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SKELETAL – attached to bone/voluntary CARDIAC – heart/ involuntary SMOOTH – other organs/involuntary 1. 2. 3. Producing body movements Stabilizing body positions Generating heat Organs Wrapped in connective tissue ◦ Extends to form tendons – attaches muscle to bone Fascicles: bundles of muscle fibers (cells). Connective tissue around each fascicle. Long, skinny cylinders – a cell Cytoplasm = glycogen Contains myofibrils ◦ Thin (actin) and thick (myosin) filaments inside Muscle surrounded by connective tissue. Inside are many bundles (surrounded by connective tissue). Many muscle fibers inside bundle (fascicles) Inside muscle fiber are myofibrils Filaments inside myofibrils What triggers it? A neuron connects to a muscle fiber [called the neuromuscular junction (NMJ)] Arrival of nerve impulse causes release of acetylcholine (ACh: a neurotransmitter – a chemical). ACh diffuses to receptors on muscular membrane, opening a Na+ ion channel, causing Na+ to enter the muscle fiber. Changes electrical conditions and produces an action potential (electrical current) Action potential triggers : ◦ Unblocks actin (thin) so myosin (thick) heads can bind to them ◦ Filaments slide past one another, shortening the muscle (Sliding filament mechanism) What triggers a muscle contraction? What is the location called where a neuron connects with a muscle? Does a muscle contraction mean it gets longer or shorter? Do muscle fibers fold or slide to get shorter? Botulinum toxin from bacterium Clostridium botulinum blocks exocytosis of ACh ◦ BOTOX Muscle fibers: all-or-none Strength of muscle contraction: depends on # of contracting fibers Affects energy usage ◦ Energy = capacity to do work ◦ Types: chemical, mechanical, heat, electrical ATP broken down during contraction Store little ATP, must produce it 3 ways: ◦ Aerobic respiration: slow, requires O2, lots ATP made ◦ Anaerobic glycolysis and lactic acid formation: faster, no O2 needed, less ATP made ◦ Creatine phosphate and ADP: CP not found in other cells, very fast, doesn’t last No contraction even with stimulation occurs from oxygen debt (lactic acid builds up and ATP runs low) The more oxygen your body can take in and use determines your endurance The reaction of creatine phosphate and ADP generates ATP quickly or slowly? The ability of your body to use oxygen to produce ATP is _____ respiration. True or False: The strength of a muscle contraction is determined by the amount of muscle fibers that are contracting. Why are some people better at endurance activities? Why are some people FAST? Is it genetic? Is it training? 1. Slow oxidative fibers 2. Fast oxidative-glycolytic fibers 3. Fast glycolytic fibers ◦ Little power (small in diameter); fatigue resistant; many mitochondria. Adapted for maintaining posture & endurance activities ◦ Intermediate in diameter, faster than #1 but briefer in duration. Adapted for: walking/sprinting ◦ Large diameter (contract strongly/quickly); tire quickly; large amount lactic acid build up ◦ Short, rapid, intense movement ◦ Adapted for intense anaerobic movements of short duration: weight lifting/throwing a ball Muscles are a combo of different fibers Proportion of fibers is individual Muscles tug on tendons which pull on bones One bone is pulled towards another Insertion towards origin Origin stays still Most cross a joint Flexion – decreases angle of joint Extension – increases joint angle. Past 180 is hyperextension Rotation – around the longitudinal axis Abduction – moving limb away from body midline Adduction – moving limb towards midline Circumduction – whole limb outlines a cone (circular)