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Group 4
Infection &
Patient Visibility
1
Infection Case Study
Hip hemiarthroplasty after displaced femoral neck fracture: a
survivorship analysis
• Femoral neck fracture – broken knee joint
• Total Hip Arthroplasty – Yes….better results for patients than
internal fixation and hemiarthroplasty.
• Some Results for age group 60 + differ from this:
“0-35 % dislocation cases” – quite high
• REASON ? Major one is comorbidities!
2
Infection Case Study
Biomarkers as a Tool for Management of Immunosuppression
in Transplant Patients
• Immuno-suppressive drugs
• Without immunosuppression therapy, transplatation surgery
could be fatal.
• Therapeutic drug monitoring –
DOES NOT reflect adverse effects to immune cells.
• Pharmacodynamic monitoring (biomarkers)
3
Infection Case Study
Problem of infection in the ICU
• Infections possible - ventilator-associated
pneumonia, catheter-associated urinary tract
infection, catheter-related bloodstream infection
• Need to be attentive to horizontal infection
and
use proper antibiotics for multi-resistant bacteria like
MRSA.
4
Infections in the ICU
• Managing infection in the critical care unit:
how can infection control make the ICU safe?
• Infection Control in the ICU
• Device Related Nosocomial Infection In ICU
5
Types of Infections
Antibiotic Resistance
Pathogens
Ventilator Associated
Pneumonia
Catheter-related
Infections
6
Example: Ventilator
Associated Pneumonia
Risk Factors
Prevention
• Modifiable
• Bronchoscopic
techniques
– Frequency of ventilator
circuit changes
– Antibiotic usage
• Nonmodifiable
– Patient age and gender
– Severity of illness
– Coma
• Nonbronchoscopic
techniques
• Balance between initial
antibiotic and overuse
7
Improvement Stories
Decrease Infection in Neonatal
Intensive Care Unit
8
Improvement Stories
Long-Term Acute Care Hospital
Hand
Hygiene
Active
Surveillance
Culture
9
Improvement Stories
Pursuing perfection in fighting with VAP
and CR-BSIs in ICU
Bundle Methodology
VAP rate per 1,000
device days
CR-BSI rate per 1,000
device days
1997
2004
2002
2004
Medical ICU
29
18
8.2
3.4
Surgical ICU
Similar declines
10.5
4.5
Burn Center
Similar declines
9.5
1.85
Year
VAP: Ventilator-Associated Pneumonia
CR-BSIs: Catheter-Related Bloodstream Infections
10
Thank You!
11