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Chemical Structures Lecture 6: Carbohydrates Atom: The smallest components of an element that have all of the properties of an element (Whitney and Rolfes) Element: A type of atom, has unique properties (for ex. iron, oxygen) Nutrition 150 Shallin Busch, Ph.D. Carbohydrates “Hydrated carbons” Molecule: Two or more atoms of the same or different elements joined by chemical bonds Simple Carbohydrates Monosaccharides • Glucose: Form of energy used in body • Fructose: From fruits and honey • Galactose: Part of lactose Molecules that are made up of water (hydrogen and oxygen) and carbon Disaccharides • Maltose = glucose + glucose + • Sucrose = glucose + fructose + • Lactose = glucose + galactose + Complex Carbohydrates “Polysaccharides” • Chains made of hundreds to thousands of glucose molecules • Glycogen - made in the body of animals to store glucose • Starch – digestable, from plants • Fiber – undigestable, from plants Glucose: The bodies energy currency • All cells in body use glucose for energy • Brain and nervous system use glucose almost exclusively • Red blood cells use only glucose (Fat is also used as an energy source) Enzymes for Carbohydrate Digestion Amylase: Facilitates the break down of starch to small polysacchrides and disacchrides; in saliva and pancreatic juices Maltase: Facilitates the break down of maltose; on wall of small intestine Sucrase: Facilitates the break down of sucrose; on wall of small intestine Lactase: Facilitates the break down of lactose; on wall of small intestine Carbohydrate Absorption • Glucose and Galactose: active transport (fast) • Fructose: facilitated diffusion (slower) • Starches: must be broken into monosaccharides before absorption (slow) Consequences of fast or slow absorption of monosacchrides…How to maintain constant blood glucose levels? Muscles and Carbohydrates • Muscles use glucose for energy • Can store glucose as glycogen (120g or 480 kcal of energy) • Uses glycogen stores when necessary Liver and Carbohydrates • Converts fructose and galactose to glucose • Stores glucose as glycogen (70g or 280kcal) • Converts excess glucose to fat and sends it to fat stores in the body Fate of Absorbed Glucose Review of Actions of Insulin and Glucagon Intestine 1 When a person eats, blood glucose rises. 2 High blood glucose stimulates the pancreas to release insulin. Pancreas Insulin 3 Liver Insulin stimulates the uptake of glucose into cells and storage as glycogen in the liver and muscles. Insulin also stimulates the conversion of excess glucose into fat for storage. Fat cell Muscle Pancreas 4 As the body's cells use glucose, blood levels decline. 5 Low blood glucose stimulates the pancreas to release glucagon into the bloodstream. 6 Glucagon stimulates liver cells to break down glycogen and release glucose into the blood.a Glucagon Key: Glucose Insulin Glucagon Glycogen Run out of Carbohydrates? • When the body runs out of glucose and glycogen store, it creates its own glucose! • Converts amino acids (proteins) into glucose (gluconeogenesis) Liver a The stress hormone epinephrine and other hormones also bring glucose out of storage. 7 Blood glucose begins to rise. Carbohydrate Deficit in Diet Exercise and Energy Source • Fat is converted into ketone bodies as an alternative energy source for the brain • Lots of ketone bodies in the blood causes ketoacidosis, which makes the blood acidic • Ketoacidosis alters body’s basic functions and damages organs (Use of fat is not necessarily through conversion to ketones.) Carb Intake • Recommended Dietary Allowance (RDA) is 130 grams/day just to supply the brain with glucose. Names of Foods that are Carbohydrates? • 45-65% of daily calorie intake should be in the form of carbohydrates. • Focus on foods high in fiber and low in added sugars. Added Sugar Homework and In-Class Activity • On Thursday, bring in a food label (original packaging or a photocopy) of a food which has lots of different ingredients (cereal, granola bar, candy etc.) • Sugar that is added to food which already has natural sugars in it (for ex, caramelized popcorn) • With a partner you will fill out the worksheet entitled “Finding carbs in your food” (on website) which will help you 1) find carbs in your food and 2) compare the carbs in two foods. • DRI suggests intake should be less than 25% of total energy intake • If class is cancelled on Thursday, use the time you would spend in class to fill out the sheet by comparing two foods from your pantry. Turn in the sheet on Friday. • Why? • WHO and FAO suggests that should be less than 10% of total energy intake Diets high in simple sugars Can cause dental problems such as cavities, tooth decay, and gum disease Diets high in simple sugars • Associated with increased levels of “bad cholesterol” • Associated with decreased levels of “good cholesterol” • Can lead to poor nutrition, due to failure to obtain necessary vitamins, minerals, fiber, etc. (empty calories) Fiber Intake • The Adequate Intake (AI) of fiber is 14 grams for every 1,000 kcal in the diet • Most Americans eat only half the recommended amounts of fiber • Too much fiber (VERY RARE) can lead to malnourishment, GI distress, limited nutrient absorption 2 Types of Fiber 1) Viscous: Soluble, more fermentable 2) Nonviscous: Insoluble, less fermentable Viscous Fiber • Gums, mucilages, pectins, psyllium • Found in: whole grain products (barley, oats, rye), fruits, legumes, seeds, vegetables, • Also extracted and used as food additives Viscous Fiber • Lowers blood cholesterol by binding bile and blocking absorption of cholesterol • Slows glucose absorption • Slows transit of food in upper GI tract • Holds moisture in stools (softening them) • Digested by bacteria and yield fatty acids the colon uses for energy Lowers risk of both heart disease and diabetes Insoluble Fiber • Cellulose, Lignins, Resistant starches, psyllium, many hemicelluloses • Brown rice, fruits, legumes, seeds, vegetables, wheat bran, whole grains • Also extracted and used as food additives Insoluble Fiber • Increase fecal weight and speed of fecal passage through colon • Provides bulk and feeling of fullness • Alleviates constipation • Lowers risk of diverticulosis, hemorrhoids, and appendicitis • May help with weight management Diverticulosis Health Problems and Carbs Three health disorders related to carbohydrate metabolism are – Diabetes – Hypoglycemia – Lactose intolerance Lactose intolerance • Insufficient lactase production causes an inability to digest lactose found in dairy products • Symptoms include intestinal gas, bloating, nausea, cramping, diarrhea • Lactose intolerant people may need to find alternate sources of calcium Diabetes • Inability to regulate blood glucose levels • Untreated diabetes can cause ketoacidosis, nerve damage, kidney damage, blindness, and can be fatal • Three types: – Type 1 diabetes – Type 2 diabetes – Gestational diabetes Type I Diabetes • Accounts for 10% of all cases • Patients do not produce enough insulin • Causes hyperglycemia – high blood sugar (glucose) • Requires insulin injections and lifestyle management(diet, exercise, sleep) • May be an autoimmune disease Type 2 Diabetes cont. Cause is unclear but obesity, genetics, and physical inactivity play a role Type 2 Diabetes • Most diabetics have Type 2 diabetes • Body cells are insensitive or unresponsive to insulin • Excess insulin is often produced • Causes hyperglycemia because cells cannot take in the glucose from the blood Diabetes and Genetics Type 2 Diabetes cont. • Treated with diet, exercise, and possibly oral medications • Healthy lifestyle choices may prevent or delay onset of type 2 diabetes Symptoms of Diabetes Type 1 Diabetes Type 2 Diabetes Frequent urination Any of the type 1 symptoms Unusual thirst Extreme hunger Unusual weight loss Extreme fatigue Irritability Hypoglycemia • Low blood sugar (glucose) • Fasting hypoglycemia results when too much insulin is produced even when the patient has not eaten • Reactive hypoglycemia results when too much insulin is produced after a meal • Causes shakiness, sweating, anxiety Frequent infections Recurring skin, gum or bladder infections Blurred vision Cuts/bruises that are slow to heal Tingling/numbness in the hands and feet Graph Blood Sugar after Meals 1) Healthy Individual 2) Diabetic 3) Individual with Hypoglycemia