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Chemical Dependency Dual Diagnosis Presence of substance abuse or dependency AND a Mental Health Diagnosis (Axis I or Axis II) 50% of clients with severe mental illness also have substance abuse problems Increases revolving door syndrome – – – – – Crisis Admission Stabilization Discharge Substance abuse Poor prognosis Alcoholism Along with heart disease and cancer Ranks as one of the leading causes of death and disability in the United States Premature death – Homicides – 47% alcohol related Drownings – 25% alcohol related Accidental Death – 50% alcohol related Suicides – 2 to 4 times higher 34% alcohol related Falls – 28% alcohol related Theories for Substance Dependence Psychodynamic – – – Easily succumb to the escape More phobic Stereotypical characteristic (the Biological Theory – result of alcoholism or the cause?) Feelings of Inferiority Dependency, low selfesteem, introversion Genetic Predisposition – Children of alcoholics are at greater risk even when raised in an alcohol free environment Can take steps to minimize risk Recognize family predisposition Avoid the use of alcohol and drugs Pharmacokinetic of Alcohol Alcohol: Tolerance Disease and Respiratory Depression Hepatic Function – – Primary metabolism is in the liver Increased hepatic drugmetabolizing enzymes – – – Respiratory Depression – – Hasten alcohol metabolism Fat accumulates in the liver because it’s primary use is no longer for energy Alcohol accumulates in the liver increasing cell death Vitamins can not be activated – Tolerance to Respiratory depressing effects does not develop The more alcohol an individual drinks the more likely respiratory depression (regardless of needing more alcohol to get a buzz) Results in deaths of longterm pharmacodynamically tolerant drinkers Alcohol: a Chemical BOMB! Alcohol: – – – – Unlike other drugs does not mimic a single neurotransmitter A small fat soluble molecule Alcohol enters the cell membrane of neurons Changes the properties Receptors are located on cell membranes Cell membranes control the release of neurotransmitters Alcohol – Unlike other drugs effects all parts of the brain and all neurotransmitters Some of the Neurotransmitters effected – Glutamate – Dopamine – Excitement and stimulation GABA – Muscle relaxation, discoordination and Black outs Anxiety reduction Endorphins Kills pain and leads to endorphin”high” Alcohol: The Central Nervous System Cerebral Intoxication Depresses psychomotor activity Relieves anxiety and tension Increases ability to socialize Decreases self- imposed social barriers REBOUND: how it starts and ends – First – Second – effects wear off greater tension and anxiety rebound psychomotor activity Third – depresses psychomotor activity relieves anxiety and tension drinker consumes more alcohol to regain anxiety free state Presenting complaints Nervousness (anxiety) Depression Alcohol and Medical Problems The Liver – Decrease liver cell function Increase in ammonia – – High lab value Hepatic encephalopathy (brain damage) Increase in bilirubin Increase in female hormones Pancreatitis – Diabetes Peripheral Nervous System – Thiamine deficiency contributes to peripheral neuritis (paresthesia in distal extremities) Wernecke- Korsakaff Syndrome Cause: Malabsorption syndrome – – – Irritation of the intestinal lining Deficiency in vitamin absorption Especially B vitamins and B1 (Thiamine) Amnesia Delirium Peripheral neuropathy Must replace Thiamine – – Give parenterally at first then orally Delirium will become a permanent Dementia if Thiamine remains deficient Alcohol Withdrawal Neuro: CNS irritation, tremulousness, nervousness, unsteady gait, difficulty concentrating. Exaggerated startle reflex Alcohol Withdrawal MH: Anxiety, sleep disturbance, craving for alcohol and other drugs, hallucinations. Delirium tremens (DTs) GI: N&V diarrhea, anorexia CV: tachycardia, high BP, profuse perspiration CIWA Clinical Institute Withdrawal Assessment Some of the CIWA measurements include: Pulse and blood pressure measurements Nausea and vomiting incidences including frequency and severity Tactile disturbances which have a wide range from feeling a pins and needles sensation to itching to severe or continuous hallucinations Tremor severity, if any Visual and auditory disturbances Sweating Anxiety and agitation which may be noted from mild to serious panic attack mode Orientation or disorientation levels Each symptoms is scored and a TOTAL score can warrant prn medication Medications: Alcohol Withdrawal: Misery and Risk of Death Medications to assist with symptoms: – – – Clonidine (Catapress) Thiamine (vitamin B1) Lactulose Disulfram (Antabuse) – – Medication is used to prevent DTs and seizures: Benzodiazepines Chlordiazepoxide (Librium) Lorazepam (Ativan) Diazepam (Valuim) – Will become ill if the person drinks Sweating, flushed face, N&V, dyspnea palpitations, dizzy weakness, Naltrexone hydrochloride (ReVia) – Aversive Therapy – Decreases ammonia levels – Opioid receptor antagonist Decreases pleasurable affects Must wear a medical alert bracelet Acomprosate (Campral) Corrects the balance between neuronal inhibition and excitation altered by alcohol Does not prevent relapse Opioid: Heroine Opioids (Narcotics) Opium, Heroine Codeine hydromorphone (Dilaudid) meperidine (Demerol) methadone (Dolophine) hydrocodone (Vicodin) oxycodone (Oxycontin) Overdose: Opioids Progressive symptoms: 1. Pinpoint pupils (mitosis) 2. Stuporous and sleeps 3. Skin is wet and warm 4. Coma and respiratory depression 5. Skin becomes cold and clammy 6. Pupils dilate 7. Death Narcotic antagonist – – – – – Naloxone (Narcan) Given IV push Client responds in a few minutes May have to administer again Blocks neuroreceptors Affected by opioids Opioid Withdrawal Withdrawal can be fatal if unassisted Neuro: leg spasms (kicking the habit). Tremor, restlessness, MH: Anxiety Opioid Withdrawal GI: diarrhea and vomiting Other: yawning, rhinorrhea, sweating chills, piloerection (goose bumps), bone pain Withdrawal from Opioids Treated Symptomatically – Naltrexone hydrochloride (ReVia) Catapress (Clonidine) can be helpful Opioid receptor antagonist Decreases pleasurable affects Must wear a medical alert bracelet Inhalants Cheap and readily available – Hydrocarbon solvents – Aerosol propellants – Spray cans Chloroform, nitrous oxide Death – – Brain Damage – – – Anesthetic gasses Gasoline and glue Amount inhaled can not be controlled Asphyxiation, suffocation and choking – – – Frontal lobe Cerebellar Hippocampal Diminished problem solving Ataxia Dementia Stimulants Cocaine – Blocks dopamine re-uptake – – – – – Euphoria, alertness, Psychological dependence Increased strength Sexual stimulation Intense paranoia Hypertension Tachycardia (can cause death) Decreased inhibitions Death: metabolic and respiratory acidosis; prolonged seizures Crack – Less expensive way of using cocaine Methamphetamine Epidemic Physical addiction Names: speed, meth, crystal, crank or ice Longer high than cocaine Causes anorexia and insomnia Rebound – – – Paranoid Hallucinations Violent rages Long-term use – – Damages Dopaminergic system Use to avoid feeling bad Hallucinogens Mescaline (peyote) – Action Religious practice protected by law Taken orally – Probably the norepinephrine synapses Lasts 12 hours Psilocybin and Psilocin (mushrooms) – – – – – Lysergic Acid Diethylamide (LSD) North American Native Indian Hallucinations Hypertension Increased temperature Involuntary movements Lasts 8 hours – – – – – – – – – – – – Binds to serotonin receptors Causes a blending of senses (smelling a color or tasting a sound) Increase in blood pressure Tachycardia Trembling Dilated pupils Flashbacks Anxiety Paranoia Acute panic Psychotic Breaks Individuals have killed themselves Marijuana Delt-9- tetrahydrocannabinol (THC) Varies in strength depending on soil conditions and climate Changed to metabolites and stored in fatty tissue (remains in the body for 6 weeks) Detected in blood and urine for 3 days to 4 weeks Effects last 2 to 4 hours Effects – – – – – – Sense of well-being Alters perception Euphoria Antiemetic Impairs balance and stability Problems Amotivational Bronchitis Memory impairment May increase anxiety Effects on the Family All family members are affected Treatment for the family is important Problems: Rescuing or Enabling – – – Making excuses for the person addicted Doing things that the person should have done Lying Family and Relapse Co-dependent – – – – – Set of behaviors that maintain the addiction Does not hold the person addicted responsible for their behavior Spouse may also be a child of an alcoholic and used to a certain pattern of behavior Takes on roles out of necessity (control) Behaviors are integrated and resistive to change Difficult to alter when the individual stops using Change – – – Hold the person who was addicted responsible Re-assign roles and responsibilities within the family Sacrifice of income – Change in job to be in a drug free environment Decrease stress Maintaining an alcohol and drug free home Assessment Interview Approaches – Encourage Honesty – Matter of Fact – Addict Alcoholic Problems with drinking Difficulties with drug use Using more than intended Tools to Screen for Alcoholism – – – Non-judgmental State: Inpatient Chemical Dependency Assessments every 4 hours or more often Michigan Alcohol Screening Test (MAST) CAGE Questionnaire Form to complete which is quantified (given a score) Avoid words like: – genuine concern for the client – – BP and heart rate are important Tremors, lacrimation, rhinorhea and cravings PRN medication is given based on the score. The Nurse is very busy with assessments and administration of medications The Nurse Patient Relationship Attempts to address: Narcissistic DENIAL and Faulty Thinking (Cognitive Distortions) i.e. better than others – – Tendency to break the rules: – “I can do my job when drinking, when other people can not.” “I can stop after just one drink.” Establish trust by expressing empathy and providing a safe environment. Assist in establishing new goals and directions. Assist the client in identifying ineffective behaviors and replace with new coping skills. Confrontation of DENIAL (telling the client what is observed and how it may differ from what is said) “I can have a drink and drive because I can handle it when others can not.” The relationship with the alcohol or drug being the most important relationship Ineffective behaviors increase the chance of relapse. Milieu Management Observe and protect the environment – – – – Familiar and comfortable with structure (i.e. plan their day in order to use alcohol or drug) Confrontation of Behavior – Must remain drug-free Suicide prevention Intervening with aggression Urine drug screens Structured and predictable schedule – – Penetrate denial and defensiveness Requires Balance Sensitivity to confront while protecting the client’s self esteem Limit Setting – Manipulation and splitting can occur (remember: the relationship with the drug or alcohol is more important than other relationships) 12 Step Programs Best Known – – Alcoholics Anonymous (AA) Narcotics Anonymous (NA) Starts with: – Both Have a religious influence Admitting powerlessness over alcohol (drugs) The 12 Steps Confront Denial Narcissism Cognitive Distortions Problems with relationships Relapse Being around other users Severe Cravings Stopping attendance of AA or NA meetings – Client does not meet the GOAL of attending 90 meetings in 90 days GOAL: In 90 days the client will go to one meeting each day Not expressing feelings Going through a major emotional crisis Addiction and Health Care Professionals Most common areas of employment: – – – – Operating Room Emergency Room Intensive Care Unit Many times these are our best and brightest (cognitive distortion: I can do my job having taken this drug when others can not) How do you know? – – Client is still in pain after pain medication is given and documented Narcotic medication count errors (hospitals checks statistics on every nurse) What do you do when your colleague asks: – I have been so busy. I already wasted that medication I did not use, do you mind witnessing it for me? (remember: the relationship with the drug or alcohol is more important than other relationships) Texas Peer Assistance Program for Nurses (TPAPN): GOALS Identify nurses experiencing – – mental health or alcohol/drug problems Assist these nurses in obtaining appropriate treatment. Monitor the nurse's return to the work force. Educate employers and nursing colleagues – – that have been or are likely to be job impairing. about the negative effects of addiction/mental illness in the work place and the potential for rehabilitation and return to productive work. http://www.texasnurses.org/displaycommon.cfm?an=1&subarticlenbr=107 The End