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Your first mentored grant proposal:
The National Institutes of Health
F and K proposals, and Foundations
Alison K. Hall, Ph.D.
Case School of Medicine
Office of Graduate Education
You are at a critical juncture in training
productive
self-reliant
about to embark on independent careers
becoming physician-scientists
Often write a grant to seek financial support and
recognition for research
Why do you want a mentored grant?
1. Makes the relationship with the PI explicit
2. Benefits associated with grant
3. Looks good on your resume
4. Great learning experience
5. The future inclues an R01…
The Number of Pre-Doctoral and Post-Doctoral Research
Training Positions on NIH Training Grants and Fellowships
(NRSA)
Fiscal Year 2005
10,000
9,000
1,267
(13.2%)
Fellowships
8,000
1,635
(22.5%)
7,000
6,000
8,367
5,000
Training Grants
(86.8%)
5,621
(77.5%)
4,000
3,000
2,000
1,000
0
Pre-Doctoral Pos itions
Post-Doctoral Pos itions
Where do you start?
Communicate
your PI, potential mentors
your chairperson
the Office of Research/ Univ Review, compliance
Are you ready?
pilot data
time to focus
deadlines
Do you qualify?
appointment status
US citizens, permanent residents
The Number of Research Training Positions on NIH
Training Grants and Fellowships
(NRSA)
Fiscal Years 1996 - 2005
Thous ands
18
16
14
Fellowships
12
10
8
Training
Grants
6
4
2
0
1996 1997 1998 1999 2000 2001 2002 2003 2004 2005
Number of Fellowship (F31) Applications Reviewed and Awarded
Fiscal Years 1990 – 2005
1500
Received
Awarded
1200
900
600
300
0
90 991 992 993 994 995 996 997 998 999 000 001 002 003 004 005
9
1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2
The F30 National Research
Service Award (NRSA) for individual
Predoctoral MD/PhD fellows
http://grants.nih.gov/grants/guide/pa-files/PA-05-151.html
set stipend scale and supplement
The F32 NRSA
Jan. 9, 2006 Stipends for Kirschstein-NRSA awards 2006
Postdoctoral
Years of Experience:
0
$36,996
1
$38,976
2
$41,796
3
$43,428
4
$45,048
5
$46,992
6
$48,852
7 or more $51,036
Institutional Allowance $5,500 Research supplies,
health insurance, travel to mtgs
Program announcements
http://grants.nih.gov/training/nrsa.htm
Components of Participating Organizations
National Institute on Aging (NIA/NIH), (http://www.nia.nih.gov/)
National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), (http://www.niaaa.nih.gov)
National Institute on Deafness and Other Communication Disorders (NIDCD/NIH),
(http://www.nidcd.nih.gov)
National Institute on Drug Abuse (NIDA/NIH), (http://www.nida.nih.gov)
National Institute of Environmental Health Sciences (NIEHS/NIH), (http://www.niehs.nih.gov)
National Institute of Mental Health (NIMH/NIH), (http://www.nimh.nih.gov)
National Institute of Neurological Disorders and Stroke (NINDS/NIH), (http://www.ninds.nih.gov)
Office of Dietary Supplements (ODS/NIH), (http://ods.od.nih.gov)
April 5
August 5
December 5
Individual fellowships (F31) for minority students or students with disabilities have special receipt
dates
The F31 NRSA
There are some 25 Institutes at NIH that each have mission
Look at CRISP database
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen
As director of the National Institute of
General Medical Sciences from 1974 to
1993, Ruth Kirschstein MD was the first
woman institute director at the National
Institutes of Health (NIH). Throughout her
career, she has worked as an administrator,
fundraiser, and scientific researcher,
investigating possible public health
responses in the midst of crisis and
conservatism.
Quick Time™a nd a
TIFF ( Unco mpre ssed ) dec ompr esso r
ar e nee ded to see this pictur e.
Stipends
20,772
(suppplement)
Tuition and fees (formula)
Health insurance
Institutional Allowance 30
fellows receive an institutional
allowance of $2,750 per 12month period to non-federal,
or nonprofit sponsoring
institutions to help defray
such awardee expenses as
research supplies,
equipment, books, and travel
to scientific meetings.
The F32 NRSA is a reasonable goal:
2002
MD
PHD
all
Number number total cost
reviewed
awarded
success
awarded 1000s
202
1,336
1,538
4,602
20,813 38.6
25,415 39.5
91
516
607
rate*
45
http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM
Grant NumberPI NameProject Title
5F32GM074554-02ARMBRUSTER, BLAINECreation of designer biogenic amine receptors
5F30DC007274-02 BALU, RAMANIIntrinsic properties of olfactory bulb mitral cells
5F30NS050913-02 COWAN, THOMASAssistive Device Control With Brain Surface Signals
1F31NR008984-01A 2DIMARCO, MARGUERITEUtilization Dental Care by Homeless Children
5F30ES011931-04 ETLING, MICHELEInitiation of Experimental Colitis by Commensal Flora
5F31HD049326-02 JAGODNIK, KATHLEENUpper Extrem. Control Using Reinforcement Learning
5F31MH073296-02 LERCH, JESSICAMolecular Genetics of the Serotonin System
5F31NR009344-02 MURROCK, CAROLYNDance and Physical Activity in Afr. American Women
1F32AA015833-01 PRITCHARD, MICHELEEgr-1 and EtOH-induced hepatic leukocyte recruitment
5F31HD041926-04 ROHDE, TREENAPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIES
5F31MH074241-02 SAMUELS, IVYERK2 Specific Function of the CNS
1F32CA115150-01A1 SWEENEY, COLINRetroviral Insertional Mutagenesis in LMO1 Stem Cells
5F32AG024031-02 WILKINSON, BRANDYMechanisms of Abeta-Stimulated ROS in Microglia
Prepare the Application: read the instructions!!
start early, seek internal reviewers
a. Candidate
US citizen or permanent resident
Doctoral degree (many ok)
b. Sponsor and Training Environment
c. Research Proposal
Up to 3 yrs
c. Training Potential-impt!
d. Vertebrate Animals, Human Subjects etc.
e. Three letters of reference
f. 3 times per year, usu Apr 5, Aug 5, Dec 5
The A1 or A2. You may have to resubmit…
http://grants.nih.gov/training/nrsa.htm
NRSA Review Criteria
•Candidate:
•previous academic and research performance
•potential to become an important contributor
•Sponsor and Training Environment:
•quality of the training environment
•qualifications of the sponsor as a mentor
for the proposed research training experience.
•Research Proposal:
•merit of the scientific proposal
•relationship to the candidate's career plans.
•Training Potential:
•value of the proposed fellowship experience
as it relates to the candidate's needs in
preparation for a career as an independent researcher.
The K08
Mentored Clinical Scientist Development Award
For clinically trained persons to pursue research
careers in basic or clinical sciences.
Must apply within 3 years of clinical
Training (residency +1 year of clinical fellowship)
K08->K02-> R01
up to $85,000 salary up to $50,000 costs/ year
up to five years, non-renewable
QuickTime™ and a
TIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and a
TIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and a
TIFF (Uncompressed) decompressor
are needed to see this picture.
The K08
Prepare the Application: read the instructions!!
a.
b.
c.
d.
e.
f.
g.
h.
Candidate
Research Plan
Career Development Plan/ Training Plan
Environment/ Institutional support
Mentor*
Vertebrate Animals, Human Subjects etc.
The A1 or A2. You may have to resubmit…
(The summary statement)
The K08
Candidate**
**some Institutes require faculty app’t (eg Instructor)
Basic Science Mentor/co Mentor:
1. Good working relationship
2. Often funded by NIH
3. Expert in this area
4. Experienced trainer
The K08
Career Development Plan (very important)
• Focused and relevant
• New techniques, new area, could be funded
• Present at meetings, review grants, external
courses
• Update didactics
• Create an oversight committee familiar with
research, career goals, meet six mos for
feedback
Research Plan
•Provide preliminary data to support rationale,
approach. Focus!
•Include study of Research Ethics, animals etc.
The K08
http://grants.nih.gov/grants/guide/pa-files
See supplementary info at each institute
Insure protected time
-Do not assume that 75% means anything
except 75% of your total working hours
-These estimates are carefully reviewed
essential that your chair state this
not contingent on receipt of the grant
-50% Neurosurgery
What happens to your application after it leaves the mailbox?
Center for Scientific Review receives the application
assigned to the Initial review group or “Study section”
Review for SCIENTIFIC MERIT and TRAINING POTENTIAL.
Summary statement, see NIH Commons
Scores and percentiles. NRSAs are not streamlined
Priority score 100-500, with 100 is best.
Rewrite? Respond to critique
Funded?Progress report each year
Inside the NIH Grant Review Process
39 min video NIH Center for Scientific Review
Includes R01/K08/ R03
Download proposals
http://www.drg.nih.gov/Video/video.asp#docs
View the video on the web
http://www.drg.nih.gov/Video/Video.asp
Helpful Hints for an NLHBI K08 Application
http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm
Grantwriting Resources
Grantpersonship: An Instruction Manual
http://www.pitt.edu/~survival
NIMH Grant Application Process
http://www.nimh.nih.gov/researchFunding/grantprocess.cfm
http://www.nimh.nih.gov/researchFunding/training.cfm
FASEB Grantsmanship Training Program
https://ns2.faseb.org/careerutilities/grantprg.htm
Grant Application Writer’s Handbook, Reif-Lehrer
What about foundations and organization fellowships?
Public charitable organizationsMDA, AHA, ACS
Derives support from members of the public
Foundations-Private, Corporate
derives support from a family, individual or corporation
see The Foundation Center
www.fdncenter.org/cleveland
(Richard Sohn, Research Admin has subscr.)
often have a disease focus
may support non US citizens
Often have one deadline per year
Where to find these other grants?
Grantsnet
http://sciencecareers.sciencemag.org/funding?CFID=380054&CFTOKEN=35995422
“Initial MD postdoc, dermatology, skin” examples:
18. LRF Postdoctoral Fellowship Awards Program
Sponsor: Medical Foundation
Program Type: Anatomy, Biochemistry, Bioengineering, Bioinformatics, Biology,
Biophysics, Cell Biology, Chemistry, Developmental Biology, Immunology, Microbiology,
Molecular Biology, Physiology, Structural Biology
Deadline(s): 11/15/2005
23. Research Grants
Sponsor: American Skin Association, Inc.
Program Type: Biology, Cancer, Cell Biology, Clinical Research, Developmental Biology,
Disease-Specific Research Skin Cancer/Melanoma, Psoriasis, Epidemiology, Immunology,
Molecular Biology, Structural Biology, Other (specify): Vitiligo, Childhood Skin
Diseases/Disfigurement, Pigment Cell Biology and Auto-immune Inflammatory Skin
Diseases
Deadline(s): 10/03/2005