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Epinephrine Hepatocytes vs. Myocytes By Elisabeth Harrell 5/24/2017 1 • Epinephrine acts to increase the breakdown of glycogen in liver and muscle tissues and its conversion to glucose • In the liver, the glucose exported to blood circulation • In muscles, the glucose enters glycolysis for conversion to energy 5/24/2017 2 Page 607 The glycogen targeting protein GM in a glycogen granule can be phosphorylated at two different sites. When phosphorylated by the action of PKA resulting from the action of epinephrine on a cell, glycogen phosphorylase is released from inhibition. 5/24/2017 3 Page 429 Action of epinephrine in hepatocytes Page 604 Action of epinephrine in myocytes 4 Footer Text 5/24/2017 5 Two pathways for epinephrine to activate Glucogen Phosphorylase in hepatocytes The first uses adenylate cyclase cAMP PKA phosphorylase kinase a The second uses phospholipase C IP3 + DAG Ca2+ phosphorylase kinase b 5/24/2017 6 Epinephrine can have either a stimulatory or inhibitory effect on muscle action It has a stimulatory on -adrenergic receptors It has an inhibitory effect on -adrenergic receptors 5/24/2017 7