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Research at Karolinska Institutet 2010 Karolinska Institutet A leading medical university Dedicated to improving people’s health through research and higher education The largest centre for medical education and research in Sweden Research – from molecule to patient 22 departments 600 research groups 1,500 researchers/teachers including 328 professors 2,000 doctoral students Traditions and innovations A few examples of our notable research achievements: SR – sedimentation rate Purification of insulin and heparin Sulphasalazin Antibodies from plasma cells Seldinger catheter Pacemaker Gamma knife Growth hormones Nanna Svartz, the first female professor at Karolinska Institutet 1937-1957, developed one of the first anti-inflammatory drugs for rheumatoid arthritis Swedish Nobel Prize Laureates in Physiology or Medicine – 5 of 8 are from Karolinska Institutet: 1955 Hugo Theorell, - the oxidation enzymes 1970 Ulf von Euler, - noradrenaline 1967 Ragnar Granit, - the visual processes 1982 Sune Bergström & Bengt Samuelsson, - prostaglandins Scientific publications 2009 About 3,000 original articles and 1,000 other publications were written by researchers at Karolinska Institutet 2009 60 per cent have co-authors outside Sweden Cited approx 50 per cent more often than the global average (2008) Research funding accounts for 83 per cent of Karolinska Institutet’s total income Undergraduate education Research and doctoral education Research revenue 2009 total SEK: 4,057 million (2008: 3,586 million) Swedish foundations and organisations 16% Non-Swedish foundations and organisations 3% Appropriations 33% EU 6% Swedish business sector 5% Non-Swedish business sector 2% Fin. revenue 0% KI-funds 1% County and municipal councils 14% Research councils 12% Other government funding 8% 9 Research funding Februari 2010 10 Revenue from EU and USA Februari 2010 11 Organisation Board of Research Strategy Research funding and recruitment Research networks Centres of excellence Core facilities Junior faculty Biosafety and ethics Veterinary unit 22 Departments Research Doctoral education The Stockholms Academic Healthcare System Fields of research Cancer Circulation and respiration Endocrinology and metabolism Infection Inflammation and immunology Neuroscience Public and international health Reproduction, growth and development Tissue and motion Nationally funded Centres of Excellence (Linné) Centre of Excellence in Developmental Biology for Regenerative Medicine STARGET – a cancer research network Center for Research on Inflammation and Cadiovascular Disease, CERIC The Human Regenerative Map Linné Centre for Prevention of Breast and Prostate Cancer Other nationally funded Centres of Excellence Aging Research Centre Centre for Allergy Research Centre for Health Equity Studies Centre for Infectious Medicine Stockholm Brain Institute Strategic Research Centre for Studies of Integrative Recognition in the Immune System Structural Genomics Consortium Swedish Brain Power Core facilities in many areas KI Biobank Registers Bioinformatics and biostatistics Clinical trial centres Experimental models Expression analysis Genomics Proteomics Visualisation techniques Strong Research Potential Basic Research and Clinical Research Come Together Translational Research Research profile Epidemiology KI Biobank - core facility for all research contains samples of tissue, blood, serum, plasma, DNA and other biological specimens Twin Registry – the largest in the world invaluable resource when correlating between genes, lifestyle and environment Medical informatics strong competences in health informatics and biostatistics Research profile Cellterapy – from stem cell to therapy Advanced stem cell research Strong clinical expertise in cell therapy and transplantation medicine International leadership in developmental biology Embryonic stem cell lines Research focus on Parkinson’s disease Spinal cord injuries Diabetes Musculature disease Tissue impairment after cardiac infarction Research profile Neuroscience Approx. 20 per cent of all research at Karolinska Institutet is in neuroscience Three world-leading research centres Spinal Cord Research Centre Gather about 10 research groups Stockholm Brain Institute Interdisciplinary research in neuroscience, psychology and computer science Alzheimer Centre Translational research in brain aging, dementia and Alzheimer's disease Research profile Infectious diseases and immunology Leading researchers in virology, bacteriology, parasitology and immunology Neighbouring the largest infection clinic in Sweden Advanced laboratory facilities Strong international collaborations Research focus Global infections – HIV, malaria, tuberculosis, pneumonia Basic immunology, inflammation and infection medicine Research profile Cancer Basic research in the emergence/origin and development of cancer Cancer epidemiology Therapy research, e.g. hormone, immune, and gene therapy Optimizing of radio therapy Clinical trials Quality of life Research profile Inflammatory diseases and allergy Reumatoid arthritis Multipel sclerosis Nerve and muscle inflammation Immune defects Autoimmunity Allergies and eczema Asthma and COPD Atherosclerosis Research profile Metabolic diseases Obesity Advanced research in adult and child obesity Close clinical collaboration Diabetes Basic research in diabetes research Treatment research Stem cell research Cardiovascular research Inflammatory factors Cholesterol metabolism Gender aspects in diagnosis and care Research profile Aging research Aging Research Centre Research from a medical, psychological and socioeconomic perspective Dementia Early diagnosis and treatment of cognitive impairment Alzheimer Centre Swedish Brain Power A national research consortium in neurodegenerative diseases Research profile Global health Partnerships on all continents Research focus on poverty and health Vaccines – HIV, malaria, tuberculosis Reproductive medicine Occupational medicine Psychiatry Geriatrics Humanitarian disaster assistance Research collaborations Health care sector Swedish and foreign universities Industrial partners International agreements with organizations in Europe, North America, Africa and Asia Offices in China and Singapore Karolinska Institutet Innovation - from brains to business Promotes the results of biomedical research to be developed into new products and applications Provides the means for researchers to develop their research results commercially Offer project management, funding for patent protection, legal advice and business development Allows researchers access to an extensive network of contacts within the international pharmaceutical industry Karolinska Institutet Innovation Reviewed more that 1 100 academic inventions More than 40 companies formed since 1996 35 license agreements concluded The system’s portfolio companies own about 100 patents 30 development project are in its portfolio pipeline More information: ki.se 09/1