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Experiences in the Use of Non-Traditional Data Sources in a Rural State – South Carolina Dan Drociuk, MT(ASCP), MSPH – Director Epidemiological Response / Enhanced Surveillance Section Division of Acute Disease Epidemiology South Carolina Department of Health and Environmental Control Outline Part I: • The “People” How we are organized to develop, implement, monitor and respond to EED system needs. Part II: • The “Push” How we disseminate information about EED systems and general epidemiological activities. Part III: • The “Products” Case studies showing the interaction and intersection of EED systems currently in use in South Carolina. Part I: The “People” A bit about South Carolina… Approximate population: 4,350,500 (sans golf courses and beaches…) • Three MSA’s in the “Top 100”: Columbia, Charleston, Rock Hill/Charlotte • Tourism a main industry along the costal areas Centralized health department structure • All public health employees are state employees regardless of location • No local boards of health Current Systems in Use Palmetto Poison Center (electronic daily feeds to public health), National Retail Data Monitoring (NRDM) for OTC sales (using “home-grown” C1, C2, C3 indicators), BioSense for DoD and VA ambulatory care procedures and ambulatory care diagnosis, Essence data monitored and “crossed” with Biosense alerts and indicators. Sentinel providers with Influenza-like Illness reporting (number/wk). Two (2) pilot hospitals providing chief-complaint data in “home-grown” categories. DIVISION OF ACUTE DISEASE EPIDEMIOLOGY Dixie F. Roberts, MPH, BSN, RN Division Director Tuesday, July 5, 2005 Information Technolocy Section Jason Collins Section Director Reportable Disease Surveillance Section Libby Greene Section Director Acute Disease Response/ Enchanced Surveillance Section Dan Drociuk Section Director DADE Program Areas Dixie Roberts Administrative Support Team Section Gloria McCurry Administrative Coordinator Program Area Staff: -Dr. Tom Fabian, BT/ HRSA Medical Director IT Staff: Mark Rahn Vacant Vacant HAN, etc: Jamey Rudisell Shana LeGrand Surveillance Staff: Claire Youngblood Ted LeBlanc Suzy Wesley All DADE staff & teams accountable to Section Director for assigned routine Surveillance Activities Dr. Eric Brenner, Medical Epidemiologist Response Staff: Julie Schlegel, Foodborne Epi Coordinator Michelle Myer, BT Epi and Response *Amy Belflower, QA Coordinator Marya Barker Dr. Lena Bretous, Medical Epidemiologist Dr. Shirley Jankelevich, Medical Epidemiologist Dr. Mary Anne Wenck EIS Officer Dr. Marcia Headrick, Public Health Veterinarian Vacant, Careful Antibiotic Use Nurse Educator Administrative Support Team: Rosa Wesley Phillipine Outing Suzy Wesley DIVISION OF ACUTE DISEASE EPIDEMIOLOGY Dixie F. Roberts, MPH, BSN, RN Division Director Tuesday, July 5, 2005 Information Technolocy Section Jason Collins Section Director Reportable Disease Surveillance Section Libby Greene Section Director Acute Disease Response/ Enchanced Surveillance Section Dan Drociuk Section Director DADE Program Areas Dixie Roberts Administrative Support Team Section Gloria McCurry Functions Functions Acute Response: · Liasion with Regional Health Departments regarding epidemiological capacity/response. Functions Carolina Health Electronic Surveillance System: (CHESS) Develop/ operate/ maintain NEDSS based electronic surveillance system (CHESS) Functions · Reportable Disease Case & Outbreak Investigations/ Coordination CHESS: Surveillance Data Entry and Notifications, Data Reports, & Dissemination · Policies & Procedures · CHESS Data Collection Coordinate with Surveillance Section on CHESS implementation. · Coordinate Data Analysis & Interpretation -Develop/ operate/ maintain CHESSImmunization Registry Coordinate with Immunization Division on CHESS-IR · Policies/Procedures -Health Alert Network Develop and maintain capacity for rapid Public Health Emergency notification system PHIN Standards: monitor quality assurance and PHIN compliance measures Coordinate with Bureau of Information Systems and Health Services Information Systems to assure compliance with Agency standards. · Data Quality Assurance · Responsible for: · List of Reportable Conditions · School and Childcare Exclusion List · Annual Report · Epi Notes · Request for Data · Web site · CHESS Training · Epi Records/Documentation · Public Health Preparedness Incident Command System · DADE SOP & Implementation · Bureau of Disease Control SOP & implementation · HAN notification coordination · On-Call System: Routine Work Day & 24/7 · Answering Service · Epidemiological Response Quality Assurance Enhanced Surveillance: · Palmetto Poison Center data analysis · Early Aberration Reporting System · Syndromic Surveillance pilot projects · Hospital Discharge data analysis Functions Accountable for program outcomes/ performance measures, grant and program budget writing, and integration of activities into the Surveillance and Response processes in the Division. Program Area assignments are not intended to restrict involvement across the DADE Sections (functional units). BT-CDC – Dan Drociuk NEDSS-IT (Vacant) Surveillance Sections – Libby Greene HAN-IT – Jamey Rudisell Agroterrorism & Zoonotic Disease Dr. Marcia Headrick BT-HRSA Dr. Tom Fabian ELC Antibiotic Resistance – Vacant (Dixie Roberts) Hepatitis – Libby Greene Influenza – Dr. Lena Bretous WNV &Vector Borne Disease Dr. Lena Bretous NEDSS-IT (Vacant) & Surveillance Sections – Libby Greene Foodborne Disease – Julie Schlegel Vaccine Preventable Diseases Dr. Shirley Jankelevich Childcare and School Health Michellle Myer Coordinator: · Admin. Supervision · Procurement · Personnel Items · Inventory · Network/Telephone/Space Coordination · Epi Notes · On Call Schedule Admin. Team: · Telephone Coverage · Mail · Travel Arrangements & Reimbursements · Minutes · DHEC Forms · Meeting/Conference/Training Preparation · Data Surveillance Activities · Data Entry · Copier Maintenance & Paper · Fax Machine Maintenance & Paper · Network Printer Maintenance · TRAMS · DHEC 1129 Cards/Case Report Letters · Mailouts · Scheduling of Conference Rooms · Epi Team Database’s Regional Epi Teams Services are delivered and surveillance happens at the local/community level Surveillance, case and outbreak investigation & response starts with the Regional Epi Team • 6-20 members • Mix of skills: nurses, Env. Health, PIO • Established 1995 to provide trained integrated teambased response to routine surveillance, case investigations, and outbreak investigations Available for Urgent Reports 24/7 via on-call rotation. Epidemiological Responses to Events of Public Health Significance “White powder events” Ricin in a U.S. Postal Facility in Greenville Chlorine tanker train derailment, Graniteville, SC Numerous point-source outbreak investigations • Food-borne (Salmonella’s), • Water-borne (Legionella cluster, rash-illness), • Respiratory (Pertussis) Hurricane Katrina Evacuation Center surveillance activities, Greenville, SC Part II: The “Push” Dissemination of Epi-related information Daily • Provided to the South Carolina Intelligence Fusion Center • Reports from our Division of Acute Disease Epidemiology on-call staff for overnight calls received, • Summary information from our Early Event Detection Systems (BioSense, OTC sales, Palmetto Poison Center) • Previous day on-call events of public health significance Weekly • Provided via the Epidemiological Weekly Report (EWR) • Summary information from our Regional and Central Office Monthly • Meetings with Regional Epidemiology Response Staff As Needed • Distribution via the SC Health Alert Network • CDC and DHEC Health Alerts/Advisories/Updates Example of a Daily SCIEx report Example of a weekly EWR EWR: Epidemiological Weekly Report The EWR is compiled weekly from Regional and DADE reports. • It includes basic summary information related to an ongoing or concluding epiinvestigations. • Submissions usually include what is known or hypothesized about etiology, geographic location, and numbers of persons affected. EWR: Epidemiological Weekly Report Circulation: • The EWR is submitted to the Deputy Commissioner for Health Services, members of the Senior Leadership Team, Central and Regional Office Leadership, the Office of Public Health Preparedness, etc. Goal: • Provide situational awareness regarding Epi activities across the state. EWR: Epidemiological Weekly Report Statistics: • In 2005, EWR’s documented 288 “new investigations” of potential outbreaks or single cases of disease or events of public health significance. • In 2005 documented outbreaks totaled 62 stratified as follows (by modes of transmission): Respiratory Foodborne Unknown Person-to-person Fecal-oral Contact Nosocomial 20 16 11 7 5 2 1 (32%) (26%) (18%) (11%) ( 8%) ( 3%) ( 2%) 2004-2005 SC Foodborne Outbreak Statistics 2004 2005 13 16 % Agent Identified 92% 79% % Source Identified 46% 29% # FB Outbreaks Part III: The “Products” Case Study 1: Chlorine Release in Graniteville, South Carolina What Happened? At 2:39 AM, a 42-car Norfolk and Southern train derailed A tanker car containing chlorine was punctured, releasing approximately 60 tons of chlorine The chlorine was released in the immediate vicinity of Avondale Mills, the commercial district, and residential areas of Graniteville SC Objectives of a Rapid Epidemiological Assessement Assess • • • • • • Extent of exposure Morbidity Health services used Identify persons at risk for long-term sequelae Risk factors for severe outcomes Location of exposure Case Definition Person treated for symptoms or complications from chlorine exposure Identified by • Hospital emergency department logs • Physician reporting Emergency Department Visits within 24 Hours Facility ED Visits, N=272 (%) Aiken Regional Medical Center 108 (39.7) Other SC hospitals 10 (3.7) Augusta, GA hospitals 154 (56.6) Signs or Symptoms Reported Symptom (N=290) Coughing Eye burning Shortness of breath Headache Chest pain Nausea Nose burning "Cough up phlegm" Choking Dizziness Vomiting % Reporting 82 77 74 63 59 53 51 50 46 42 34 Deaths, Hospitalizations, and Emergency Department Visits Following Train Derailment, Graniteville, SC - 2005 280 260 ED Visit, Not Admitted Admitted to Hospital Deceased, at Site of Accident 100 Number 80 of Events 60 40 20 0 1 3 5 7 9 11 13 15 17 Day(s) Since Accident 19 21 23 25 Hospitals that Treated Patients for Chlorine Exposure – January 6-7, 2005 40 Barnwell Edgefield Lexington St. Josephs Doctors MCG University Aiken 35 30 25 Number 20 of Patients 15 10 5 0 Time Situational Awareness Issues Healthcare providers are going to treat people first, and worry about the “coding” later • Review of charts showed a broad span of chief complaints (n=81), primary diagnosis (n=48) and ICD-9 codes (n=51) used. Data used for situational awareness, many are going to be relying upon the data to make decisions. This is a “paradigm shift” beyond being simple early event detection system. Opportunities Use of Early Event Detection systems for monitoring an emerging event must be flexible and sensitive to be able to answer the questions being asked, an EED must have the flexibility to allow local users to create ad hoc syndrome categories. The wealth of information present via an electronic medical record only tells part of the story. The ability to identify the needs of the people impacted greatly contributes to the overall situational awareness of an emerging event. Next Steps Within the 3-digit ZIP code area (ZIP3) 298 that surrounds Graniteville, BioSense identified a data anomaly based on the graphical visualization in the Respiratory syndrome category that corresponded to day 2 of the exposure. However this anomaly was only apparent for 1 day (1/7/05) and the source of this anomaly has not been validated to determine both the source of this anomaly and its relationship to chlorine toxicity. Case Study 2: Use of Poison Control Center data Palmetto Poison Center 1-800-222-1222 Located in Columbia, SC Serves the entire state of South Carolina Staff consists of pharmacists and nurses Medical Director is trained in toxicology and emergency medicine Palmetto Poison Center Services Provided • 24 hours/7 days a week • Phone service to provide poison treatment information For the public and health care professionals • Information requests Medications Pesticides Plants Food poisoning Chemicals Statistics South Carolina • 2005: Over 37,000 calls to the Center 74% of total calls involved human poison exposures 30% involved adults over 21yo 80% managed by Poison Center without further medical evaluation needed Documentation Every incoming call documented • Follow up calls included Record includes name, phone number and zip code of caller Patient data: • • • • • • • Age, gender weight Exposure substance, route and amount Reason for exposure Time of exposure Symptoms Treatment provided Outcome State Surveillance - DHEC Notification Require notification of Public Health for: • Potential food poisoning/food tampering cases • Occupational pesticide exposures • Questionable exposure to current public health concerns, i.e. anthrax (‘suspicious powder calls’), West Nile Virus, chlorine toxicity • Animal bites State Surveillance - DHEC Notification Currently faxing cases and providing downloads of toxidromes every 24hrs into Toxitrak • Case information from Poison Center is included in the upload • Reports can be generated Ex. How many cases had vomiting, diarrhea, fever in Clarendon county in the last 4 weeks; number of suspected food poisoning cases from restaurants per county, city or zip code The “Epi” of Poisonings in SC Who? • 62% of calls involve children <5 Where and When? 92% of all accidental exposures occur in the home 0.8% at school Early evening at meal time most likely, followed by late morning. The “Epi” of Poisonings in SC What? 38.8% 9.0% 9.1% 9.1% 8.5% 4.5% Prescription and OTC medications, e.g. analgesics, cough/cold Household cleaning substances Cosmetics and personal care products Plants Insecticides, herbicides, rodenticides Bites/envenomations Case Study 3: Parris Island, South Carolina – “Respiratory” Sentinel Alerts Disease Surveillance at Marine Corps Recruit Depot (MCRD), Parris Island Marine Corps Recruit Depot, Parris Island Marine Corps Air Station, Beaufort SC Naval Hospital, Beaufort SC Personnel Assigned to NHB 728 Officers - 113 Enlisted - 330 Civilian - 263 MC - 30 NC - 45 Recruit Training Regiment Within 1st, 2nd, and 3rd Battalions, there are four companies. Each company contains an average of six platoons with 60 to 80 recruits in each. 360 – 480 per company. 1440 – 1920 per Battalion. Within 4th Battalion (350-400), there are three companies, N, O, and P. Each company contains an average of two platoons with 50 to 60 recruits in each. Fourth Battalion trains only female recruits. Beaufort Naval Hospital Provides general medical services to all Active Duty Navy and Marine Corps Personnel, as well as Retired military personnel and all military dependents residing in the Beaufort area, a total population of approximately 30,000 beneficiaries. Officers – 28 Enlisted – 158 Civilians – 22 Total 208 Hospital Director Clinical Support Services Branch Health Clinic, MCAS Branch Health Clinic, MCRD Parris Island 1st BAS Director Clinical Support Services 2nd BAS 3rd BAS Preventive Medicine 4th BAS Methods of Disease Detection Traditional reportable disease surveillance • State processes. • Navy Disease Reporting System (NDRS) Sentinel Surveillance • Naval Health Research Center’s FRI surveillance at recruit training centers Astute clinicians Syndromic surveillance • ESSENCE IV 14 admissions to BMH in September and October 2005 2 from 1st Battalion • Charlie company – 2 7 from 2nd Battalion • Foxtrot company - 3 • Gulf company – 4 5 from 3rd Battalion • Lima company - 2 • Kilo company – 3 Recruit Admission to Beaufort Naval Hospital and Beaufort Memorial Hospital for Pneumonia 2005 30 25 Beaufort Naval (BNH) 20 15 Beaufort Memorial (BMH) 10 5 Ja nu Fe a ry br ua ry M ar ch Ap ril M ay Ju ne Ju A u ly Se gu pt st em b O er ct ob er 0 Patients are admitted to BMH when a chest tube is needed MCRD Parris Island, Data from ESSENCE 500 450 400 Visits/Week for Respirtatory Complaints Medical Visits/Week for Pneumonia NOS # of Patients with Pneumonia NOS Positive GABS throat cultures/wk 300 250 200 150 100 50 10/2/2005 9/18/2005 9/4/2005 8/21/2005 8/7/2005 7/24/2005 0 7/10/2005 Patients 350 10/2/2005 9/25/2005 9/18/2005 9/11/2005 9/4/2005 8/28/2005 8/21/2005 8/14/2005 8/7/2005 7/31/2005 7/24/2005 7/17/2005 7/10/2005 Weekly Penumonia visits: MCRD Parris Island. Data From ESSENCE 300 250 200 150 100 50 0 10/9/2005 9/25/2005 9/11/2005 8/28/2005 8/14/2005 7/31/2005 7/17/2005 7/3/2005 6/19/2005 6/5/2005 5/22/2005 5/8/2005 4/24/2005 4/10/2005 MCRD Pneumonia visits (all types) weekly incidence for every 100 Recruits 3 2.5 2 1.5 Series1 1 0.5 0 -0.2 12/2/2005 11/2/2005 10/2/2005 9/2/2005 8/2/2005 7/2/2005 6/2/2005 5/2/2005 4/2/2005 3/2/2005 2/2/2005 1/2/2005 Weekly incidence of positive GABS cultures MCRD PI 1.2 1 0.8 0.6 GABS + 0.4 0.2 0 Why the rise? Why the rise? We considered: Crowed Living Conditions. Poor hygiene? • Always a struggle, but the Marine leadership is more cooperative than ever in this area. • Random interviews of recruits in the clinic indicate that they have been properly instructed re: hand hygiene. Recruits presenting too late? • Interviews of the admitted recruits indicate that they were encouraged vs. discouraged to seek medical care early. Why the rise? We considered Something in the buildings? • Mold and moisture is a problem in some buildings aboard MCRD PI. Toxic mold was discovered in one building where all recruits are massed together for training. Slow recognition of cases by providers? • Some recruits admitted to BMH have been ill with respiratory symptoms for 3-4 weeks prior to admission, and they had been seen in “medical” two or more times prior to admission. Too high a turnover in medical staff to ensure effective leadership and staff competency? • 3 SMOs in last 4 months • Nearly 100% turnover of BAS staff in Sept-Oct. Lab Results Nine of the 17 admission to BMH have grown GABS from pleural fluid, including 5 out of last 6 admitted in October. Nothing atypical about resistance patterns Actions Taken Chemo prophylaxis with Bicillin provided to all recruits in high incident Companies, to their DI’s and to their medical staff (BAS). Presented data to MCRD Providers 12/26/2005 10/26/2005 8/26/2005 6/26/2005 4/26/2005 2/26/2005 12/26/2004 10/26/2004 8/26/2004 6/26/2004 4/26/2004 2/26/2004 12/26/2003 10/26/2003 1/16/2006 11/16/2005 9/16/2005 7/16/2005 5/16/2005 3/16/2005 1/16/2005 11/16/2004 9/16/2004 7/16/2004 5/16/2004 3/16/2004 1/16/2004 11/16/2003 9/16/2003 7/16/2003 5/16/2003 3/16/2003 1/16/2003 11/16/2002 Pneumonia Visits 7-day Moving Avg. 60 50 40 30 Series1 20 10 0 MCRD Recruit Population 8000 7000 6000 5000 4000 3000 2000 1000 0 Series1 Early Event Detection: Over-the-Counter Drug Sales In South Carolina as of February 2006: • 536 distinct sources are represented in the data Which is approx 2.6% of the National data sources Possible Uses for OTC Sales Data: • If OTC sales data indicate an increase in use of antidiarrheals, this could point to a foodborne outbreak. • An increase in the use of cold/flu remedies might give information on severity of the influenza season or an acute respiratory event (i.e. release of chlorine). Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 18-Dec-05 29657 Pickens Pickens 1 4.49 2 Sunday 29696 West Union Oconee 1 4.62 6 Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/D ay County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 18-Dec05 Pickens 12 1 8% 7 2 29% Sunday Oconee 5 1 20% 6 6 100% Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 19-Dec-05 n/a n/a n/a n/a n/a n/a Monday Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 19-Dec05 n/a n/a n/a n/a n/a n/a n/a Monday Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 20-Dec-05 29601 Greenville Greenville 2 24.75 3 Tuesday 29356 Landrum Spartanburg 2 3.01 6 29654 Honea Path Anderson 2 3.01 4 29669 Pelzer Anderson 2 3.21 7 Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 20-Dec05 Greenville 69 2 3% 88 3 3% Tuesday Spartanburg 30 2 7% 37 6 16% Anderson 21 4 19% 35 11 31% Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 21-Dec-05 n/a n/a n/a n/a n/a n/a Wednesday Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 21-Dec-05 n/a n/a n/a n/a n/a n/a n/a Wednesday Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 22-Dec-05 29669 Pelzer Anderson 2 3.14 7 Thursday Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 22-Dec05 Anderso n 21 2 10% 28 7 25% Thursday Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 23-Dec-05 29601 Greenville Greenville 2 19.92 4 Friday 29611 Greenville Greenville 6 3.65 8 29690 Traveler's Rest Greenville 2 4.27 10 Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 23-Dec05 Greenville 69 8 12% 105 22 21% Friday Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 24-Dec-05 29605 Greenville Greenville 6 3.02 16 Saturday 29680 Simpsonville Greenville 4 4.39 16 29303 Spartanburg Spartanburg 4 3.22 6 Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 24-Dec05 Greenville 69 10 14% 138 32 23% Saturday Spartanburg 30 4 13% 52 6 12% Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 25-Dec-05 29611 Greenville Greenville 6 3.33 5 Sunday Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 25-Dec05 Greenville 69 6 9% 63 5 8% Sunday Date/Day Zip Code City County Number of Stores (zip) Standard Deviation Raw Count 26-Dec-05 n/a n/a n/a n/a n/a n/a Monday Stores (by zip code) % of stores represented Count (by zip code) % of count represented Date/ Day County Stores (county) w/ > 3 SD indicator by zip code w/ aberration Count (county) w/ > 3 SD indicator by zip code w/ aberration 26-Dec05 n/a n/a n/a n/a n/a n/a n/a Monday Next Steps Currently engaged in retrospective studies for all documented outbreaks from 2005, by mode of transmission, to determine if an temporal association can be made and at what level. Bottom-line “Syndromic surveillance is another “arrow in our quiver” of ways to detect and respond to both our routine outbreaks of public health significance and also those large-scale events that will require exceedingly complex reporting and situational awareness requirements”. Acknowledgements SC DHEC Amy Belflower Claire Youngblood Marya Barker Amy Roach Michelle Myer Mary Anne Wenck, EIS Officer Marine Corps Recruit Depot (MCRD), Parris Island • LT Allen D. Wright, Preventive Medicine Department, Naval Hospital Beaufort CDC Palmetto Poison Center Jill Michaels, PharmD William Richardson, MD Leslie Z Sokolow Roseanne English Haobo Ma Questions?