorin
d) Drosophillin
4. rDNA and water are mixed with ____________ to produce liposomes.
a) phospatidylcholine b) phospatidyllysine c) phospatidyluracil d) phospatidylleucine
5. _____________ drug design relies on knowledge of molecules to bind to the target.
a) Structure
b) Ligand
c) Pharmacophore
d) Biolgics
II State whether the following are True or False. If False, give reasons
(5 x 1 = 5)
6. Beauveria bassiana is used in pest control.
7. What the body does to the drug is termed as Pharmacodynamics .
8. Neoflavonoids are derived from 4-phenyl coumarin.
9. Thymidine kinase gene converts ganciclovir into ganciclovir triphosphate.
10. The alveoli of the deep lung is characterized by B-cells
.
III Complete the following
(5 x 1 = 5)
11. ______________ causes low respiratory tract disease.
12. The first radio immunotherapy approved by NHL was ______________ .
13. ______________ is a psychoactive stimulant drug.
14. The charge due to ______________ gene therapy would be passed to generations.
15. ______________ are the mostly used targets for drug discovery.
1
IV Answer the following each in about 50 words
(5 x 1 = 5)
16. Define synthetic spice.
17. Briefly explain the biochemical assay for characterizing recombinant proteins.
18. State any four properties of prostaglandins.
19. How efficient does the bone marrow acts as a target for DNA delivery?
20. Explain oral administration of drug.
Part B
V Answer any FIVE of the following, each in about 350 words
(5 x 8 = 40)
21. How do prokaryote and eukaryotes play a vital role in biotech product production?
22. Define gene expression and the mechanism of gene regulation?
23. Explain the characterization and bioanalytical aspects of recombinant proteins.
24. Write a note on protein engineering.
25. Briefly explain the sources and significance of halo metabolites.
26. Explain the pharmaceutical properties of steroids and prostaglandins.
27. How can cancer and neurological diseases be treated by gene therapy?
28. Enumerate the points in formulating biotech products.
Part C
VI Answer the following, each in about 1500 words; draw diagrams where necessary
(2 x 20 = 40)
29. (a) What are the technical and economic aspects of vaccine research and development?
Explain.
OR
(b) Briefly explain the clinical development of Rituximab.
30. (a) Explain the pharmaceutical properties of terpenoids, alkaloids, flavonoids, coumarins and
nitrogen compounds..
OR
(b) Briefly explain the demand, animal source, immunological aspects and clinical
applications of xenotransplantation.
************
2