Download Lectins in food

Lectins in food
This is an alphabetical list of Foods containing Lectins, from edible Plant and
Animal sources.
Most lectins, in plant species, are NOT ABO blood type specific.
Even fewer EDIBLE plants have lectins that are ABO type specific.
This list does conflict with the information of the various
incarnations of 'blood type diets', as far as specific foods agglutinating
certain of the ABO blood types only. However, this information
below has been derived directly from the published scientific
literature and studies which are listed in the references which follow
this list. It is not known where the authors of these diet books came
up with their ABO blood-type agglutination data, it is definitely false
when compared to published scientific studies.
The first section has a list of foods, in alphabetical order for easier
searching, their scientific names, and which blood types are
agglutinated by them. The researchers who did this testing have
published their findings. Their work covers many medicinal plants
too, which I did not list here.
Also included below the table is additional information on the
allergenic potential of the foods where this information is available;
even though allergy is not associated with lectin specificity, this
information may be helpful to those using this list.
Agglutination activity, mitogenesis, etc. are all from results of
laboratory study of the lectin with blood and cells in vitro, unless
noted.
Most interesting to those who follow the blood type diet may not be
whether a food causes agglutination or not, but that almost every food reacts
identically with each blood type. So, what is the basis for the Blood
Type Diet??? Answer: There IS NO basis. It is a pure scam.
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1
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
Pimenta
Allspice
Leaf
++
++
++
dioica
Prunus
Nut
Almond
amygdalus
kernel
Aloe vera
Aloe vera
Leaf
Pimpinella
Anise
Fruit
anisum
Annatto, achiote Bixa orellana Seed
+
+
+
Apple varieties
Malus pumila Seed
Persea
Avocado
Seed
+
+
+
americana
Musa
Raw fruit
Banana
paradisiaca
pulp
Hordeum
Barley
Fruit
+
+
+
vulgare
Ocimum
Basil
Leaf
lysis lysis lysis
basilicum
Mormordica Fruit
Bitter melon
charantia
pulp
Black pepper
Piper nigrum Fruit
Vigna
Black-eyed pea
Seed
unguiculata
Broad or fava
Vicia faba
Seed
+++ +++ +++
bean
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O
++
+
+
+
lysis
+++
2
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
Brassica
Cabbage & Kale
Head
oleracea
Brassica
Cabbage, Savoy
Seed
lysis lysis lysis
oleracea
Elettaria
Cardamom
Seed
cardamomum
Apium
Celery
Fruit
graveolens
Sechium
Fruit and
Chayote
edule
seed
Chickpea or
Cicer
Seed
+
+
+
Garbanzo
arietinum
Chinese melon,
Benincasa
Fruit
hairy melon
hispida
Cinnamomum Stem
Cinnamon
++
++
++
zeylanicum
bark
Rind,
Citron
Citrus medica fruit,
pulp
Cocos
Coconut
Fruit
nucifera
Common bean,
fresh string or
snap and all dried Phaseolus
Seed
++++ ++++ ++++
varieties, kidney, vulgaris
Frijol, field bean,
etc.
Coriander &
Coriandrum Leaf and www.healthoracle.org
O
lysis
+
++
-
++++
3
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
Cilantro
sativum
fruit
Corn, maize
Zea mays
Kernels Corn, popping,
Zea mays
Kernels +
+‘Everta’ ssp.
everta
Fruit,
Cucumis
Cucumber
rind and sativa
seed
Cuminum
Cumin
Fruit
cyminum
Phoenix
Fruit,
Dates
dactylifera
dried
Anethum
Leaf and
Dill
graveolens
fruit
Sambucus
Elderberry
Seeds
++
+
++
nigra
Chicorum
Endive
Root
endivia
Foeniculum
Fennel
Fruit
vulgare
Trigonella
Fennugreek
foenumSeed
graecum
Allium
Garlic
Clove
sativum
Zingiber
Ginger, gingerroot
Rhizome officinale
Guava
Psidium
Unripe +
+
+
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O
+
+
4
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
guajava
fruit
Artocarpus
Leaf and
Jackfruit
++
++
++
heterophyllus seed
Jerusalem
Helianthus
Tuber
++
+
++
artichoke
tuberosus
Brassica
Kohlrabi
oleracea var. Stem
gonglylodes
Allium
Leek
Leaf
porrum
Rind &
Lemon
Citrus limon
fruitpulp
Ocimum
Lemon basil
Seed
americanum
Cymbopogon
Lemon grass
Leaf
citratus
Lentil
Lens culinaris Seed
++++ ++++ ++++
Lettuce
Lactuca sativa Leaf
Glycyrrhiza Root and
Licorice root
glabra
leaf
Phaseolus
Lima bean
Seed
++++ ++++
lunata
Citrus
Lime
Fruitpulp ++
++
++
aurantifolia
Myristica
Aril (seed
Mace
+
+
+
fragrans
coat)
Mango
Mangifera
Rind
+++ +++ +++
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++
+
++++
++
+
+++
5
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
indica
Majorana
Marjoram
Leaf
hortensis
Pennistum
Millet, Pearl millet
Fruit
americanum
Mung bean, azukia Vigna mungo Seed
Mung bean,
Vigna radiata Seed
golden gram
Myristica
Seed and
Nutmeg
fragrans
nut
Onion
Allium cepa Bulb
Orange, sweet;
Fruit and
Citrus sinensis
Navel
seed
Origanum
Oregano
Leaf
vulgare
Papaya
Carica papaya Fruitpulp +
+
+
Passiflora
Passion fruit
Fruit
lysis lysis lysis
edula
Pawpaw, custard Annona
Fruit
apple
squamosa
pulp
Pisum
Pea
Seed
+++ +++ +++
sativum
Prunus
Rind and
Peach
+
+
+
persica
fruitpulp
Arachis
Seed and
Peanut
hypogaea
shell
Peppermint
Mentha
Leaf and www.healthoracle.org
O
+
lysis
+++
+
6
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
piperita
stem
Peppers -Cayenne,
Capsicum
chili, Hungarian,
Seed
frutescens
Tabasco
Pigeonpea
Cajanus cajan Seed
Ananas
Rind and
Pineapple
comosus
fruitpulp
Prunus
Plum, purple plum
Fruit
domestica
Punica
Fruitpulp
Pomegranate
granatum
and seed
Citrus
Stem
Pommelo, pomelo
maxima
bark
Solanum
Potato
Tuber
++
++
++
tuberosum
Plantago
Seedcoat
Psyllium
ovata
and seed
Cucurbita
Fruit and
Pumpkin
maxima
seed
Raphanus
Root and
Radish
sativus
leaf
Rice
Oryza sativa Fruit
+
+
+
Rosamarinus
Rosemary
Leaf
lysis lysis lysis
officinalis
Rye
Secale cereale Seed
++
++
++
Sesamum
Sesame seed
Seed
orientale
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O
++
+
lysis
++
7
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
Allium
Shallot
Bulb
ascalonicum
Sorghum
Sorghum
Fruit
+
+
+
vulgare
Soya bean
Glycine max Seed
++
++
++
Fruitpulp,
Spaghetti squash, Lagenaria
rind and Kampyo
siceraria
seed
Mentha
Leaf and
Spearmint
spicata
stem
Sinacea
Spinach
Seed
oleracea
Illicium
Fruit and
Star Anise
verum
seed
Sugar beet
Beta vulgaris Leaf
Saccharum
Stem,
Sugar cane
officinarum stem pulp
Cucurbita
Summer squash
Fruit
pepo
Ipomoea
Sweet potato
Tuber
batatas
Tamarindus Fruit and
Tamarind
indica
leaf
Tangerine,
Citrus
Fruit and
Mandarin,Tangelo,
reticulata)
seed
Clementine
Tapioca, manioc, Manihot
Tuber
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O
+
++
8
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
cassava
esculenta
Colocasia
Taro
Tuber
+
++
+
esculenta
Young &
Tea; green,
Camellia
Mature +
+
+
oolong, black
sinensis
leaves
Thymus
Thyme
Leaf
lysis lysis lysis
serpyllum
Tomatoes;
Lycopersicon Rind &
beefsteak, plum,
esculentum
fruitpulp
cherry, Italian
Tomatoes;
Lycopersicon
beefsteak, plum,
Extract ++++ ++++ ++++
esculentum
cherry, Italian
Cucurma
Turmeric
Rhizome domestica
Walnut, black
Kernel
Juglans regia
walnut
and shell
Citrullus
Watermelon
Fruit
++
++
++
vulgaris
Triticum
Wheat germ
Seed
++
++
++
aestivum
White
fruitpulp
Blue
Wine grapes
Vitis vinifera
fruitpulp
& blue
seed
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O
+
+
lysis
-
++++
++
++
-
9
Lectins in Common Foods and Their Blood Type Specificity
agglutination = +
| no agglutination = Part used
Scientific
Common Name
for
A
B
AB
Name
testing
White
rind &
Wine grapes
Vitis vinifera
+
+
+
seed and
Blue rind
O
+
Banana (Musa paradisiac)
• Lectin Group: Unknown
• Lectin Designation: BanLec-I
• Lectin Location: the banana lectin is in the fruit itself.
• Agglutination: It does not agglutinate untreated human or
sheep erythrocytes (red blood cells), but does agglutinate rabbit
red blood cells.
• Mitogenic: Yes. Banana lectin stimulates T-cell proliferation (Tcells are one type of immune system white cell).
• Allergenic: Yes. IgG4 antibodies to banana were found to occur
more frequently than expected
Barley (Hordeum vulgare)
• Lectin Group: Chitin-binding lectins (Chitin is the horny outer
covering, especially of insects and crustaceans, composed of
carbohydrates of two or more molecules of simple sugars)
• Lectin Designation: HVA, ‘Hordeum vulgare agglutinin’
• Lectin Location: The barley lectin was first isolated from barley
embryos. It has also been isolated from roots and leaves of
adult plants.
• Agglutination: It is specific for GlcNAc, and most probably has
a higher affinity for GlcNAc-oligomers than for GlcNAc, like
the closely related wheat germ agglutinin (WGA). The barley
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•
•
lectin agglutinates all human and rabbit erythrocytes (red blood
cells).
Mitogenic:
Allergenic:
Black pepper - Peppercorns, includes black and white (Piper nigrum)
• Lectin Group: None found
• Lectin Designation: None found
• No information found on any lectin in Piper nigrum
Blackberry (Rubus fruticosus)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• The lectin is specific for glucosamine oligomers.
Broad bean, Fava bean (Vicia faba)
• Lectin Group: Legume lectins
• Lectin Designation: VFA, favin
• Lectin Location: The lectin is in the seeds.
• Agglutination: The lectin agglutinates human, mouse, rat, rabbit
and guinea pig erythrocytes, but not sheep erythrocytes. It is
specific for mannose/glucose and oligosaccharides
(oligosaccharides are sugars composed of a few simple sugars,
or saccharides) containing these sugars in the alphaconfiguration.
• Mitogenic: Yes. The lectin is mitogenic to lymphocytes (induces
division of white cells).
• Allergenic:
• Other: VFA in the diet of rats had no effect on the animals.
Cheryimoya, custard apple (Anona cherimoya)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• No specific information found on this lectin, other than brief
mention of it being isolated.
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Chestnut (Castanea spp.) belonging to the Fagaceae family (beech)
• Lectin Group:
• Lectin Designation:
• Lectin Location:
• Agglutination:
• Mitogenic:
• Allergenic: Yes. Linked with latex and avocado allergy, patients
may be cross-reactive to this group.
Chick pea, Garbanzo, Ceci Bean (Cicer arietinum)
• Lectin Group: Legume lectins
• Lectin Designation: CAA, CPA
• Lectin Location: The lectin is in the seeds of chickpeas.
• Agglutination: It agglutinates all human erythrocytes (red blood
cells), it is not blood type specific.
• Mitogenic: No. The lectin is non-mitogenic to human
lymphocytes (does not cause division of white cells).
• Allergenic:
Chicken (Gallus gallus)
• Lectin Group: S-Lectins, galectins
• Lectin Designation: Unknown
• Lectin Location:
• Agglutination: Binds beta-galactoside
• Mitogenic:
• Allergenic:
Corn, Maize (Zea mays)
• Lectin Group: Unknown
• Lectin Designations: ZMA-I, ZMA-II, Corn Coleoptile lectin
• Lectin Location: The ZMA lectins are in the kernels of corn.
• Agglutination: ZMA-I interacts with GalNAc, and ZMA-II
with mannose. These corn lectins agglutinate rabbit
erythrocytes, not human RBCs. There is also a lectin first
isolated from corn coleoptiles (coleoptiles are the first leaves of
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•
•
•
monocot plants) with a high agglutinating activity for human
Type O and B red blood cells.
Mitogenic:
Allergenic: Yes, high incidence known to occur.
Other: Corn is one of the major food crops that has been
genetically modified, large quantities grown in the U.S. of the
GMO varieties.
Corn 'Everta' ssp. (Zea mays everta)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• Lectin Location: An anti-B lectin was isolated from Zea mays
'everta' ssp. seeds. 'Everta' is a variety used as popping corn.
Zea mays L. var. everta common names: Popcorn, strawberry
popcorn, popping maize, Ayacucho popcorn, Popcorn 'Confite
Morocho,' 'Confite Puntiago,' South American popcorn.
• Agglutination: Serological studies showed anti-B specificity.
The lectin will agglutinate A1B erythrocytes significantly more
weakly than erythrocytes of B and A2B blood groups.
• Mitogenic:
• Allergenic: Yes.
Cranberry (Vaccinium macrocarpon Ait)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• Lectin Location:
• Agglutination: There is a lectin in cranberries which acts against
insects only, little info is found on it.
• Mitogenic:
• Other: Cranberries inhibit the lectin binding of bacteria of
human uropathogens (urinary tract bacteria).
Eel (Conger myriaster)
• Lectin Group: S-lectins (galectin)
• Lectin Designation: Congerin-I
• No other information found on this lectin yet
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13
Eel, freshwater (Anguilla anguilla)
• Lectin Group: Agglutinin
• Lectin Designation: AAA, AanA
• No other information found on this lectin
Eggplant (Solanum melongena)
• Lectin Group: None found
• Lectin Designation: None found
• No information found yet as to any lectin associated with
eggplant
Elderberry (Sambucus nigra)
• Lectin Group: Unknown
• Lectin Designation: SNA-III
• Lectin Location: SNA-III is found in elderberry seeds.
• Agglutination: It agglutinates animal and human erythrocytes. It
has a slight preference for type A over B and O erythrocytes.
• Mitogenic:
• Allergenic:
• Other: Elderberry fruits contain several different lectins.
Elderberry Bark (Sambucus nigra)
• Lectin Group: Unknown
• Lectin Designation: SNA
• Lectin Location: The lectin is found in elderberry bark.
• Agglutination: SNA is not blood group specific. It is widely
used to study surface antigens of viruses, bacteria and
mycoplasms.
• Mitogenic:
• Allergenic:
Flounder (Platichythys flesus)
• Lectin Group: None found
• Lectin Designation: None found
• No information found as to any lectin associated with flounder
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14
Garden Pea (Pisum sativum)
• Lectin Group: Legume lectins
• Lectin Designations: PSA, PsA
• Lectin Locations: One lectin is in the seed, and one in the root
of the plant.
• Agglutination: PSA possesses no specific affinity to blood
group antigens. The lectin has affinity towards mannose and
glucose. Fucose residues have been shown to be determinant in
the tight binding of glycopeptides to pea lectin. The specificity
is similar to lens culinaris (lentils).
• Mitogenic: Pea lectin is a mitogen (induces cellular division). It
is non-toxic to several insects.
• Allergenic:
Garlic (Allium sativum)
• Lectin Group: Monocot mannose-binding lectins
• Lectin Designations: ASA-I, ASA-II, ASA-L, ASA-RI
• Lectin Locations: Four lectins have been found in garlic. The
first two listed are from the bulbs, the third is from the leaves,
and the last one from the roots of the plant.
• Agglutination: All the garlic lectins agglutinate rabbit but not
human erythrocytes (red blood cells). The two in the bulb
(ASA-I and ASA-II) are highly specific for mannose. ASA-I
and ASA-II show some anti-insect properties.
• Mitogenic:
• Allergenic: Human antiserum contains natural antibodies to the
mannose-specific lectins from garlic bulbs.
Halibut, Atlantic (Hippoglossus hippoglossus)
Halibut, California (Paralichtys californicus)
Halibut, Greenland (Reinhardtius hippoglossoides)
• Lectin Group: None found
• Lectin Designation(s): None found
• No information located on lectins in any halibut varieties
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Jackfruit - tropical relative of breadfruit (Artocarpus heterophyllus)
• Lectin Group: Mannose binding lectins
• Lectin Designation: JFL, Jacalin
• Lectin Location:
• Agglutination: This is a mannose binding lectin. It has been
used in research for the isolation of human secretory IgA of
IgA1 and IgA2 subclass.
• Mitogenic:
• Allergenic:
Jerusalem Artichoke (Helianthus tuberosus)
• Lectin Group: Jacalin-related lectins
• Lectin Designations: HTA, HTA-I, HTA-II
• Location: HTA is found in the tubers of Jerusalem artichokes.
Two lectins (HTA-I and HTA-II) have been found in the callus
of the tuber.
• Agglutination: The HTA lectin has the highest agglutination
with blood group A erythrocytes in humans. HTA-I and HTAII agglutinate rabbit erythrocytes only.
• Mitogenic:
• Allergenic:
Kidney bean - This group includes the related Black beans (or turtle
beans), pinto beans, etc. (Phaseolus vulgaris)
• Lectin Group: Legume lectins
• Lectin Designationss: PHA-E, PHA-L, Pinto lectin
• Lectin Locations: The lectins are in the seeds, and PHA is
present in all parts of the bean plant, but amounts present
change during the life of the plant.
• Agglutination: PHA is highly reactive with most differentiated
mammalian cells which express membrane glycoconjugates
containing complex oligosaccharide chains. It agglutinates
erythrocytes of most animal species. PHA-L agglutinates
lymphocytes (white blood cells). PHA-E is NOT blood group
specific
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•
•
•
Mitogenic: PHA is a very strong mitogen and can react with
mast cells causing an IgE-independent histamine release and
degranulation in vitro. PHA-E is mitogenic to lymphocytes
(causing cell division to occur).
Allergenic:
Other: There are many different varieties of beans included in
this grouping. The lectins may vary slightly between different
types of these beans. PHA reacts with the insulin receptors of
fat cell membranes and mimics most of the biological effects of
insulin. At high levels of dietary intake, PHA appears to be
nutritionally toxic for most animals, including insects, rats,
birds, and humans.
Kiwi (Actinidia chinensis)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• There is a lectin in kiwi fruit, but it affects only insects
Leek (Allium porrum)
• Lectin Group: Monocot mannose-binding lectins
• Lectin Designation: APA
• Lectin Location: The lectin is isolated from the leaves of the
leek. High lectin concentrations are found in the nectar of leek
flowers.
• Agglutination: It agglutinates rabbit, but not human red blood
cells. It is a minor bulb protein and is highly specific for
mannose.
• Mitogenic:
• Allergenic:
Lentil (Lens culinaris)
• Lectin Group: Legume lectins
• Lectin Designations: LcH, LCA
• Lectin Location: The lectins are in the seeds.
• Agglutination: It agglutinates human and rabbit erythrocytes.
There is NO specific affinity to blood group antigens. The
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•
•
lectin binds to multiple sugar residues more than single alphamannose residue.
Mitogenic: LcH is a mitogen (causes cells to divide).
Allergenic:
Lima Bean (Phaseolus limensis) aka (P. lunatus)
• Lectin Group: Legume lectins
• Lectin Designations: PLA, LBA, LBL
• Lectin Location: Two lectins are in the seeds of lima beans.
• Agglutination: They specifically bind glycoconjugates
containing terminal non-reducing alpha-GalNAc residues. They
also exhibit blood group specificity towards human Type A
erythrocytes.
• Mitogenic: Lima bean lectin (LBL) is mitogenic for T- but not
B-lymphocytes (types of white blood cells).
• Allergenic:
Litchi (Litchi chinensis)
• Lectin Group: Unknown
• Lectin Designation: LCL, Litchi chinensis lectin
• No information found on this lectin yet
Lobster (Homarus americanus)
• Lectin Group: Unknown
• Lectin Designation: HAA, Homarus americanus agglutinin
• No information found on this lectin yet
Mango - leaves and bark (Mangifera indica)
• Lectin Group: Unknown
• Lectin Designation: MIA, Mangifera indica agglutinin
• Lectin Location: The leaves of the mango tree contain the
lectin, which has also been isolated from the bark.
Mung Bean (Vigna radiata) aka (Phaseolus aureus)
• Lectin Group: Unknown
• Lectin Designation: MBA, Mung bean agglutinin
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•
•
•
•
Lectin Location: The lectin is in the seeds.
Agglutination: It agglutinates trypsinized (treated) rabbit
erythrocytes but not human erythrocytes.
Mitogenic:
Allergenic:
Mushroom, common button (Agaricus bisporus)
• Lectin Group: Unknown
• Lectin Designations: ABA, AbiA, ABL
• No information located on these lectins yet
Okra (Abelmoschus esculentus)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• There is a lectin in okra, it is thought to be non-toxic and
present at low levels
Onion (Allium cepa )
• Lectin Group: Monocot mannose-binding lectins
• Lectin Designation: ACA, Allium cepa agglutinin
• Lectin Location: The lectin is found in the bulb.
• Agglutination: ACA is a minor bulb protein. It agglutinates
rabbit but not human red blood cells. It is specific for mannose.
• Mitogenic:
• Allergenic:
Peanut (Arachis hypogaea)
• Lectin Group: Legume lectins
• Lectin Designations: PNA, GNL, MNL, PRA-I, PRA-II
• Lectin Locations: Lectins have been isolated from the seeds
(PNA), the nodules and the roots of peanuts.
• Agglutination: PNA will NOT agglutinate human erythrocytes
unless the cells are treated with neuraminidase. This applies to
other cells, such as lymphocytes, as well. Agglutination of PNA,
from the nuts, can be inhibited by galactose and lactose. PNA
is specific for terminal beta-D-galactose residues.
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•
•
Mitogenic: PNA is a mitogen for human blood peripheral
lymphocytes, colon cells, and stimulates proliferation in colon
cells removed from patients with inflammatory bowel disease
and colon polyps in vitro.
Allergenic: Yes, high incidence known to occur
Pineapple (Ananas comosus)
• Lectin Group: None found
• Lectin Designation: None found
• No lectin found associated with pineapple, but a small protein,
called bromelain inhibitor VI, which is a cysteine protease
inhibitor.
Pinto bean (see Kidney Bean, Phaseolus vulgaris)
• Lectin Group: Legume lectins
• Lectin Designationss: PHA-E, PHA-L, Pinto lectin
• Lectin Locations: The lectins are in the seeds, and PHA is
present in all parts of the bean plant, but amounts present
change during the life of the plant.
• Agglutination: PHA is highly reactive with most differentiated
mammalian cells which express membrane glycoconjugates
containing complex oligosaccharide chains. It agglutinates
erythrocytes of most animal species. PHA-L agglutinates
lymphocytes (white blood cells). PHA-E is NOT blood group
specific
• Mitogenic: PHA is a very strong mitogen and can react with
mast cells causing an IgE-independent histamine release and
degranulation in vitro. PHA-E is mitogenic to lymphocytes
(causing cell division to occur).
• Allergenic:
• Other: There are many different varieties of beans included in
this grouping. The lectins may vary slightly between different
types of these beans.
Potato (Solanum tuberosum)
• Lectin Group: Chitin-binding lectins
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Lectin Designation: STA, Solanum tuberosum agglutinin
Lectin Location: The lectin was first found in the tubers.
Agglutination: The potato lectin agglutinates all human and
animal erythrocytes, including bovine, sheep, goat, horse, pig,
cat guinea pig, rat, mouse and rabbit. It is NOT blood group
specific. It is specific towards oligomers of Nacetylglucosamine. GlcNAc does not inhibit the agglutination
of STA.
Mitogenic:
Allergenic:
Other: The lectin is non-toxic to insects. It is considered a
tuber protein, but occurs also in the roots, leaves and stems.
The lectin content varies a great deal according to the variety.
Pumpkin, Marrow, Winter Squash (Cucurbita maxima)
• Lectin Group: Cucurbitaceae phloem lectins
• Lectin Designation: CMA, Cucurbita maxima agglutinin
• Lectin Location: The lectin was isolated from the phloem
exudate of Cucurbita maxima. Phloem 'exudate' is sap.
• Agglutination: It is specific for oligomers of Nacetylglucosamine (oligomers are compounds containing a few
structural units of polymers, which are made of 2 or more small
molecules that combine to form larger molecules of basically
repeating structures).
• Mitogenic:
• Allergenic:
Pumpkin, Summer Squash, Gourd (Cucurbita pepo)
• Lectin Group: Cucurbitaceae phloem lectins
• Lectin Designation: CPA
• Lectin Location: The lectin was found in the fruit of cucurbita
pepo. It is a major protein in the phloem exudate. It is possible
it has an anti-parasitic function.
• Agglutination: The lectin agglutinates rabbit erythrocytes. It is
strongly inhibited by chitin oligosaccharides but only weakly by
N-acetlyglusocamine.
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Mitogenic:
Allergenic:
Rice (Orysza sativa)
• Lectin Group: Chitin-binding lectins
• Lectin Designation: OSA, RL
• Lectin Location: Rice lectin was first isolated from rice bran. It
is also found in rice embryos.
• Agglutination: Rice lectin agglutinates all human and rabbit
erythrocytes. It is specific for GlcNAc and its oligomers.
• Mitogenic: It is mitogenic (causes the cells to divide) towards
mouse spleen lymphocytes and human peripheral (in the
bloodstream) lymphocytes.
• Allergenic: Not usually in the U.S., allergy to rice is much more
prevalent in Asia.
• Other: Rice lectin has activity against the cowpea weevil.
Rye (Secale cereale)
• Lectin Group: Chitin-binding lectins
• Lectin Designation: SCA
• Lectin Location: The lectin is in the rye embryos.
• Agglutination: It agglutinates all human and rabbit erythrocytes.
It is specific for GlcNAc. It is very closely related to wheat
germ agglutinin (WGA).
• Mitogenic:
• Allergenic:
Saffron crocus (Crocus sativus)
• Lectin Group: Unknown
• Lectin Designation: LECp.CroSat.bu.HMA1
• Lectin Location: Four lectins have been found in crocus bulbs,
but not in the edible part, the pollen (saffron).
Scarlet Runner Bean (Phaseolus coccineus)
• Lectin Group: Legume lectins
• Lectin Designations: PCA,
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Lectin Locations: There are two lectins in scarlet runner beans.
This lectin is found in the seeds.
Agglutination: It agglutinates all types of human erythrocytes. It
has low agglutinating activity.
Mitogenic: Yes. One of the lectins stimulates mitosis of
lymphocytes (stimulates division of the white cells).
Allergenic:
Shallot (Allium ascalonicum)
• Lectin Group: Monocot mannose-binding lectins
• Lectin Designation: AAA
• Lectin Location: The lectin is found in the bulbs. It is a minor
bulb protein.
• Agglutination: It agglutinates rabbit but not human red blood
cells. It is highly specific for mannose.
• Mitogenic:
• Allergenic:
Snail, Roman or edible (Helix Pomatia)
• Lectin Group: Unknown
• Lectin Designation: HPA
• Lectin Location:
• Agglutination: Possess anti-A blood group specificity. HPA also
has affinity for terminal alpha-N-acetyl-D-galactosaminyl
residues.
• Mitogenic:
• Allergenic:
Sole (Solea solea)
• Lectin Group: None found
• Lectin Designation: None found
• No information found on any lectin associated with sole
Soyabean (Glycine max)
• Lectin group: Legume lectins
• Lectin Designation: SBA
• Lectin Location: The lectin is in the seeds.
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Agglutination: Soybean lectin agglutinates red cells from
humans and several animal species; it is not blood group
specific. Soybean lectin shows the greatest affinity for Nacetylgalactosamine, its glycosides and oligosaccharides
containing terminal N-acetylgalactosamine. It also reacts with
galactose. It precipitates (causes to separate from solution or
suspension) human A1 blood group substances, but reacts
poorly with A2 and B substances and not at all with H
substances.
Mitogenic:
Allergenic: Yes, high incidence of allergy known to occur to
soyabeans and soya products.
Other: Soya is another major food crop that has been
genetically modified and widely grown in the GMO format.
Soyabean agglutinin in the diet reduces the growth rate of
young monogastric (single stomach) animals and induces doseand polyamine-dependent and reversible hyperplastic growth
(abnormal increase of in volume of a tissue or organ caused by
the formation and growth of new normal cells) of the small
intestine and pancreatic hypertrophy (increase in volume of a
tissue or organ produced entirely by enlargement of existing
cells). The lectin in the duodenal lumen stimulates pancreatic
secretion via pancreatic cholecystokinin-A receptors and
interferes with the absorption of Fe2+ (iron). Parenteral
administration ('parenteral' means by injection, either
subcutaneous, intramuscularly, or intravenously) of the soybean
lectin modulates the host’s immune response and inhibits
tumor growth.
Steelhead trout - eggs- (Oncorhynchcus mykiss)
• Lectin Group: Unknown
• Lectin Designations: STL1, STL2
• No information found on these lectins yet
Sunflower seed (from Helianthus annuus L.)
• Lectin Group: No information found on this lectin
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Lectin Designation:
Lectin Location:
Agglutination:
Mitogenic:
Allergenic:
Tamarillo, Tree Tomato (Cyphomandra betacea)
• Lectin Group: Chitin-binding lectins
• Lectin Designation: CBL-1
• Lectin Location: This lectin is in the fruit of the tree tomato. In
the fruit, the lectin is mostly located in the cell wall of fruit
tissues and the seed coat. No lectin was detected in the leaves,
stems, flowers or roots of the plant.
• Agglutination: The lectin agglutinates rabbit erythrocytes, not
human. Oligomers of N-acetylglucosamine were the only
carbohydrates that showed inhibition of CBL-1 induced
agglutination. The lectin is heat stable.
• Mitogenic: It showed no mitogenic activity against human
lymphocytes.
• Allergenic:
Taro (Colocasia esculenta)
• Lectin Group: Monocot mannose-binding lectins
• Lectin Designations: CEA, and a new taro lectin
• Lectin Location: The lectin in taro is found in the tubers, and is
very abundant.
• Agglutination: CEA agglutinates rabbit but not human
erythrocytes. A new taro lectin has been discovered and it
specifically agglutinates immature sperm.
• Mitogenic:
• Allergenic:
Tomato (Lycopersicon esculentum)
• Lectin Group: Chitin-binding lectins
• Lectin Designations: LEA, TL, LEL
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Lectin Location: Tomato lectin was first isolated from ripe
fruits. The lectin is located predominantly in the locular fluid
and seeds. of ripe tomatoes.
Agglutination: LEA agglutinates all human, and animal
erythrocytes. It has specificity towards GlcNAc-oligomers.
Researchers consider LEA apparently harmless even when
eaten raw.
Mitogenic: It is non-mitogenic for mouse and chicken
lymphocytes. It is non-toxic to several insects.
Allergenic:
Turbot (Scophthalmus maximus)
• Lectin Group: Unknown
• Lectin Designation: Unknown
• No information found on any lectin associated with turbot yet
Wheat Germ (Triticum aestivum) aka (T. vulgare)
• Lectin Group: Chitin-binding lectin
• Lectin Designation: WGA
• Lectin Location: The agglutinin was isolated originally from
wheat germs. It has also been found in root tips and leaves of
wheat seedlings.
• Agglutination: It agglutinates both human and animal
erythrocytes. Has NO specific affinity to blood group antigens.
It is specific for GlcNAc and GlcNAc-oligomers. WGA also
binds sialic acid containing oligosaccharides.
• Mitogenic:
• Allergenic: Yes, high incidence of allergy is known to occur to
wheat and wheat products.
• Other: It is toxic to several insects. WGA in the diet of rats
reduced the digestibility and utilization of dietary proteins and
the growth of the rats. The lectin binds to the epithelial cells
and is a growth factor for the intestine. WGA inhibits herpes
simplex virus absorption and rabies virus attachment to
susceptible cells. WGA can inhibit the histamine release
induced by basic secretagogues (an agent that stimulates
secretion) from mast cells. WGA is virtually identical with the
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lectins found in numerous other triticum species, such as, T.
bicorne, T. comosum, T. speltoides, T. umbellulatum, etc.
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