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World Science Forum Budapest 2003 Knowledge and Quality of Life Hans Wigzell President, Karolinska Institutet Quality of Life defined - at micro and individual levels - at pheno and group levels - at social levels - at national, regional, global levels challenges, gives rise to measurement communication and understanding Hans Wigzell Karolinska Institutet Knowledge in some form drives Quality of Life Evolutionary knowledge implies self-organization Managed knowledge implies power - implying opportunism, technology, innovation - implying forms and distribution of Quality of Life Hans Wigzell Karolinska Institutet Knowledge defined as “coded information in the brain” - but 100 billion neurons, synapses in the brain - and the working of the brain only partially known - and we have evolutionary learning and hidden knowledge (interaction brain and environment over time) - hence always limited knowledge - hence behaviour is always systematic and random Hans Wigzell Karolinska Institutet Knowledge in Quality of Life-Contexts: • Evolutionary knowledge (learning, tacit knowledge, experience) Very broad scope – the winner in the end? • Knowledge by intuition and power Middle range scope • Knowledge produced by scientific methods Limited scope? Hans Wigzell Karolinska Institutet Knowledge and science create value and reduce cost Uncured diseases ranked by cost to society: • Heart disease • Cancer • Alzheimer´s • Diabetes • Arthritis • Depression • Stroke • Osteoporosis The expected benefits from investment in medical science are enormous and will remain so Hans Wigzell Karolinska Institutet Quality of Life: Cancer Survival Rates - Acute Lymphatic Leukaemia 1964-66: 4% 1994-96 89% -BBreast Cancer 1964-66 65% 1994-96 84% -PProstate Cancer 1964-66 45% 1994-96 72% -TTesticle Cancer 1964-66 49% 1994-96 95% Lung Cancer 1964-66 1994-96 women men 11% 10% 8% 10% (Source: The National Board of Health and Welfare) Hans Wigzell Karolinska Institutet Knowledge allows control of one´s destiny? Hans Wigzell Karolinska Institutet ” A PREVENTATIVE LIFESTYLE IS BETTER THAN ANY CURE ” DO: Educate yourself DON'T: Smoke Eat balanced food Have sex without protection Sleep Stress Be physically active Vaccinate yourself Strengthen your social life Hans Wigzell Karolinska Institutet Knowledge about brain function Better insight into the processes of brain function New strategies for improving and restoring brain function Therapy for children with ADHD Therapy for patents with stroke Improved Quality of Life Hans Wigzell Karolinska Institutet Living in the Information Society • The knowledgeable and demanding patient • Easy access to information/knowledge • Rapidly information turnover/transfer • Patient wants involvement in treatment • Interest in self care/home care Hans Wigzell Karolinska Institutet Accessibility to useful information is a bottleneck Hans Wigzell Karolinska Institutet Artificial self-assembling information systems are badly needed Hans Wigzell Karolinska Institutet Scientific knowledge is built on logic Seemingly logical assumptions can create major errors in “knowledge” Example: Allergies are increasing all over the world Earlier considered reasons: Allergy is caused by bad indoor milieu etc = Increasing hygiene is “good” advice! New facts: Early contact with micro organisms and allergens give protection! Hans Wigzell Karolinska Institutet Will increased knowledge always improve quality of life? Hans Wigzell Karolinska Institutet