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CURRICULUM VITAE January 8, 2013 NAME: YING, Gui-shuang HOME ADDRESS: 1523 Brookhaven Road Wynnewood, PA 19096 OFFICE ADDRESS: 3535 Market Street, Suite 700 Philadelphia, Pennsylvania 19104-3309 Email: [email protected] TELEPHONE: (610) 645-0836 -Home (215) 615-1514 -Work PLACE OF BIRTH: Zhejiang, P. R. China Visa Status/Citizenship Permanent Resident of United States / P. R. China EDUCATION: 1988-1993 M.D., Zhejiang Medical University (Preventive Medicine) 1993-1996 M.P.H., Zhejiang Medical University (Toxicology) 1998-2000 M.S., University of Michigan School of Public Health (Biostatistics) 2000-2004 Ph.D., University of Pennsylvania School of Medicine (Biostatistics) ACADEMIC APPOINTMENTS: 2004- Assistant Professor (Clinician-Educator Track, 10-Years Appointment), Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine 2004- Director, Biostatistics Consulting Service, Center for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, University of Pennsylvania School of Medicine 2005- Associate Scholar, Biostatistics Unit Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine 2005- Faculty Member, Graduate Group in Epidemiology & Biostatistics Biomedical Graduate Studies Program University of Pennsylvania School of Medicine HONORS AND AWARDS: 1 1989-1993 Scholarship from Zhejiang Medical University 1993 Best Bachelor Thesis Award from Zhejiang Medical University 1993 Outstanding Graduate Award from Zhejiang Medical University 1994-1995 Graduate Fellowship from Graduate School of Zhejiang Medical University 2007 McCabe Pilot Award to research proposal “Optimal prediction of patient accrual, trial length and cost in randomized clinical trials”, University of Pennsylvania 2008 The ARVO Foundation for Eye Research/ Retina Research Foundation/ Joseph M. and Eula C. Lawrence Travel Scholarship Travel Grant PROFESSIONAL EXPERIENCE: 1993-1996 Research Assistant, Department of Toxicology, Zhejiang Medical University 1996-1998 Research Assistant, Department of Disability and Human Development, University of Illinois at Chicago 1998 Teacher Assistant, Department of Biostatistics, School of Public Health, University of Michigan 1999 (Summer) Biostatistician Internship, Department of Biostatistics, STATPROBE Inc. 1999-2000 Research Assistant, Department of Environmental Health Sciences, School of Public Health, University of Michigan 2000- 2004 Biostatistician, Clinical Trial Coordinating Center, Department of Ophthalmology, University of Pennsylvania School of Medicine 2004- Senior Biostatistician, Clinical Trial Coordinating Center, Department of Ophthalmology, University of Pennsylvania School of Medicine MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES: 2001- Society for Clinical Trials, Member 2001- Association for Research in Vision and Ophthalmology, Member 2003- American Statistical Association, Member 2003- The International Biometrics Society, Member March, 2008 Ad Hoc Grant Reviewer, National Eye Institute May, 2009 June, 2012 Grant Reviewer, Juvenile Diabetes Research Foundation Data Safety Monitoring Committee (DSMB) member for a NIH-funded clinical trial “Anastrozole in Patients with Pulmonary Arterial Hypertension (AIPH) study” EDITORIAL POSITIONS: Reviewer: 2 2002- Ophthalmology 2006- Archives of Ophthalmology 2007- Diabetes Care 2008- The American Statistician 2009- Journal of American Association for Pediatric Ophthalmology and Strabismus 2009- Clinical Ophthalmology 2009- Clinical Intervention in Aging, Clinical Medicine: Therapeutics 2010- Statistics in Medicine 2011- Investigative Ophthalmology & Visual Science 2011- Pharmaceutical Statistics 2011 - Biometrical Journal 2011- Diabetes 2011- Clinical Trials 2011- Contemporary Clinical Trials 2012- BMC Research Notes 2012- Ophthalmic & Physiological Optics 2012- Expert Review of Clinical Pharmacology 2012- BMC Medical Research Methodology 2012- Archivum Immunologiae et Therapiae Experimentalis 2012 - Ophthalmic Epidemiology 2012- International Journal of Ophthalmology 2012- Journal of Biopharmaceutical Statistics 2011- Book Editor for the book titled "Age Related Macular Degeneration", ISBN: 978-953-307-591-4. Editorial Board: 20122012- Journal of Medical Sciences Dataset Papers in Medicine COMMITTEE MEMBERSHIPS: Executive Committee member, Vision in Preschoolers (VIP) Study. 2004 – 2007. Executive Committee member, Telemedicine approaches to evaluating acute-phase ROP, 2010Executive Committee member, Postnatal growth and retinopathy of prematurity (G-ROP), 2012- PUBLICATIONS: Research Publications, peer reviewed: 3 Schenk M, Schwartz AG, O’Neal E, Kinnard M, Greenson JK, Fryzek JP, Ying GS, Garabrant DH. Familial risk of pancreas cancer. J Natl Cancer Inst 2001; 93:640-4. Garabrant DH, Roth HD, Parsad R, Ying GS. Latex sensitization in health care workers and in the U.S. general population. Am J Epidemiol 2001; 153:515-21. Aleman TS, LaVail MM, Montemayor R, Ying GS, Maguire MG, Laties AM, Jacobson SG, Cideciyan AV. Augmented rod bipolar cell function in partial photoreceptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats. Vision Research 2001; 41:2779-97. Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002; 120:1435-42. Loman J, Quinn GE, Kamoun L, Ying GS, Maguire MG, Hudesman D, Stone RA. Darkness and near work: myopia and its progression in third-year law students. Ophthalmology 2002; 109:1032-8. Heller T, Ying GS, Rimmer JS, Marks BA. Determinants of exercise in adults with cerebral palsy. Public Health Nurs 2002; 19:223-31. Vannas AE, Ying GS, Stone RA, Maguire MG, Jormanainen V, Tervo T. Myopia and natural lighting extremes: risk factors in Finnish army conscripts. Acta Ophthalmol Scand 2003; 81:588-95. Hahn P, Lindsten T, Ying GS, Bennett J, Milam AH, Thompson CB, Dunaief JL. Proapoptotic Bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Invest Ophthalmol Vis Sci 2003; 44:3598-605. Quinn GE, Francis EL, Nipper KS, Flitcroft DI, Ying GS, Rees R, Schmid G, Maguire MG, Stone RA. Highly precise eye length measurements in children aged 3 through 12 years. Arch Ophthalmol 2003; 121:985-90. Prenner JL, Rosenblatt BJ, Tolentino MJ, Ying GS, Javornik NB, Maguire MG, Ho AC, the CNVPT Research Group. Risk factors for choroidal neovascularization and vision loss in the Fellow Eye Study of CNVPT. Retina 2003; 23:307-14.. Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi L, Pfohl DC, Mills M, Bowen J, Ford C, Heidenreich FR, Jacobs DA, Markowitz CE, Stuart WH, Ying GS, Galetta SL, Maguire MG, Cutter CR. Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite. Neurology 2003; 61:1367-73. Lee MS, Balcer LJ, Volpe NJ, Liu GT, Ying GS, Galetta SL. Laser pointer visual field screening. Neuroophthalmol 2003; 23:260-3. 4 PUBLICATIONS - Research Publications, peer reviewed (Continued): Stone RA, Quinn GE, Francis EL, Ying GS, Flitcroft DI, Parekh P, Brown J, Orlow J, Schmid G. Diurnal axial length fluctuations in human eyes. Invest Ophthalmol Vis Sci 2004; 45:63-70. Ying GS, Heitjan DF, Chen T. Nonparametric prediction of event times in randomized clinical trials. Clinical Trials 2004; 1:352-61. Ibarra MS, Hsu J, Mirza N, Wu I-H, Ying GS, Mainster MA, Tolentino MJ. Retinal temperature increase during transpupillary thermotherapy: effects of pigmentation, subretinal blood, and choroidal blood flow. Invest Ophthalmol Vis Sci 2004; 45:3678-82. Hahn P, Lindsten T, Lyubarsky A, Ying GS, Pugh EN, Thompson CB, Dunaief JL. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death and Differentiation 2004; 11:1192-7. Metelisina TI, Grunwald JE, Dupont JC, Ying GS. Effects of Niacin on the choroidal circulation of patients with Age-related Macular Degeneration (AMD). British Journal of Ophthalmology 2004; 88:1568-72. Roman AJ, Schwartz SB, Alman TS, Cideciyan AV, Chico JD, Windsor E, Gardner LM, Ying GS, Smilko EE, Maguire MG, Jacobson SG. Quantifying rod photoreceptor-mediated vision in retinal degenerations: darkadapted thresholds as outcome measures. Experimental Eye Research 2005; 80:259-72. Grunwald JE, Metelitsin TI, DuPont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 2005; 46:1033-8. Heidary G, Ying GS, Maguire MG, Young TL. The impact of sphere on cylinder type and severity in a high myopia cohort. Optom Vis Sci 2005, 82:244-7. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of Viagra on the ocular circulation of AMD patients. Experimental Eye Research 2005, 81:159-64. Kupersmith MJ, Ying GS. Ocular motor dysfunction in ocular myasthenia gravis: effects of treat. British Journal of Ophthalmology 2005, 89:1330-4. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of systemic hypertension on foveolar choroidal blood flow in age rated macular degeneration (AMD). British Journal of Ophthalmology 2006, 90:342-6. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Liu CC. Effect of Viagra on the retinal vein diameter in AMD patients. Experimental Eye Research 2006, 83:128-32. Wilson LB, Quinn GE, Ying GS, Francis EL, Schmid G, Lam A, Orlow J, Stone RA. The relation of axial length and intraocular pressure fluctuations in human eyes. Invest Ophthalmol Vis Sci 2006, 47:1778-84. Komaromy AM, Garg CD, Ying GS, Liu CC. The effect of head position on intraocular pressure in horses. American Journal of Veterinary Research 2006, 67:1232-5. Stone RA, Wilson LB, Ying GS, Liu CC, Criss JS, Orlow J, Lindstrom JM, Quinn GE. Associations between Childhood Myopia and Parental Smoking. Invest Ophthalmol Vis Sci 2006, 47:4277-87. Tania TY, Mills MD, Beck AD, Joos KM, Ying GS, Liu CC, Piltz-Seymour JR. Central Corneal Thickness and Corneal Diameter in Patients with Childhood Glaucoma. Journal of Glaucoma 2006, 15:524-8. PUBLICATIONS - Research Publications, peer reviewed (Continued): 5 Hahn P, Ying GS, Beard J, Dunaief JL. Iron levels in human retina: sex difference and increase with age. Neuroreport 2006, 17:1803-6. Rabinowitz MP, Grunwald JE, Karp KA, Quinn GE, Ying GS, Mills MD. Progression to severe retinopathy predicted by retinal vessel diameter between 31 and 34 weeks of postconception age. Archives of Ophthalmology 2007;125:1495-500. Orlin A, Mills MD, Ying GS, Liu CC. A Comparison of Hang-Back with Conventional Recession Surgery for Exotropia. J AAPOS 2007;11:597-600. Cote ML, Schenk M, Schwartz AG, Vigneau FD, Kinnard M, Greenson JK, Fryzek JP, Ying GS, Garabrant DH. Risk of other cancers in individuals with a family history of pancreas cancer. Journal of Gastrointestinal Cancer 2007;38:119-26. Ying GS, Heitjan DF. Weibull Prediction of Event Times in Randomized Clinical Trials. Pharmaceutical Statistics 2008; 7:107-20. Metelitsina TI, Grunwald JE, Dupoint JC, Ying GS, Brucker AJ, Dunaief JL. Foveolar choroidal blood flow and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 2008;49:358-63. Greller AL, Hoffman AB, Liu C, Ying GS, Vudathala D, Acland GM, Komáromy AM. Effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs. Am J Vet Res 2008;69:273-8. Ranchod TM, Guercio JR, Ying GS, Brucker AJ, Stoltz RA. Effect of aspirin therapy on photodynamic therapy with verteporfin for choroidal neovascularization. Retina 2008; 28:711-6. Skalet AH, Quinn GE, Ying GS, Gordillo L, Dodobara L, Cocker K, Fielder AR, Ells AL, Mills MD, Wilson C. Gilbert C. Telemedicine screening for Retinopathy of Prematurity (ROP) in developing countries using digital retinal images: A feasibility project. J AAPOS 2008; 12:252-8. Zaveri M, Conger A, Salter A, Frohman TC, Galetta SL, Markowitz CE, Jacobs DA, Cutter GR, Ying GS, Maguire MG, Calabresi PA, Balcer LJ, Frohman EM. Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis. Archives of Neurology 2008; 65:924-8. Ying GS, Maguire MG, Liu CC, Antoszyk A, and Complications of Age-related Macular Degeneration Prevention Trial Research Group. Night vision and progression of Age-related Macular Degeneration (AMD) in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2008; 115:1876-82. Brown JS, Flitcroft DI, Ying GS, Francis EL, Quinn GE, Stone RA. In Vivo human choroidal thickness measurements: Evidence of diurnal fluctuations. Invest Ophthalmol Vis Sci. 2009; 50:5-12. Okeke CO, Quigley HA, Jampel HD, Ying GS, Plyler RJ, Jiang YZ, Friedman DS. Adherence with Topical Glaucoma Medication Monitored Electronically: The Travatan Dosing Aid Study. Ophthalmology 2009; 116:191-9. Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, Amado D, Ying GS, Sparrow J, Dunaief JL. Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci. 2009; 50:1440-7. PUBLICATIONS - Research Publications, peer reviewed (Continued): 6 Ranchod TM, Brucker AJ, Liu CC, Cukras CA, Hopkins TB, Ying GS. Evaluation of actual versus expected PDT spot size. Am J Ophthalmol. 2009; 147:859-64. Friedman DS, Okeke CO, Jampel HD, Plyler RJ, Ying GS, Jiang YZ, Quigley HA. Risk factors of poor adherence with eyedrops in electronically monitored glaucoma patients. Ophthalmology 2009; 116:1097-1105. Grunwald L, Mills MD, Johnson K, Karp KA, Quinn GQ, Ying GS, Grunwald JE. Does change in retinal vessel diameter over time predict severe retinopathy of prematurity? Am J of Ophthalmol 2009; 147:1086-1091. Hahn P, Song Y, Ying GS, He X, Beard J, Dunaief JL. Age-dependent and gender-specific changes in mouse tissue iron by strain. Experimental Gerontology 2009; 44:594-600. Iacovelli J, Mlodnicka AE, Veldman P, Ying GS, Dunaief JL, Schumacher A. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res. 2009; 1289:85-95. Ying GS, Maguire MG, Alexander J, Martin R, Antoszyk A. Description of the AREDS 9-step severity scale applied to participants in CAPT. Archives of Ophthalmology 2009;127:1147-51. Shah DN, Wilson C, Ying GS, Karp K, Fielder A, Ng J, Mills MD, Quinn GE. Semiautomated digital image analysis of posterior pole vessels in retinopathy of prematurity. J APPOS 2009;13:504-6. Shah DN, Karp K, Ying GS, Mills MD, Quinn GE. Image analysis of posterior pole vessels identifies type I retinopathy of prematurity. J APPOS 2009;13:507-8. Volpe NJ, Dadvand L, Kim SK, Maguire MG, Ying GS, Moster ML, Galetta SL, M. D. Computerized Binocular Pupillography of the Swinging Flashlight Test Detects Afferent Pupillary Defects. Current Eye Research 2009;34:606-13. Maguire AM, High KA, Auriccho A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli J, Ying GS, Rossi S, Marshall KA, Banfi S, Chung D, Morgan JA, Hauck B, Zelanaia O, Zhu X, Raffini L, Coppieters F, Elfride DB, Schindler K, Volpe N, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, , McDonnell JW, Leroy BP, Simonelli F, Bennett J. Phase I gene therapy shows reversal of congenital blindness: Agedependent effect of treatment. Lancet 2009; 374:1597-605. Maguire MG, Ying GS, McCannel C, Liu CC. Dai Y. Statin use and the incidence of advanced age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 2009;116:2381-5. Okeke CO, Quigley HA, Jampel HD, Ying GS, Plyler RJ, Jiang YZ, Friedman DS. Interventions Improve Poor Adherence with Once Daily Glaucoma Medications in Electronically Monitored Patients. Ophthalmology: 2009;116:2286-93. Garcia MM, Ying GS, Cocores CA, Tanaka JC, Komaromy AM. Behavioral method form objective vision testing and identification of achromatopsia in dogs. Am J Vet Res 2010;71:97-102. 7 PUBLICATIONS - Research Publications, peer reviewed (Continued): Simonelli F, Maguire AM, Testa F ,Pierce EA, Mingozzi F, Bennicelli J, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond M, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, DcDonnel JW, High KA, Bennett J, Auricchio A. Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5 years after vector administration. Molecular Therapy 2010; 18:643-50. Zaida AA, Ying GS, Daniel E, Gangaputra S, Rosenbaum JT, Suhler EB, Throne JE, Foster CS, Jabs DA, LevyClarke GA, Nussenblatt RB, Kempem JH. Hypopyon in patients with uveitis. Ophthalmology 2010; 117:36672 Cyert L, Ying GS, Dobson V, Quinn G, Magure M, Kulp MT, Ciner E, Schmidt P, Moore B, and Vision in Preschoolers (VIP) Study Group. Age Comparison for Lea Symbols and HOTV in Preschool Vision Screening. Optom Vis Sci 2010:87:87-95. Ying GS, Dobson V, Quinn G, Maguire M, Kulp MT, Cyert L and Vision in Preschoolers (VIP) Study Group. Impact of Confidence Number on the Accuracy of SureSight Vision Screener. Optom Vis Sci 2010;87:96-103. Ghodasra DH, Karen KA, Ying GS, Mills MD, Wilson C, Fielder AR, Ng J, Quinn GE. Risk stratification of eyes with preplus ROP by semi-automated analysis of digital images. Arch Ophthalmol. 2010; 128:719-23. Talman LS, Sackel D, Long DA, Bisker ER, Ratchford JN, Farrell SK, Loguidice MJ, Conger A, Frohman TC, Jacobs DA, Markowitz CE, Cutter GR, Ying GS, Dai Y, Maguire MG, Galetta SL, Frohman EM, Calabresi PA, Balcer LJ. Longitudinal study of vision and retinal nerve fiber layer thickness in MS. Ann Neurol 2010; 67:749-60. Xu W, Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Martin ER, Dunaief JL, Brucker AJ. Risk factors for choroidal neovascularization in AMD are associated with decreased foveolar choroidal circulation. Am J of Ophthalmol 2010; 150:40-47. Stone RA, Ying GS, Pearson DJ, Dansal M, Puri M, Miller E, Alexander J, Piltz J, Nyberg W, Maguire MG, Eledath J, Sawhney H. Utility of dignitial stereo images for optic disc evaluation. Invest Ophthalmol Vis Sci 2010; 51:5667-5674. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of isometric exercise on choroidal blood flow in patients with age-related macular degeneration (AMD). British Journal of Ophthalmology 2010; 94:1629-31. Ying GS, Maguire MG, and the CAPT Research Group. Development of a Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 2011; 118:332-8. Tamhankar MA, Kim JH, Ying GS, Volpe NJ. Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. Eye 2011; 25:91-6. Binenbaum G, Ying GS, Quinn GE, Dreiseitl S, Karp K, Roberts RS, Kirpalani H, and the Premature Infants in Need of Transfusion Study Group. A Clinical prediction model to stratify ROP risk using postnatal weight gain. Pediatrics 2011; 127:607-614. Tamhankar MA, Ying GS, Volpe NJ. Effectiveness of prisms in the management of diplopia due to fourth nerve palsy. J Neuroophthalmology 2011; 31:206-9. PUBLICATIONS - Research Publications, peer reviewed (Continued): 8 Shah DN, Wilson CM, Ying GS, Karp KA, Cocker KD, Fielder A, Mill MD, Quinn EQ. Comparison of expert graders to computer assisted image analysis of the retina in Retinopathy of Prematurity. Br J Ophthalmol. 2011; 95:1442-5. Jensen AK, Ying GS, Huang JY, Karp K, Quinn GE, Binenbaum G. Thrombocytopenia and retinopathy of prematurity. J APPOS 2011, 15(1): e3-e4. Smolen H, Ying GS, Martin ER, Maguire MG. New grading criteria allow for earlier detection of geographic atrophy in clinical trials. Invest Ophthalmol Vis Sci 2011, 52(12):9218-9225 Ying GS, Maguire MG, Quinn G, Kulp MT, Cyert L, and Vision in Preschoolers (VIP) Study Group. ROC analysis of the accuracy of noncycloplegic retinoscopy, Retinomax autorefractor and SureSight Vision Screener for Preschool vision screening. Invest Ophthalmol Vis Sci 2011; 52:9658-9664. Berenberg TL, Metelitsina TI, Madow B, Dai Y, Ying GS, DuPont JC, Grunwald L, Brucker AJ, Grunwald JE. The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration. Retina 2012, 32:25-31. Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM. AAV2 gene therapy readministration in three adults with Congenital blindness. Science Translational Medicine 2012, 4:120ra15. Tamhankar MA, Ying GS, Volpe NJ. Effectiveness of prisms in the management of diplopia in patients due to diverse etiolgies. J Pediatric Ophthalmology & Strabismus 2012, Feb 28:1-7 [Epub ahead of print].. Mehta SM, Loevner LA, Mikityansky I, Langlotz C, Ying GS, Tamhankar MA, Shindler K, Volpe NJ.The diagnostic and economic yield of neuroimaging in neuro-ophthalmology. J Neuroophthalmol. 2012; 32:139144. Charkoudian LD, Ying GS, Pujari SS, Gangaputra S, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Kempen JH. High-dose intravenous corticosteroids for ocular inflammatory diseases. Ocul Immunol Inflamm 2012, 20(2):91-99. Udoetuk JD, Dai Y, Ying GS, Daniel E, Gangaputra S, MD, MPH, Rosenbaum JT, Kempen JH. Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases. Ophthalmology 2012; 119:1569-74. Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, deZoeten E, Dunaief JL. DNA Methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci. 2012, 53:2089105. Grunwald JE, Ying GS, Maguire M, Pistilli M, Daniel E, Alexander J, Whittock-Martin R, Parker C, Mohler E, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Coleman M, Keane MG and CRIC Study Group. Association between retinopathy and cardiovascular disease in patients with Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Cardiol. 2012, 110:246-53. Tamhankar MA, Ying GS, Volpe NJ. Prisms are effective in resolving diplopia from incomitant, large and combined strabismus. Eur J Ophthalmol. 2012 Mar 29:0. doi: 10.5301/ejo.5000144. [Epub ahead of print] PUBLICATIONS - Research Publications, peer reviewed (Continued): 9 Shindler KS, Revere K, Dutt M, Ying GS, Chung DC. In Vivo detection of experimental optic neuritis by pupillometry. Experimental Eye Research. 2012; 100:1-6 Kwon JY, Ghodasra DH, Ying GS, Wilson CM, Karp KA, Huang JY, Mills MD, Fielder AR, Quinn GE. Retinal vessel changes after laser treatment for retinopathy of prematurity. J APPOS 2012; 16;350-3. Khitri MR, Mills MD, Ying GS, Davidson SL, Quinn GE. Visual acuity in pediatric glaucomas. J APPOS 2012; 16:376-81. Grunwald JE, Daniel E, Ying GS, Pistilli M, Maguire MG, Alexander J, Whittock-Martin R, Parker CR, Sepielli K, Blodi BA, Martin DF, and CATT Research Group. Photographic Assessment of Fundus Morphology in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology 2012; 119:1634-41. Grunwald JE, Alexander J, Ying GS., Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek J, Xie D, Jaar,BG The CRIC Study Group. Retinopathy and Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort (CRIC) Study. Arch.Ophthalmol. 2012;130:1136-1144. Dunaief DM, Fuhrman J, Dunaief JL, Ying GS. Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet. Journal of Preventive Medicine 2012; 3:364-371. Ghodasa DH, Thuangtong A, Karp K, Ying GS, Mills M, Wilson CM, Fielder AR, Ng J, Quinn GE. The rate of Change in retinal vessel width and tortuosity in eyes at risk for retinopathy of prematurity. J AAPOS 2012; 16:431-6. Ying GS, Huang J, Maguire MG, Jaffe GJ, Grunwald JE, Cynthia T, Daniel E, Klein M, Pieramici D, Wells J, Martin DF, and CATT Research Group. Baseline predictors for one year visual outcomes with Ranibizumab or Bevacizumab for Neovascular Age-related Macular Degeneration. Ophthalmology 2012 [Epub ahead of print]. Ying GS, Huang J, Maguire MG, Quinn G, Kulp MT, Ciner E, Cyert L, Orel-Bixler D, and Vision In Preschoolers (VIP) Study Group. Association of anisometropia with unilateral amblyopia, interocular acuity difference and stereoacuity in preschoolers. Ophthalmology 2012 [Epub ahead of print]. Binebaum G, Ying GS, Quinn G, Huang J, Dreiseitl S, Antigua J, Forough N, Abbasi S. The CHOP postnatal weight gain, birth weight, and gestational age retinopathy of prematurity risk model. Archives Ophthalmology 2012; 130(12):1560-5. Hadziahmetovic M, Pajic M, Grieco S, Song Y, Li Y, Cwanger A, Iacovelli J, Chu S, Ying GS, Connelly J, Spino M, Dunaief J. The Oral iron chelator deferiprone protects against retinal degeneration induced through diverse mechanisms. Transitional vision science & technology 2012 (in press). Hagstrom S, Ying GS, Pauer GJ, et al. for the CATT Research Group. Pharmacogentics of anti-VEGF therapy in the Comparison of AMD Treatments Trials (CATT). Ophthalmology 2012 (in press). Yaffe K, Ackerson L, Hoang TD, Go AS, Maguire MG, Ying GS, Daniel E, Bazzano LA, Coleman M, Cohen DL, Glenn M, Kusek JW, Ojo A, Seliger S, Xie D, Gunwald GE, and CRIC Study Investigators. Retinopathy and cognitive impairment among older adults with chronic kidney disease. American Journal of Kidney Diseases 2012.[Epub ahead of print]. Cohen AM, Cook N, Harris MC, Ying GS, Binebaum G. The pain response to mydriatic eye drops in preterm infants. J. Perinatol. Dec. 13, 2012. [EPub ahead of Print]. Ying GS, Heitjan DF. Prediction of Event times in the REMATCH Trial. Clinical Trials (in press). 10 Contributions to peer-reviewed clinical research publications as a writing team leader or member: Choroidal Neovascularization Prevention Trial Research Group (Writing team member). Laser treatment in fellow eyes with large drusen: updated findings from a pilot randomized clinical trial. Ophthalmology 2003; 110:971-8. Vision in Preschoolers (VIP) Study Group (Writing team member, Biostatistician for the Coordinating Center). Visual acuity results in school-aged children and adults: Lea Symbols chart versus Bailey-Lovie chart. Optom Vis Sci 2003; 80:650-4. Vision in Preschoolers (VIP) Study Group (Writing team member; Biostatistician for the Coordinating Center). Comparison of Preschool Vision Screening Tests as Administered by Licensed Eyecare Professionals in the Vision in Preschoolers (VIP) Study. Ophthalmology 2004; 111:637-50. Complications of Age-related Macular Degeneration Prevention Trial Research Group (Writing team leader, Biostatistician for the Coordinating Center). Baseline Characteristics, the NEI-VFQ-25, and Their Associations in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 2004; 111:1307-16. Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating Center). Sensitivity of screening tests for detecting VIP-targeted vision disorders when specificity is 94%. Optom Vis Sci 2005; 82:432-8. Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Preschool vision screening tests administered by nurse screeners compared to lay screeners in the Vision in Preschoolers Study Invest Ophthalmol Vis Sci 2005; 46:2639-48. Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Writing team member, Senior Biostatistician for the Coordinating Center). Laser treatment in patients with bilateral large drusen - The Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2006; 113:1974-86. Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating Center).Impact of confidence number on the screening accuracy of the Retinomax Autorefractor. Optom Vis Sci 2007; 84:181-188. Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Does Assessing eye alignment along with refractive error or visual acuity increase sensitivity for detection of strabismus in Preschool Vision Screening? Invest Ophthalmol Vis Sci. 2007; 48:3115-3125. Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Writing team leader, Senior Biostatistician for the Coordinating Center). Risk factors for Choroidal Neovascularization and Geographic Atrophy in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2008; 115:1474-79. Contributions to peer-reviewed clinical research publications as a writing team leader or member (Cont’d): Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Findings from the Vision in Preschoolers (VIP) Study. Optom Vis Sci. 2009;86:619-23. 11 Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Comparison of Retinomax and Palm-AR Auto-Refractors: A Pilot Study. Optom Vis Sci. 2011;88:830836. Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Age Comparison for Lea Symbols and HOTV in Preschool Vision Screening. Optom Vis Sci 2010:87:8795. Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating Center). Impact of Confidence Number on the Accuracy of SureSight Vision Screener. Optom Vis Sci 2010;87:96-103. Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Comparison of the Retinomax Autorefractor and Palm-automatic refractometer: a pilot study in the Vision in Preschoolers Study. Optom Vis Sci.2011;88:830-6. Comparison of AMD Treatment Trials (CATT) Study Group. (One of the 6 Writing team member; Senior Biostatistician for the Coordinating Center). Ranibizumab and Bevacizumab for Neovascular Age-related Macular Degeneration(AMD). New England Journal of Medicine 2011, 364:1897-908. Comparison of AMD Treatment Trials (CATT) Study Group. (One of the 9 Writing team member; Senior Biostatistician for the Coordinating Center). Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology 2012, 119:1388-98. Contributions to peer-reviewed clinical research publications, participation cited or acknowledged but not by authorship: Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating Center). Preschool vision screening: evidence-based guidelines from the Vision in Preschoolers (VIP) Study. Submitted to Pediatrics. Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Ying GS as Biostatistician for the Coordinating Center). The Complications of Age-related Macular Degeneration Prevention Trial (CAPT): Rationale, design and methodology. Clinical Trials 2004; 1:91-107. The Age-Related Macular Degeneration Radiotherapy Trial (AMDRT) Research Group. (Ying GS as Biostatistician for the Coordinating Center). The Age-Related Macular Degeneration Radiotherapy Trial (AMDRT): One year results from a pilot study. Am J Ophthalmol 2004; 138:818-28. Vision In Preschoolers (VIP) Study Group. (Ying GS as Biostatistician for the Coordinating Center). Development and implementation of a Preschool Vision Screening program in a mobile setting. NHSA Dialog 2005; 8:16-24. Kulp MT, Vision in Preschoolers Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Findings from the Vision in Preschoolers (VIP) Study. Optom Vis Sci. 2009; 86:619-23. Soltz RA, Carolyn GH, Tolentino MJ, Maguire AM (Ying GS acknowledged). Transmission of retinal wavelengths though blood. Retina 2005; 25:498-502. Beltran WA, Hammond P, Acland GM, Aguirre GD (Ying GS acknowledged). A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa. Invest Ophthalmol Vis Sci 2006; 47:1669-81. Vision in Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Predictive value of photoscreening and traditional screening of preschool children. J AAPOS 2006; 10:377-8. 12 Vision In Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Children unable to perform screening tests in Vision In Preschoolers Study: Proportion with ocular conditions and impact on the measures of test accuracy. Invest Ophthalmol Vis Sci 2007; 48:83-87. Vision In Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Random Dot E stereotest: Testability and reliability in 3- to 5-year-old children. J AAPOS 2006; 10:507-14. Murphy BR, Moayedpardazi HS, Gewirtz AM, Diamond SL, Pierce EA (Ying GS acknowledged). Delivery and mechanistic considerations for the production of knock-in mice by single-stranded olignucleotide gene targeting. Gene Therapy 2006; 5:1-12 Roman AJ, Boye SL, Aleman TS, Pang JJ, McDowell JH, Boye SE, Jacobson SG, Hauswirth WW (Ying GS acknowledged). Electroretinographic analyses of Rpe65-mutant rd12 mice: Developing an in vivo bioassay for human gene therapy trials of Leber congenital amaurosis. Molecular Vision 2007;13:1701-10. Ying X, Sulaiman P, Feddresen R, Liu J, Smith RG, Vardi N (Ying GS acknowledged). Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response. The Journal of Neuroscience 2008; 28:887384. Chen W, Stambolian D, Edwards AO et al (Ying GS as member of CAPT Data Coordinating Center acknowledged). Genetic variants TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA 2010; 107:7401-6. 13 ABSTRACTS, Past 5 years: Ying GS, Vision in Preschoolers Study Group. Impact of confidence number on the accuracy of the Retinomax and SureSight autorefractors as screening tools. IOVS 2006; 47:ARVO E-Abstract 693. Glassman RD, Wilson LB, Quinn GE, Francis EL, Ying GS, Orlin A, Orlow J, Schmid GF, Stone RA. The relation of axial length and corneal thickness fluctuations in human eyes. IOVS 2006; 47:ARVO E-Abstract 1798. Grunwald JE, Metelitsina TI, DuPont JC, Ying GS. Decreases in the foveal chroidal circulation precede the appearance of choroidal neovascularization (CNV) in age related macular degeneration (AMD). IOVS 2006; 47:ARVO EAbstract 2167. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Alexander J, Martin RE, Matias KM. Association between agerelated macular degeneration (AMD) fundus feature and foveal choroidal circulation. IOVS 2006; 47:ARVO EAbstract 2169. Stone RA, Criss JS, Wilson LB, Quinn GE, Ying GS, Liu CC, Orlow J, Lindstrom JM. Childhood refraction: Associations with parental smoking. IOVS 2006; 47:ARVO E-Abstract 5456. Wilson LB, Madjarov BD, Liu CC, Ying GS, Ells AL, Fielder A, Cocker K, Mills M, Davidson S, Quinn GE. Can digital ROP images be optimized for remote readers? IOVS 2006; 47:ARVO E-Abstract 5298. Lei T, Odhner D, Mishra S, Schwarta E, Ying GS, Iwanaga T, Desiderio L, Balcer L. A methodology to study multiple sclerosis (MS) based on distributions of standardized intensities in segmented tissue regions. SPIE 2005 annual conference paper. Ying GS, Folk J, CAPT Research Group. Risk factors for Choroidal Neovascularization and Geographic Atrophy in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). IOVS 2007; 48:ARVO E-Abstract 1153. Grunwald L, Niknam RM, Ying GS, Sankar P, Nduaguba C, Miller E. Effect of corneal thickness on intraocular pressure reduction. IOVS 2007; 48:ARVO E-Abstract 1279. Ranchod TM, Brucker AJ, Liu C, Ying GS, Cukras CA, Hopkins TB. Evaluation of actual versus expected PDT spot size. IOVS 2007; 48:ARVO E-Abstract 1800. Liu C, Maguire M, Ying GS, CAPT Research Group. Refractive error in the complications of Age-related Macular Degeneration Prevention Trial (CAPT): Risk of late AMD and 5-year changes. IOVS 2007; 48:ARVO EAssociation for Research in Vision and Ophthalmology. Abstract 2090. Baumritter A, Clark CM, Martin R, Steinberg JD, Stoltz RA, Ying GS. Prevalence of Age-related Macular Degeneration among patients with Alzheimer’s Disease. IOVS 2007; 48:ARVO E-Abstract 2092. Metelitsina TI, Figueroa M, Schocket LS, Ying GS, Dupoint JC, Alexander J, Grunwald JE. Laser induced resolution of drusen is associated with increases in choroidal blood flow. IOVS 2007; 48:ARVO E-Abstract 2150. ABSTRACTS, Past 5 years (Cont’d): 14 Grunwald JE , Metelitsina TI, Dupoint JC, Ying GS. Decreases in choroidal circulation precede choroidal neovascularization (CNV) formation and visual acuity loss in Age-related Macular Degeneration (AMD). IOVS 2007; 48:ARVO E-Abstract 2153. Rabinowitz MP, Grunwald JE, Karp KA, Quinn GE, Ying GS, Mills MD. Does retinal vessel diameter between 31 and 34 weeks post-conceptional age predict progression to severe retinopathy? IOVS 2007; 48:ARVO E-Abstract 3089. Grunwald L, Mills MD, Johnson K, Karp KA, Ying GS, Grunwald JE. Does change in retinal vessel diameter over time predict severe retinopathy of prematurity? IOVS 2008; 49:ARVO E-Abstract 1383. Nemani D, Wilsonm CM, Karp KA, Ying GS, Maguire M, Prince JB, Ng J, Fielder AR, Mills MM, Quinn GE. Semi-automated digital image analysis for eyes with and without retinopathy of prematurity (ROP). IOVS 2008; 49:ARVO E-Abstract 1384. Ying GS, Maguire MG, Alexander J, Martin RW, Antoszyk AN, and the CAPT Research Group. The AREDS 9step AMD severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT): Baseline classification, risk of advanced AMD, and longitudinal path analysis. IOVS 2008; 49:ARVO E-Abstract 1762. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of iosmetric exercise on cloroidal blood flow in patients with age-related macular degeneration (AMD). IOVS 2008; 49:ARVO E-Abstract 2240. Garcia MM, Cocores C, Ying GS, Tanaka JC, Komaromy AM. Behavioral test for visual assessment of Canine Achromatopsia. IOVS 2008; 49:ARVO E-Abstract 3839. Berenberg TL, Metelitsina TI, DuPont JC, Madow B, Dai Y, Ying GS, Brucker A., Grunwald JE. Association Between Drusen Extent and Foveolar Choroidal Blood Flow in AMD. IOVS 2009; 49:ARVO E-Abstract 231. Grunwald GE, Metelitsina RI, Dupont JC, Ying GS, Xu W, Martin ER, Brucker AJ. Risk Factors for Choroidal Neovascularization in Age-Related Macular Degeneration (AMD) Are Associated With Decreased Foveolar Choroidal Circulation. IOVS 2009; 49:ARVO E-Abstract 234. Maguire MG, Ying GS. Evaluation of Incident Advanced Age-Related Macular Degeneration and of Progression on the AREDS 9-Step Severity Scale as Surrogate Outcome Measures in Clinical Trials. IOVS 2009; 49:ARVO E-Abstract 263. Bisker E, Chang S, Conger A, Hiremath G, Dai Y, Ying GS, Maguire M, Frohman E, Calabresi P, Balcer L. Clinical and Ocular Imaging Characteristics of Eyes With Visual Loss Over Time in Multiple Sclerosis. IOVS 2009; 49:ARVO E-Abstract 927. Ying GS, Maguire MG, and the CAPT Research Group. Development of a Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). IOVS 2009; 49:ARVO E-Abstract 1662. ABSTRACTS, Past 5 years (Cont’d): Grunwald L, Mills MD, Ying GS, Karp KA, Grunwald JE, Dai Y, Fiorin D, Quinn GE. Retinal Vessel Width in Infants at Risk for Retinopathy of Prematurity Between 31 and 34 Weeks Post-Menstrual Age. IOVS 2009; 15 49:ARVO E-Abstract 3134. Ghodasra DH, Karp KA, Ying GS, Wilson C, Fielder AR, Mills MD, Quinn GE. Predicting the Progression of ROP With Preplus. IOVS 2009; 49:ARVO E-Abstract 3135. Smolen H, Ying GS, Martin ER, Maguire MG, and the CAPT Research Group. Characteristics of Early Geographic Atrophy in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). IOVS 2009; 49:ARVO E-Abstract 3915. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Xu W, Martin RE, Drucker AJ. Association Between Geographic Atrophy and Choroidal Blood Flow Parameters in Age-Related Macular Degeneration (AMD). IOVS 2009; 49:ARVO E-Abstract 4916. Stone RA, Ying GS, Pearson D, Bansal M, Puri M, and the CODA Study Group. Utility of Stereo Digital Images for Optic Disc Evaluation. IOVS 2009; 49:ARVO E-Abstract 5808. Wang J, Gu Y, Chen Y, Zhou W, Ying GS. Prevalence and causes of visual disability in the Eastern China. IOVS 2010; 49:ARVO E-Abstract 131. Maguire MG, Ying GS, Ciner E, Cyert L, Kulp MT, and Vision in Preschoolers Study Group. Prevalence of vision disorders by racial and ethnic group among children participating in Head Start. IOVS 2010; 49:ARVO EAbstract 138. Ying GS, Maguire MG, Dobson V, Quinn GE, Kulp MT, Cyert L, and Vision in Preschoolers Study Group. Validity of noncycloplegic retinoscopy, retinomax autorefractor and suresight vision screener for detecting VIP-targeted eye conditions. IOVS 2010; 49:ARVO E-Abstract 1704. Canver MS, Revere KE, Ying GS, Canver AC, Bennett J, Chung DC. Impairment of papillary light responses in Murine Models of retinal degeneration. IOVS 2010; 49:ARVO E-Abstract 4048. Charkoudian LD, Ying GS, Thorne JE, Foster C Jabs DA, Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Kempen JH. Intravenous pulsed corticosteroids for ocular inflammatory diseases. IOVS 2010; 49:ARVO EAbstract 5257. Grunwald L, Ying GS, Quinn GE, Dai Y, Karp KA, Fiorin D, Ruggeri A, Grunwald JE, Mills MD. Retinal vessel tortuosity in infants at risk for retinopathy of prematurity between 31 and 34 weeks post-menstrual age. IOVS 2010; 49:ARVO E-Abstract 5919. Ghodasa DH, Thuangtong A, Karp K, Ying GS, Mills M, Wilson CM, Fielder AR, Ng J, Quinn GE. Change in retinal vessel width and tortuosity in eyes at risk for retinopathy of prematurity. IOVS 2010; 49:ARVO EAbstract 5925. Wang YZ, Ying GS, Mitzel G, He YG. Sensitivity and specificity of shape discrimination hyperacuity for discriminating exudating AMD from moderate AMD. 2011 ARVO E-Abstract 100. Iwabe S, Ying GS, Aguirre GD, Beltran WA. Visual behavior and retinal structure following acute light exposure in normal and T4R RHO dogs. 2011 E-Abstract 1352. ABSTRACTS, Past 5 years (Cont’d): Simon MA, Forbes BJ, Christian CW, Ichord RN, Ying GS, Romero K, Binenbaum G. Association between retinal hemorrhage and pediatric brain injury patterns on diffusion-weighted magnetic resonance imaging. 2011 EAbstract 1569. 16 Kulp MT, Ying GS, Huang J, Maguire MG, Quinn GE, Ciner E, Cyert LA, Moore B, Orel-Bixler DA. Validity of noncycloplegic retinoscopy, retinomax autorefractor and SureSight vision screener for detecting significant refractive errors. 2011 E-Abstract 1601. Rhodes JL, Iwabe S, Ying GS, Huang J, Komaromy AW. Measurement of retinal thickness in Canine models of outer retinal disease using Spectral Domain Optical Coherence Tomography (SD-OCT). 2011 E-Abstract 1729. Kown JY, Karp K, Ghodasra DH, Ying GS, Wilson CM, Fielder AR, Quinn GE. Quantitative analysis of retinal vessel parameters following ROP treatment. 2011 E-Abstract 3145. Jensen A, Huang J, Ying GS, Quinn GE, Karp K, Binenbaum G. Exploring critical windows in the association between serum platelet deficit and retinopathy of prematurity. 2011 E-Abstract 3395. Pistilli M, Ying GS, Maguire MG, Peskin EP, Dentone PG, Asbell PA, and DREAM Research Group. Symptom Questionnaires for Dry Eye Disease: A comparative Rasch Analysis of the OSDI, BODI and IDEEL. 2011 EAbstract 3865. Ying GS, Huang J, Maguire MG, Quinn GE, Kulp MT, Ciner E, Cyert LA, Baumritter A, and Vision in Preschoolers (VIP) Study Group. Association between amblyopia and sperical and cylindrical anisometropia in Preschoolers. 2011 E-Abstract 6328. Huang J, Ying GS, Maguire MG, Quinn GE, Kulp MT, Ciner E, Cyert LA, Baumritter A, and Vision in Preschoolers (VIP) Study Group. The Association between anisometropia measured by vector analysis and unilateral amblyopia in Preschoolers. 2011 E-Abstract 6330. EDITORIALS, LETTERS TO THE EDITOR, CHAPTERS, COMMITTEE REPORTS, PROCEEDINGS: Ying GS, Huang XS. The methods for assaying the estrogenicity of environmental xenoestrogens (Review). Journal of Foreign Medicine - Public Health Division 1995; 22:216-9. Ying GS. The primary culture of Sertoli cells and its use in testicular toxicity assay of diethylstilbestrol, casmium , and endosulfan. Master Thesis (advisor: Xingshu Huang). Zhejiang Medical University, Hangzhou, Zhejiang, June 1996. Garabrant DH, Ying GS. Case-control study of leukemia and lymphoma at the Ford Sharonville plant. Report submitted to United Auto Workers/Ford Motor Company and National Joint Committee on the Health and Safety, 1999. Garabrant DH, Roth HD, Parsad R, Ying GS. Author reply Re: Latex sensitization in health care workers and in the US general population. Am J Epidemiol 2001; 153:527-8. Garabrant DH, Roth HD, Parsad R, Ying GS. Author reply Re: Latex sensitization in health care workers and in the US general population. Am J Epidemiol 2001; 154:190-1. Garabrant DH, Pastula S, Fryzek J, Ying GS. A mortality study of the Transmission & Chassis and Stampling plant workers. Report submitted to United Auto Workers/Ford Motor Company and National Joint Committee on Health and Safety, 2002. Ying GS. Prediction of event times in randomized clinical trials. Ph.D. Dissertation (advisor: Daniel F Heitjan. Ph.D.). University of Pennsylvania, Philadelphia, Pennsylvania, May 2004. 17 Maguire MG, Fine SL, Ying GS. Intravitreal injection of VEGF siRNA (Correspondence). Retina 2005; 25: 101-2. Ying GS, Liu CC. Analysis of the clustered data using SAS® systems. NESUG Conference Proceedings. 2006. Mills MD, Orlin A, Ying GS. Response to a Letter to the Editor Re: A Comparison of Hang-Back with Conventional Recession Surgery for Exotropia. J AAPOS 2008; 12:215-6. Mills MD, Quinn GE, Grunwald JE, Ying GS, Karp K, Rabinowitz M. Author Reply Re: Retinal vessels and Retinopathy of Prematurity. Archives of Ophthalmology 2008; 126:869-70. Ying GS, Maguire MG. Account for correlation in regression analysis of longitudinal data from paired eyes. JSM Proceedings 2008; 1190-97. Ying GS. Is Drusen Really So Important? Invest Ophthalmol Vis Sci 2012;53:4407-4408. 18 PRESENTATIONS: Non-parametric prediction of event times in randomized clinical trials. ENAR Spring meeting. Pittsburgh, Pennsylvania. March, 2004. Night-vision symptoms as a risk factor for vision loss, choroidal neovascularization, and geographic atrophy in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). 131st Anniversary Meeting of Department of Ophthalmology, University of Pennsylvania. May, 2005. Weibull predictions of event times in randomized clinical trials. 26th annual meeting of Society of Clinical Trials. Portland, Oregon. May, 2005. Weibull predictions of event times in randomized clinical trials. Sanofi-Aventis, Malvern, PA. July 27, 2005. Predictions of patient enrollment in randomized clinical trials. 27th annual meeting of Society of Clinical Trials. Orlando, FL. May 23, 2006. Real-time Predictions of event times in randomized clinical trials. New Researchers Meeting, Seattle, WA. August 1-5, 2006. Analysis of clustered data using SAS® systems. NESUG 2006. Philadelphia, PA. September 19, 2006. Night vision and risk of vision loss, choroidal neovascularization, and geographic atrophy in the Complications of age-related Macular Degeneration Prevention Trial (CAPT). 4th U.S. Symposium on Ocular Epidemiology. Sarasota, Florida. January 31, 2007. Risk Factors for Choroidal Neovascularization (CNV) and Geographic Atrophy (GA) in the Complications of Agerelated Macular Degeneration Prevention Trial (CAPT). Association for Research in Vision and Ophthalmology Annual Meeting. Fort Lauderdale, Florida. May 8, 2007. Real-time prediction of patient accrual and trial length that minimizes cost in randomized clinical trials. 28th Society of Clinical Trial Annual Meeting. Montreal, Canada. May 22, 2007. Different risk factors for Choroidal Neovascularization (CNV) and Geographic Atrophy (GA): Results from the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). 133rd Anniversary Meeting of Department of Ophthalmology, University of Pennsylvania. June, 2007. Prediction of patient accrual and trial length that minimizes cost in randomized clinical trials. The First International Symposium on Biopharmaceutical Statistics. Shanghai, China, June 30 – July 2, 2008. Account for correlation in regression analysis of longitudinal data from paired eyes. Joint Statistical Meeting, Denver, August 3, 2008. Development of a Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). Association for Research in Vision and Ophthalmology Annual Meeting. Fort Lauderdale, Florida. May 4, 2009. Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). 135th Anniversary Meeting of Department of Ophthalmology, University of Pennsylvania. May 27, 2009. Biostatistician and Biostatistics—Today and the Future. School of Public Health, Zhejiang University. Hangzhou, Zhejiang, P.R. China. June 1, 2010 19 PRESENTATIONS (Continued): Series of Introduction of Biostatistics. Zhejiang University. Hangzhou, Zhejiang, P.R. China. May 24-June 2, 2010 Weibull prediction of event times in randomized clinical trials. PSI’s Pharmaceutical statistical journal club. October 27, 2010. Introduction to Good Biostatistics Practice. Short course Director. International Conference on Good Medical Research. Istanbul, Turkey, March 27, 2011. Analysis of Correlated Eye Data. ARVO short course Director and Faculty Presenter. Association for Research in Vision and Ophthalmology Annual Meeting. Fort Lauderdale, Florida. April 30, 2011. One Year Results of AMD comparison trials (CATT). Scheie Eye Institute Visiting Professor and Guest Lecture Series, May 12. 2011 Validation of geographic atrophy risk score in Age-related Eye Disease Participants. 137th Scheie Eye Institute Alumni Meeting. May 13, 2011 Prediction in Randomized Clinical Trials. International Chinese Statistics Association Applied Statistics Symposium. Invited Speaker. June 26-28, 2011, New York City, New York. Predictions in Clinical Trials. Roundtable Speaker. FDA/Industry Statistics Workshop. September 20, 2011. Washington DC. Principles and concepts in clinical trials for eye researchers. One of the Invited speaker for ARVO Clinical Trials Course. December 2-3, 2011, Shanghai, P.R.China. Evaluation of the medical diagnostic tests for correlated data. Invited Speaker. March 4, 2012. Omaha, Nebraska. Baseline predictors for one year visual outcomes with Ranibizumab or Bevacizumab for Neovascular Age-related Macular Degeneration. Association for Research in Vision and Ophthalmology Annual Meeting. Fort Lauderdale, Florida. May 8, 2012 GRADUATE COURSES TAUGHT: Biostatistics 659: Design of Biomedical Studies, Spring 2006. Co-taught with Dr. Heitjan. I gave two lectures on Clinical Trial, including Randomization, Operation of multi-center randomized clinical trial, Intent-to-Treat analysis and Data Safety Monitoring Board Meeting (DSMB) Biostatistics 659: Design of Biomedical Studies, Spring 2007. Co-taught with Dr. Heitjan. I gave two lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB) meetings, and prediction of event times in randomized clinical trials. Epidemiology 523: Inference and Linear Regression, Fall 2007. I gave five STATA lab lectures (each lecture lasts 1.5 hours) to 12 MSCE students on how to use STATA software for data management, data analysis, sample size/power calculations, and generating graphics. Biostatistics 659: Design of Biomedical Studies, Spring 2008. Co-taught with Dr. Heitjan. I gave three lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB), and optimal prediction of enrollment duration, trial length and cost of a clinical trial. Biostatistics 659: Design of Biomedical Studies, Spring 2009. Co-taught with Dr. Heitjan. 20 I gave three lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB), and optimal prediction of enrollment duration, trial length and cost of a clinical trial. Special Topics in Ophthalmology 2009-2010: A course designed to teach medical students, fellows and junior faculties interested in vision-related research (total of about 10 attendees). The topics cover study design, data analysis, interpretation of results, cases studies in clinical trials and epidemiology studies in Ophthalmology. I taught 5 sessions that covers data analysis of correlated data, and prediction models. MSCE Independent Study, Fall 2009: Co-instructor for Gil Binenbaum’s MSCE independent study project on “The Postnatal Weight Gain Measurement for ROP Risk Stratification.” Meet weekly about 2 hours/week to teach him on literature review of prediction model of ROP and performed the development of a prediction model using data from a clinical trial of ROP by using SAS. Biostatistics and Epidemiology in Ophthalmology, Fall 2010: I am director for this course, which was designed for ophthalmology residents and fellows (total of 12+). I gave 4 hours presentation on the “Biostatistics for conduct eye research” and one case study. Biostatistics 659, Spring 2011: Design of Biomedical Studies, Spring 2011. Co-taught with Dr. Heitjan. I gave two lectures (total of 4 students) on Clinical Trial, including Data monitoring in clinical trials (Interim analysis, Data Safety Monitoring Board (DSMB)), and predictions in clinical trials. 21 Research Support ACTIVE U10EY017014 (Quinn) 07/01/2010 – 06/30/2014 40% NEI/NIH Direct cost: $8,497,054 Title: Telemedicine approaches to evaluating acute-phase ROP – e-ROP Major goal: To evaluate the validity, reliability, feasibility, safety and relative cost-effectiveness of an ROP telemedicine evaluation system to detect eyes of at-risk babies who meet RW-ROP criteria and therefore need of a diagnostic evaluation by an ophthalmologist experienced in ROP. Role: Principal Investigator for Data Coordinating Center R01 EY021137-01A1 (Binebaum) 09/30/2012 – 09/29/2017 10% NIH/NEI Direct Cost: $2,500,000 Title: Postnatal growth and retinopathy of prematurity (G-ROP) Major Goal: To develop a sensitive and specific ROP prognostic model that incorporates postnatal growth measurements with birth weight and gestational age to greatly reduce the number of infants requiring exams in the US. Role: Principal Investigator for Data Coordinating Center R21EY018908 (Ying) 08/01/09 – 07/31/13 30% NEI/NIH Direct cost: $275,000 Title: Analysis of data from Vision in Preschoolers (VIP) Study Major Goal: To evaluate the validity of four best screening tools for preschool vision screening, and to examination the vision disorders among Head Start preschoolers. Role: Principal Investigator 2-P30-EY01583-26 (Brainard) 09/01/10 – 08/31/15 NIH/ NEI Vision Research Center – Core Grant To further vision research activities through provision of biostatistical support. Role: Core Grant Director 20% U10-EY017823 (Maguire) 09/01/06 – 07/31/13 NEI/NIH Title: Coordinating Center for the Comparison of AMD Treatments Trials Major Goal: To evaluate the efficacy and safety of 4 forms on anti-VEGF treatment for choroidal neovascularization secondary to age-related macular degeneration. Role: Senior Biostatistician 20% R01 EY017299 (Stone) 08/01/07 - 07/31/13 20% NEI/NIH Title: Computer analysis of optic disc images in glaucoma. Major Goal: Collaborate with Sarnoff laboratories to develop computer vision methods for detecting change in optic discs in patients with glaucoma. Role: Collaborator USA MRMC Number: 08100002 (Doty) 07/01/09 – 06/30/13 Department of Defense Direct cost: $4,121,115 Title: Sensory dysfunction in early Parkinson’s disease Major Goal: To define the sensory deficits present in the early Parksinson’s disease. Role: Co-investigator COMPLETED U10-EY12547 (Maguire) 09/30/00 – 09/01/06 22 5% NIH/NEI Coordinating Center: Vision in Preschoolers The major goal of this project is to evaluate vision screening tests for preschool children. Role: Senior Biostatistician U10 EY12279 (Maguire) 12/01/06 - 11/30/08 NIH / NEI Title: Coordinating Center for the Age-related Macular Degeneration Prevention Trial (CAPT) Major Goal: to evaluate low intensity laser photocoagulation as a preventive treatment for the advanced complications of age-related macular degeneration (AMD) in patients with large drusen in each eye. Role: Senior Biostatistician R01-EY12769 (Grunwald) 07/01/06 - 06/30/09 NEI/NIH Title: Choroidal Circulation in Age-related Macular Degeneration Major Goal: To evaluate the association of choroidal hemodynamics in patients with age-related macular degeneration. Role: Senior Biostatistician R01 DK074151 (Grunwald) 03/01/06 - 02/28/11 NIDDK/NIH Title: Retinopathy in Chronic Renal Insufficiency Major Goal: To assess features of diabetic and hypertensive retinopathy as risk factors for progression of renal and cardiovascular disease in patients with chronic renal insufficiency. Role: Senior Biostatistician 23