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RT 210 A&P Cardiovascular Blood is Composed of Plasma & Cells Plasma About 90% water About 10% solutes Proteins Albumin Thickens blood Globulin Includes antibodies Fibrinogen & Prothrombin Necessary for clotting Blood is Composed of Plasma & Cells Plasma (cont) Energy Molecules Glucose Lipids Amino acids Blood is Composed of Plasma & Cells Plasmas (cont) Electrolytes use values from Egan text Sodium (Na+) Chloride (CL-) Bicarbonate (HCO3-) Potassium (K+) Calcium (Ca+) Magnesium (Mg+) Phosphate Sulfates Organic Acids Normal Electrolyte Values Sodium (Na+) 135-145 mEq/L Chloride (CL-) 96-105 mEq/L Bicarbonate (HCO3-) 22-26 mEq/L Potassium (K+) 3.5 - 5 mEq/L Calcium (Ca++) 4.25-5.25 mEq/L Magnesium (Mg++) 1.4-2.2 mEq/L Blood is Composed of Plasma & Cells Cells Erythrocytes- Red blood cells Produced in bone marrow Contain hemoglobin Normally 12-18gms Hb/100ml blood Normally higher in males Hematocrit approx. 3 * Hb (normally 40-50%) Hb carries O2 4.2-6.2 million RBCs per cubic mm Blood is Composed of Plasma & Cells Cells (cont) Leukocytes: White blood cells Eosinophils Basophils Function in the immune mechanism Polymorphonuclear neutrophils Phagocytes Lymphocytes Secrete heparin Mononuclear Monocytes Protects body from parasites & allergens Phagocytes Normally white count 5,000-10,000 white blood cells per cubic mm Blood is Composed of Plasma & Cells Cells (cont) Platelets Plays a role in clotting 150,000-400,000 per cubic mm Blood Makes Up the Intravascular Fluid There is fluid in the body in 2 other areas also Interstitial: between cells Intracellular: within cells Purpose of the Blood Transport respiratory gases Circulate defenses (Leukocytes) Nutrients to cells Remove wastes from cells Clotting Electrolytes Lab Norms RBC- Measures the total volume of RBCs Male 4.6 – 6.2 Million Female: 4.2 – 5.4 Million WBC: Measures the total volume of WBCs Male / Female: 5,000 - 10,000 Lab Norms DIFF: Percentage of which should add up to 100% Neutrophils – 40-75% Lymphocytes – 20-45% Monocytes – 2-10% Basophils – 0-1% Eosinophils – 0-6% Lab Norms HCT- Percentage of packed cell volume Male : 40-54% Female: 38-47% HGB: Measurement of amount of hemoglobin Male 14 - 18 gm Female: 12 - 14 gm SED Rate: Determines rate of fall in 1 hour of RBCs. Male : 0 - 10 mm Female: 0 - 20 mm Lab Norms Finger--Puncture: (Bleeding Time) Measures amount of time takes for blood to clot Male / Female: 2 - 9 Minutes Finger pinch check Pinch fingernail until it blanches Checks for cardiovascular integrity Lab Norms Finger--Puncture: (Bleeding Time) Measures amount of time takes for blood to clot Male / Female: 2 - 9 Minutes Finger pinch check Pinch fingernail until it blanches Checks for cardiovascular integrity Clinical Laboratory Studies Hematology Complete Blood Cell Count White Blood Cells Primary role is fighting infection. Five types: neutrophil, basophil, eosinophil, lymphocyte, and monocyte. Clinical Laboratory Studies WBC Differential Counts the number of each type of white cell present in a known volume of blood. Neutrophils normally make up 40% to 75% of the total white cell count. They are produced in the bone marrow and have a life span of about 10 days. Neutrophils are released into the circulating blood by the bone marrow when acute infection is present. Neutrophils contain enzymes that destroy bacteria. Clinical Laboratory Studies Eosinophils make up a very small part of the total white cell count normally. They account for zero to 6% of WBCs. Appear to help with allergic reactions Are present in the sputum of asthmatics in many cases Clinical Laboratory Studies Basophils also make up a small percent of the total WBC (zero-1%) Lymphocytes make up a significant portion of the WBC. They fight against viral, fungal, and tuberculosis infections. They make up 20% to 45% of the circulating WBC normally. Lymphocytes come in two types: T cells and B cells. T cells are important for antibody production and immunity. Clinical Laboratory Studies Monocytes make up 2% to 10% of the circulation WBC count. In the tissue the monocyte becomes a macrophage. Its primary role is phagocytosis of foreign material. White Blood Cell Abnormalities Leukocytosis is present when the total white cell count is elevated. Leukocytosis caused by neutrophils is known as neutrophilia. Neutrophilia is common with bacterial pneumonia and other infections. Acute neutrophilia caused by infection typically results in an increase in the immature neutrophils known as bands. This is called a left shift. Pseudoneutrophilia occurs when marginated cells are released into the circulation. This is common with acute trauma and stress. White Blood Cell Abnormalities Leukopenia is present when the total white cell count is reduced. Leukopenia caused by the lack of neutrophils is known as neutropenia. Neutropenia is common when the bone marrow fails or when a severe infection is present and neutrophils are destroyed faster than they are produced. Neutropenia is an ominous sign. White Blood Cell Abnormalities Lymphocytosis is present when the circulating lymphocytes are elevated in count. Caused by viral infections and infectious mononucleosis. Lymphocytopenia is seen with trauma and acute infection. Is common with HIV patients White Blood Cell Abnormalities Monocytosis is characteristic of chronic infections including tuberculosis (TB), syphilis, typhoid fever, and subacute bacterial endocarditis. It is a sign of active disease in TB patients. Red Blood Cells Produced in the bone marrow Have a life span of about 120 days Assume the shape of a biconcave disk to facilitate carrying oxygen Made up largely of hemoglobin The portion of the total blood volume made up by the formed elements such as red blood cells is known as the hematocrit. Red Blood Cells The amount of hemoglobin on the red cells is measured and reported as the hemoglobin count. Special red cell indices are determined to measure the size of the average red cell, and the amount of hemoglobin present in the average red blood cell of each patient. These indices are important to interpret when abnormalities are present. Red Blood Cells Red cell abnormalities Anemia is an abnormal decrease in the RBC count. Microcytic anemia indicates that the cells are too small. Hypochromic anemia is present when the cells have too little hemoglobin. Anemia with normal red cells is termed normochromic, normocytic anemia. It is common with acute blood loss. The most common cause of anemia is iron deficiency. Red Blood Cells Polycythemia is an abnormal increase in the red cell count. Primary polycythemia is uncommon but is due to bone marrow disease. Secondary polycythemia is common and often a result of chronic hypoxemia. Heavy smoking and COPD are common causes. Platelet Count Platelets are the smallest formed element in the blood. Serve an important role in blood coagulation The platelet count should be checked before arterial puncture by the RT. Coagulation Studies In addition to the platelet count, the bleed time, APTT, and PT/INR are used to measure the patient’s ability to clot the blood. These tests are particularly useful in monitoring heparin therapy in the patient being treated for pulmonary embolism. Obtaining Vital Signs and Clinical Impression The four classic vital signs are pulse, respiratory rate, body temperature, and blood pressure. Pulse oximetry results, sensorium, and ECG monitoring results are also often reported as well, as part of the vital signs. Frequency of Vital Sign Measurement Routine vital signs on stable patients are typically measured every 4 to 6 hours. They are usually recorded before and after each respiratory care treatment. Vital signs are measured more often when the patient’s condition may change abruptly such as immediately after surgery or any invasive procedure Trends in the Vital Signs A series of vital sign measurements over time establishes a trend and is far more important than a single measurement. Recording the vital signs on a graph allows better visualization of changes over time. Abrupt and gradual changes over time are important to note. Comparing Vital Sign Information Comparing the vital signs to other clinical findings such as chief complaints and other physical examination findings helps determine a more exact cause of the abnormalities. Height and Weight Height and weight are routinely measured as part of the initial physical examination and as part of every outpatient visit. They are often recorded in the patient chart in the same general location as the vital signs. General Clinical Presentation Part of the vital sign assessment is to document the patient’s general clinical presentation. This is determined by observation of the patient’s breathing pattern, facial expression, level of consciousness, nutritional status, etc. A single summary statement about the patient’s general presentation is included with the vital sign measurement for the initial evaluation of the patient. Level of Consciousness (Sensorium) Patients who are alert and oriented to time, place, and person are said to be “oriented × 3.” An abnormal sensorium is indicative of inadequate cerebral oxygenation. Glasgow Coma Scale (GCS) The GCS is one of the most popular tools used to document the patient’s level of consciousness. The GCS is the gold standard for assessing the neurologic function of patients. Temperature Normal body temperature is 37º C, or 97° to 99.5º F. Body temperature is maintained by the hypothalamus in the brain. The respiratory system plays a role in temperature balance by providing another method for heat release. Temperature Fever Fever is the abnormal elevation of body temperature due to disease. One of the most common causes of fever is infection. Patients with a poor immune system may not generate a fever when infection is present. Elevation of body temperature increases oxygen consumption and increases the demand for CO2 removal. This may be a problem in patients with lung disease. Hypothermia is present when the body temperature drops below normal. It is not common but is seen in patients with head injuries and those exposed to a cold environment. Temperature Measurement of Body Temperature Body temperature is measured at several sites. Rectal temperatures are not often used but may be measured in comatose patients. Axillary temperatures are popular for pediatric patients. Axillary temperatures run about one degree F below oral measurements. Oral temperature measurements are very popular. They are affected by recent oral ingestion of cold or hot liquids and food. Tympanic (ear) sites are common practice today especially in the outpatient settings. In most cases tympanic measurement of temperature run a few tenths of a degree below core temperature. Pulse Measurement of Pulse Rate Pulse is often measured by palpating the radial or brachial impulse. It should be measured for 30 seconds and the total multiplied by two. If the pulse is irregular, measuring it for 1 full minute is recommended. Rapid heart rate is tachycardia (>100 beats/min); slow heart rate is bradycardia (<60 beats/min). Pulse Pulse Rhythm and Pattern The pulse normally is very regular with only slight variations seen with breathing. Irregular pulse could be a sign of serious heart disease and should be investigated. The volume of the pulse is also important to note. Weak peripheral pulses are a sign of heart failure. Extreme drops in the strength of the pulse with inspiration are known as pulsus paradoxus. Respiratory Rate Measurement of Respiratory Rate The respiratory rate should be counted without the patient being aware of the measurement. Watching the patient’s chest move up and down while continuing to palpate the radial pulse is a good approach. Rapid respiratory rate is known as tachypnea. Slow respiratory rate is bradypnea Blood Pressure Arterial blood pressure has two components: the peak pressure that results during ventricular systole and the baseline pressure that occurs during ventricular diastole. The peak pressure is known as the systolic pressure and the resting pressure is the diastolic pressure. The difference between the systolic and diastolic pressures is the pulse pressure. Hypotension is present when the BP is below 90/60 mm Hg. Hypertension is present when the BP is 140/90 mm Hg. Blood Pressure Measurement of Blood Pressure Most commonly measured with a blood pressure cuff. The cuff is wrapped around the patient’s arm and inflated to a pressure believed to be higher than the patient’s systolic pressure. The cuff pressure is released slowly while monitoring a pressure monometer. The initial Korotkoff sound is the systolic pressure, and when the Korotkoff sounds disappear, the diastolic pressure is noted. Effects of the Respiratory Cycle on Blood Pressure Normally the changes in blood pressure with breathing are very slight. The systolic pressure drops slightly with normal inspiration. When it drops significantly with inspiration, pulsus paradoxus is present. This may be a sign of cardiac (e.g., cardiac tamponade) or respiratory problems (e.g., asthma The Heart Location Posterior to the sternum Superior to diaphragm To the left side The Heart Layers of the heart Pericardium - sac surrounding the heart Epicardium - exterior heart wall Endocardium - inner heart wall Myocardium – heart muscle The Heart Chambers of the heart (4) RA - right atria RV - right ventricle RA and RV – pulmonary circulation LA – left atria LV – left ventricle LA and LV – systemic circulation The Heart Valves of the heart Tricuspid - between RA and RV Pulmonary valve – between RV and pulmonary artery Bicuspid or mitral valve - between LA and LV Aortic valve – between LV and aorta The Heart Types of vessels Arteries – carries blood away from heart Veins –carries blood to heart Capillaries - between arteries and vein exceptions - pulmonary arteries and veins Circulation Pathway beginning with Superior and inferior vena cava Right atria Tricuspid valve Right ventricle Pulmonic valve Pulmonary artery Pulmonary capillaries oxygenation Pulmonary vein Left atria Mitral or bicuspid valve Left ventricle Aortic valve Aorta Pulse Reflects contraction of the left ventricle – systole Take pulse with fingers, not thumb Pulse sites Radial Carotid Femoral Temporal Ulnar Brachial Dorsalis pedis Blood Pressure Monitoring equipment Sphygmomanometer Column of mercury in a glass tube used to measure blood pressure sounds, as reflected through a stethoscope. The anometer is attached by hollow rubber tubing to the cuff. Stethoscope Ear pieces attached to an amplification diaphragm by hollow rubber tubing. Blood Pressure Procedure Stethoscope over brachial pulse point Inflate cuff until blood flow stops (no pulse) Slowly deflate cuff 1st sound is systolic blood pressure Change of muffling sound is diastole Blood pressure is always recorded in patient chart Spread of Infection Source Host Pathogens Transmission route Contact Airborne Droplet Vehicle Vector Spread of infection to the lungs Infection Control Strategies Decreasing host susceptibility Eliminating the source of pathogens Interrupting routes of transmission Equipment Processing Cleaning Disinfection Sterilization Cross contamination Equipment handling procedures Maintenance of in-use equipment Processing reusable equipment Disposable equipment Fluids and medications precautions Barrier Measures and Isolation Precautions CDC General Barrier measure (Standard Precautions) Handwashing Gloves Mask, eye protection or face shield Cover gown Isolation precautions Cardiac Cycling Pathway to Stimulation SA - sinoatrial node initiates at rate of 60-100 bpm AV - atrioventricular node or junction delays and delivers impulse from atria to ventricles Referred to as the pace maker of the heart Can act as a back up pace maker Rate of 40-60 bpm Bundle of His – divides into left & right bundle branches Left & right bundle branches Purkinje Fibers - dispense impulse to muscles Pathway to Stimulation Vagal nerve stimulation of the parasympathetic nervous system can slow heart rate Terminology Systole –contraction Diastole –relaxation Tachycardia - heart rate greater than 100 Bradycardia - heart rate less than 60 Electrophysiology Intracellularly elevated levels of potassium (K+) Extracellularly elevated levels of sodium (NA-) Negative electrical imbalance across cell membrane with a positive charge on outside and negative on inside Electrophysiology Depolarization - change in intracellular charge from negative to positive due to influx of sodium ions into the interior of the cell which results in muscle contraction Repolarization – electrical imbalance is restored by “pumping” sodium ions out of the cell-results in muscle relaxation Basic EKG Parts of the EKG wave P – atrial depolarization Atrial repolarization is buried under QRS QRS - ventricle depolarization T – ventricular repolarization Basic EKG Basic interpretations of EKG waves Sinus rhythms Start at the SA node Normal sinus rhythm Sinus bradycardia - less than 60 Sinus tachycardia - greater than 100 Sinus arrhythmia – irregular Basic EKG Atrial rhythms Abnormal P wave Premature atrial contraction (PAC) Atrial flutter Rapid atrial rate of 240-400 bpm Characterized as having a saw tooth pattern Atrial fibrillation Early atrial beat caused by an ectopic stimulus in the atria Chaotic twitching of atrial tissue Rate of 360-700 bpm May cause decrease in cardiac output because of impaired ventricular filling Not life threatening Basic EKG Junctional or nodal rhythms Often inverted P wave Stimulus originates near AV node Basic EKG Ventricular arrhythmias Premature Ventricular Contractions Large, wide, bizarre QRS Early in the cycle May not follow P wave Can be dangerous when: Multiple configuration More than 1 in 10 beats Landing near a T wave Basic EKG Ventricular Tachycardia Rapid rate-140-300 bpm Appear like a continuous series of PVC's Dangerous Untreated may cause ventricular fibrillation Ventricular Flutter may appear between ventricular tachycardia and ventricular fibrillation Basic EKG Ventricular Fibrillation Life ending Physiologically the same as cardiac standstill CPR must be initiated Defibrillation Electric shock to totally depolarize heart to allow synchronization of repolarization Stand clear of the bed to avoid shock Stop ventilation Basic EKG Asystole – straight line, no electrical activity, cardiac standstill EMD – electrical mechanical dissonance, electrical activity with no pulse. Also known as Pulseless Electrical Activity Cardiovascular Diseases Hypertension (high pressure in the CV system); Caused by Driving pressure of heart Resistance of vascular system Normal blood pressure is 120/80 systolic/diastolic Cardiovascular Diseases Myocardial Infarction (M.I., "heart attack") Coronary arteries become blocked Tissue become ischemic Tissue becomes necrotic Muscle is weakened Cardiovascular Diseases Cor Pulmonale Right-sided heart failure Usually due to pulmonary disease Right-sided hypertrophy Can cause left-sided failure Venous distension may be noted in neck veins with patient sitting up at 30' angle Cardiovascular Diseases Congenital Abnormalities May cause right to left shunt Blood may be unable to oxygenate Discuss common occurrences VSD ASD Transposition Coarctation Cardiovascular Diseases Vascular Disease Aneurysm Arteriosclerosis Ballooning out of vessels Weakening of vessel Can rupture and cause death Hardening of the arteries by calcium Atherosclerosis Fat deposits Narrowed arteries Cardiovascular Diseases Vascular Disease (cont) Ischemia Decrease blood flow to area For variety of reasons Blood clots Low BP Hemorrhage (loss of the blood) Uncontrolled bleeding Usually a ruptured or torn vessel Cardiovascular Diseases Vascular Disease (cont) Shock Acute peripheral circulatory failure due to: Derangement of circulatory control Loss of circulating fluid Brought about by injury Marked by Pallor Clamminess of the skin Decreased blood pressure Feeble, rapid pulse Decreased respiration Restlessness Anxiety Sometimes unconscious Cardiovascular Diseases Vascular Disease (cont) Phlebitis Inflammation of veins Thrombus stationary clot Cardiovascular Diseases Cardiac Inflammation Endocarditis – inflamed endocardium Myocarditis - inflamed heart muscle Pericarditis - inflamed pericardium May lead to cardiac tamponade (blood in pericardial sac causing compression of the heart muscle.) Cardiovascular Diseases Rheumatic Fever May damage heart valves or muscle Decrease blood flow Angina Pectoris Pain Located over heart, left shoulder or in jaw Due to decreased blood supply (ischemia) to heart by the coronary arteries Cardiovascular Diseases Congestive Heart Failure Impaired cardiac pumping; Caused by: Myocardial infarction Ischemic heart disease Cardiomyopathy