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Chapter 6: Muscular System Anatomy & Physiology Kasprowicz The essential function of muscle is contraction – making it responsible for almost all body movement. Types of Muscle 1) Skeletal 2) Cardiac 3) Smooth Types of Muscle • muscle cells are elongated = muscle fibers (smooth, skeletal) • contain myofilaments (ability to contract) • terminology: myo-, mys- = muscle sarco- = flesh General Muscle Characteristics 1) 2) 3) 4) Very large, multinucleated cells Striated (visible stripes or banding pattern) Voluntary (conscious) control; can be reflexive too muscle fibers (cells) are bundled together by strong connective tissues exert great force, but tire easily Skeletal Muscle Deep fascia Connective Tissues in Skeletal Muscle Endomysium – around single muscle fiber Perimysium – around a fascicle (bundle) of fibers Epimysium – covers the entire skeletal muscle Deep Fascia – on the outside of the epimysium Connective Tissues in Skeletal Muscles Connective Tissues in Skeletal Muscle tendon – dense connective tissue attaching muscle to bone (cord-like) aponeuroses – attach muscles indirectly to bone,cartilages or connective tissue coverings (sheetlike) Epimysium blends into a connective tissue attachment Connective Tissues in Skeletal Muscles Connective Tissues in Skeletal Muscles Aponeurosis of the external oblique Connective Tissues in Skeletal Muscles Refer to pg. 272 in your textbook Connective Tissues in Skeletal Muscles Spindle-shaped cells with one nucleus 2) no striations 3) Involuntary (no conscious control) 4) Found in hollow visceral organs 5) Have small amount of endomysium 1) Smooth Muscle 6) 7) slow, sustained, tireless movement often layers in opposite directions Smooth Muscle Smooth Muscle: Stomach Wall Branching cells with one nucleus connected by intercalated discs 2) Striated 3) Involuntary (no conscious control) 4) small amounts of endomysium 1) Cardiac Muscle 5) Cardiac fibers are arranged in spiral or 8shaped bundles Cardiac Muscle 1) Producing movement 2) Maintaining posture 3) Stabilizing joints 4) Support soft tissues 5) Generating heat 6) Guard entrances and exits Muscle Functions Muscle Functions Skeletal Muscle Fiber (Cell) Formation Skeletal Muscle Fiber (Cell) Formation Cells are multinucleate Nuclei are just beneath the sarcolemma (1) sarcolemma - specialized plasma membrane of muscle cells Microscopic Anatomy of Muscle (2) Cytoplasm filled with myofibrils myofibrils – perfectly aligned, ribbonlike organelles; give muscle fiber its striped appearance Microscopic Anatomy of Muscle (2) Cytoplasm filled with myofibrils A closer look at the myofibril Light (I) bands Dark (A) bands Microscopic Anatomy of Muscle (2) Cytoplasm filled with myofibrils Banding Pattern: Light (I) bands contain the Z disc Dark (A) bands contain the H zone M line - holds adjacent filaments together; center of H zone Microscopic Anatomy of Muscle An even closer look at the myofibril… (3) Sarcomere - contractile unit of the myofibril - Z disc to Z disc Microscopic Anatomy of Muscle An even closer look at the myofibril… (3) Sarcomere Microscopic Anatomy of Muscle Zooming in on the sarcomere… (4) Myofilaments - special proteins that cause muscle to contract Two Types: a) myosin (thick filament) b) actin (thin filament) Microscopic Anatomy of Muscle Two Types: a) myosin (thick filament) protein with heads that form cross bridges b/t thick & thin filaments during muscle contraction Contain ATPase enzymes Microscopic Anatomy of Muscle Two Types: b) actin (thin filament) Made of the contractile protein actin & some other regulatory proteins Microscopic Anatomy of Muscle Zooming in around the H zone…. Microscopic Anatomy of Muscle (5) Sarcoplasmic reticulum (SR) specialized smooth ER surrounding each myofibril stores calcium which is released when muscle is stimulated to contract Microscopic Anatomy of Muscle Sarcoplasmic reticulum (SR) Microscopic Anatomy of Muscle Sarcoplasmic reticulum (SR) Microscopic Anatomy of Muscle Microscopic Organization of Muscle: Level 1 (refer to Fig. 10-6, pg. 278) Let’s put this all together…. Microscopic Organization of Muscle: Level 2 Let’s put this all together…. Microscopic Organization of Muscle: Level 3 Let’s put this all together…. Microscopic Organization of Muscle: Level 4 Let’s put this all together…. Microscopic Organization of Muscle: Level 5 Let’s put this all together…. Skeletal Muscle Activity: Initiating the Contraction Irritability – ability to receive and respond to a stimulus (a property shared with neurons) Contractility – ability to shorten when an adequate stimulus is received Special Functional Properties of Muscle Skeletal muscles must be stimulated by a nerve to contract (motor neuron). Quick Review of Neurons & Synapses Quick Review of Neurons & Synapses Quick Review of Neurons & Synapses Motor unit: One neuron & the muscle cells stimulated by that neuron Nerve Stimulus to Muscle Neuromuscular junctions the neuron & muscle fibers do NOT touch separated by a gap called the synaptic cleft which is filled w/ interstitial fluid Nerve Stimulus to Muscle Neuromuscular junctions Nerve Stimulus to Muscle Neurotransmitters chemical released by neurons used to “carry” the impulse across the synaptic cleft Acetylcholine (ACh) is the neurotransmitter used at the neuromuscular junction of skeletal muscle Transmission of Nerve Impulse to Muscle Steps in Impulse Transmission ACh is released by the pre-synaptic axon terminal of the motor neuron ACh crosses the synaptic cleft & attaches to receptors on the sarcolemma Sarcolemma becomes permeable to sodium (Na+) Transmission of Nerve Impulse to Muscle Steps in Impulse Transmission Sodium floods into the cell generating an action potential (electrical current) Once started, muscle contraction cannot be stopped !! ACh is broken down by the enzyme acetylcholinesterase This prevents continued contraction of the muscle cell in the absence of additional nerve impulses. Transmission of Nerve Impulse to Muscle Steps in Impulse Transmission When an action potential sweeps along the sarcolemma and a muscle cell is excited, calcium ions are released from the sarcoplasmic reticulum Transmission of Nerve Impulse to Muscle Steps in Impulse Transmission The flood of Ca+ ions is the final trigger for the contraction of the muscle Transmission of Nerve Impulse to Muscle Skeletal Muscle Activity: Sliding Filament Theory of Muscle Contraction Sliding Filament Theory: Overview Myosin heads form cross bridges with binding sites on actin Myosin heads detach & then bind to the next site on actin Resting Sarcomere Sarcomere Contracts Mechanism of Muscle Contraction Sliding Filament Theory: Overview This action continues, causing the myosin & actin to slide past each other Resting Sarcomere Sarcomere Contracts Mechanism of Muscle Contraction Sliding Filament Theory: Overview Collective shortening of Resting Sarcomere the muscle cell sarcomeres = muscle contraction Sarcomere Contracts Mechanism of Muscle Contraction Step 1: Ca+ ions released from the SR attach to the troponintropomyosin complex Binding sites on the actin filament are exposed The Contraction Cycle : The Nitty Gritty Step 1: The Contraction Cycle : The Nitty Gritty Step 2: myosin heads attach to actin binding sites, forming cross bridges ATP was required to prep the myosin head (ATP ADP + P) The Contraction Cycle : The Nitty Gritty Step 2: The Contraction Cycle : The Nitty Gritty Step 3: ADP + P released from myosin head myosin head flexes/pivots = “power stroke” The Contraction Cycle : The Nitty Gritty Step 3: The Contraction Cycle : The Nitty Gritty Step 4: ATP binds to myosin head, causing it to detach from the actin filament The Contraction Cycle : The Nitty Gritty Step 5: myosin head re-energized (ATP ADP + P) Step 6: Ca+ ions pumped back into the SR troponin-tropomyosin complex moves back to its original position The Contraction Cycle : The Nitty Gritty The Contraction Cycle : The Nitty Gritty The Contraction Cycle : The Nitty Gritty Muscle Contraction Animations http://www.mhhe.com/biosci/bio_animations/09_MH_MuscleContraction_Web/index.html Muscle Contraction 3-D Animation http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter10/animation__action_potentials_and_muscle_contraction.html Action Potentials & Muscle Contraction https://highered.mcgrawhill.com/sites/0072495855/student_view0/chapter10/animation__breakdown_of_atp_and_crossbridge_movement_during_muscle_contraction.html Break Down of ATP & Cross Bridge Attachment https://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter10/animation__sarcomere_contraction.html Sarcomere Contraction The “all-or-none” response of muscle contraction refers to the muscle cell, NOT the whole muscle Whole muscle reacts with a graded response (different degrees of shortening) Contraction of the Whole Muscle Graded responses are produced in 2 ways: 1) Change the frequency of stimulation 2) Change the # of muscle cells stimulated/time - more activated muscle cells stronger FORCE of contraction Contraction of the Whole Muscle Changing Stimulation Frequency 1 Muscle Twitch – 1 stimulus; single, brief, jerky contraction Contraction of the Whole Muscle Changing Stimulation Frequency 2 Wave Summation– frequency of stimulus increases; less time to relax; contraction strength “summed” Contraction of the Whole Muscle Changing Stimulation Frequency 3 Incomplete Tetanus – frequency of stimulation increases even more Contraction of the Whole Muscle Changing Stimulation Frequency 4 Tetanus – frequency of stimulation very rapid; no evidence of relaxation; smooth, sustained contraction Contraction of the Whole Muscle Initially, muscles used stored ATP for energy ATP is hydrolyzed into ADP + P Only 4-6 seconds worth of ATP is stored by muscles After this, other metabolic pathways must be used to produce ATP Energy for Muscle Contraction Pathway 1: Direct Phosphorylation Muscle cells contain creatine phosphate (CP) CP is a high-energy molecule that transfers energy to ADP, regenerating ATP CP supplies are exhausted in about 20 seconds Energy for Muscle Contraction Pathway 1: Direct Phosphorylation Energy for Muscle Contraction Pathway 2: Anaerobic Respiration (a.k.a. lactic acid fermentation) breaks down glucose without oxygen Glucose is broken down to pyruvic acid; 2 ATP are produced Pyruvic acid lactic acid Energy for Muscle Contraction Pathway 2: Anaerobic Respiration (lactic acid fermentation) Energy for Muscle Contraction Pathway 2: Anaerobic Respiration This reaction is not as efficient, but it is fast Huge amounts of glucose are needed Lactic acid produces muscle fatigue Duration: 30-60 seconds Energy for Muscle Contraction Pathway 3: Aerobic Respiration Series of metabolic pathways that occur in the mitochondria & require oxygen Glucose is broken down to carbon dioxide and water releasing energy This is a slower reaction that requires continuous oxygen High energy pay-off: 36 ATP Energy for Muscle Contraction Pathway 3: Aerobic Respiration Energy for Muscle Contraction When a muscle is fatigued, it is unable to contract The common reason for muscle fatigue is oxygen debt Oxygen must be “repaid” to tissue to remove oxygen debt Oxygen is required to get rid of accumulated lactic acid Increasing acidity (from lactic acid) and lack of ATP causes the muscle to contract less Muscle Fatigue & Oxygen Debt Isotonic Muscle Contraction The myofilaments slide past each other muscle shortens movement occurs Examples: bending knee, rotating the arms, smiling Types of Muscle Contraction Isometric Muscle Contraction muscle is not able to shorten muscle tension keeps increasing Examples: lifting a 1000 lb. object alone; pushing against an object that doesn‘t move Types of Muscle Contraction state of continuous partial contractions Different fibers contract at different times to provide muscle tone muscle remains firm, healthy & ready for action Increasing muscle tone increases metabolic energy used, even at rest Muscle Tone Muscle Tone If the nerve supply to a muscle is destroyed, the muscle is no longer stimulated in this manner, and it loses tone and becomes paralyzed. Soon after, it becomes flaccid (soft and flabby) and begins to atrophy (waste away). Muscle Tone Muscle Tone “use it or lose it” Aerobic (Endurance) Exercise Examples: jogging, biking, swimming stronger, more flexible muscles w/ greater resistance to fatigue Effects of Exercise Aerobic (Endurance) Exercise Physiological Effects 1) increased blood supply to muscles 2) more mitochondria 3) increased metabolism 4) keeps bones strong 5) improves neuromuscular coordination Effects of Exercise “use it or lose it” Resistance (Isometric) Exercise Examples: weight training increased muscle size and strength Effects of Exercise Aerobic (Endurance) Exercise Physiological Effects 1) increased # of myofilaments increased size of muscle fibers 2) more connective tissue 3) keeps bone strong Effects of Exercise 1) All (almost ) skeletal muscle cross a least one joint 2) Most of a skeletal muscle lies proximal to the joint crossed 3) All skeletal muscles have at least 2 attachments: the origin and the insertion 4) Skeletal muscles can only PULL (create tension) 5) When a muscle contracts, the insertion moves toward the origin “Golden Rules” of Skeletal Muscle Activity Movement occurs when a muscle contracts and moves an attached bone Muscles are attached to at least two points Origin – attachment to a immoveable bone Insertion – attachment to an movable bone Types of Body Movements When a skeletal muscle contracts, its insertion moves toward its origin Types of Body Movements prime mover – muscle primarily responsible for a certain movement Example: biceps, hamstrings (a.k.a. agonist) Antagonist – muscle that opposes or reverses a prime mover Triceps when biceps flexes; quads when hamstrings flex Body Movements: Muscle Interactions Prime Mover – biceps Antagonist – triceps Prime Mover – triceps Antagonist – biceps Synergist – muscle that aids a prime mover in a movement and helps prevent rotation Example: finger flexor muscles brachioradiulus & brachialis in the forelimb Body Movements: Muscle Interactions 1) Flexion decreases angle of joint, bringing 2 bones closer together common in hinge, ball & socket joints 2) Extension increases the angle of a joint, moving the bones apart hyperextension >180° angle Types of Body Movements Hyperextension Flexion & Extension Flexion & Extension 3) Rotation movement of a bone around its longitudinal axis common in ball & socket joints atlas (C1) around the axis (C2) Types of Body Movements Rotation 4) Abduction movement of a limb away from the medial plane also used to refer to fanning of finger or toes 5) Adduction movement of a limb toward the midline Types of Body Movements Abduction & Adduction Abduction & Adduction 6) Circumduction proximal end is stationary; distal end moves in a circle limb moves in a cone shape common in ball & socket joint combo of flexion, extension, abduction & adduction Types of Body Movements Circumduction 1) Dorsiflexion (point toes up towards shin) & Plantar Flexion (pointing the toes) Special Body Movements 2) Inversion (turn sole of foot medially) & Eversion (turn sole of foot laterally) Special Body Movements 3) Supination & Pronation movements of the radius around the ulna supination: palm forward; radius & ulna are parallel (anatomical position); thumb lateral pronation: palm facing back; radius crosses ulna; thumb medial Special Body Movements 3) Supination & Pronation Special Body Movements 4) Opposition movement of thumb across palm to touch fingertips Special Body Movements Elevation & Depression Protraction & Retraction 1) Direction of muscle fibers in reference to an imaginary line (midline of body, long axis of limb) ie. Rectus (fibers parallel to line) Oblique (fibers at a slant to line) Naming Skeletal Muscles 2) Relative Size Longus = long Longissimus = longest Teres = long and round Brevis = short Magnus = large Major = larger Maximus = largest Minor = small Minimus = smallest Naming Skeletal Muscles 3) Location of the Muscle in reference to the associated bone ie. temporalis (temporal bone) frontalis (frontal bone) Naming Skeletal Muscles 4) Number of origins ie. biceps, triceps, quadriceps 5) Location of the muscle’s origin and insertion ie. Sternocleidomastoid muscle Naming Skeletal Muscles 6) Shape of the muscle ie. Deltoid (triangular) 7) Action of the muscle ie. adductor muscle, extensor muscle Naming Skeletal Muscles Head & Neck Muscles Facial Muscles • Frontalis raises eyebrows and wrinkles the forehead • Orbicularis Oculi close, squint, blink and wink the eyes • Orbicularis Oris closes the mouth and protrudes the lips; the “kissing” muscle Head and Neck Muscles • Buccinator flattens the cheek (whistling or playing a trumpet); also a chewing muscle • Zygomaticus “smiling” muscle; raises the corners of the mouth upward Head and Neck Muscles Chewing Muscles • Buccinator • Masseter closes the jaw by elevating the mandible (prime mover) • Temporalis helps masseter close the jaw (synergist) Head and Neck Muscles Frontalis Temporalis Orbicularis oculi Zygomaticus Orbicularis oris Buccinator Masseter Temporalis Frontalis Orbicularis oculi Orbicularis oris Masseter Zygomaticus Buccinator Frontalis Temporalis Orbicularis oculi Zygomaticus Buccinator Orbicularis oris Masseter Neck Muscles • Platysma pulls down corners of the mouth, downward sag of the mouth • Sternocleidomastoid two-headed muscle; flex your neck (bowing of head); tilt head to side Head and Neck Muscles Frontalis Temporalis Orbicularis oculi Zygomaticus Orbicularis oris Masseter Buccinator Platysma Sternocleidomastoid Frontalis Temporalis Orbicularis oculi Orbicularis oris Masseter Zygomaticus Buccinator Sternocleidomastoid Plastysma Frontalis Temporalis Orbicularis oculi Zygomaticus Buccinator Orbicularis oris Sternocleidomastoid Masseter platysma Trunk Muscles • move the vertebral column (mostly posterior, anti-gravity muscles) • anterior thorax muscles (move ribs, head & arms) • muscles of the abdominal wall (help move vertebral column & form the “girdle” holding internal organs in place) Trunk Muscles Anterior Muscles: Thorax • Pectoralis Major - fan-shaped muscle - origin: sternum, pectoral girdle, ribs - insertion: humerus - adduct & flex the arm Trunk Muscles Pectoralis major Pectoralis minor Anterior Muscles: Thorax • Intercostal Muscles - deep muscles between the ribs - aid in breathing (external – inhale, internal – forcible exhale) Trunk Muscles Internal intercostals External intercostals Anterior Muscles: Abdominal Girdle • Rectus abdominus - pubis to rib cage - flex the vertebral column - compression of abdominal contents Trunk Muscles Anterior Muscles: Abdominal Girdle • External Oblique - lateral walls of abdomen - origin: ribs insertion: illium - flex the vertebral column, rotate/bend trunk Trunk Muscles Anterior Muscles: Abdominal Girdle • Internal Oblique - origin: iliac crest insertion: ribs - function same as external oblique • Transversus abdominis - deepest muscle in abdomen - fibers run horizontally - compresses the abdominal contents Trunk Muscles Posterior Muscles • Trapezius - kite-shaped muscle - origin: occipital bone to last thoracic vertebrae insertion: scapula & clavicle - head extension & movement of scapula Trunk Muscles Posterior Muscles • Latissimus Dorsi - 2 large, flat muscles in the lower back - origin: lower spine & ilium insertion: proximal end of humerus - arm extension & adduction (“power stroke”) Trunk Muscles Posterior Muscles • Erector Spinae - prime mover of back extension (keep your body “erect”); control bending at the waist - paired; deep in the back - span vertebral column Trunk Muscles Posterior Muscles • Qudratus lumborum - posterior abdominal wall - flex spine laterally, extend vertebral column - origin: iliac crest insertion: upper lumbar vertebrae Trunk Muscles Posterior Muscles • Deltoids - triangular muscle forming shoulder - origin: spine of scapula to clavicle insertion: proximal humerus - prime mover of arm abduction Trunk Muscles • The anterior arm muscles cause elbow flexion strongest: brachialis biceps brachii “weakest”: brachioradialis • posterior arm: triceps brachii Muscles of the Upper Limb Anterior Arm Muscles • Biceps brachii - origin: 2 heads in pectoral girdle insertion: radius - prime mover of forearm flexion & supination Muscles of the Upper Limb Anterior Arm Muscles • Brachialis - origin: humerus - forearm flexion insertion: ulna • Brachioradialis - origin: humerus insertion: distal forearm Muscles of the Upper Limb Posterior Arm Muscles • Triceps brachii - origin: 3 heads in pectoral girdle insertion: olecranon process of ulna - prime mover of elbow extension - biceps brachii antagonist Muscles of the Upper Limb • cause movement of hip, knee & foot joints • some of the largest, strongest muscles in the body • specialized for walking & balance • many of the muscles cross 2 joints and can cause movement at both Muscles of the Lower Limb Muscles that Move the Hip Joint • Gluteus Maximus - forms most of the flesh of the buttock - origin: sacrum & illiac insertion: femur & iliotibial tract - hip extensor (important when climbing and jumping) Muscles of the Lower Limb Muscles that Move the Hip Joint • Gluteus Medius - beneath gluteus maximus - hip abductor; steadies pelvis when walking • Iliopsoas (two, fused muscles) - prime mover of hip flexion; keeps upper body from falling backward when standing Muscles of the Lower Limb Muscles that Move the Hip Joint • Adductor Muscles - group of muscles; medial thigh - adduct, or press, thighs together - origin: pelvis insertion: femur - tend to get flabby Muscles of the Lower Limb Iliopsoas Adductor muscles Anterior View Gluteus medius Gluteus maximus Adductor magnus Iliotibial tract Posterior View Muscles that Move the Knee Joint • Hamstring Group - group of muscles; posterior thigh - biceps femoris, semimembranosus, semitendinosus - origin: ischium insertion: tibia - prime movers of thigh extension & knee flexion Muscles of the Lower Limb Muscles that Move the Knee Joint • Sartorius - thin, strap-like, relatively weak flexor - most superficial thigh muscle - synergist in sitting “criss cross applesauce” Muscles of the Lower Limb Muscles that Move the Knee Joint • Quadriceps Group - group of muscles; anterior thigh - rectus femoris & 3 vastus muscles - origin: pelvis & thigh insertion: tibia via patellar ligament - prime movers of knee extension; hip flexion Muscles of the Lower Limb Iliopsoas Q U A D S Sartorius Iliopsoa Rectus femoris s Adductor muscles Vastus lateralis Vastus medialis Anterior View Posterior View Muscles that Move the Ankle & Foot • Tibialis Anterior - superficial muscle of anterior leg (shin) - origin: tibia insertion: tarsals - dorsiflex & invert the foot • Fibularis Muscles - plantar flexion and eversion - origin: fibula insertion: metatarsals Muscles of the Lower Limb Muscles that Move the Ankle & Foot • Gastrocnemius - forms curved calf; 2 parts - origin: femur insertion: heel using Achille’s tendon - prime mover of plantar flexion Muscles of the Lower Limb Muscles that Move the Ankle & Foot • Soleus - deep to gastrocnemius - origin: tibia & fibula (no effect on knee) insertion: heel using Achille’s tendon - plantar flexion Muscles of the Lower Limb Posterior View Anterior View