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Download Scisense Electrophysiology Minimally Invasive Intracardiac Biopotential Measurements for Rodent Models Electrophysiology
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Electrophysiology Scisense Electrophysiology Minimally Invasive Intracardiac Biopotential Measurements for Rodent Models •Eight electrodes (octopolar) for measuring up to four simultaneous intracardiac biopotentials •Stimulate and record from the same Catheter •Compatible with most biopotential amplifiers and stimulators RL-200-fly-A4 Rev. B 12/13 Intracardiac Biopotential Measurements Traditional surface ECG measurements provide total cardiac electrical signal but lack the precision for detailed signal propagation studies or regional measurements. It is possible to use epicardial surface electrodes to measure regional electrical potentials; however, it is an invasive procedure. Scisense EP Catheters offer a minimally invasive means for a more in-depth analysis of biopotential propagation through the heart. ELECTROPHYSIOLOGY PARAMETERS VARIABLE DESCRIPTION QR-I QR Interval QT-I QT Interval RR-I RR Interval PR-I PR Interval ST-I ST Interval ERP Effective Refractory Periods QRS QRS, P Widths QTD QT Dispersion HR Instantaneous Heart Rate R-H R Wave Height P-H P Wave Height T-H T Wave Height *Please contact Transonic for a more complete list of parameters based upon specific analysis software package being used. Principles of Operation Each of the 8 electrodes on a Scisense EP Catheter are controlled independently by either an Interface Box or unique Interface Cable. The Interface Box (FI893B) allows connection to any bioamplifier or stimulator via 2 mm pin receptacles. This provides the researcher complete control over which electrodes are used for recording or stimulation (pacing). In addition, reference pins are provided to achieve an appropriate ground. Alternatively, an Interface Cable can be used that terminates in 2 mm pins relating to electrodes 1-8: this is particularly convenient if the bioamplifier or stimulator has 2 mm pin receptacles (FC-EPPIN8-4). For those researchers with proprietary connections or a unique interface on their bioamplifier or stimulator we offer an Interface Cable with striped ends, allowing you to complete the connection as desired (FC-EP-OPEN-5). Considering these options, any commercially available stimulator or biopotential amplifier can be used in conjunction with a Scisense EP Catheter. Likewise, any data acquisition system which is compatible with the stimulator/ bioamplifier may be used to collect and analyze data. Please Contact Transonic® or your nearest Sales Representative for suggested third party systems. Electrophysiology (EP) Catheters Transonic Scisense offers a 1.1F octapolar (8 electrode) Catheter for use in mice and a 1.6F octapolar Catheter for use in rats. These Catheters come with a standard ring spacing of 0.5 mm and 1.0 mm, respectively, but can be customized to suit any specific application. Our octapolar EP Catheters offer advantages over traditional surface ECG in that you can gain detailed information about the propagation and timing of atrial and ventricular electrical signals. Up to 4 intracardiac electrograms can be recorded simultaneously. The same Catheter can be used to pace the heart as well as record electrical activity. SMOOTH PROFILE: • Reduces potential damage to endothelial lining during catheterization • Allows for easy passage through valves (can be inserted and withdrawn repeatedly) • Ability to pass through remodeled arteries TUBING MATERIAL: • Provides ideal balance of flexibility and rigidity, ensuring easy insertion and maneuverability • Will not fray like many other Catheter materials which, over time, will irritate vascular lining and valves • Small diameter of tubing minimizes impact on aortic flow, resulting in more physiologic data APPLICATIONS • Bundle of His characterization • SA node characterization • General signal propagation • Comparison between basal, medial and apical regions in the left ventricle • Endocardial ECG assessment Endocardial Electrogram recording from right ventricle (bipolar measurement from electrodes 7 and 8 at the apex) • Regional atrial assessment • Conduction studies • Qualification of cardiac insult INSERTION & PLACEMENT • Right Jugular Vein insertion for placement within the RA or RV • Right Carotid Artery insertion for placement within the LV • Esophageal insertion for placement beside the heart Endocardial Electrogram recording from right atrium (bipolar measurement from electrodes 7 and 8 at the valve) Electrophysiology Electrophysiology Control Unit & Cables ELECTROPHYSIOLOGY CATHETER INTERFACE BOX INTERFACE CABLE OPTIONS The Scisense FI893B EP Catheter Interface Box is a simple device designed to connect a Scisense EP Catheter to any bioamplifier and/or stimulator. The Interface Box has eight pin receptacles which correspond to one of eight electrodes positioned on the Catheter. A cable from the bioamplifier and/or stimulator which terminates in a 3 mm pin connection is then used to connect any single, pair, or multiple electrodes for recording/stimulating. • FC-EPEC-4 - Scisense Extension Cable for Octapolar EP Catheter (Redel-Redel) • FC-EP-OPEN-5 - Scisense Extension Cable for Octapolar EP Catheter (Redel-Open End) • FC-EPPIN8-4 - Scisense Octapolar EP Catheter Cable (Redel-8x 2mm PIN) Transonic® carries a selection of third party stimulators and amplifiers along with acquisition hardware/software solutions to create a fully functional cardiac biopotential setup for your research lab. OCTAPOLAR CATHETER SPECIFICATIONS PARAMETER VALUE Electrode Dimensions (Mouse) 0.010” or .254 mm wide 0.014” or 0.37 mm diameter Electrode Dimensions (Rat) 0.010” or 0.254 mm wide 0.025” or 0.635 mm diameter Electrode Material 80/20 Platinum/Iridium Catheter Material Polyimide single lumen Catheter Color Black Catheter Length 18” or 457 mm Connector Redel 8 pin. Pin 1= electrode 1 Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected]
