Download Adam E. Cohen, Ph.D. Distinguished Lecture Series in Physiology "All-optical electrophysiology”

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Transcript
Distinguished Lecture Series
in Physiology
Physiology and Membrane Biology
University of California, Davis
Adam E. Cohen, Ph.D.
Harvard University
Howard Hughes Medical Institute
"All-optical electrophysiology”
To study a neural circuit, one would like to probe the activity of many
neurons, with high resolution in space and time. A key challenge has
been the difficulty of visualizing changes in transmembrane potential.
We discovered that a protein derived from a Dead Sea microorganism
could function as an exquisitely fast and sensitive fluorescent reporter
of membrane voltage. We developed optical tools for simultaneous
optical perturbation and optical readout of membrane voltage. Using
these tools we have studied electrical activity in primary neurons in
vitro, in acute brain slice, and in live mice. We have also studied
human iPSC-based neuronal models of diseases such as pain, epilepsy,
and ALS. Optical electrophysiology provides new insights into these
complex bioelectric phenomena.
Genome Auditorium
Thursday, May 5, 2016
10:00 a.m.
Host: Jon Sack [email protected]