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Food and Agriculture
Organization of the
United Nations
The Global Control of FMD
Tools, Ideas and Ideals
Erice, Sicily
14-17 October 2008
Monday 13
October
13:00
Registration opens – Palazzo Sales
17:00
First view of posters – Palazzo Sales
19:00-21:00
Tuesday 14
Welcome reception – San Giovanni
October
09:00-09:30
Opening
09:30-10:00
Keynote
FAO/OIE representative: Global FMD control: opportunities and constraints
10:00-10:15
Global FMDV distribution and regional virus reservoirs:
an opportunity to divide and control?
J. Hammond 10:15-10:30
Hemispheric Program for the Eradication of FMD (PHEFA)
Successes and Challenges
V. Saraiva
10:30-10:45
FMD Type C situation – The first target for eradication
P. Roeder
10:45-11:15
11:15-11:30
11:30-11:45
Coffee break (Posters and YouTube viewing)
11:45-12:00
Constraints and opportunities for the control of foot-and-mouth disease in India
D. Hemadri
Session 1
Global FMD control through regional co-ordinated actions:
opportunities and constraints
Progress in FMD control in Iran: and perspective on longer term control in the region
V. Otarod
Virus diversity and vaccine selection: Russia, CIS-countries and Mongolia 2000–2007
A. Scherbakov
12:00-12:15
The global FMD research alliance (GFRA) - an R&D response to the major constraints
to global FMD control
C. G. Gay
12:15-13:00
Lunch break (Posters and YouTube viewing)
Session 2A
Vaccination 2A: optimizing programs in a situation of limited resources
13:00-13:30
Keynote
Vaccination: overcoming the constraints to achieving effective immunity rates
A. Dekker
13:30-13:45
Intra-dermal vaccination with 1/10 dose against FMDV protects pigs as well against clinical disease and subclinical virus shedding as intra-muscular vaccination with a full dose
P. Eblé
13:45-14:00
Vaccination strategies in sheep and lambs by using commercial polyvalent oil adjuvanted vaccines
E. Smitsaart
14:00-14:15
Longevity of protection following vaccination with high potency FMD vaccines in cattle – preliminary results
S. Cox
14:15-14:30
Discussion of session 2A
14:30-14:45
High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus
B. Haas
14:45-15:00
Predicting antigenic sites on the FMDV capsid from cross-reactivity data
F. Maree
15:00-15:15
Vaccine matching: reliability of foot-and-mouth disease r-values determination
N. Mattion
Coffee break (Posters and YouTube viewing)
15:15-15:45
15:45-16:00
Session 2 B
Vaccination - 2B: overcoming antigenic diversity in simplifying preventive programs.
OIE/FAO FMD lab network
Towards vaccine selection guidelines for each regional virus pool
16:00-16:15
Discussion of session 2B
Session 2C
Novel vaccine delivery approaches: progress updates
16:15-16:30
16:30-16:45
16:45-17:00
Expression of foot-and-mouth disease virus capsid proteins in
Silkworm-Baculovirus expression system and its utilization as an empty capsid vaccine
Zhifang Zhan
Potential of modified vaccinia Ankara (MVA) virus as a vaccine delivery
vector for foot-and-mouth disease virus (FMDV)
J. Castillo-Olivares
Marker potential of a vaccine prepared from a foot-and-mouth disease virus with a partial VP1 G-H loop deletion
P. V. Barnett
17:00-18:30
Poster session
18:30-20:30
Dinner
20:30-21:15
Frenkel Lecture: B. Charleston
FMD vaccine development - past and future
Wednesday 15
October
08:15-08:45
08:45-09:00
Session 2D
FMD vaccine standards required for global control
09:00-09:15
Can serological methods reliably replace existing vaccine challenge tests?
R. Reeve
Keynote
Vaccine quality tests: the value of alternative methods?
N. Goris
A standardized direct contact challenge method for FMDV in swine
L. Rodriguez
09:15-09:30
Correlating vaccine induced protection with humoral and cellular immune responses to FMDV: Potential in vitro assays for replacement of potency test
S. Parida
09:30-09:45
Altenative Potency Test in FMD vaccines
G. Aynagoz
09:45-10:00
Discussion of session 2D
10:00-10:30
Coffee break (Posters and YouTube viewing)
Session 3
Biosecurity and buy-in
10:30-11:00
11:00-11:15
11:15-11:30
11:30-11:45
Keynote
Biosecurity: what’s in it for me?
N. Honhold
FMD control in endemic settings: critical controls approach using livestock market chain and risk analysis
J. Pinto
Bridging the divide between two bona fide guardians of society’s interests:
the disease exterminators and the sustainable growth advocates
B. Perry
Discussion of session 3
Session 4
Measure progress in global and regional FMD control,
and early warning of FMDV emergence
11:45-12:15
12:15-12:45
Keynote
New options for old problems: endemic strains and early warning of emergence
D. Paton
12:45-13:30
13:30-13:45
13:45-14:00
Lunch break (Posters and YouTube viewing)
Global surveillance of foot-and-mouth disease:
concepts, considerations and requirements
A. M. Perez
Sampling, shipping, organisation and testing of inactivated samples to take advantage of molecular analysis methods
S. Alexandersen
Discussion of session 4
14:00-14:15
Use of infrared thermography to detect signs of foot-and-mouth disease in wild ungulates
M. R. Dunbar
14:15-14:30
Sequence identification and genetic profile of FMDV in disease outbreaks using rapid full length genomic analysis
S. Metwally
14:30-14:45
Identification of virulence determinants in FMDV: potential use of functional genomics to predicting viral pathotypes
L. Rodriguez
14:45-15:00
The distribution of NSP positive animals in regular vaccinated herds as criterion for
effectiveness of vaccine and vaccination during endemic year
H. Yadin
15:00-15:15
Measuring the success of vaccination programs: lessons learnt from surveys in Brazil 2005-2006
H. Barbosa
15:15-20:00Excursion and dinner
21:15-22:00
Fred Brown debate, Gavin Thomson:
Management of FMD caused by SAT-type viruses in southern Africa:
present approaches to control and trade standards are inappropriate
Thursday 16
October
Session 5
Diagnostics: making quality services available where need
Parallel Session 5
Epidemiology
08:15-08:45 Keynote
Diagnostics: a new era in access to high
performance diagnostics?
D. King
08:45-09:00 FMD and SVD combined proficiency test
studies 2008 – Virological Assays
N. Ferris
08:15-08:30
Anticipatory control measures:
geographical information systems-based
identification of topographic factors acting as
obstacles or disseminators in the 2001
Uruguayan FMD epidemics
A. Rivas
08:30-08:45
Network analysis of livestock movements to
estimate potential silent spread of
foot-and-mouth disease in Canada
C. Dubé
08:45-09:00
Modelling of FMD outbreaks in the
Netherlands, and the impact of vaccination on freedom of infection
H. Roermund
09:00-09:15
09:15-09:30
Defining the period of infectiousness of cattle
naturally infected with
foot-and-mouth disease virus
P. V. Barnett
09:00-09:30
09:30-09:52
FMD and SVD combined proficiency test
studies 2008 serology
Y. Li
09:52-10:15
To be announced
Keynote
Driving up global standards for
FMD diagnostic: a key role for proficiency
testing and international organisations
K. De Clercq
10:15-10:45 Coffee break (Posters and YouTube viewing)
10:45-11:00 An advanced field deployable “Pen Side”
sample preparation and PCR system
C. Volpe
Sequence data to support a possible case of
airborne spread of foot-and-mouth disease virus that occurred during the UK
2001 epidemic
G. König
11:00-11:15
Validation of real-time RT-PCR: matrix effect,
uncertainty of measurement and precision
K. De Clercq
09:30-09:45
Localisation of foot-and-mouth disease virus
after acute infection
N. Juleff
11:15-11:30
Development of prototype solid phase
competitive ELISAs based on monoclonal antibodies for the serology of
FMDV serotypes SAT1 and SAT2
E. Brocchi
09:45-10:00
Investigations into findings of FMD
seropositive sheep and goats in Cyprus, an FMD-free country
D. Paton
11:30-11:45
Full genome sequencing to support tracing of
UK outbreaks of FMD
N. Knowles
10:00-10:15
Results of molecular testing of samples
from Pakistan
S. Alexandersen
10:15-10:45
Coffee break (Posters and YouTube viewing)
10:45-11:00
Tracing 2007–2008 foot-and-mouth
disease emergency episodes
in South America: molecular epidemiology
I.E. Bergman
11:00-11:15
Sero-prevalence of foot-and-mouth disease
in small ruminants under contrasting
husbandry practices in Western Uganda
S. Balinda
11:15-11:30
The study on Sero-prevalence of
foot-and-mouth disease (FMD) in Ethiopia
G. Ayelet
Session 6
Components and capacity for effective control
14:00-14:15 Factors influencing global FMD reporting
and risk
R. Garabed
Parallel Session 6
Diagnostics
11:45-12:00 DIVA test evaluation in Jordanian sheep
and cattle
S. Parida
12:00-12:30 Panel discussion and debate
Diagnostic kits -what are the gaps? RL and
NRL viewpoints from across the globe
R. Dwarka, N. Thanh Long, R. Venkataraman
12:30-14:00
Lunch break and poster session
14:15-14:30
14:30-14:45
Participatory epidemiology as compared to
conventional FMD surveillance tool
T. Rufael
14:45-15:00
Development of an improved capability in
support of national bio-security for the
surveillance and control of foot-and-mouth
disease in cattle and pigs in Viet Nam
C. Morrissy
15:00-15:15
OIE Statement discussion
To be announced
13:45:14:00
To be announced
14:00-14:15
Detection of FMDV serotypes O, A and Asia 1
by real-time RT-PCR
S. Reid
14:15-14:30
Linear-After-The-Exponential (LATE) PCR:
New detection technologies for pan-FMDV and serotype-specific assays
in the fiel
K. E. Pierce
14:30-14:45
Evaluation of a lateral flow device for
the pen-side diagnosis of foot-and-mouth
N. Ferris
14:45-15:00
Detection of persistently FMDV infected cattle
by Salivary IgA Test
J. Biswal
15:00-15:15
Development and evaluation of IgM test for
detection of FMDV
U. Waheed
Session 7
Prospects for integrating anti-viral approaches
15:15-15:30
Enhanced prospects for FMDV anti-virals targeted to the 3C protease
S. Curry
15:30-15:45
In Vivo Activity of T-1105 against the highly pathogenic,
pig-adapted strain, FMDV O/Taw/1997
K. Sakamoto
15:45-16:15
Coffee break (Posters and YouTube viewing)
Session 8
Strategy for regional and global control
16:15-16:30
Elements of a global strategy
FAO 16:30-17:00
Panel discussion and debate
Session 9
Final Session
17:00-17:30
Recommendations of the Session
EuFMD
17:30
Closing cerimony
Friday 17
17:30-20:00
Dinner
October
8:30-13:00
14:00-17:00
Closed session of the Standing Technical Committee
GFRA meeting
Food and Agriculture
Organization of the
United Nations
poster session
Diagnostics
A. Yakovleva Development of indirect ELISA for detection of antibodies to foot-and-mouth disease virus
non-structural proteins
Foetal goat tongue cell line is highly sensitive for foot-and-mouth disease virus
B. Haas B.S. Chang Validation of solid phase epitope blocking ELISA (SPEBE) to detect antibodies against type O
foot-and-mouth disease virus using recombinant pentamer like structure proteins
C. Morrissy
Development of a foot-and-mouth disease (FMD) 3ABC nonstructural antibody C-ELISA using
chicken anti-3ABC as the completing antibody
E. Brocchi Evaluation of profiling ELISA for antibodies to non structural proteins of foot-and-mouth disease
virus for DIVA-serology
E. Brocchi
K. Morioka Preliminary evaluation of panels of monoclonal antibodies developed against four vaccine strains
of FMD viruses of serotype A for antigenic profiling and vaccine matching of field isolates
L. Bakkali-Kassimi
Baculovirus expression of non-structural protein 3D of FMDV and its use as antigen in ELISA for
differentiation of infected from vaccinated animals
Diagnostic strategy for FMDV - the Bulgarian approach
L. Polihronova
FMDV antigen detection ELISA using multi-serotype reactive monoclonal antibodies
R. Mistry Detection of foot-and-mouth disease virus on an automated sample preparation and
PCR point-of-care instrument
S. Grazioli
Mapping of linear antigenic sites of the non structural protein 3D of foot-and-mouth disease
relevant for the recognition of an infection status
Epidemiology
C. Wright
Human nasal FMDV carriage after exposure to infected animals
J. Gloster
Airborne spread of foot-and-mouth disease – model intercomparison
M. Habiela Epizootiological study of FMD in Sudan (The situation after two decades)
M. Shalev
Foot-and-mouth disease in North American wildlife and potential strategies for
its detection monitoring, and management
N. Knowles Genetic variation of foot-and-mouth disease viruses isolated from free-living African buffalo
(Syncerus Caffer) in Zimbabwe
N. Knowles
Virus nomenclature and framework of reference strains for phylogenetic analysis
D. Abdollahi
NSP and Sp induced by FMD vaccines used in I. R. Iran
S. M. Jamal
Status of foot-and-mouth disease in Pakistan
Global Control
D. Geale
Novel Funding Sources for Hemispheric Improvement of foot-and-mouth disease (FMD)
preparedness and response: Project scope & Progress to date
Inter-American group for the eradication of foot-and-mouth disease (GIEFA)
D. Geale
A. Seitzinger
Estimating the economic impact of potential FMD outbreaks based on the North American animal
disease spread model (NAADSM) simulation results
Other
J. H. Park Effective inhibition of foot-and-mouth disease virus by multiple short hairpin RNAS expression
in A adenovirus
R. Waters
An in-vitro cell culture model, investigating infection of novel cell types
with foot-and-mouth disease
Z. Zhang Development of a cell line stably expressing T7 RNA polymerase using retroviral gene transfer
technology for efficient rescue of infectious foot-and-mouth disease virus from cloned cDNA
M. Rémond Immunity,
Vaccines and
Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus
major antigen
Z. Zhang
Impact of cytokine response on FMDV infection outcome in cattle
Measurement of FMDV antigen stability using single domain antibody fragments
Vaccination
M. Harmsen
A. Dekker
A. Summerfield
The relation antibody and protection after foot-and-mouth disease vaccination cannot
be standardized
A. Timina
Study of immnunobiologic characteristics of type Asia-1 No. 1987/Amursky/2005 FMD virus
A. Dekker Intratype heterologous vaccination in cattle can confer antibody response in presence of
maternally derived antibodies
Population dynamics of a SAT type FMD chimeric vaccine strain
B. Blignaut Innate immune defences induced by CpG formulation in a conventional foot-and-mouth disease
vaccine do not promote protection
D. Gibson
Understanding FMDV transmission between vaccinated cattle – preliminary data from
animal experiment
E. Blanco Dendrimeric peptides as potential subunit vaccines against FMD
E. Lefevre
A quantitative assessment of primary and secondary immune responses in cattle
using the B cell ELISPOT assay
Piglets with maternally derived antibodies can be vaccinated at 2 weeks of age
G. Chenard
M. Mahapatra
Use of recombinant alpha v beta 6 integrin to improve the antigenic profiling ELISA for
FMD vaccine strain selection
M. Trotta In vivo and in vitro test to detect non-structural proteins in foot-and-mouth disease vaccines.
M. Windsor Dissecting the early immune response to FMD in cattle.
P. Eblé
Quantification of transmission of FMDV strain Asia-1 Turkey among vaccinated and
non-vaccinated lambs
Cliptox increased the protection levels induced by an FMDV inactivated vaccine
P. Zamorano R.B.Borrego
Targeting FMDV minigenes to SLA II positive cells enhances the induction of cellular responses in
swine and confers protection against viral challenge
CD4+ T cell Responses to foot-and-mouth disease virus (FMDV) in vaccinated Cattle.
V. Carr
V. Quattrocchi
Development of a fast release immunomodulated vaccine against foot-and-mouth disease virus.
Induced immunity