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Infant and Toddler Growth and Development Elisa A. Mancuso RNC, MS, FNS Professor of Nursing Growth of Infant • Cephalocaudal (head → toe) • Proximodistal (trunk → periphery) • General → Specific (Large → fine muscles) • 1” a month during 1st 6 months • Average Ht 6 months 25 ½ inches 12 months 29 inches • Use recumbent length until 3 years • than standing (vertical height) Weight • 5-7oz/wk until 5-6 months • Birth weight doubles at 6 month • Birth weight triples at one year • Always refer to kilograms 2.2 lbs = 1 kg • All medications based on weight in kg! Head Circumference = HC Reflects brain growth • Posterior fontanele closes @ 2 mos. • Anterior fontanel closes @12-18 mos. • Measure (Forehead → Occiput) – For 1st 3 years Chest (CC) and Abdomen Chest = Head circumference @ 1 year • Measure @ nipple line. • Barrel chested as infant • Chest > Head after 3 years • After 1 year of age, – A/P transverse diameter = 1:2 Abdominal Girth • Measure above umbilicus • √ Abdominal distention • R/O liver or intestinal diseases Growth Charts • Serial exams to assess growth progress • Plotted as percentiles: – 25th %, 50th %, 75th %, 95th %. – @ 95th % = Pt > 95% of kids. • Used to notice any ↓ or ↑ in weight, height, or HC. • Specific charts for premature infants Denver Developmental Screening Test (DDST) Denver II • Assesses from birth → 6 years • Age divided monthly → 24 months, – then q 3 mos. → 6 years • Not an intelligence test Four categories • Personal/Social • Fine motor/Adaptive • Language • Gross motor Infant Reflexes • Moro - Startle – Loud sound = extension & abduction of extremities • Tonic neck – Fencing – Turn head to one side ® – arm & leg extend on ® side • Babinski – Dorsiflexion of big toe and toes fan out • All of above disappear in about 3-4 months Developmental Skills Trust vs Mistrust (Birth to one year) • Social responsiveness to others • Trust develops with regular consistent, loving care • Self reliance and develops confidence Early infancy 0 - 3 months Smiles at significant other Holds head & chest up when prone Reaches for objects-grasp Laughs Developmental Skills Early Infancy 4-6 months • Pulls self to sitting position • Sits with support • Rolls over = “Safety issue” – Tummy → back first at 2-3 months – Back → tummy by 6 months • stronger head and arm control • Transfers objects from hand to hand • Makes vowel sounds oh-oh Developmental Skills Late Infancy 6-9 months • Hold own bottle • Develops preference for dominant hand • Probes with index finger • Feeds self finger foods • Pincer grasp @ 9 months – thumb and index finger used • Sits erect-unsupported • Crawls • Separation Anxiety ↑cries with strangers Object Permanance Searches for items outside field of vision Developmental Skills 9-12 months • Triple birth weight and ↑ height by 50% • Releases objects • Pulls self to feet • Sits from standing position • Walks with help – independent walking can be as late as 18 months! • Responds to name • Recognizes no • Says 4 -5 words: mama, dada, no, bye • Teething (age – 6 = # of teeth) 12 mos – 6 = 6 teeth Cool cold items to chew on Tylenol 10-15 mg/kg q 4-6 hours Developmental Tasks • Achieve physiological equilibrium – Rest, eat, play patterns • Develop basic social interaction – Desire for affection • Manage a changing body – ↑motor skills & eye-hand coordination • Learn to understand and control world • Develop a beginning symbol system – Communication Immunizations • Regulated by CDC and American Academy of Pediatrics (AAP) www.cdc.gov/nip/vacsafe www.immunize.org • ↓ Infectious diseases = ↓morbidity & mortality • ↑ incidence of recent outbreaks: – immigration from poorly compliant countries – religious beliefs or cultural influences – ↓ trust of medical care or poor education • 2003 Nigeria stopped IPV – Rumors that IPV could transmit AIDS 2006 20% of kids<5 no IPV and ↑ polio outbreak • 2005 Amish Polio outbreak 2009 Immunizations Hep B Hepatitis B Vaccine (IM) • Birth, one month and six months • Mom (+) HBsAg – give baby HBIG (0.5mL) & Hep B within 12H – @ 2 separate sites – 90% infected infants → chronic Hep B carriers • 25%-50% infected before age 5 RT HBV Carriers • ↑ Transmission risk in adolescents – All kids entering 7th grade must have Hep B 3 dose series Immunizations IPV - Inactivated Polio Vaccine (SC) • 2, 4, (6-18) months and (4-6) years • Formerly used OPV –Virus shed • Contraindication; Allergy to neomycin HIB - Hemophilus Influenza Type B (IM) • 2, 4, 6 and (12-15) months • Not associated with Flu • Protects against many serious infections: – Epiglottitis and Bacterial Meningitis Immunizations PCV7 - Polysaccaride Conjugate Vaccine(Prevnar) (IM) • 2,4,6 and (12-15) months PPV – Pneumococcal Polysaccharide (IM) • One dose > 2 years Protects against Strep pneumonia • 6-12 months of age at high risk for S. pneumoniae ↑ Risk patients – Sickle cell disease, HIV/immune deficiency – chronic cardiac or pulmonary etc – Must receive PPV vaccine in addition to PCV Immunizations DTaP - Diptheria, Tetanus and acellular Pertussis (IM) Diptheria • Rare throat infection – Gray/yellow film • difficult to remove – Air flow obstruction – Sepsis Tetanus • Clostridium produced in infected wounds – Severe muscle extension Immunizations Pertussis • Gram negative bordetella pertussis • “whooping cough” – Post-tussive vomiting – Cyanosis – Subconjuctival hemorrhage Three stages: • catarrhal, paroxysmal (2 weeks) and decline • ↑ outbreaks in Adolescents and Adults RT ↓ titers www.pertussis.com Immunizations DTaP Schedule • 2,4,6,15 months and 4-6 years for DTaP • √ Side Effect: Redness & swelling @ site • New booster recommendations 2005: – “Tdap” Adacel: one dose 11- 64 years or – Boostrix: single dose 10 -18 years of age – Adolescents 11-12 years of age should receive single dose of Tdap instead of Td (if up to date and have not yet received Td booster) • Need 5 year interval from Td to Tdap to ↓SE Contraindication: – Encephalopathy in 7 days of DTaP Immunizations MMR - Measles, Mumps and Rubella (IM) Measles • Viral illness - macular/papular rash • Kopliks spots oral mucosa • Encephalitis/pneumonia Mumps • Inflammation salivary glands/parotid • Boys develop orichitis/sterility Rubella • Viral illness- rash (face → body → extremities) Pregnancy exposure: – Fetal deafness, cataracts, cardiac defects, encephalitis Immunizations • MMR is live attenuated (weakened) vaccine • 12-15 months and 4 - 6years • Contraindication: Pregnancy Immunocompromised Allergy to neomycin Immunizations Varicella (SC) • Varicella “chickenpox” • Live attenuated virus healthy children only • 12-18 months • 2nd dose @ 4-6 years • 2005 - All kids entering 6th grade – ↑Risk > 13 years • Give with MMR – MMRV new vaccine Contraindication – Pregnancy – Immunocompromised or – Allergy to neomycin Immunizations MCV4 - Meningococcal Conjugate Vaccine 4 (IM) MPSV4 - Meningococcal Polysacharide (SC) • Protects against N.meningitids (not all strains!) • MCV4/ Menactra: – One dose 11-12 years or @ high school entry or college freshman in dormitories – (↑risk smoking and crowds) • MPSV4/Menomune: Children> 2- 10 years ↑risk factors Sickle cell disease. Immunizations TIV -Trivalent Inactivated Vaccine – Influenza (IM) • Influenza virus → pneumonia and death – 2004 -152 pediatric deaths – ↑↑ # of cases in February • • • • 6 mos - 5 years of age annually > 5 years only high risk population. 0.25ml<3 years or 0.5ml>3 years Contraindication – Egg Allergy – √ Eat baked goods can have vaccine LAIV - Live Attentuated Influenza Vaccine > 5 years (2 doses 1st time) New Vaccines Added Rotavirus vaccine Rototeq • Rotavirus is primary cause of acute gastroenteritis in US – – – – Three oral doses given at 2, 4 and 6 months Dosing must be complete by 8 months of age No catch-up for older infants Do not re-administer if infant spits up New Vaccines Added Human Papillomavirus (HPV) • Non-enveloped dbl stranded DNA virus • >100 types with 15-20 oncogenic types • 75% of sexually experienced men and women age 15-49 years have had some type of HPV Quadrivalent HPV vaccine (Gardasil) • Protects against HPV 6,11, 16 & 18 • Type 16 and 18 account for approx 70% of cervical cancers • ACIP recommended 6/29/06 • Routine vaccination of girls 11-12 years but may begin @ 9 • Catch-up vaccination for adolescents and young women who have not been previously vaccinated • Not indicated in pregnancy or hypersensitivity to substances New Vaccines Added HPV administration (3 separate doses 0.5ml IM ) • 1st dose on elective date • 2nd 2 months from first • 3rd 6 months after first dose SE: Very painful Syncope & tonic –clonic movements √ Pt remains seated or lies down x 15 minutes Compliancy Issues: – Moral issues can intervene – Study with boys shows = a good immune response – ↑ Vaccinate girls RT ↑↑ risk of Cervical CA Only true contraindications to vaccine administration • Fever >102 • Immunocompromised: (No MMR & Varicella) – HIV, Leukemia, Lymphoma – Alkylating agents or Antimetabolites – Daily Corticosteroids Dose: > 2 mg/kg or 20 mg/day • Allergy to vaccine component • Vaccine Adverse Event Reporting System • (VAERS) Congenital defects Cleft palate • 1/750 births cleft lip • 1/2500 births cleft palate • Incomplete closure of the roof of the mouth – 6th -10th week of gestation • Opening from uvula→ soft palate → hard palate → lip • Cleft palate 1st sign – Formula coming out of nose • • Gloved finger to assess soft and hard palate in newborn Etiology Multifactorial – Genetic-familial tendency • ↑ in Asians and lowest in African Americans – ↑ Caffeine – ↑ ETOH – Dilantin or Valium – ↓Folic Acid ↓ Vit A Sequella – Feeding difficulties – Speech difficulties – High risk for Otitis Media Serous and Bacterial Interventions • Review defect – Impact on infant – Before and after photos – Support Groups • 3P Feeding technique – Position - upright – Pore - soft, premie nipples • enlarged opening – Patience - burp frequently Surgery • Lip repair usually 1-3 months – Protect incision line after operation • • • • Palate repair @ 18 months Supine with ↑ HOB Elbow restraints √I&O Tracheoesophageal (TEF) Fistula • Fistula – – – – Opening between trachea and esophagus Fluids enter lungs ↑ Aspiration PN Large amounts of air into stomach Esophageal Atresia EA • Esophagus ends in a blind pouch • ↑ in Pre-term and/or Polyhydramnois 30-50% multiple anomalies TEF/ EA Clinical Signs • Increased salivation • Drooling • “3 C’s” – Choking – Coughing – Cyanotic episodes • Laryngospasms • Abdominal distension • Unable to pass NGT with atresia Interventions • • • • • NPO ↑ HOB>30º Maintain patent airway NGT to low intermittent suction Prophylactic antibiotics – Aspiration PN • • Surgery correction of fistula ASAP Safety in Infants Accidents leading cause of death btwn 6-12 mos Suffocation/Aspiration # 1 cause of fatal injuries <1 year √ toys, mobiles No H2O mattress or pillows Falls Walkers 45% Burns H2O temp @ 160 scalds skin in 10 seconds ↓ Temp to 120 Poisonings Plants, Cleaners, Grandma’s purse √ meds Cars Car seat < 1 year back seat, facing rear Nutrition Vitamins for Infants • Fluoride – 0.25mg/day > 6 months - 3 years – Poly-vi-flor 1cc QD – >3 years ↑ 0.50mg/day • FeSO4 – 0.5mg/kg/day > 6 months – if BF mother not taking supplements – after 6 months fetal stores are depleted) Vit D 400 IU/day if BF mother not taking supplements Breast Milk • Contains all nutrients and – A,B, E – Immunoglobulin IgA, T and B cells • Lacks Vit C, D and Fe • Twice sugar (lactose)= laxative effect – ↑ # of stools • ↑↑ lactalbumun more complete protein • ↓↓ caesin easier to digest Formula • No more than 32 oz/day • No whole milk in infants! – No iron in milk – Infants unable to properly digest – ↑ ↑ irritation of intestinal mucosa, bleeding and anemia Solids • Begin at 4-6 months • Too early introduction of solids – ↑ incidence of allergies and celiac disease. – No cereal in formula bottle! • Assess physiological readiness – ↓ Tongue extrusion reflex – ↑ Coordinated suck & swallow – Tooth eruption – ↑ biting & chewing – ↑ Pancreatic enzymes for complex nutrients • Introduce foods one at time – New food after 3 days: – Cereal → vegetables → fruits →meats → egg yolks No egg whites <1 year No honey/corn syrup <2 years ↑ Risk of botulism No Nuts, Seeds or Popcorn Kwashikor • Severe protein deficiency • Adequate caloric intake and ↑ ↑ carb diet • Mycotoxin mold found in intestines Signs and Symptoms • Scaly, dry skin and ↓ pigmentation • Hair thin/dry and coarse • Ascites – Edema RT ↓ protein • Muscle atrophy • Irritable, lethargic, withdrawn • Permanent Blindness Diarrhea→Infection →Death Nursing Interventions • Assess degree of malnutrition • Neurological/muscular impairments • • • • • – √ Developmental milestones Hyperalimentation ↑ Protein diet Antibiotics Skin Care Collaborate with OT and PT Skin Disorders Eczema (5-7% Infants) • RT allergies (egg, soy and cow’s milk) – ↑ Ig E levels RT ↑ Histamine, Prostaglandins, Cytokines • ↑ with stress • 90% develop asthma Signs and Symptoms • ↑ in winter • Skin Rash – Erythematous, edematous, – Pruritic, dry and cracked – ↑ Lesions in skin creases, Cheeks, forehead & scalp • ↑ Risk of secondary infections Treatment • Hydrate • • • • – Brief bath with Dove soap – Lubricants –Eucerin cream Topical steroids Antibiotics if secondary infections Elidel and Protopic 0.03% non-steroidal Pimercrolimus and Tacrolimus – Only for children > 2 years – Black box warning – ?↑ risk of cancer Impetigo • Toddlers and Preschoolers • ↑ incidence in Summer (hot/humid) • 1st Skin is broken via bug bite • • • • – infected - staph A or B strep Very contagious 1st Macular & Pruritic 2nd Honey crusted, thick & bleed Therapy – Wash lesion c warm soapy H2O – Soak and remove crusts – Bactraban BID 7 days PO Antibiotics PCN, EES, Lorabid, Zithromax Sebborrheic Dermatitis Cradle Cap • Chronic inflammatory condition • Dysfunction of sebaceous glands • Infants produce a lot of sebum • Yellow scales from eyelids → Scalp • Therapy – Apply lotion, massage scalp Fine comb remove scales Toddler 12-36 months • • • • • • Growth slows – Physiological anorexia Average weight gain 4-6 lbs/year BW quadrupled by 2 ½ years Height 3 inches/year HC growth slows A/P diameter 1:2 • Visual acuity 20/40 – Eyes can accommodate objects @ distance ↑ Neuromuscular control Manipulates objects & people Psychosocial Development Autonomy vs. Shame and Doubt • “Me do” stage • Intense exploration of environment • Fighting for autonomy • Negativism “No” • Ritualistic behavior to control their environment • Body Image develops Psychosocial • 2nd Separation Anxiety – Cling and cry when left by parent – Be honest regarding separation do not disappear!! • Body image develops – knows certain body parts: eye, “pee pee” • Begins to acquire socially accepted behaviors Toilet training • Holding on and letting go is very important! • Need to recognize the urge to “let go” 1st Bowel control after 18 months 2nd Bladder control @ 2½ - 3½ years • • • • • Daytime bladder control before nighttime Regular BM and patterns or child will alert you Needs ↑ awareness and self discipline Harder to train children with history of constipation Temper tantrums • Common response to helplessness or frustration • Inadequate verbal skills – Can’t communicate needs! – Strike out physically Monitor for speech delay children! Interventions • Set appropriate, clear and consistent limits • Safely isolate and ignore behavior – Remove from situation • Redirect or introduce another activity to restore self-esteem • Time out = minute per age • Do not let toddler get too tired, hungry or stimulated • After tantrum subsides provide love and attention Developmental skills • 300 words by 2 years. – Understand more than they say – 2 yr old 65% of speech should be comprehendible • Knows first and last name • Dressing - takes off own clothes • Walk, run, and jump with both feet • Ride tricycle, build tower of blocks • Parallel play – Possession = ownership • Ritualism Comforting & ↓ Anxiety Intellectual development 5th Stage of Sensorimotor @12-18 months • Object permanence – Exists when not visible “Where’d it go?” – “Peek a Boo” • Active experimentation • Time perception – Holidays, morning, noon, night – 1 minute = 1 hour • Space perception – Nesting – Stands on stool to get object Magical thinking Pre-operational Stage Transitional Stage 18 - 24 mos • ↓ Trial and error – Memory and imitates actions. – sweeping floor with broom is mom cleaning • ↑ Problem solving • Egocentric- “I” “me” “mine” • Concrete thinking – Literal translation – “A little stick” for IV = tree branch • Sense of Time – Orientation RT activities – Mom will be back after nap instead of at 2 o’clock. Toddler Developmental Tasks • Differentiate self from others • Toleration of separation of parents • Slight delayed gratification • Basic toilet training • Socially acceptable behavior – Biting and spitting bad! • Communicates effectively Transitional objects Favorite toy, blanket ↓ stress Nutrition • ↓ Growth period = ↓ protein and fluids • Physiological Anorexia @ 18 mos – ↓ nutritional need = ↓ ↓appetite • Daily diet – Milk 2-3 cups/day – ↑ FE, CA, PO4 • Very fussy and food jags (1-2 items only!) – Only peanut butter and bananas! • Want to feed themselves = MESSY! • May eat a lot one day • and not much following day Nutrition • Offer small, frequent nutritious snacks – Toddlers love to graze • Not too much milk or juice (↑ sugar) – Fills them up = won’t eat • Do not force child to eat. – Will eat when hungry. – If child is not losing weight it is ok. Dentition • Twenty primary teeth by 30 months • Brush teeth 2 x/day! • No bottles of juice or milk at bedtime. • Dental carries can occur. Safety • Toddlers have no sense of danger • ↑↑ Locomotion = DANGER!! • Injuries cause > death in ages 1-4 Motor Vehicle Crash (MVC) = #1! • ↑ Caused by lack or improper restraint • SUV – toddlers wander behind truck and get hit. • DWI – – 2500 kids/year 7/10 in car with impaired parent Car Seat Safety Rules • Universal Child Safety System (UCSS) – 2 point attachment with tether system – by 2002 all new cars must have entire UCSS • • • • <12 years of age = sit in back of car Infant = rear facing (1 yr and 20 lbs) Forward facing convertible seat till 40 lbs >40 lbs belt positioning booster seat New York State Seatbelt Laws • March 2005 any child <7 years of age – appropriate restraint system or booster seat 80 lbs or 4 ft 9 inches may use seatbelt Seat belt must fit properly: on hips not stomach on shoulder not neck Drowning • # 2 cause of death for toddlers – Totally Preventable! • Only need 1” of H2O to drown – – – – Bucket to clean car Ponds Pools Beach • Always supervise near water! Burns • 3rd cause of death (boys) – 2nd among girls • 20,000 injuries/year and 1,000 deaths – 16% RT child abuse Types • Thermal- flames, scalds (85%),hot objects • Electrical- socket, chewing wires • Chemical- Ingesting cleaning products • Radiation- sunburn First Degree/Superficial (epidermis) • Minor sunburn • Red, dry and painful • Heals spontaneously – 3-7 days • No therapy needed Second Degree Partial Thickness • Involves epidermis and upper layer of dermis • Moist, bulla • Skin bright red • Painful Heals in 14 - 21 days with scarring Third Degree/ Full Thickness • • • • Includes subcutaneous tissue Dry, pale or brown/black PAINLESS Eschar– thick leather like – dead skin Healing requires skin grafting »↑ painful Fourth Degree/ Full thickness • Extends all the way to bone • Dry, whitish leathery appearance • ↓Sensation to pain • Scarring and contractures Total Body Surface Area (TBSA) • Varies with age – ↓ age = ↑ TBSA – ↑ surface area = ↑ Injury “Rule of Nines” – Determines % of burns – Transfer to burn unit BSA>10% Open palm of hand = 1 % of BSA Thorax 18% Head 19% Arm 8% Leg 13% Management Respiratory • Maintain patent airway • R/O Inhalation injury – Smoke, steam, toxic fumes – Charred lips, singed nasal hairs, – soot covered nares • Humidified 100% O2 • Assess for: – Respiratory Acidosis: • ↑ RR, retractions, nasal flaring, ↑↑effort, ↓O2 Moist Breath sounds = Pulmonary edema √ Carboxyhemoglobin (CoHb) levels > 10% need hyperbaric chamber Fluid Resuscitation Hypovolemic “Burn” Shock – ↑↑ capillary permeability – Leakage of intravascular fluids – ↓↓ Perfusion, ↓↓ BP, ↑↑ HR, ↓ Output • Parkland Formula = 4mL LR x kg x %TBSA 1st 24 - 48 hours until capillary integrity is restored • IV Maintenace Fluids: 4:2:1 Rule 4mL/kg for 1st 10 kg 2mL/kg for 10-20 kg 1mL/kg >20 kg • 45 kg child: 4 x 10 = 40 mL 2 x 10 = 20 mL 1 x 25 = 25 mL 85 mL/H Maintain urine output 1-2ml/kg/hour-(foley) Strict I & O! √ SG √ Wt. √ VS and LOC Monitor Lab values Hyperglycemia • ↑ NE/E, ↑stress, insulin resistance, glycogen released Hyponatremia – 3rd spacing 1st 24 hours = ↑NA excretion Hyperkalemia • 1st 24 hours = ↑ cell release of K+ Hypokalemia • 2nd 24 -48 fluid shifts back to cell ↓ K+ Hypoalbuminia (<2) • ↓ serum proteins 3rd spacing • Albumin 1 gm/kg/day Metabolic acidosis • Renal failure, tissue damage RT sepsis ↑BUN ↑Creatine = ↑ SG • Dehydration & renal failure Pain Management • Acute – Burned skin and exposed nerves – Moaning, grimacing, restlessness, guarding, dilated pupils, clenched fists,↓↓ movement • Procedures: PAIN – Dressing changes ↑↑ anxiety & ↑↑ fear • Medicate prior to all procedures. – MSO4, Propofol, Fentanyl, Hydromorphone • Imagery, relaxation, distraction Therapeutic Touch Wound Care • Aseptic/sterile technique – ↓↓risk of infection – Invasive lines, compromised immune • Protective Isolation • Debridement – Remove dead tissue • Hydrotherapy – Soaking wounds - remove old dsg – 10 mins to prevent electrolyte and fluid loss – Washing area • Clean area & assess wound • √ color, drainage, odor, sloughing, granulation tissue Antimicrobial creams Mafenide Acetate (Sulfamylon cream) • • • • Painful but penetrates eschar Gram (+)/(-) coverage Apply & leave OTA or light dsg √ Sulfa allergies – Hypersensitivity reaction • SE: Metabolic acidosis Antimicrobial creams Silver Sufadiazine (Silvadene) • Painless • Gram (-)/(+) coverage • Not to use on face or electrical burns • 1st Clean wound • Apply & leave OTA or light dsg • √ Sulfa allergy • SE: Transient leukopenia Antimicrobial creams Silver nitrate 0.5% • Most gram (+) & some gram (-) • Painless soak – Dampen dsg q 2H or TID – Need large bulky dsgs • Stains clothing and linens -black • SE: ↓ K+ ↓ Na+ ↓Cl+ – √ lytes Skin Grafts • Autograft – Patient’s own skin – ↓ risk for Host Versus Graft (HVG) response • Transcyte – Newborn foreskin – Bioactive skin substitute – ↑ Re-epithelialization • ↓ dsg changes ↓ hospitalization • ↓scarring Nutritional Support • NPO x 24 hours – √ Bowel sounds √ Abd girth √ N & V • Curling’s Ulcer – ↓ GI perfusion ↑ occult blood via NGT & stool • 2-3 times daily calories for wound healing – ↑ BMR RT ↓ Protein & N loss • Protein 25% of calories– eggs, peanut butter and milk ↑↑ Vit A and C important for skin oranges, grapefruit strawberries, broccoli Psychological Needs • • • • ↑ Contractures & ↓ROM RT scars Pressure Ace wrap cover to ↓↓ scars Increase involvement in care Play therapy & counseling – Ease transition → community • Prepare friends and school – Wounds/scarring & emotional needs • Support groups Poisoning • 150,000 kids < 5 years old = 120 deaths/year • ↑ risk @ 2 years (improper storage) • Poison Control # = 1-800-222-1212 www.lirpdic.org Aspirin Intoxication• # 1 most ingested drug • ASA acetylsalicylic Acid • ↑ Availability in home – Combination OTC meds: – Peptol bismal, cough and cold, wart preparations Therapeutic Dose 40 -100 mg/kg Toxic dose 200mg/kg Severe toxicity 300 - 500mg/kg Signs and symptoms 6 H delay before toxicity signs noted – Hyperventilation • ↑↑ RR ↓↓CO2 – ↑ Metabolism • ↑↑BMR ↑↑ O2 use ↓↓ Glucose – Metabolic acidosis • ↑ ketones and organic acids – Bleeding • ↓↓ platelets Interventions • √ Serum salicylate levels – Therapeutic 5-20mg/dl – Toxic >25mg/dl • Gastric lavage up to 4 hours post ingestion • Activated Charcoal (1g/kg) – ↓ absorption & ↑ elimination via GI tract • Vit K for bleeding • Correct lyte imbalances– ↑↑ Ca+ ↑↑ K+ • ↑↑ Hydration – Flush kidneys • ↑↑Calories • May need hemodialysis Acetaminophen Overdose • Most common acute drug poisoning – ↑↑ Risk c combination drugs • ↑↑ Risk for liver damage – RT metabolites binding to hepatocytes • • • • ½ life = 3 hours Liver necrosis within 2-5 days if not treated Therapeutic dose = 90 mg/kg Toxic dose = 150mg/kg Clinical signs • Phase one (1st 24 hours) – N/V, anorexia and malaise • Phase two (24-36 hours) – Hepatomegaly, RUQ pain, ↑↑LFT’s – ↑INR, PT, hyperbillirubin and oliguria • Phase three (2-5 days) – Encephalopathy, cardiomyopathy, anorexia, emesis, liver failure, hypoglycemia, coagulopathy, renal failure and death Phase four (7-8 days) Recovery or fatal hepatic failure Interventions √ Serum acetaminophen levels – – – – – ↑ validity 4 hours post ingestion. Therapeutic level = 2 -20 mg Toxic level > 50 mg If extended release √ level 8 hours after ingestion. Must know actual ingestion time. √ INR (1.0 WNL) – Earliest and most sensitive for hepatotoxicity √ LFTs (AST Aspartate Transaminase) – Bilirubin, PT – Released with hepatic injury √ BMP/ Panel 7 √ Renal- BUN Interventions cont • Gastric lavage most effective with extended release • Activated charcoal most effective 1-2 hours after injestion. • N-acetylcystein-”Mucomyst”- PO – – – – – – • Loading dose = 140 mg/kg x 1 PO then 70 mg/kg x 17 doses PO q 4H. Most effective with-in 8 hours of ingestion Must be initiated with-in 16 hours. Mix with coke smells like rotten eggs Charcoal may bind with mucomyst give 1 hour apart May use IV mucomyst if pt not tolerating PO Lead poisoning Plumbism • Home built before 1960’s – ↑ Risk for lead based paint (banned in 1978) – Recent ongoing renovations • Nearby industry – Battery plants, gas stations – Leaded gasoline in soil children place hands in mouth • Old furniture, ceramic pottery and lead toys • Folk Remedies – Azarcon, Greta, Ligra & Surma (200x Pb!) • ↑Risk < 6 years Urban areas Medicaid recipients 3 x’s lead levels Lead Screening Screen at 9 months to 1 year and then 2 years Earlier/ASAP with risk factors Clinical signs • Most kids are asymptomatic! √ Level – Pb serum level > 10 is toxic – Pb > 45 = RX – Pb > 70 = Medical Emergency (RX & ICU) 90% Pb attaches to RBC – Interferes binding of iron to heme molecules – √ H and H , Fe – ↓ HgB = Anemia • Absorption of Pb > Excretion • 24 H Urine (lead) >3 mg – Damages cells of proximal tubules • Lead deposits in tissues, bones, gums and abdomen Lead lines (bones, nails) X-rays; Femur and Tib/Fib for deposits Abdominal pain (paint chips on X-Ray) Vomiting & Constipation CNS Symptoms • • • • • • Hyperactivity Aggression-irritability Impulsiveness Learning disabilities Developmental delays Lead Encephalopathy = Irreversible! – – – – ↑ ICP Seizures Cortical atrophy- • Permanent brain damage→ Mental retardation Coma and death Treatment Chelation Therapy for level >45mg/dl Binds Pb to H20 water soluble form → excretion via urine • Must use two meds if levels >70mg/dl 1. CaNa EDTA (calcium disodium edetate) IM/IV (20 doses) • √ adequate kidney function • Painful injections – Apply EMLA 2 H before and inject with procaine. 2. • • • • • BAL (dimercaprol) IM (24 doses) √ renal function Contraindicated with peanut allergy or G6PD Usually not single therapy use in conjunction with EDTA 3.Succimer (Chemet or DMSA) PO (43 doses) Alternate treatment for EDTA 19 day therapy Hydrocarbons • Gasoline and kerosene • • • • • • – ↑Risk for aspiration/pulmonary toxicity Turpentine = systemic toxicity Antifreeze Carbon Tetrachloride Baby Oil Camphor (Moth Balls) Inhaled or ingested Signs and symptoms • Gagging, Choking, Cyanosis • N & V • ↑↑ RR Retractions Dyspnea Grunting • Aspiration PN in RUL • Seizures • Renal failure • Coma Therapy • • • • • No emesis RT ↑Risk of aspiration Gastric lavage Humidified ↑ O2 + PEEP Hydration Antibiotics – Prophylactic for PN Lye, Corrosives • Strong alkali with ↑↑ PH – – – – Dishwasher detergent (Electrosol tablets) Batteries Denture cleaners Oven/ Drain cleaners • Erodes esophagus can cause perforation Signs and symptoms • Severe Burning Pain – Mouth, throat and stomach • White swollen mucous membranes: – lips, tongue, pharynx • Inspiratory stridor & Dyspnea RT – Esophageal and tracheal edema • Drooling • Violent vomiting - blood & tissue ↑↑ Anxiety Treatment • • • • Don’t induce Vomiting! Maintain patent airway Administer analgesics NPO or Dilute corrosive with 120 ml H2O only! • Steroids Methylprednisolone 2mg/kg/day • Humidified O2 • Surgery – Batteries can cause esophageal and gastric burns – Esophageal strictures