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Group 4 Infection & Patient Visibility 1 Infection Case Study Hip hemiarthroplasty after displaced femoral neck fracture: a survivorship analysis • Femoral neck fracture – broken knee joint • Total Hip Arthroplasty – Yes….better results for patients than internal fixation and hemiarthroplasty. • Some Results for age group 60 + differ from this: “0-35 % dislocation cases” – quite high • REASON ? Major one is comorbidities! 2 Infection Case Study Biomarkers as a Tool for Management of Immunosuppression in Transplant Patients • Immuno-suppressive drugs • Without immunosuppression therapy, transplatation surgery could be fatal. • Therapeutic drug monitoring – DOES NOT reflect adverse effects to immune cells. • Pharmacodynamic monitoring (biomarkers) 3 Infection Case Study Problem of infection in the ICU • Infections possible - ventilator-associated pneumonia, catheter-associated urinary tract infection, catheter-related bloodstream infection • Need to be attentive to horizontal infection and use proper antibiotics for multi-resistant bacteria like MRSA. 4 Infections in the ICU • Managing infection in the critical care unit: how can infection control make the ICU safe? • Infection Control in the ICU • Device Related Nosocomial Infection In ICU 5 Types of Infections Antibiotic Resistance Pathogens Ventilator Associated Pneumonia Catheter-related Infections 6 Example: Ventilator Associated Pneumonia Risk Factors Prevention • Modifiable • Bronchoscopic techniques – Frequency of ventilator circuit changes – Antibiotic usage • Nonmodifiable – Patient age and gender – Severity of illness – Coma • Nonbronchoscopic techniques • Balance between initial antibiotic and overuse 7 Improvement Stories Decrease Infection in Neonatal Intensive Care Unit 8 Improvement Stories Long-Term Acute Care Hospital Hand Hygiene Active Surveillance Culture 9 Improvement Stories Pursuing perfection in fighting with VAP and CR-BSIs in ICU Bundle Methodology VAP rate per 1,000 device days CR-BSI rate per 1,000 device days 1997 2004 2002 2004 Medical ICU 29 18 8.2 3.4 Surgical ICU Similar declines 10.5 4.5 Burn Center Similar declines 9.5 1.85 Year VAP: Ventilator-Associated Pneumonia CR-BSIs: Catheter-Related Bloodstream Infections 10 Thank You! 11