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Mini-Toober Beta-Globin Folding © Kit© Teaching Points Proteins become real in your students’ hands as they fold 3 Mini-Toober β-globin fragments and discover primary, secondary and tertiary structure in this model. Maps guide students in marking the levels of structure onto 3 Mini-Toober fragments before folding each into its 3D shape. These three fragments are then assembled to form the completed structure. Connectors simulating hydrogen bonds help to stabilize the structure, and selected sidechains are added to demonstrate salt bridges, heme binding, and the site of the mutation leading to sickle cell anemia. Oxygen binding at the heme group can also be demonstrated with the completed model. Models in this Collection • 2 Mini-Toober β-Globin Folding Kits© Model Details • Each Mini-Toober β-Globin Folding Kit contains: o 3 Mini-Toobers (blue, green, red) o 3 Mini-Toober β-Globin Folding Maps (blue, green, red) o 4 Zip bags with parts for each Mini-Toober (blue, green, red and yellow*) Sidechains Heme Group and Heme Connectors Metal Clips Markers Support Posts Colored Dots Iron atom Oxygen atom o 3 Laminated Amino Acid Sidechain Lists o 3 Wooden Dowels o 1 CD Teacher Notes Blue Segment – Intro and Directions Green Segment – Intro and Directions Red Segment – Intro and Directions Jmol images of folded segments Documentation included • • Teaching points and inventory How do the models fit in the suitcase? Copyright © 1998 - 2008 Center for BioMolecular Modeling. All rights reserved.