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DEVICE FOR EXTRACORPORAL PURIFICATION OF BIOLOGICAL BODY FLUIDS
FROM TOXINS BY APPLICATION OF
MAGNETICALLY CONTROLLED MICROPARTICLES OF SORBENTS
Danilin A.N., Zakharov A.P., Yanovskiy Yu.G.
Institute of applied mechanics RAS, Moscow, e-mail: [email protected]
Geydel А.А., Sidorin Yu.Yu.
Scientific-production association “Nanometric powder materials - Kemerovo” , Kemerovo, e-mail: [email protected]
Alehin A.I., Goncharov N.G.
Central clinical hospital RAS, Moscow, e-mail: [email protected]
Schematic diagram of the stand for investigating the detoxication processes of
biological fluids by application of magnetically controlled sorbents
1 – tank, containing biological
fluid with toxins;
2 – unit for preparing the
suspension of magnetic sorbent;
3 – unit for mixing;
4 – peristaltic pump;
5 – magnetic filter;
6 – tank for collecting the biological
fluid purified from toxins.
Version of magnetic filter design
1, 2 – end bushings with inlet and outlet pipes; 3 – bushing for additional biasing of particles;
4 – bushing for rough filtration; 5 – bushing for precise filtration; 6 – bushing made of
magnetically soft material; 7 – plastic insert in the area of precise filtration with spiral canals on
its outer surface in order to arrange the flow of magnetic fluid crosswise the magnetic
field lines.
Creation of high-gradient magnetic fields
Monolithic magnetic bushings (niodim-ferrum-boron),
creating high-gradient magnetic fields
Axial section of diametrically
magnetized bushing of the first
stage of magnetic separator
Versions of bushing magnetization of precise filtration
area of separator in order to create high-gradient
magnetic fields (0.3-1.0 tesla/cm)
Structural versions of mixer-reactor
Mixer-reactor. Assembled view
Spiral canals
Spiral
canals
Insert
Housing
Right and left caps (side pieces)
with branch pipes
Labyrinth mixer
Functional scheme of the device for purification of biological body fluids from toxins and viruses
by application of nano- and micro- particles of magnetically controlled sorbents
Development, magnetic sorbents, testing: IAM RAS, PSA «NPM-КЕМЕRОVО», CCH RAS
Magnetic filter
N
N
N
S
S
N
N
Multipole bushing
of separation area S
N
Diametrically
magnetized
bushing of
aggregation zone
Main pipe
N
S
N
N
S
S
N
N
N
S
- medium to be purified (blood)
- toxins and viruses
- micro particles of magnetically
controlled sorbent
Mixer
Ultrasonic disperser
Dosing pump
Peristaltic pump
Schematic diagram of the device for extracorporal detoxication of
biological body fluids by application of micro-dimension magnetically
controlled sorbents
Solution of
anticoagulant
(heparin)
1- Ultrasonic unit for dispersion
of suspension of magnetically
controlled components
Suspension
“concentrate”
in syringe
2 - peristaltic pumps
from the vein
3 - mixer-reactor
4 – magnetic trap
Control,
monitoring
and supply
unit
Ultrasonic
radiator
Air trap
Ultrasonic level sensor
to the vein
Ultrasonic sensor
of air presence
Experimental model of the device for detoxication of biological
body fluids by application of magnetically controlled sorbents
DEVICE FOR EXTRACORPORAL
DETOXICATION OF BIOLOGICAL
BODY FLUIDS
Investigation of sorption capacity of particles and their microstructure
Optical density, relative units
Wave length, nm
Fig.9. Absorption spectrums of
methylene blue in physiological
solution (pH 7,2) at control (1), after
adsorption by ferrocarbon (FC) for
mass ratios of FC/adsorbate: 20 (2),
30 (3), 50 (4)
Optical density, relative units
Wave length, nm
Fig.10. Absorption spectrums of
cyanocobalamin (vitamin B12) in
physiological solution (pH 7,2) at
control (1), after adsorption by
ferrocarbon (FC) for mass ratios of
FC/adsorbate: 20 (2), 30 (3), 50 (4)
Optical density, relative units
Wave length, nm
Fig.11. Absorption spectrums of
hemoglobin in physiological solution
(pH 7,2) at control (1), after
adsorption by ferrocarbon (FC) for
mass ratios of FC/adsorbate: 20 (2),
30 (3), 50 (4)