Download Bild 1

Department of Genetics, Microbiology
and Toxicology (GMT)
Radiation Biology
Prof. Andrzej Wojcik
Prof. Mats Harms-Ringdahl
Toxicology
Prof. Thomas Helleday
Prof. Ulf Rannug
Prof. Dag Jenssen
/ Dag Jenssen, GMT
Centre for Radiation
Protection Research
(CRPR)
Molecular Mechanisms
in Cancer
Radiation Biology (AW & MHR)
2 Profs
1 Postdoc
5 PhD students
2 Master students
Mechanisms of cellular and systemic
effects of exposure to ionising radiation
EU grants
Swedish Radiation Safety Authority
Radiation Biology (AW & MHR)
Mechanisms of individual sensitivity to
ionising radiation:
• Differences in DNA-damage response pathways
between cohorts of patients with normal or severe
healthy tissue reactions to tumour therapy.
•
Screening for polymorphisms in genes for DNArepair, cell cycle regulation and apotosis
• Search for diagnostic tools to identify the
persons at risk.
Patient with severe side-effect
following radiotherapy
Radiation Biology (AW & MHR)
What are the risks of radiation at low doses?
Can we improve biological dosimetry?
Is the dose response curve
non-linear?
Identification of new response
pathways for very low doses.
Epidemiological data
(excess
cancers)
?
(above background)
New technologies will
determine doses with
high precision?
New biomarkers for DNAdamage response pathways
Professor Thomas Helleday’s group
SU group
1 Prof
10 Postdocs & senior scientists
8 PhD students
1 Master students
Oxford group
6 Postdocs
7 DPhil students
DNA repair in cancer therapy
Main grants from:
Swedish Scientific Research Council (VR)
Swedish Pain Relief Foundation (Smärtafonden)
Swedish Cancer Foundation (Cancerfonden)
Swedish Children’s Cancer Foundation (Barncancerfonden)
SU - DNA Repair team
Niklas Schultz, Helge Gad, Fredrik Johansson, Anne Lagerkvist,
Linda Savolainen, Ingegerd Elvers, Cecilia Ström, Petra Groth,
Firas Al-Ubadi, Ivaylo Stoimenov, Kristian Grimberg, Guoli Liu,
Muntasir Mamun
Research areas
•
•
•
•
Stalling of Replication fork and Replication Restart
Homologous recombination
DNA replication termination
DNA repair in cancer (cells + clinical material)
SU - Biochemistry/proteomics
Ann-Sofie Jemth, Olga Loseva
Research areas
• Poly (ADP ribose) polymerases
• Proteomics after DNA damage
• Purification of protein targets for cancer treatment
SU – Cancer Biology
Tatjana Djureinovic, Evgenia Gubanova
Research areas
• DNA damage signalling in cancer
• Evaluation of targets for cancer treatment
SciLifeLab - High-Throughput Screening
Bo Lundgren
Research areas
• RNAi library screens in cells
• Identify targets for cancer treatments
• Map functional genetic networks
SU – Medical Chemistry
Martin Scobie, Tobias Koolmeister
Research areas
• Lead optimisation - Parallell organic chemistry synthesis
Professor Ulf Rannugs group
1
1
3
1
Prof
Postdoc
PhD students
Master student
Natural non-persistent bioactive
aryl hydrocarbon receptor ligands
in humans
The Swedish research Council FORMAS
Professor Ulf Rannug, cont.
Formation and metabolism of
the suggested physiological
Ah receptor ligand 6-formylindolo[3,2-b]carbazole (FICZ)
HPLC, LC/MS/MS
Recombinant human enzymes
Human cells in vitro
Human blood, plasma and
urine samples
NFĸB
AhR
Professor Ulf Rannug, cont.
The new AhR paradigm
TRYPTOPHAN
TRYPTAMINE
PROLIFERATION/APOPTOSIS
OTHER
RECEPTORS (LXR)
DEVELOPMENT
DIFFERENTIATION
I-3-A
FICZ
Active ligand
CYP1
ARYL HYDROCARBON
RECEPTOR (AhR)
Genomic and
non-genomic
regulation
HOMEOSTASIS
IMMUNE RESPONS
INFLAMMATION
STRESS RESPONSES
AOX
NEUROENDOCRINE
oxFICZ
Inactiveligand
SECOND
MESSENGERS
FUNCTIONS
Professor Dag Jenssen’s group
2
2
2
3
Profs
Postdocs
PhD students
Master students
Molecular/cellular mechanisms
for induced mutations
EU grants
Swedish Cancer Society
Swedish Radiation Protection Authority
/ Dag Jenssen, GMT
Professor Dag Jenssen, cont.
Mechanisms involved in the repair of genomic
DNA intra-strand cross-links (Cf, 2010-2013)
Cell culture models
DNA repair
DNA replication
Mutation assay
DNA sequencing
The basis for cancer risk assessment of
lifestyle factors
/ Dag Jenssen, GMT
Professor Dag Jenssen, cont.
Molecular/cellular protection mechanisms against
carcinogenic constituents in food (EU, 2010-2014)
The basis for developing Functional Foods
/ Dag Jenssen, GMT