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The Autonomic Nervous System Human Anatomy & Physiology, Sixth Edition Elaine N. Marieb 14 Autonomic Nervous System (ANS) Motor neurons that: Innervate smooth & cardiac muscle & glands Subconscious control ANS differs from the SNS Effectors SNS – skeletal muscle ANS – non-skeletal muscle & gland cells Efferent pathways SNS – single PNS neuron ANS – 2 PNS neurons Target organ responses SNS – contraction of muscle ANS – contraction or relaxation, excretion Neurotransmitters used SNS – acetylcholine ANS – acetylcholine, norepinephrine & epinephrine Distinctions of Efferent Pathways SNS motor neurons Single neuron extends from CNS to effector Heavily myelinated axons ANS motor neurons Two-neuron PNS chain Preganglionic neuron & postganglionic neuron Lightly myelinated preganglionic axon from CNS to ganglion Unmyelinated postganglionic axon extends to effector Neurotransmitter Differences SNS neurons release acetylcholine (ACh), which has an excitatory effect In the ANS: Preganglionic fibers release ACh Postganglionic fibers release norepinephrine or ACh effect is stimulatory or inhibitory effect depends on neurotransmitter receptor in cells of effector tissue Comparison of Somatic & Autonomic Systems Figure 14.2 Anatomy of ANS Long preganglionic Short postganglionic Short preganglionic Long postganglionic Ganglia on/in target organ Ganglia close to spinal cord Figure 14.3 Divisions of the ANS Sympathetic (SANS) mobilizes the body during stressfull situations Parasympathetic (PANS) stimulates maintenance activities & conserves body energy The two divisions counterbalance each other’s activity SANS signals usually override PANS Examples of ANS Effects PANS Lowers BP, heart & respiratory rates Increases gastrointestinal tract activity Superficial arterioles open (smooth muscle relaxed) Pupils are constricted SANS Blood flow to organs/skin reduced, flow to muscles increased Heart & respiratory rates increased Iris contracts - Pupils dilate Parasympathetic Division Outflow Cranial Outflow Sacral Outflow Cranial Nerve Ganglion Effector Organ(s) Occulomotor (III) Ciliary Eye Facial (VII) Pterygopalatin Submandibular Salivary, nasal, & lacrimal glands Glossopharyngeal (IX) Otic Parotid salivary glands Vagus (X) Located within the walls of target organs Heart, lungs, & most visceral organs S2-S4 Located within the walls of the target organs Large intestine, urinary bladder, ureters, & reproductive organs Parasympathetic Division Outflow Longer preganglionic axons Ganglion near/on target organ Short postganglionic axons Vagus nerve (CN X) innervates all visceral organs Sympathetic Outflow Sympathetic neurons in lateral horns of spinal cord segments T1 through L2 T1-T4 preganglionic fibers pass through the white rami communicantes & synapse in sympathetic chain ganglia T5-L2 preganglionic fibers pass through the gray rami communicantes & chain ganglia to form splanchnic nerves & synapse in collateral ganglia around abdominal aorta Postganglionic fibers innervate the numerous organs of the body Sympathetic Outflow Sympathetic neurons in lateral horns of spinal cord segments T1- L2 T1-T4 preganglionic fibers synapse in sympathetic chain ganglia T5-L2 preganglionic fibers form splanchnic nerves & synapse in collateral ganglia on abdominal aorta Sympathetic Trunks & Pathways Pathways to the Head T1-T4 preganglionic axons synapse in the superior cervical ganglion Serve skin & blood vessels of the head Stimulate dilator muscles of the iris Inhibit nasal & salivary gland secretions Pathways to the Thorax T1-T6 preganglionic axons synapse in cervical chain ganglia Postganglionic axons from middle & inferior cervical ganglia enter spinal nerves C4-C8 to innervate the heart, thyroid & skin of neck Other T1-T6 preganglionic axons synapse in nearest chain ganglia to directly serve the heart, aorta, lungs, & esophagus Pathways with Synapses in Collateral Ganglia T5-L2 preganglionic axons exit sympathetic chain ganglia & form splanchnic nerves Splanchnic nerves form aortic plexus & numerous ganglia Postganglionic axons from abdominal ganglia innervate viscera Pathways with Synapses in the Adrenal Medulla Axons of the thoracic splanchnic nerve go directly to the adrenal medulla Upon stimulation, medullary cells secrete norepinephrine & epinephrine into the blood greater thoracic splanchnic nerve Visceral Reflexes Visceral reflexes have the same elements as somatic reflexes Afferent fibers are found in spinal & autonomic nerves ANS Neurotransmitters PANS Acetylcholine (ACh) released by pre- & postganglionic axons SANS ACh released by preganglionic axons ACh or norepinephrine (NE) released by postganglionic axons Cholinergic fibers – ACh-releasing axons Adrenergic fibers –NE-releasing postganglionic SANS axons Excitatory or inhibitory effects depend upon the receptor type Cholinergic Receptors Bind ACh Nicotinic receptors Muscarinic receptors Named & distinguished by interaction w/ agonists Nicotine Muscarine Agonist – stimulates effect Antagonist – blocks effect Cholinergic Receptors Nicotinic Receptors Locations: Skeletal muscle motor end plates, CNS neurons SANS & PANS ganglionic neurons Adrenal medulla cells Ion channels ACh always stimulatory Muscarinic Receptors Locations Cells stimulated by postganglionic PANS fibers, CNS ACh inhibition or excitation depends on receptor subtype subtypes – M1, M2, M3 Adrenergic Receptors Receptors that bind to norepinephrin & epinephrine In cells innervated by SANS postganglionic axons Alpha subclasses - 1, 2, NE is stimulatory Beta Subclasses - 1, 2 , 3 NE is generally inhibitory Exception – NE binding to receptors of the heart is stimulatory Drugs that Influence the ANS Table 14.4.1 Levels of ANS Control Figure 14.9 Interactions of the Autonomic Divisions Most visceral organs innervated by both sympathetic & parasympathetic fibers results in dynamic antagonisms that precisely control visceral activity Sympathetic fibers increase heart & respiratory rates, & inhibit digestion & elimination Parasympathetic fibers decrease heart & respiratory rates, & allow for digestion & the discarding of wastes