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Muscular System Muscle Tissue The Muscular System Muscle Tissue Introduction Skeletal Muscle Tissue & The Muscular System Anatomy of Skeletal Muscle Contraction of Skeletal Muscle Muscle Mechanics Muscle Tissue Aging & the Muscular System Integration With Other Systems Cardiac Muscle Tissue Smooth Muscle Tissue Introduction • Importance to body function • Importance to human activity • Active & passive forces Learning Objectives • Importance: Discuss the central role of muscle tissue in a variety of human activities and necessary body functions • Active Forces: Compare & contrast tension, compression, & resistance Importance: Function & Activity • Human activity gross movements of the body communication speaking facial expression & gestures • Body function circulation respiration digestion reproduction Body Movement Communication Bodily Functions Active & Passive Forces • Resistance passive force opposing movement dependent on weight, shape, friction, etc • Tension active force applied to an object to produce movement when applied tension > resistance, object is pulled toward source of tension • Compression (not assoc. w/ muscle movement) active force applied to an object to produce movement when applied compression > resistance, object is pushed away from source of compression Muscle Contraction Produces Tension RESISTANCE TENSION Skeletal Muscle Tissue & The Muscular System • Tissue characteristics • Functions of muscle tissue Learning Objectives • Characteristics & Functions: Describe the characteristics & functions of muscle tissue Muscle Tissue • One of 4 primary tissue types of the body • Types of muscle tissue skeletal cardiac smooth • Body muscles are organs that contain skeletal muscle tissue, connective tissues, nerves, epithelial tissue & smooth muscle tissue (in blood vessels) Muscle Tissue Types skeletal muscle smooth muscle cardiac muscle Functions of Skeletal Muscle Tissue • Produce skeletal movement • Maintain posture & body position • Support soft tissues • Guard entrances into & exists out of the body • Maintain body temperature Mr. G Before he got married Anatomy of Skeletal Muscle • Connective tissue organization • Blood vessels & nerves • Microanatomy of skeletal muscle fibers Learning Objectives • Tissue Structure: Describe the organization of muscle at the tissue level • Cellular Structure: Explain the unique characteristics of skeletal muscle fibers • Organelle Structure: Identify the structural components of a sarcomere Connective Tissue Organization • Surrounding Sheaths – Epimysium – Perimysium – Endomysium • Tendons Connective Tissue Organization • Epimysium outer connective tissue layer dense layer of collagen fibers deep fascia surrounds entire muscle • Perimysium middle connective tissue layer collagen & elastic fibers contains blood vessels & nerves surrounds fascicles: dividing muscle into compartments Connective Tissue Organization • Endomysium inner connective tissue layer delicate c.t. surrounds muscle fibers & satellite cells satellite cells (stem cells) Connective Tissue Organization Epimysium, perimysium, & endomysium unite at muscle ends to form: • Tendons – linear bundle attaching muscle to bone • Aponeuroses – broad sheet attaching muscle to bone [same function as “tendon”] Connective AnimationTissue Organization Blood Vessels & Nerves blood vessels nerve Microanatomy • Organelles of Skeletal Muscle Fibers • Sarcomere Organization • Microfilament Structure Microanatomy of Skeletal Muscle Fibers • Muscle fiber: muscle cell long, thin (among largest cells in body) multinucleate – peripheral, oval nuclei • Sarcolemma: cell membrane openings for penetrating tubules established membrane potential due to Na-K ion exchange pumps Microanatomy of Skeletal Muscle Fibers • Sarcoplasm: cytoplasm contains contractile proteins contains numerous mitochondria • Sarcoplasmic reticulum (SR): endoplasmic reticulum terminal cisternae – fused SR tubules triads – regions where T tubules & SR cisternae contact Microanatomy of Skeletal Muscle Fibers • Transverse tubules: T tubules continuous w/ sarcolemma network throughout cell close contact w/ SR • Myofibrils 100s-1000s of bundles of myofilaments thin filaments thick filaments Microanatomy of Skeletal Muscle Fibers • Sarcomere repeating units in myofibrils linked end-to-end functional unit of a muscle fiber components thick protein filaments thin protein filaments proteins stabilizing thick & thin filaments proteins regulating interaction btw/ thin & thick filaments Sarcomere Organization • Banded appearance due to overlap of thick & thin filaments A bands – appear dark I bands – appear light • A band – contains thick & thin filaments M line center of sarcomere thick filaments only - connected by stabilizing protein Sarcomere Organization • A band (cont) H zones lateral to M line thick filaments only Zones of overlap lateral to H zones thick & thin filaments overlap Sarcomere Organization • I bands – contain thin filaments only edges of sarcomere • Z lines boundaries btw/ adjacent sarcomeres protein complexes attached to thin filaments Note A & I bands & peripheral nuclei Sarcomere Organization A I Functional Organization Thin Filaments • Composition (proteins) F actin twisted filament of G actin globular proteins contains active sites that can bind to thick filaments tropomyosin protein cover over active sites of F actin troponin binds tropomyosin to active site contains Ca2+ receptor Thin Filaments • Troponin-tropomyosin complex reacts to bound Ca2+ by uncovering active sites on F actin of thin filament necessary for contraction Thick Filaments • Composition (protein) myosin subunits – tail & head tail – binds to other myosin molecules head – projects outward toward thin filament called cross-bridges Thick & Thin Filament Structure Contraction Of Skeletal Muscle • The control of skeletal muscle activity • Relaxation • The contraction cycle • Length-tension relationships Learning Objectives • Neuromuscular Junction: Identify the components of the neuromuscular junction & summarize the events involved in the neural control of skeletal muscle function • Muscle Cell Contraction: Explain the key steps involved in the contraction of a skeletal muscle fiber Control of Skeletal Muscle Activity • Neuromuscular junction neural axon branch terminates w/ synaptic terminal at every muscle fiber synaptic terminal – contains neurotransmitter acetylcholine (ACh) synaptic cleft – separates terminal from muscle fiber sarcolemma Control of Skeletal Muscle Activity • Neuromuscular junction motor end plate – sarcolemma surface w/ ACh receptors acetylcholinesterase (AChE) – in cleft; breaks down ACh • ACh receptors of motor end plate bind to ACh released from synaptic terminal and respond by opening gated ion channels in sarcolemma Membrane Potential: Electrochemical Gradient positive charge due to [Na+] negative charge due to [protein] [a.a.] [F.A.] Neural Stimulation of Muscle Fibers Step 1. Arrival of action potential. action potential – electric impulse travels down axon of neuron enters synaptic terminal of neuron Step 2. Release of ACh. exocytosis – synaptic vesicles containing ACh fuse w/ neurolemma ACh enters synaptic cleft Neural Stimulation of Muscle Fibers Step 3. ACh binds at motor end plate. ACh diffuses across cleft & binds to ACh receptors of sarcolemma gated Na-channel proteins open & sarcolemma becomes permeable to Na+ Na+ floods into sarcoplasm Neural Stimulation of Muscle Fibers Step 4. Appearance of action potential in sarcolemma. Na+ influx results in action potential at motor end plate action potential spreads across the “excitable” sarcolemma & down T tubules action potential affects SR Neural Stimulation of Muscle Fibers Step 5. Return to initial state. AChE in cleft breaks down ACh ACh unbinds from receptors gated Na-channels close & Na+ is pumped back out of sarcoplasm by Na-K ion pumps Steps 1 – 5 Contraction & Relaxation • Excitation-Contraction Coupling action potential impulses cause release of Ca2+ from SR Ca2+ binds to F actin of myofibrils to initiate sarcomere contraction continued reception of impulses causes continued contraction • Relaxation Ca2+ is reabsorbed by SR sarcomeres cease contraction Sarcomere Contraction Cycle Step 1. Active site exposure. Ca2+ released from SR binds to troponin troponin pulls tropomyosin away from active site on F actin Step 2. Cross-bridge attachment. myosin heads (cross-bridges) bind to exposed active sites of F actin Sarcomere Contraction Cycle Step 3. Pivoting of myosin head. “cocked” myosin heads are bent away from M line due to stored energy from breakdown of ATP to ADP + Pi ADP & Pi remain bound to heads in resting sarcomere attachment of myosin head to active site of F actin releases stored energy to create a power stroke of head toward M line ADP & Pi are released as stroke occurs Sarcomere Contraction Cycle Step 4. Cross-bridge detachment. ATP binds to myosin head following stroke head unbinds from active site exposed active site available for binding to next myosin head along length of myosin filament Sarcomere Contraction Cycle Step 5. Myosin reactivation. ATP ADP + Pi released energy “recockes” myosin head Cycle can now be repeated under conditions: [Ca2+] maintained [ATP] maintained Observations of Sarcomere During Muscle Contraction sliding filament theory Sarcomere Contraction • To View Video: – Move mouse cursor over slide titlelink – When hand appears, click once • MOV Video plays about 3-1/4 min Additional Animation Muscle Mechanics • Tension production • Energetics of muscular activity • Muscle performance Learning Objectives • Muscle Contraction: Explain the all-or-nothing principle of muscle contraction Discuss the structure & function of a motor unit Distinguish between isotonic & isometric contraction • Energetics: Describe the mechanisms by which muscle fibers obtain the energy to power contractions Muscle Contraction: Tension Production • All-or-None Principle muscle fibers are either stimulated to the point of contraction or not once stimulated, the entire muscle fiber contracts • Tension produced by whole skeletal muscle due to: 1) frequency of stimulation 2) # of fibers stimulated w/in muscle Muscle Contraction: Motor Unit • Motor unit A single motor neuron & all the muscle fibers controlled by it • Motor unit size 4-6 fibers in eye muscles – provide precise control of movement 1000-2000 in leg muscles – provide less precise control Muscle Contraction: Motor Unit • Recruitment Smooth, steady increase in the number of motor units involved in a muscle contraction a.k.a., multiple motor unit summation • Muscle tone some motor units w/in a muscle are always active switch off w/ resting units regularly to distribute activity Isotonic Muscle Contraction • Isotonic contraction Tension plateaus & muscle changes length concentric contraction – tension > resistance: muscle shortens ex: lifting weight eccentric contraction – peak tension < resistance: muscle elongates due to contraction of another muscle or gravity ex: lowering weight Isometric Muscle Contraction • Isometric contraction tension varies but does not overcome resistance muscle does not shorten Note: individual muscle fibers shorten until tendons are taught & external tension = internal tension generated by fibers ex: holding a weight stationary; pushing against an immovable object Charles Atlas Muscle Relaxation: Return to Resting Length Causes of muscle relaxation: • Recoil of stretched elastic fibers in perimyzium • Contractions of opposing muscles • Gravity Energetics of Muscle Activity • ATP is produced by cellular respiration in muscle fibers • At rest, excess ATP energy stored as creatine phosphate (CP) ATP + creatine ADP + creatine phosphate Energetics of Muscle Activity • During contraction myosin crossbridges beak down ATP to ADP + Pi • Energy stored as creatine phosphate (CP) “recharges” ADP ADP + creatine phosphate ATP + creatine Aerobic Energy Metabolism : O2 Present • Glycolysis in cytosol of cytoplasm C6H12O6 2 pyruvate yields 2 ATP (net) • Aerobic cellular respiration in mitochondria 2 pyruvate + 6O2 6CO2 + 6H2O yields 25-34 ATP Storage Compounds O=O glycogen stores glucose myoglobin stores O2 Anaerobic Energy Metabolism: O2 Absent • Glycolysis in cytosol of cytoplasm C6H12O6 2 pyruvate yields 2 ATP (net) • Lactic acid fermentation in cytosol 2 pyruvate 2 lactic acid yields 0 ATP Muscle Muscle Activity: Activity: Resting Moderate Strenuous Learning Objectives • Fiber Types: Relate the types of muscle fibers to muscle performance • Aerobic & Anaerobic Endurance: Distinguish between aerobic & anaerobic endurance & explain their implications for muscle performance Fiber Types: Fast • Fast twitch muscle fibers contract w/in 0.01 sec after stimulation large diameter densely packed myofibrils reserves: glycogen; ↓ myoglobin few mitochondria • Powerful contraction w/ rapid fatigue deplete ATP reserves rapidly activity supported by anaerobic metabolism • Pale reddish color Fiber Types: Slow • Slow twitch muscle fibers contract w/in 0.03 sec after stimulation small diameter fewer myofibrils reserves: myoglobin; lipid; ↓ glycogen many mitochondria • Moderate contraction w/ slow fatigue deplete ATP reserves more slowly activity supported by aerobic metabolism • Dark reddish color Fiber Types: Intermediate • Intermediate muscle fibers properties intermediate btw/ fast twitch & slow twitch • Pale reddish color Note: Human muscles contain mixtures of 3 types Content varies w/ genetics & use Muscle Size • Hypertrophy increase in muscle mass # muscle fibers constant diameter of muscle fibers • Atrophy decrease in muscle mass # muscle fibers constant diameter of muscle fibers Anaerobic Endurance • Length of time muscular contraction can continue supported by glycolysis & existing reserves of ATP & CP • Limited by Amount of ATP & CP on hand Amount of available glycogen ability of muscle to tolerate lactic acid Anaerobic Endurance • Training regimen Frequent, shortduration exercise w/ intensive levels of muscular activity Ex: sprinting; speed swimming; weight lifting; basketball Aerobic Endurance • Length of time muscular contraction can continue supported by mitochondrial activity • Limited by Amount of substrates from breakdown of carbohydrates, fatty acids, &/or amino acids Amount of available oxygen Aerobic Endurance • Training regimen Sustained, long duration exercise w/ low levels of muscular activity Ex: jogging; cross country running; distance swimming; dance movements Aging & The Muscular System • Effects of aging on the body’s skeletal muscles • Effect of life style on aging of muscles Learning Objectives • Aging: Specify 4 effects of aging on muscles Discuss how regular exercise early in life can counter the effects of aging on the muscular system Effects of Aging • Skeletal muscle fibers decrease in diameter – in myofibrils • Skeletal muscles lose elasticity – fibrosis collagen content • Tolerance for exercise decreases – thermoregulatory ability – rate of fatigue • Ability to recover from muscular injuries decreases – # satellite cells – collagen content Life Style & Aging • Rate of decline in muscle performance is same for all individuals regardless of exercise patterns or lifestyle • To be in good shape late in life …… you must be in very good shape early in life • Regular, moderate exercise is more important than extremely demanding exercise Integration With Other Systems • Dependence on other body systems • Responses of body systems to muscular activity Learning Objectives • Integration: Discuss the interaction & responses of 5 specific body systems to muscular activity Integration: Support From Other Body Systems • Cardiovascular System heart rate & dilation of blood vessels cause O2 delivery & CO2 removal transports heat to skin for radiation to environment • Respiratory System respiratory rate & depth of respiration O2 delivery & CO2 removal • Integumentary System dilation of blood vessels & sweating removes excess heat that would interfere w/ muscle protein activity Integration: Support From Other Body Systems • Nervous System controls voluntary muscle contraction regulates/coordinates cardiovascular, respiratory, & integumentary system activities • Endocrine System regulates/coordinates cardiovascular, respiratory, & integumentary system activities maintains [Ca2+] & [-PO43-] in blood & other body fluids via skeletal, digestive, & urinary systems Integration: Bones, Joints, & Muscles • To View Video: – Move mouse cursor over slide titlelink – When hand appears, click once • ASX Video plays about 24 min • A Video Quiz is included in the presentation Cardiac Muscle Tissue • Structural differences between cardiac & skeletal muscle tissues • Functional differences between cardiac & skeletal muscle tissues • The role of cardiac muscle in the body Learning Objectives • Structure & Function: Identify the structural & functional differences between cardiac muscle tissue & the other types of muscle tissue Discuss the role that cardiac muscle plays in the cardiovascular system Cardiocytes: Structural Organization • • • • • • • Single nucleus Branched cellular structure Striated – myofibrils & sarcomeres T tubules – short & broad; no triads SR – no terminal cisternae Mitochondria – # Intercalated discs – btw/ adjacent cells; transfer contractions from one cell to several others instantaneously Cardiocytes: Functional Features • Automaticity – contraction w/out neural stimulation – “pacemaker” cells • Innervation – alters pace of contraction • Duration of contraction – 10 X longer • Sarcolemma characteristics – prevent summation & tetany • Dependent on aerobic metabolism – # mitochondria & [myoglobin] Smooth Muscle Tissue • Structural differences between smooth & skeletal muscle tissues • Functional differences between smooth & skeletal muscle tissues • The role of smooth muscle in body systems Learning Objectives • Structure & Function: Identify the structural & functional differences between smooth muscle tissue & the other types of muscle tissue Discuss the role that smooth muscle plays in various body systems Smooth Muscle Cells: Structural Organization • Single nucleus • Spindle-shaped cellular structure • Non-striated – no myofibrils or sarcomeres; thick & thin filaments scattered through cytoplasm • Dense body network – attach to thin filaments & to sarcolemma • No T tubules • SR – loose network • Connective tissue sheaths – do not unite to form tendons or aponeuroses Smooth Muscle Cell: Functional Features • Excitation-Contraction coupling – Ca2+ enter cell from extracellular fluid & bind to calmodulin which activates myosin light chain kinase to break down ATP & initiate contraction • Plasticity – length-tension relationship allows for variable contraction length Smooth Muscle Cell: Functional Features • Control of contraction – involuntary; many cells not innervated; respond to nearby smooth muscle cells multiunit smooth muscle cells – connected to 1 or more motor neurons; leisurely contraction loci – iris of eye; ♂ reproductive tract; large arteries; arrector pili muscles smooth muscle sheet visceral smooth muscle cells – many lack direct neural contact loci – digestive tract; urinary & gall bladders; many internal organs The Muscular System Introduction Biomechanics & Muscle Anatomy Muscle Terminology The Axial Muscles The Appendicular Muscles Introduction • Voluntary control • Form & function • Factors determining the effects of contraction Muscles • To View Video: – Move mouse cursor over slide titlelink – When hand appears, click once • ASX Video plays about 5 min Learning Objectives • Muscle Control: Relate the muscular system to nervous control • Muscle Shape: Discuss how the structure of a muscle provides clues to its primary function • Effects of Muscle Contraction: Discuss 2 factors that interact to determine the effect of a muscle’s contraction Voluntary Muscles • Muscular System All muscles controlled voluntarily 700 identified 20% studied in book ~ 30 studied for course • Form & function locomotor muscles - stretch across joints soft tissue support muscles - form sheets or slings muscles guarding body entrances - form rings Voluntary Muscles • Effects of contraction determined by anatomical arrangement of muscle fibers attachment points of muscle to bones Biomechanics & Muscle Anatomy • Organization of skeletal muscle fibers • Skeletal muscle length-tension relationships • Levers Learning Objectives • Fascicles: Describe the arrangement of fascicles in the various types of muscles & explain the resulting functional differences • Levers: Describe the different classes of levers & how they make muscles more efficient Organization of Skeletal Muscle Fibers • Fascicles bundles of muscle fibers w/in a muscle • Patterns of fascicle organization parallel muscles – fascicles parallel to long axis of muscle central body or belly w/ tendons at ends (most muscles) some w/ broad attachments – aponeuroses Ex: biceps brachii Organization of Skeletal Muscle Fibers • Patterns of fascicle organization convergent muscles – fascicles begin over a broad area & narrow to a single tendon or tendinous sheet raphe – some attach to band of collagen fibers Ex: pectoralis major Organization of Skeletal Muscle Fibers • Patterns of fascicle organization pennate muscles – fascicles form common angle w/ tendon feather-shaped unipennate – all fascicles on same side of tendon; Ex: tensor digitorum bipennate – fascicles on both sides of tendon; Ex: rectus femoris multipennate – tendon & fascicles branch; Ex: deltoid Organization of Skeletal Muscle Fibers • Patterns of fascicle organization circular muscles – fascicles concentrically arranged around opening or recess contraction decrease in diameter Ex: orbicularis oris Fascicle Arrangements Length-Tension Relationships • Muscles develop maximum tension over a narrow range of sarcomere length stretched muscle – less overlap of thick & thin filaments in sarcomere contracted muscle – normal thick-thin filament relationship is disrupted Ex: when curling weights flexion is harder to achieve when arm muscles are stretched in extended arm, becomes easier as muscles contract, then harder after full flexion is achieved Length-Tension Relationships • During complex movement – muscles work in groups smaller muscles aid larger muscles to reach length where maximum tension can be achieved Levers • Lever – rigid structure that moves on a fixed point called the fulcrum • In body, each bone is a lever; each joint is a fulcrum Lever action 1) change direction of an applied force 2) change distance & speed of movement produced by applied force 3) change the effective strength of an applied force Classes of Levers • First-class - fulcrum btw/ AF & R like see-saw Ex: muscles that extend neck • Second-class - R btw/ AF & fulcrum like loaded wheelbarrow Ex: calf muscles during plantar flexion • Third-class - AF btw/ R & fulcrum opposite of 2nd-class most common lever action of body Ex: biceps brachii during flexion Muscle Terminology • Origins & insertions • Actions • Names of skeletal muscles • Divisions of the muscular system Learning Objectives • Origins & Insertions: Predict the actions of a muscle on the basis of the relative positions of its origin & insertion • Movements: Explain how muscles interact to produce or oppose movements • Muscle Names: Explain how the name of a muscle can help identify its location, appearance, and/or function Origins & Insertions • Origin beginning point of muscle attachment usually remains stationary – bone that moves little or not at all usually proximal on limb • Insertion end point of muscle attachment usually moves – bone that moves usually distal on limb Actions • Actions include flexion, extension, adduction, etc • In terms of bone affected textbook ex: “flexion of the forearm” • In terms of joint affected professional ex: “flexion of the elbow” Primary Actions • Agonist – prime mover muscle chiefly responsible for a movement Ex: biceps brachii flexes elbow • Antagonist – prime mover muscle chiefly responsible for the opposite action of the agonist Ex: triceps brachii extends elbow Primary Actions • Synergist – assists action of prime mover agonist or antagonist aid in action of prime mover fixator - stabilizes origin of prime mover by preventing competing movement at a joint Naming Skeletal Muscles • Fascicle organization rectus = straight: fascicles parallel to long axis of body transversus = across: fascicles perpendicular to long axis of body obliquus = oblique: fascicles angled to long axis of body • Location brachii = arm femoris = thigh Naming Skeletal Muscles • Relative position externus, extrinsic, superficialis = outer body surface internus, intrinsic, profundus = beneath the body surface • Structure biceps = 2 tendons of origin quadriceps = 4 tendons of origin • Shape deltoid = triangular orbicularis = circular Naming Skeletal Muscles • Size & length longus & longissimus = long & longest (respectively) vastus = large teres = long & round brevis = short magnus, major, & maximus = big, bigger, & biggest (respectively) minor & minimus = smaller & smallest (respectively) Naming Skeletal Muscles • Position relative to body axis anterior = front posterior = back lateralis = toward side medialis = toward midline • Origin & insertion sternohyoid = origin on sternum, insertion on hyoid bone Naming Skeletal Muscles • Action flexor = causes flexion extensor, tensor = causes extension depressor = causes lowering of body part buccinator = trumpeter (muscle that purses lips) sartorius = tailor-like (muscle that allows crossing of legs) Muscular System • Divisions of the Muscular System axial musculature positions head & spinal column moves rib cage 60% of all muscles appendicular musculature stabilizes & moves the arms & legs 40% of all muscles Axial Muscles • Muscles of the head & neck • Muscles of the spine • Oblique & rectus muscles • Muscles of the pelvic floor Learning Objectives • Axial Muscles: Identify the principal axial muscles of the body together with their origins, insertions, actions, & innervation Muscles of the Head & Neck • • • • • • • • orbicularis oris orbicularis oculi oculomotor muscles zygomaticus major & minor buccinator masseter sternocleidomastoid platysma Muscles of the Face Oculomotor Muscles Muscles of the Torso • • • • • • scalenes external intercostals internal intercostals external oblique rectus abdominis diaphragm Appendicular Muscles • Muscles of the shoulders & upper limbs • Muscles of the lower limbs • Musculoskeletal compartments Learning Objectives • Appendicular Muscles: Identify the principal appendicular muscles of the body together with their origins, insertions, actions, & innervation Compare the major muscle groups of the upper & lower limbs & relate their differences to their functional roles Muscles of the Shoulder • • • • • • trapezius serratus anterior pectoralis minor pectoralis major latissimus dorsi deltoid Muscles of the Upper Limb • • • • • triceps brachii biceps brachii brachioradialis brachialis extensor muscles (general locus) • flexor muscles (general locus) Muscles of the Anterior Thigh • • • • • • rectus femoris vastus lateralis vastus medialis vastus intermedius sartorius gracilis quadriceps femoris Muscles of the Anterior Thigh Muscles of the Lateral & Posterior Thigh • • • • • tensor fasciae latae gluteus maximus semitendinosis biceps femoris semimembranosis hamstrings Muscles of the Lower Leg • gastocnemius – calcaneal tendon (Achilles tendon) • • • • soleus tibialis anterior peroneus longus peroneus brevis Muscles of the Anterior Lower Leg Musculoskeletal Compartments Muscular System Overview