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Disease Disease - Any change, other than an injury, that interferes with normal functioning of the body Pathogen – a disease-causing microorganism Infection – when a body is successfully invaded by a pathogen Infectious disease – a disease that can be transmitted from person to person, or animal to person, or insect to person, etc. How do diseases spread? It depends on the disease Air, wounds, contaminated water, food, infected animals, insects, sex, etc. Germ Theory Before the theory (mid-1800s), people believed that disease was caused by bad luck or evil spirits Germ theory states that microorganisms cause disease Louis Pasteur – first scientist to create a vaccine Anton VanLeeuenhook – invented the microscope, could see microscopic organisms for the first time Viruses Virus – non-cellular, non-living Invade the host cells (humans) and use those cells to reproduce themselves – CANNOT do this without the host Hard to “cure”, but vaccines help to prevent the disease Bacteria Single cells Prokaryotes Most bacteria are harmless Can cause disease by killing your cells, producing toxins, or invading your cells like a virus Many can be killed with antibiotics Fungus Mushrooms and molds are harmless examples Most fungi are harmless Athlete’s foot, ring worm and San Joaquin Valley Fever are examples of fungal diseases Protozoa Single celled eukaryotes Most common in humid regions of the world Malaria – caused by Plasmodium (infects red blood cells) Hard to cure because protozoa are similar to our cells, so drugs that kill them, also kill our own cells Helminths (worms) Enter through human digestive tract or skin Can be ingested: trichinosis (under cooked pork), guinea worm disease (contaminated water), Can enter through skin: schistosoma (schistosomiasis) – through snail infested water, Filaria worms cause elephantiasis – from mosquito bites Classifying disease Emerging – apparently “new” diseases Re-emerging – diseases that have recently increased in incidence after a period of decline Endemic – diseases that have remained relatively constant in incidence throughout recorded history Emergin g diseases Re-emerging diseases Endemic Diseases AIDS, Cholera, Ebola, influenza, legionnaire disease, lyme disease Tuberculosis, malaria, schistosomiasis Pneumonia, polio, guinea worm disease, plague, strep throat