Download Dr Sinéad Corr

Dr Sinéad Corr
Short CV
2002-2006 Ph.D Molecular Microbiology (Investigation of the interaction of Listeria
monocytogenes with the gastrointestinal epithelium), Alimentary Pharmabiotic Centre &
Department of Microbiology, University College Cork.
2006-2008 Postdoctoral Research Fellow, IBD early drug discovery, Alimentary
Pharmabiotic Centre & Galaxosmithkline, University College Cork.
2008-2012 Postdoctoral Research Fellow, Inflammation Research Group, School of Biochemistry &
Immunology, Trinity College Dublin.
2012-2015 Senior Research Fellow, Immunology, Trinity College Dublin.
2012-present Starting Investigator Research Grant (SFI)
2015-present Assistant Professor in Microbiology & Prinicpal Investigator Host-Microbe Interface Group,
Department of Microbiology, Trinity College Dublin.
Research
My research interests lie at the host-microbe interface within the gastrointestinal tract. This work focusses
on understanding the molecular mechanisms which govern the interplay that occurs between pathogenic
bacteria, the microbiota and the host organism, namely the epithelial barrier and innate immunity. The
subsequent maintenance of health or development of disease is of particular interest. Gastroenteritis,
including bacterial infectious diseases, are a major cause of morbidity and mortality worldwide, while
inflammatory bowel diseases (IBDs) affect over 2 million people in Europe. Our work hopes to characterize
the host mechanisms which mediate gut health in response to infectious and resident microbes and to
determine how microbes can alter this intestinal homeostasis giving rise to disease. This will enable strategic
manipulation of intestinal epithelial defences or probiotic treatment strategies with the ultimate goal of
reducing the severity of intestinal infectious and inflammatory diseases.
Selected Publications
Corr, S.C., Palsson-McDermott, E.M, Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.,
Keely, S.J., Dandekar, S., Fallon, P.G. and O’Neill, L.A. MyD88 adaptor-like (Mal) functions in the epithelial
barrier and contributes to intestinal integrity via protein kinase C. Mucosal Immunol. 2013 Apr 24.
doi:10.1038/mi.2013.24.
Corr, S.C., Aubry, C., Wienerroither, S., Goulard, C., Jones, R., Jamieson, A., Decker, T., O’Neill, L.A.,
Dussurget, O. and Cossart, P. Both TLR2 and TRIF contribute to interferon-β production during Listeria
infection. PloS One 2012 7(3):e33299
Corr, S.C. and O’Neill, L.A. Genetic Variation in TLR signalling and the risk of inflammatory and immune
diseases. J. Innate Immun. 2009 1(4):350-357.
Corr, S.C., Li, Y., Riedel, C.U., O’Toole, P.W., Hill, C. and Gahan, C.G. From the Cover: Bacteriocin production
as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118. Proc. Natl. Acad. Sci. U.S.A.
2007 104(18):7617-7621.
Corr, S.C., Gahan, C.G. and Hill, C. Impact of selected Lactobacillus and Bifidobacterium species on Listeria
monocytogenes infection and the mucosal immune response. FEMS Immunol. Med. Microbiol. 2007
50(3):380-388.
Contact
Department of Microbiology,
The Moyne Institute of Preventive Medicine,
Trinity College Dublin,
Dublin 2,
Ireland
Tel: +353 1 8961195; E-mail: [email protected]