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The Blood System Arteries Veins 1 Objectives After studying this chapter, you will be able to •Name the parts of the blood system and discuss the function of each part •Define combining forms used in building words that relate to the blood system •Identify the meaning of related abbreviations •Name the common diagnoses, clinical procedures, and laboratory tests used in treating the blood system 2 Objectives Part 2 •List and define the major pathological conditions of the blood system •Explain the meaning of surgical terms related to the blood system •Recognize common pharmacological agents used in treating the blood system 3 Blood Structure and Function •complex mixture of cells, ______, proteins and sugars •transports nutrients, _______, and hormones to all parts of the body •helps regulate _____ temperature •helps maintain stability of the body’s fluid ______ •transports ______ products away from body cells 4 Blood Composition Without blood, human life is impossible Blood Composition Fluid Portion Cellular Portion -_________ consisting of: -Blood cells consisting •water of: •proteins •____ blood cells •________ •_____ blood cells •nutrients •platelets •vitamins NOTE: If some proteins and blood cells •___________ were removed from plasma the remaining fluid would be called serum. 5 Plasma Plasma Proteins Clear liquid made up of __% water and 8% organic and inorganic biochemicals. globulin albumin Plasma Proteins fibrinogen _____________ 6 Red Blood Cells Red Blood Cells •Also known as ________cytes •Produced in the bone marrow in response to ______poietin •Mature red blood cells have no nucleus and appear biconcave •______globin is a protein in red blood cells that is essential to the transport of oxygen •Red blood cells live about ____ days 7 Red Blood Cells Part 2 Red Blood Cell Hemoglobin heme globin Red Blood Cell Count Average red blood cells in a cubic millimeter of blood Male = ___ to 6.4 Female = 4.2 to ____ 8 Leukocytes Leukocytes •Also known as ______ blood cells •Function to destroy foreign substances •Two main groups are granulocytes and agranulocytes (a= without) Granulocytes Agranulocytes _______phils Monocytes Eosinophils Lymphocytes ______phils 9 Red blood cells Platelets •Also known as ________cytes. •Live for about 10 days •Assist in blood ___________ Platelets Platelets Damaged Platelets begin to adhere to tissue edges and to each other as blood escapes. They form a soft platelet plug. Other clotting factors make this a stable plug or clot. Tissue mends and antithrombin, and other agents break down the 10 clot. Blood Types Blood Types •Four human blood types or groups exist •Individuals needing a blood transfusion must be _________typed. •Blood typing is based on the presence of antigens and antibodies. Blood Types A, B, AB, O People with type O blood can donate to all other types and are called universal ________. Individuals with type AB are called universal __________. 11 Individuals receiving incompatible blood during a Rh Factor Rh Factor transfusion will have agglutination or clumping of the blood which can be fatal. In addition to the blood type, there is a positive or negative element found in the blood. •Rh positive blood contains an antigen first identified in the ________ monkeys. •Rh negative blood does not contain the antigen. The Rh factor is very important during ________ because a mother that is Rh negative carrying a Rh positive fetus will develop _________ to fight Rh positive blood cells with future pregnancies. 12 Rh Antibodies First Pregnancy Rh negative mom with Rh positive fetus Antibodies develop Second Pregnancy Another Rh positive fetus If this mother did not receive _________ after her first delivery, this baby’s blood cells will be attacked (erythroblastosis fetalis) which could be fatal for the baby. 13 Combining Forms (agglutin) Meaning Combining Form agglutin (o) agglutinin eosino ___________ erythr (o) red hemat (o) ________ leuk (o) white phag (o) eating, devouring thromb (o) blood ______ 14 Combining Forms (APTT) Meaning Abbreviation APTT activated partial thromboplastin time baso __________ BCP biochemistry panel BMT bone _________ transplant CBC complete blood count diff differential ______ count eos eosinophils 15 Meaning Combining Forms (ESR) Abbreviation ESR erythrocyte sedimentation rate G-CSF ________cyte colony-stimulating factor GM-CSF granulocyte macrophage colonystimulating factor HCT ________crit HGB hemoglobin MCH mean corpuscular _____globin 16 Meaning Combining Forms (MCV) Abbreviation MCV mean corpuscular volume mono Mono____ PCV packed cell volume PLT ________ count PMN polymorphonuclear neutrophil PT Pro________ time PTT partial thromboplastin time 17 Combining Forms (RBC) Meaning Abbreviation RBC _____ blood cell count SR sedimentation rate seg segmented mature white blood cells WBC _____ blood cell count 18 Diagnostic, Procedural & Laboratory Terms The withdrawal of blood for examination, known as venipuncture or _____otomy, is used very frequently as a diagnostic tool. 19 Common Blood Analyses Common Blood Analyses •________blood count -common screen for basic medical checkup -measures rate at which red blood cells fall through plasma •blood indices -measures size, volume and content of red blood cells •_________cyte sedimentation rate •hematocrit •_____________ test -tests for antibodies on red blood cells -measures packed red blood cells in a sample 20 Common Blood Analyses Part 2 Common Blood Analyses •blood chemistry •blood culture -tests a blood specimen in a culture to identify the presence of _______organisms -tests plasma for various substances such as glucose and electrolytes •______ blood cell differential -tests number and types of leukocytes •prothrombin time •hemoglobin -measures level of hemoglobin in the blood -tests for ____________ defects 21 Anemia Dyscrasia is a general term for any disease of the blood with abnormal material present. •___________ •General term for a condition in which red blood cells do not transport enough oxygen to the tissues •Causes may be related to a low number of cells or due to a low amount of hemoglobin Common Types of Anemia •____-deficiency anemia •aplastic anemia •pernicious anemia •_______ cell anemia •hemolytic anemia 22 •posthemorrhagic anemia Hemophilia Disorders Related to Excessive Bleeding Hemophilia •Hereditary disorder in which there is a lack of the ________ factor VIII •Treated with medications and blood transfusions Thrombocytopenia •Bleeding disorder with a _____ of platelets •Occurs in the condition called _______ which is the presence of multiple tiny hemorrhages under the skin 23 Common Disorders Disorders Related to Substances in the Blood erythropenia pancytopenia •Low number of ____ blood cells hemochromatosis •Hereditary disorder that causes excessive ____ to build up in the blood Common Disorders •Low number of ____ blood cells poikilocytosis •Irregularly shaped ___ blood cells reticulocytosis •Abnormal number of immature red blood cells 24 Common Disorders Part 2 polycythemia hemolysis •Breakdown in red blood cell ____________ Common Disorders cont’d microcytosis macrocytosis •Abnormally _____ red blood cells •Abnormal increase in red blood cells and hemoglobin aniosocytosis •Abnormally small red blood cells •Red blood cells vary in size and shape 25 White Blood Cell Disorders White Blood Cell Disorders ____________ Granulocytosis •Neoplastic disorder in which there is an excessive increase in white blood cells •Abnormal increase of granulocytes in the bloodstream. Commonly seen during times of infection Multiple Myeloma •Malignant tumor of the bone _________ 26 Surgical Terms Common Procedures Bone Marrow Biopsy •_______ is inserted into the bone marrow cavity and bone marrow is removed for analysis Bone Marrow Transplant •Performed for serious conditions such as __________ •Donor bone marrow is inserted into the patient’s bone marrow 27 Anticoagulants Anticoagulants Prevents blood from _________ Common Anticoagulants Generic Name •________ Trade Name Coumadin® •________ Calciparine® •aspirin Bayer® 28 Coagulants Coagulants ____ in the clotting of blood Common Coagulants Generic Name Trade Name •phytonadione Mephyton® •__________ Konakion® 29 Hemostatics Hemostatics Stops blood _______ within the vessels Common Hemostatics Generic Name Trade Name •desmopressin Concentraid® •aminocaproic acid ___________® 30 Thrombolytics Thrombolytics Dissolves blood clots Common Thrombolytics Generic Name •alteplase Trade Name __________® •anistreplase Eminase® •streptokinase ___________® •urokinase Abbokinase 31