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“Chance favors the prepared mind.” Louis Pasteur SYMBIOSIS ◦ NEUTRALISM ◦ COMMENSUALISM ◦ MUTUALISM ◦ PARASITISM Def: living together or close association of two dissimilar organisms; usually different species Beneficial to both species Marriage would have been a good example but we are not different species. Just from different planets…. Neither symbiont benefits from the relationship. They live in the same space but do not notice each other. Sort-of like polite but soon to be divorced parents. The microorganism benefits from the relationship but not the host. When the indigenous flora remains in its usual place, the host is not harmed but the microorganism lives. Mutual benefits to microorganism and host E. Coli benefits from the nutrients in the bowel of the host. The host benefits from the production of Vitamin K by the E. coli. Lichen is an algae and a fungus living together on a rock. Must live together to survive. Beneficial to the parasite at the cost of the host. A smart parasite does not harm the host but only takes the nutrients it needs – like an orchid on a tree. A “dumb” parasite causes a disease in the host which can make the host die; so will the parasite. Chemotherapy is not only to treat cancer. The use of any drug is a chemotherapeutic use. Started with bark, herbs and teas; moved on to mercury and arsenic 1940’s penicillin (Andrew Fleming) was discovered from mold. Other antibiotics come from bacteria. Many drugs have been synthesized from E. coli 1. Type of genetic material ◦ DNA or RNA 2. 3. 4. 5. 6. 7. 8. 9. Shape of the capsid (protein coat) Number of capsomeres (small protein units) Size of the capsid Presence or absence of an envelope Type of host it infects Type of disease it produces Target cell Immunologic or antigenic properties Possess either DNA or RNA Unable to replicate on own Do not divide by binary fission, mitosis or meiosis Lack genes and enzymes necessary for energy production Use host cell’s ingredients for protein and nucleic acid production Contact can be airborne or contact Virus settles into/ onto the body and enters an open portal. *Virus attaches to cell membrane, injects nucleic acids, “cons” cell’s DNA into synthesizing the new material. New viruses are made until the cell bursts, sending more viral material into the interstitial space. Repeat from *; repeat from *, repeat from *, repeat from * etc Virulent = Lytic cycle ◦ ◦ ◦ ◦ ◦ Attachment Penetration Biosynthesis Assembly Release Temperate ◦ DNA remains integrated with bacterial cell’s chromosomes, generation after generation; this is one way bacteria acquire new genetic information Epstein-Barr virus = nasopharyngeal cancer, Burkitt’s lymphoma, B cell lymphoma Herpesvirus 8 = Karposi’s sarcoma Hepatitis B & C = liver cancer Human papillomavirus = cervical cancer Papillomavirus – Warts Polyomavirus – some tumors; some cancers Herpes Simplex 1 – Cold sores or fever blisters Herpes Simplex 2 – Genital herpes Herpervirus 8 – Kaposi’s sarcoma Herpes zoster – Shingles Varicella - Chicken pox Respiratory infections, pneumonia, conjunctivitis, some tumors Rhinovirus – Colds Poliovirus – Poliomyelitis Hepatitis types A and B – Hepatitis Coxsackievirus – respiratory infections, meningitis Orthomyxoviruses types A and B – Influenza Myxovirus parotidis – Mumps Paramyxovirus – Measles (rubeola) Rhabdovirus - Rabies HIV (main one of this generation) – AIDS HTLV virus (RNA) – Leukemia RNA tumor virus - Tumors Theory 1 - They were around before cells Theory 2 – They came after cells and are made of fragments of cellular materials What do you think?